{"id":"https://openalex.org/W1507175671","doi":"https://doi.org/10.1016/s0021-9258(17)30604-x","title":"The effect of GDP on rod outer segment G-protein interactions.","display_name":"The effect of GDP on rod outer segment G-protein interactions.","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W1507175671","doi":"https://doi.org/10.1016/s0021-9258(17)30604-x","mag":"1507175671","pmid":"https://pubmed.ncbi.nlm.nih.gov/2121732"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)30604-x","doi":"https://doi.org/10.1016/s0021-9258(17)30604-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)30604-x","pdf_url":"https://doi.org/10.1016/s0021-9258(17)30604-x","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)30604-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021536993","display_name":"Joseph Panico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Panico","raw_affiliation_strings":["From the Department of Anatomy , University of Pennsylvania School of Medicine , Philadelphia , Pennsylvania 19104-6058","From the Department of Anatomy, University of Pennsylvania","School of Medicine, Philadelphia, Pennsylvania 19104-6058"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anatomy , University of Pennsylvania School of Medicine , Philadelphia , Pennsylvania 19104-6058","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"From the Department of Anatomy, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"School of Medicine, Philadelphia, Pennsylvania 19104-6058","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"J.H. Parkes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.H. Parkes","raw_affiliation_strings":["From the Department of Anatomy , University of Pennsylvania School of Medicine , Philadelphia , Pennsylvania 19104-6058","From the Department of Anatomy, University of Pennsylvania","School of Medicine, Philadelphia, Pennsylvania 19104-6058"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anatomy , University of Pennsylvania School of Medicine , Philadelphia , Pennsylvania 19104-6058","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"From the Department of Anatomy, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"School of Medicine, Philadelphia, Pennsylvania 19104-6058","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110123184","display_name":"Paul A. Liebman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.A. Liebman","raw_affiliation_strings":["From the Department of Anatomy, University of Pennsylvania","School of Medicine, Philadelphia, Pennsylvania 19104-6058"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Anatomy, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"School of Medicine, Philadelphia, Pennsylvania 19104-6058","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.8441,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.69472653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"265","issue":"31","first_page":"18922","last_page":"18927"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gross-domestic-product","display_name":"gross domestic product","score":0.8980000019073486},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.6909999847412109},{"id":"https://openalex.org/keywords/rod-outer-segments","display_name":"rod outer segments","score":0.8880000114440918},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.7039999961853027},{"id":"https://openalex.org/keywords/guanosine-triphosphate","display_name":"GTP","score":0.6930000185966492},{"id":"https://openalex.org/keywords/gtp-hydrolysis","display_name":"GTP hydrolysis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/phototransduction","display_name":"phototransduction","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4549048840999603},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4247586727142334},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3437499403953552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29588258266448975}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003624","descriptor_name":"Darkness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003624","descriptor_name":"Darkness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003624","descriptor_name":"Darkness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)30604-x","doi":"https://doi.org/10.1016/s0021-9258(17)30604-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)30604-x","pdf_url":"https://doi.org/10.1016/s0021-9258(17)30604-x","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:2121732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2121732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)30604-x","doi":"https://doi.org/10.1016/s0021-9258(17)30604-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)30604-x","pdf_url":"https://doi.org/10.1016/s0021-9258(17)30604-x","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/8","display_name":"Decent work and economic growth","score":0.6899999976158142}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1364376174","display_name":null,"funder_award_id":"EY00012","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4432813807","display_name":null,"funder_award_id":"EY01853","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7435445364","display_name":"MICROPHOTOMETRIC STUDIES ON RETINAL RODS AND CONES","funder_award_id":"5r01ey000012-36","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1507175671.pdf","grobid_xml":"https://content.openalex.org/works/W1507175671.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W95161820","https://openalex.org/W1497290644","https://openalex.org/W1533788848","https://openalex.org/W1544256708","https://openalex.org/W1552426354","https://openalex.org/W1565793031","https://openalex.org/W1566050966","https://openalex.org/W1603066709","https://openalex.org/W1605233189","https://openalex.org/W1653853239","https://openalex.org/W1946180631","https://openalex.org/W1965325003","https://openalex.org/W1978789853","https://openalex.org/W1980322773","https://openalex.org/W1980596504","https://openalex.org/W1989389355","https://openalex.org/W1992905126","https://openalex.org/W2007195248","https://openalex.org/W2011742392","https://openalex.org/W2022708486","https://openalex.org/W2058093402","https://openalex.org/W2072550433","https://openalex.org/W2075676530","https://openalex.org/W2075869274","https://openalex.org/W2080875376","https://openalex.org/W2092721615","https://openalex.org/W2131019594","https://openalex.org/W2146848900","https://openalex.org/W2155832793","https://openalex.org/W2171688993","https://openalex.org/W2178536469"],"related_works":["https://openalex.org/W2411444503","https://openalex.org/W287837525","https://openalex.org/W1497290644","https://openalex.org/W2155832793","https://openalex.org/W2075701361","https://openalex.org/W1573530429","https://openalex.org/W166035736","https://openalex.org/W2016758816","https://openalex.org/W1993471926","https://openalex.org/W1600119412"],"abstract_inverted_index":{"The":[0,120],"role":[1],"of":[2,12,39,43,50,65,69,74,85,105,118,124,138,148,204],"GDP":[3,40,66,133,162,173],"has":[4],"heretofore":[5],"been":[6],"little":[7],"studied":[8],"in":[9,47,71,83,189],"the":[10,37,48,72,103,136,142,170],"analysis":[11],"visual":[13],"receptor":[14,59,210],"G-protein":[15,51,139,155,165,176,197],"(G)":[16],"interactions.":[17],"Here":[18],"we":[19,159],"use":[20],"kinetically":[21],"resolved":[22],"absorption":[23],"and":[24,32,57,77,82,146],"light":[25],"scattering":[26],"spectroscopy,":[27],"centrifugation,":[28],"porous":[29],"membrane":[30,143,171],"filtration,":[31],"enzyme":[33],"assay":[34],"to":[35,53,112,157,182,186,193,199,208],"compare":[36,63],"effectiveness":[38,64],"with":[41,67],"that":[42,68,91,126,161],"GTP":[44,70,113,125,178],"or":[45,130],"gamma-thio-guanosine-5'-triphosphate":[46],"modulation":[49],"binding":[52,156,185,198,203],"rod":[54],"disc":[55],"membranes":[56],"activated":[58,200],"(R*).":[60],"We":[61,89],"also":[62,116],"separation":[73],"G":[75,78,106],"alpha":[76],"beta":[79],"gamma":[80],"subunits":[81,140],"activation":[84,147],"effector,":[86],"cGMP":[87],"phosphodiesterase.":[88,149],"find":[90],"when":[92],"different":[93],"nucleotide":[94],"affinities":[95],"are":[96,115],"taken":[97],"into":[98,144],"account,":[99],"actions":[100,123],"such":[101],"as":[102],"release":[104,137],"from":[107,141],"R*":[108],"binding,":[109],"earlier":[110],"ascribed":[111],"alone,":[114],"typical":[117],"GDP.":[119],"principal":[121],"specific":[122],"occur":[127],"only":[128],"weakly":[129],"undetectably":[131],"for":[132],"are,":[134],"respectively,":[135],"solution":[145],"While":[150],"GDP,":[151],"like":[152],"GTP,":[153],"releases":[154],"receptor,":[158],"argue":[160],"cannot":[163],"mediate":[164],"subunit":[166],"separation,":[167],"even":[168],"on":[169,175,196],"surface.":[172],"retained":[174],"after":[177],"hydrolysis":[179],"may":[180,206],"function":[181,207],"prevent":[183],"tight":[184],"quiescent":[187],"receptors":[188],"a":[190],"manner":[191],"analogous":[192],"its":[194],"action":[195],"receptors.":[201],"Weak":[202],"G.GDP":[205],"accelerate":[209],"catalyzed":[211],"amplification":[212],"during":[213],"transduction.":[214]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}