{"id":"https://openalex.org/W1507877151","doi":"https://doi.org/10.1016/s0021-9258(17)41903-x","title":"Competition between motor molecules (kinesin and cytoplasmic dynein) and fibrous microtubule-associated proteins in binding to microtubules.","display_name":"Competition between motor molecules (kinesin and cytoplasmic dynein) and fibrous microtubule-associated proteins in binding to microtubules.","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W1507877151","doi":"https://doi.org/10.1016/s0021-9258(17)41903-x","mag":"1507877151","pmid":"https://pubmed.ncbi.nlm.nih.gov/8106402"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)41903-x","doi":"https://doi.org/10.1016/s0021-9258(17)41903-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)41903-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)41903-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026709124","display_name":"Hiroki Hagiwara","orcid":"https://orcid.org/0000-0002-8956-7649","observed_orcids":["https://orcid.org/0000-0002-8956-7649"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Hagiwara","raw_affiliation_strings":["Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064257218","display_name":"Hiroshi Yorifuji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Yorifuji","raw_affiliation_strings":["Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048066394","display_name":"Reiko Sato-Yoshitake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Sato-Yoshitake","raw_affiliation_strings":["Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065735206","display_name":"Nobutaka Hirokawa","orcid":"https://orcid.org/0000-0002-0081-5264","observed_orcids":["https://orcid.org/0000-0002-0081-5264"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Hirokawa","raw_affiliation_strings":["Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.458,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.79701363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"269","issue":"5","first_page":"3581","last_page":"3589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinesin","display_name":"kinesin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cytoplasmic-dynein","display_name":"cytoplasmic dynein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microtubule-associated-proteins","display_name":"microtubule-associated proteins","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9670000076293945},{"id":"https://openalex.org/keywords/map2","display_name":"MAP2","score":1.0},{"id":"https://openalex.org/keywords/steric-hindrance","display_name":"steric hindrance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.931922972202301},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.9261672496795654},{"id":"https://openalex.org/C106987784","wikidata":"https://www.wikidata.org/wiki/Q410134","display_name":"Dynein","level":3,"score":0.797658383846283},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6704745292663574},{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.641886830329895},{"id":"https://openalex.org/C134729014","wikidata":"https://www.wikidata.org/wiki/Q21105411","display_name":"Dynactin","level":4,"score":0.6166168451309204},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.552807092666626},{"id":"https://openalex.org/C61081601","wikidata":"https://www.wikidata.org/wiki/Q1102066","display_name":"Microtubule-associated protein","level":3,"score":0.5051727890968323},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.4385635256767273},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3951011300086975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37832921743392944},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32001248002052307}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002499","descriptor_name":"Centrifugation, Density Gradient","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004398","descriptor_name":"Dyneins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004398","descriptor_name":"Dyneins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008961","descriptor_name":"Models, Structural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014461","descriptor_name":"Ultracentrifugation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)41903-x","doi":"https://doi.org/10.1016/s0021-9258(17)41903-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)41903-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8106402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8106402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)41903-x","doi":"https://doi.org/10.1016/s0021-9258(17)41903-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)41903-x","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1484194388","https://openalex.org/W1487975069","https://openalex.org/W1534841581","https://openalex.org/W1542193956","https://openalex.org/W1670681606","https://openalex.org/W1679165404","https://openalex.org/W1685478544","https://openalex.org/W1966298372","https://openalex.org/W1971165215","https://openalex.org/W1975040221","https://openalex.org/W1981791822","https://openalex.org/W1982275607","https://openalex.org/W1989742599","https://openalex.org/W1990033214","https://openalex.org/W1990276386","https://openalex.org/W1998110299","https://openalex.org/W1998503322","https://openalex.org/W2002127644","https://openalex.org/W2004290556","https://openalex.org/W2005759705","https://openalex.org/W2007871841","https://openalex.org/W2012116143","https://openalex.org/W2015229379","https://openalex.org/W2015645618","https://openalex.org/W2023150579","https://openalex.org/W2023864357","https://openalex.org/W2026771024","https://openalex.org/W2028919573","https://openalex.org/W2031316544","https://openalex.org/W2032025357","https://openalex.org/W2033490500","https://openalex.org/W2039270622","https://openalex.org/W2039348923","https://openalex.org/W2042458678","https://openalex.org/W2048464939","https://openalex.org/W2051358675","https://openalex.org/W2055761836","https://openalex.org/W2057963096","https://openalex.org/W2065655530","https://openalex.org/W2067759086","https://openalex.org/W2069677899","https://openalex.org/W2082178278","https://openalex.org/W2082631326","https://openalex.org/W2083068431","https://openalex.org/W2089514327","https://openalex.org/W2090588007","https://openalex.org/W2091143605","https://openalex.org/W2097611008","https://openalex.org/W2100837269","https://openalex.org/W2101405368","https://openalex.org/W2103138603","https://openalex.org/W2113630941","https://openalex.org/W2125763225","https://openalex.org/W2128536686","https://openalex.org/W2128635872","https://openalex.org/W2137231995","https://openalex.org/W2159159780","https://openalex.org/W2163001678","https://openalex.org/W2166585705","https://openalex.org/W2169832500","https://openalex.org/W2173145139","https://openalex.org/W2173789363","https://openalex.org/W2313478411","https://openalex.org/W2411356470","https://openalex.org/W2415732408"],"related_works":["https://openalex.org/W2305072358","https://openalex.org/W1998110299","https://openalex.org/W7130571450","https://openalex.org/W1542193956","https://openalex.org/W3093807067","https://openalex.org/W1981662243","https://openalex.org/W2089863620","https://openalex.org/W2953010568","https://openalex.org/W2012323104","https://openalex.org/W2039348923"],"abstract_inverted_index":{"In":[0],"neuronal":[1],"cells,":[2],"microtubule-associated":[3],"proteins":[4],"(MAPs)":[5],"can":[6],"be":[7],"classified":[8],"into":[9],"two":[10],"distinct":[11],"groups.":[12],"One":[13],"consists":[14],"of":[15,21,32,58,104,108,114,125,158,164,169,175,179,185,207],"force-producing":[16],"MAPs,":[17,34],"the":[18,46,56,60,73,96,105,112,115,149,155,161,167,173,183,204],"main":[19],"components":[20],"which":[22,35],"are":[23],"kinesin":[24,76,138,186],"and":[25,38,53,80,91,127,142,160,177],"cytoplasmic":[26,78,140,188],"dynein.":[27],"The":[28],"other":[29,65],"is":[30,68,99],"composed":[31],"fibrous":[33],"include":[36],"tau":[37,81,126,143],"MAP2.":[39],"Many":[40],"studies":[41],"have":[42],"been":[43],"performed":[44,85],"on":[45,66,118,154],"respective":[47],"groups":[48,61],"to":[49,190],"understand":[50],"their":[51],"structures":[52],"functions.":[54],"However,":[55],"problem":[57],"how":[59],"interact":[62],"with":[63],"each":[64],"microtubules":[67,191],"still":[69],"unresolved.":[70],"To":[71,93],"elucidate":[72],"interaction":[74],"between":[75],"or":[77,82,110,139,144,187],"dynein":[79,141,189],"MAP2,":[83,180],"we":[84,120],"three":[86],"experiments:":[87],"competition,":[88],"motility":[89],"assay,":[90],"cosedimentation.":[92],"distinguish":[94],"whether":[95],"binding":[97,116,123,151,184],"competition":[98,113],"caused":[100],"by":[101,111,192],"steric":[102,193],"hindrance":[103],"projection":[106,174],"domains":[107,124,152],"MAPs":[109],"sites":[117],"microtubules,":[119],"used":[121],"microtubule":[122],"MAP2":[128,145],"as":[129,131],"well":[130],"native":[132],"proteins.":[133],"Our":[134],"results":[135],"revealed":[136],"that":[137],"complete":[146],"for":[147],"almost":[148],"same":[150],"located":[153],"carboxyl-terminal":[156],"side":[157,163],"alpha-":[159],"amino-terminal":[162],"beta-tubulin":[165],"from":[166],"site":[168],"subtilisin":[170],"cleavage.":[171],"Furthermore,":[172],"tau,":[176],"probably":[178],"might":[181],"inhibit":[182],"hindrance.":[194],"These":[195],"findings":[196],"will":[197],"provide":[198],"a":[199],"useful":[200],"step":[201],"toward":[202],"understanding":[203],"regulation":[205],"system":[206],"intracellular":[208],"organelle":[209],"transport.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}