{"id":"https://openalex.org/W1507034019","doi":"https://doi.org/10.1111/j.1474-9726.2012.00852.x","title":"Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness","display_name":"Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness","publication_year":2012,"publication_date":"2012-06-19","ids":{"openalex":"https://openalex.org/W1507034019","doi":"https://doi.org/10.1111/j.1474-9726.2012.00852.x","mag":"1507034019","pmid":"https://pubmed.ncbi.nlm.nih.gov/22712469","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3444670"},"language":"en","primary_location":{"id":"doi:10.1111/j.1474-9726.2012.00852.x","doi":"https://doi.org/10.1111/j.1474-9726.2012.00852.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2012.00852.x","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3444670","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064986666","display_name":"Edward P. Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward P. Weiss","raw_affiliation_strings":["Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. eweis4@slu.edu","Department of Nutrition and Dietetics, Saint Louis University, St. Louis, MO 63104, USA","Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. eweis4@slu.edu","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Nutrition and Dietetics, Saint Louis University, St. Louis, MO 63104, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004945324","display_name":"Dennis Tan Villareal","orcid":"https://orcid.org/0000-0003-1365-7960","observed_orcids":["https://orcid.org/0000-0003-1365-7960"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210154741","display_name":"New Mexico VA Health Care System","ror":"https://ror.org/04n9z8z70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210154741"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis T. Villareal","raw_affiliation_strings":["Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","Division of Geriatrics, University of New Mexico School of Medicine and New Mexico VA Health Care System, Albuquerque, NM 87131, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Geriatrics, University of New Mexico School of Medicine and New Mexico VA Health Care System, Albuquerque, NM 87131, USA","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4210154741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056703809","display_name":"Ali A. Ehsani","orcid":"https://orcid.org/0000-0001-7873-5371","observed_orcids":["https://orcid.org/0000-0001-7873-5371"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210104016","display_name":"St. Louis VA Medical Center","ror":"https://ror.org/014c68a74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104016","https://openalex.org/I4210150881","https://openalex.org/I4210165236"]},{"id":"https://openalex.org/I4210141150","display_name":"John Cochran VA Medical Center","ror":"https://ror.org/03jt5gp45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210141150","https://openalex.org/I4210150881","https://openalex.org/I4210165236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali A. Ehsani","raw_affiliation_strings":["Cardiology Division, Saint Louis Veterans Administration Medical Center \u2013 John Cochran Division, Saint Louis, MO 63106, USA","Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Saint Louis Veterans Administration Medical Center \u2013 John Cochran Division, Saint Louis, MO 63106, USA","institution_ids":["https://openalex.org/I4210104016","https://openalex.org/I4210141150"]},{"raw_affiliation_string":"Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025203839","display_name":"Luigi Fontana","orcid":"https://orcid.org/0000-0001-8500-5537","observed_orcids":["https://orcid.org/0000-0001-8500-5537"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Luigi Fontana","raw_affiliation_strings":["CEINGE Biotecnologie Avanzate, Napoli, Italy","Department of Medicine, Salerno University Medical School, Salerno, Italy","Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEINGE Biotecnologie Avanzate, Napoli, Italy","institution_ids":["https://openalex.org/I4210128854"]},{"raw_affiliation_string":"Department of Medicine, Salerno University Medical School, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110123538","display_name":"John O. Holloszy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John O. Holloszy","raw_affiliation_strings":["Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5064986666"],"corresponding_institution_ids":["https://openalex.org/I204465549","https://openalex.org/I47838141"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":2.2604,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.89111255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"5","first_page":"876","last_page":"884"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.2272000014781952,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dhea-replacement-therapy","display_name":"DHEA replacement therapy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.9940000176429749},{"id":"https://openalex.org/keywords/carotid-augmentation-index","display_name":"carotid augmentation index","score":0.8080000281333923},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.9639999866485596},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.953000009059906},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dehydroepiandrosterone-sulfate","display_name":"dehydroepiandrosterone sulfate","score":0.8550000190734863},{"id":"https://openalex.org/keywords/free-testosterone","display_name":"free testosterone","score":0.9350000023841858},{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.9279354810714722},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.8454285860061646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6912586688995361},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6183726787567139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6015130877494812},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.5903272032737732},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5746229887008667},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.5308213233947754},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4375859797000885},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.281084269285202},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.27758485078811646},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.266596257686615},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059289","descriptor_name":"Vascular Stiffness","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1474-9726.2012.00852.x","doi":"https://doi.org/10.1111/j.1474-9726.2012.00852.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2012.00852.x","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmid:22712469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22712469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2777516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3444670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3444670","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3444670","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Aging Cell","raw_type":"Text"},{"id":"pmh:oai:iris.unibs.it:11379/305118","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/305118","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2777516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3444670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1182707082","display_name":null,"funder_award_id":"AG020076","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1329088937","display_name":null,"funder_award_id":"DK-080886","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3345799211","display_name":null,"funder_award_id":"DK56341","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4467312596","display_name":null,"funder_award_id":"RR-024992","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G507895129","display_name":null,"funder_award_id":"AG 00078","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7223240130","display_name":"Caloric restriction, exercise, and glucoregulation in humans","funder_award_id":"K01DK080886","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G725115302","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7870180514","display_name":"Washington University Institute of Clinical and Translational Sciences (UL1)","funder_award_id":"UL1RR024992","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8326671572","display_name":"Is DHEA Replacement Therapy Beneficial?","funder_award_id":"R01AG020076","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8584432167","display_name":"EXERCISE AS PREVENTIVE MEDICINE IN THE AGING PROCESS","funder_award_id":"T32AG000078","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G889535532","display_name":null,"funder_award_id":"RR.00036","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000868406","display_name":"Washington University Nutrition Obesity Research Center","funder_award_id":"P30DK056341","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G994453094","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000036","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W122349615","https://openalex.org/W178868123","https://openalex.org/W1498903464","https://openalex.org/W1906567327","https://openalex.org/W1963767129","https://openalex.org/W1966355383","https://openalex.org/W1970423626","https://openalex.org/W1982191008","https://openalex.org/W1987686245","https://openalex.org/W1989366358","https://openalex.org/W2005598262","https://openalex.org/W2011581813","https://openalex.org/W2016913364","https://openalex.org/W2024952507","https://openalex.org/W2034566257","https://openalex.org/W2035182977","https://openalex.org/W2038654926","https://openalex.org/W2058350561","https://openalex.org/W2060638797","https://openalex.org/W2064784013","https://openalex.org/W2065544294","https://openalex.org/W2081225653","https://openalex.org/W2088506591","https://openalex.org/W2095427240","https://openalex.org/W2103164548","https://openalex.org/W2103970084","https://openalex.org/W2110882681","https://openalex.org/W2120098038","https://openalex.org/W2121098010","https://openalex.org/W2125914602","https://openalex.org/W2130213534","https://openalex.org/W2132497033","https://openalex.org/W2133761842","https://openalex.org/W2138209376","https://openalex.org/W2143275861","https://openalex.org/W2144829836","https://openalex.org/W2147047643","https://openalex.org/W2154888535","https://openalex.org/W2158519975","https://openalex.org/W2158528045","https://openalex.org/W2160377398","https://openalex.org/W2162471694","https://openalex.org/W2162508286","https://openalex.org/W2169841521"],"related_works":["https://openalex.org/W4317663726","https://openalex.org/W1983346224","https://openalex.org/W1963767129","https://openalex.org/W2167202416","https://openalex.org/W1967206609","https://openalex.org/W2083177427","https://openalex.org/W2041579049","https://openalex.org/W2062354797","https://openalex.org/W1988185378","https://openalex.org/W2084966393"],"abstract_inverted_index":{"Serum":[0],"dehydroepiandrosterone":[1],"(DHEA)":[2],"concentrations":[3],"decrease":[4],"approximately":[5],"80%":[6],"between":[7,131,147],"ages":[8],"25":[9],"and":[10,32,64,96,103,110,175,188,193,203,232,244,268],"75":[11],"year.":[12,107],"Aging":[13],"also":[14,144,213],"results":[15],"in":[16,19,41,56,101,115,120,126,173,181,197,211,229,256],"an":[17,24,246],"increase":[18],"arterial":[20,46,73,237,266],"stiffness,":[21],"which":[22],"is":[23,36,245],"independent":[25,247],"predictor":[26],"of":[27,72,85,236],"cardiovascular":[28],"disease":[29],"(CVD)":[30],"risk":[31,248],"mortality.":[33],"Therefore,":[34,252],"it":[35],"conceivable":[37],"that":[38,260],"DHEA":[39,53,89,122,227,261],"replacement":[40,54,90,228,262],"older":[42,57],"adults":[43,58],"could":[44],"reduce":[45,269],"stiffness.":[47,74,238],"We":[48],"sought":[49],"to":[50,81],"determine":[51],"whether":[52],"therapy":[55],"reduces":[59],"carotid":[60],"augmentation":[61],"index":[62,218],"(AI)":[63],"carotid-femoral":[65],"pulse":[66],"wave":[67,142],"velocity":[68,143],"(PWV)":[69],"as":[70],"indices":[71,235],"A":[75],"randomized,":[76],"double-blind":[77],"trial":[78],"was":[79],"conducted":[80],"study":[82,258],"the":[83,121,127,163,253],"effects":[84],"50":[86],"mg":[87],"day(-1)":[88],"on":[91],"AI":[92,118,136,174,212],"(n":[93,98],"=":[94,99,139,155,169,201,220,223],"92)":[95],"PWV":[97,176],"51)":[100],"women":[102,233],"men":[104,231],"aged":[105],"65-75":[106],"Inflammatory":[108],"cytokines":[109,183],"sex":[111],"hormones":[112],"were":[113,177],"measured":[114],"fasting":[116],"serum.":[117],"decreased":[119,145],"group,":[123],"but":[124],"not":[125],"placebo":[128],"group":[129],"(difference":[130,146],"groups,":[132,148],"-6":[133],"\u00b1":[134,150],"2":[135],"units,":[137],"P":[138,154,190,206,222],"0.002).":[140],"Pulse":[141],"-3.5":[149],"1.0":[151],"m":[152],"s(-1),":[153],"0.001);":[156],"however,":[157],"after":[158],"adjusting":[159],"for":[160,250],"baseline":[161],"values,":[162],"between-group":[164],"comparison":[165],"became":[166],"nonsignificant":[167],"(P":[168],"0.20).":[170],"The":[171,209],"reductions":[172,210],"accompanied":[178],"by":[179],"decreases":[180],"inflammatory":[182],"(tumor":[184],"necrosis":[185],"factor":[186,249],"\u03b1":[187],"IL-6,":[189],"<":[191,207],"0.05)":[192],"correlated":[194,214],"with":[195,215,242],"increases":[196,241],"serum":[198],"DHEAS":[199],"(r":[200,219],"-0.31":[202],"-0.37,":[204],"respectively,":[205],"0.05).":[208],"free":[216],"testosterone":[217],"-0.23,":[221],"0.03).":[224],"In":[225],"conclusion,":[226],"elderly":[230],"improves":[234],"Arterial":[239],"stiffness":[240],"age":[243],"CVD.":[251],"improvements":[254],"observed":[255],"this":[257],"suggest":[259],"might":[263],"partly":[264],"reverse":[265],"aging":[267],"CVD":[270],"risk.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
