{"id":"https://openalex.org/W1507784087","doi":"https://doi.org/10.1016/s0021-9258(19)67825-7","title":"Inhibition of human seminal fluid and Leishmania donovani phosphatases by molybdate heteropolyanions","display_name":"Inhibition of human seminal fluid and Leishmania donovani phosphatases by molybdate heteropolyanions","publication_year":1991,"publication_date":"1991-02-01","ids":{"openalex":"https://openalex.org/W1507784087","doi":"https://doi.org/10.1016/s0021-9258(19)67825-7","mag":"1507784087","pmid":"https://pubmed.ncbi.nlm.nih.gov/1995614"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)67825-7","doi":"https://doi.org/10.1016/s0021-9258(19)67825-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)67825-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)67825-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068371835","display_name":"Asish K. Saha","orcid":"https://orcid.org/0000-0003-1001-5110","observed_orcids":["https://orcid.org/0000-0003-1001-5110"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A K Saha","raw_affiliation_strings":["Colorado State University, Fort Collins, Colorado 80523, and the TDepartment of Chemistry,","From the $Department of Biochemistv, School of Medicine, University of New Mexico, Albuquerque New Mexico 87131, the \u00a7Department of Chemistry,","Georgetown University, Washington, D. C. 20057"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorado State University, Fort Collins, Colorado 80523, and the TDepartment of Chemistry,","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"From the $Department of Biochemistv, School of Medicine, University of New Mexico, Albuquerque New Mexico 87131, the \u00a7Department of Chemistry,","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Georgetown University, Washington, D. C. 20057","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052889522","display_name":"Debbie C. Crans","orcid":"https://orcid.org/0000-0001-7792-3450","observed_orcids":["https://orcid.org/0000-0001-7792-3450"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D C Crans","raw_affiliation_strings":["Colorado State University, Fort Collins, Colorado 80523, and the TDepartment of Chemistry,","From the $Department of Biochemistv, School of Medicine, University of New Mexico, Albuquerque New Mexico 87131, the \u00a7Department of Chemistry,","Georgetown University, Washington, D. C. 20057"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorado State University, Fort Collins, Colorado 80523, and the TDepartment of Chemistry,","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"From the $Department of Biochemistv, School of Medicine, University of New Mexico, Albuquerque New Mexico 87131, the \u00a7Department of Chemistry,","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Georgetown University, Washington, D. C. 20057","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011868858","display_name":"Michael T. Pope","orcid":"https://orcid.org/0000-0002-4166-3746","observed_orcids":["https://orcid.org/0000-0002-4166-3746"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M T Pope","raw_affiliation_strings":["Colorado State University, Fort Collins, Colorado 80523, and the TDepartment of Chemistry,","From the $Department of Biochemistv, School of Medicine, University of New Mexico, Albuquerque New Mexico 87131, the \u00a7Department of Chemistry,","Georgetown University, Washington, D. C. 20057"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorado State University, Fort Collins, Colorado 80523, and the TDepartment of Chemistry,","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"From the $Department of Biochemistv, School of Medicine, University of New Mexico, Albuquerque New Mexico 87131, the \u00a7Department of Chemistry,","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Georgetown University, Washington, D. C. 20057","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015026075","display_name":"Carmen M. Simone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M Simone","raw_affiliation_strings":["Department of Biochemistry, School of Medicine, University of New Mexico, Albuquerque 87131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, University of New Mexico, Albuquerque 87131","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051421325","display_name":"Robert Hayes Glew","orcid":"https://orcid.org/0000-0003-2453-4771","observed_orcids":["https://orcid.org/0000-0003-2453-4771"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R H Glew","raw_affiliation_strings":["Colorado State University, Fort Collins, Colorado 80523, and the TDepartment of Chemistry,","From the $Department of Biochemistv, School of Medicine, University of New Mexico, Albuquerque New Mexico 87131, the \u00a7Department of Chemistry,","Georgetown University, Washington, D. C. 20057"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorado State University, Fort Collins, Colorado 80523, and the TDepartment of Chemistry,","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"From the $Department of Biochemistv, School of Medicine, University of New Mexico, Albuquerque New Mexico 87131, the \u00a7Department of Chemistry,","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Georgetown University, Washington, D. C. 20057","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.2315,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.91963568,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"266","issue":"6","first_page":"3511","last_page":"3517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11286","display_name":"Polyoxometalates: Synthesis and Applications","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11286","display_name":"Polyoxometalates: Synthesis and Applications","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tartrate-resistant-acid-phosphatase","display_name":"tartrate-resistant acid phosphatase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/prostatic-acid-phosphatase","display_name":"prostatic acid phosphatase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/leishmania-donovani","display_name":"Leishmania donovani","score":0.9409999847412109},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.8629999756813049},{"id":"https://openalex.org/keywords/selective-inhibition","display_name":"selective inhibition","score":0.5799999833106995},{"id":"https://openalex.org/keywords/molybdenum-coordination","display_name":"molybdenum coordination","score":0.5770000219345093},{"id":"https://openalex.org/keywords/ph-dependent-inhibition","display_name":"pH-dependent inhibition","score":0.5659999847412109},{"id":"https://openalex.org/keywords/vanadate","display_name":"vanadate","score":0.7639999985694885},{"id":"https://openalex.org/keywords/arsenate","display_name":"arsenate","score":0.984000027179718},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.871999979019165},{"id":"https://openalex.org/keywords/alpha-mannosidase","display_name":"alpha-mannosidase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/enzyme-active-site","display_name":"enzyme active site","score":0.4189999997615814},{"id":"https://openalex.org/keywords/inhibitor-binding-site","display_name":"inhibitor binding site","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2781116636","wikidata":"https://www.wikidata.org/wiki/Q426228","display_name":"Vanadate","level":2,"score":0.6979469656944275},{"id":"https://openalex.org/C2777699559","wikidata":"https://www.wikidata.org/wiki/Q425046","display_name":"Tartrate","level":2,"score":0.6922664642333984},{"id":"https://openalex.org/C21547065","wikidata":"https://www.wikidata.org/wiki/Q418243","display_name":"Acid phosphatase","level":3,"score":0.6331444978713989},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6330264210700989},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.6281661987304688},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6142557263374329},{"id":"https://openalex.org/C2781333301","wikidata":"https://www.wikidata.org/wiki/Q1950752","display_name":"Leishmania donovani","level":4,"score":0.5864430665969849},{"id":"https://openalex.org/C150757390","wikidata":"https://www.wikidata.org/wiki/Q1985205","display_name":"Non-competitive inhibition","level":3,"score":0.5501488447189331},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5250717997550964},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5231721997261047},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4722428023815155},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.41553381085395813},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3844771385192871},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3102042078971863},{"id":"https://openalex.org/C2778689377","wikidata":"https://www.wikidata.org/wiki/Q2046113","display_name":"Visceral leishmaniasis","level":3,"score":0.11829870939254761},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007893","descriptor_name":"Leishmania donovani","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008982","descriptor_name":"Molybdenum","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013644","descriptor_name":"Tartrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)67825-7","doi":"https://doi.org/10.1016/s0021-9258(19)67825-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)67825-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1995614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1995614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)67825-7","doi":"https://doi.org/10.1016/s0021-9258(19)67825-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)67825-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1920820727","display_name":null,"funder_award_id":"AI18945","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G347229888","display_name":null,"funder_award_id":"GM-40525","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7021465708","display_name":"LEISHMANIA DONOVANI ACID PHOSPHATASE","funder_award_id":"R01AI018945","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1481148204","https://openalex.org/W1549345480","https://openalex.org/W1604651145","https://openalex.org/W1759044010","https://openalex.org/W1845439488","https://openalex.org/W1850881834","https://openalex.org/W1964552130","https://openalex.org/W1978676513","https://openalex.org/W1992033847","https://openalex.org/W1997787363","https://openalex.org/W1997839321","https://openalex.org/W1998872445","https://openalex.org/W2027623283","https://openalex.org/W2056023196","https://openalex.org/W2056766188","https://openalex.org/W2060751180","https://openalex.org/W2063631179","https://openalex.org/W2071893453","https://openalex.org/W2078386170","https://openalex.org/W2080671562","https://openalex.org/W2093157034","https://openalex.org/W2128635872","https://openalex.org/W2969273703","https://openalex.org/W2991986622"],"related_works":["https://openalex.org/W2429223730","https://openalex.org/W45181366","https://openalex.org/W2063689471","https://openalex.org/W2798184021","https://openalex.org/W7199072866","https://openalex.org/W2026761188","https://openalex.org/W2041028236","https://openalex.org/W2991986622","https://openalex.org/W1892531395","https://openalex.org/W2079828878"],"abstract_inverted_index":{"Inhibition":[0],"of":[1,25,40,58,64,91,102,116,158,171,188,207,214,225,233,249,254,257,264],"a":[2,23,77],"tartrate-resistant":[3],"acid":[4,118,236],"phosphatase":[5],"(ACP)":[6],"from":[7,14,123],"Leishmania":[8],"donovani":[9],"and":[10,86,96,131,144,229,252,259],"the":[11,38,59,80,88,94,117,134,138,156,159,185,199,203,212,215,250,262],"tartrate-sensitive":[12],"ACP":[13,104,167,190],"human":[15,124,164,265],"seminal":[16,97,135,165],"fluid":[17,98,136,166],"(prostatic":[18],"ACP)":[19],"was":[20,126],"examined":[21],"using":[22],"series":[24],"13":[26],"molybdate-containing":[27],"heteropolyanions.":[28],"The":[29,100,223],"heteropolyanions":[30],"were":[31,83],"divided":[32],"into":[33],"four":[34,60],"groups":[35],"based":[36],"on":[37,148,163,198],"number":[39],"molybdenum":[41],"atoms":[42],"they":[43],"contain:":[44],"Group":[45,48,51,54],"I,":[46],"Mo4;":[47],"II,":[49],"Mo6-8;":[50],"III,":[52],"Mo12;":[53],"IV,":[55],"Mo18.":[56],"Two":[57],"groups,":[61],"those":[62],"consisting":[63],"compounds":[65,241],"that":[66,180,201,239],"contain":[67],"either":[68],"an":[69,73],"Mo4":[70],"unit":[71,75],"or":[72,121],"Mo18":[74],"with":[76,128,142,175],"heteroatom":[78],"in":[79,261],"central":[81],"cavity,":[82],"potent":[84],"inhibitors":[85,219],"exhibited":[87],"highest":[89],"degree":[90],"selectivity":[92],"against":[93],"leishmanial":[95],"ACPs.":[99],"inhibition":[101,115,232],"prostatic":[103,189],"by":[105,112],"complex":[106,181,192,208],"E2":[107],"could":[108],"be":[109],"completely":[110],"reversed":[111],"dialysis.":[113],"Little":[114],"phosphatase,":[119,137],"beta-glucuronidase,":[120],"alpha-mannosidase":[122],"spleen":[125],"observed":[127],"complexes":[129,228],"B'":[130],"E2.":[132],"For":[133],"Ki":[139],"values":[140],"obtained":[141],"arsenate":[143],"vanadate":[145],"depended":[146],"markedly":[147],"pH,":[149],"suggesting":[150],"that,":[151],"unlike":[152],"most":[153],"other":[154,218],"phosphatases,":[155],"conformation":[157],"inhibitor":[160,177],"binding":[161],"site":[162,187,197],"is":[168],"pH-dependent.":[169],"Results":[170],"competition":[172],"experiments":[173],"performed":[174],"various":[176],"pairs":[178],"indicated":[179],"D2":[182],"binds":[183,194],"to":[184],"active":[186,204],"while":[191],"M":[193,209],"at":[195],"some":[196],"enzyme":[200,216,258],"affects":[202],"site.":[205],"Binding":[206],"also":[210],"modifies":[211],"affinity":[213],"for":[217,247],"such":[220],"as":[221,245],"vanadate.":[222],"potency":[224],"several":[226],"heteropolyanion":[227],"their":[230],"selective":[231],"pathophysiologically":[234],"significant":[235],"phosphatases":[237],"indicate":[238],"these":[240],"may":[242],"have":[243],"value":[244],"tools":[246],"study":[248],"structure":[251],"function":[253],"this":[255],"class":[256],"perhaps":[260],"therapy":[263],"disease.":[266]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}