{"id":"https://openalex.org/W1506887248","doi":null,"title":"Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.","display_name":"Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W1506887248","mag":"1506887248","pmid":"https://pubmed.ncbi.nlm.nih.gov/9731479"},"language":"en","primary_location":{"id":"pmid:9731479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9731479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086229141","display_name":"Toyoaki Hida","orcid":"https://orcid.org/0000-0003-3537-0020","observed_orcids":["https://orcid.org/0000-0003-3537-0020"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]},{"id":"https://openalex.org/I4405286927","display_name":"Aichi Cancer Center Hospital","ror":"https://ror.org/03kh0z432","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286927"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Hida","raw_affiliation_strings":["Department of Internal Medicine, Aichi Cancer Center Hospital, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Aichi Cancer Center Hospital, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851","https://openalex.org/I4405286927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065196329","display_name":"Yasushi Yatabe","orcid":"https://orcid.org/0000-0003-1788-559X","observed_orcids":["https://orcid.org/0000-0003-1788-559X"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Yatabe","raw_affiliation_strings":["Aichi Cancer Center Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center Hospital and Research Institute","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082083626","display_name":"Hiroyuki Achiwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Achiwa","raw_affiliation_strings":["Aichi Cancer Center Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center Hospital and Research Institute","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077700276","display_name":"Hideki Muramatsu","orcid":"https://orcid.org/0000-0002-8801-0021","observed_orcids":["https://orcid.org/0000-0002-8801-0021"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Muramatsu","raw_affiliation_strings":["Aichi Cancer Center Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center Hospital and Research Institute","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111904400","display_name":"Ken\u2010ichi Kozaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kozaki","raw_affiliation_strings":["Dental School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dental School","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113553546","display_name":"Shigeo Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Nakamura","raw_affiliation_strings":["Aichi Cancer Center Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center Hospital and Research Institute","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Ogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Ogawa","raw_affiliation_strings":["Aichi Cancer Center Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center Hospital and Research Institute","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081110935","display_name":"Tetsuya Mitsudomi","orcid":"https://orcid.org/0000-0001-9860-8505","observed_orcids":["https://orcid.org/0000-0001-9860-8505"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Mitsudomi","raw_affiliation_strings":["Aichi Cancer Center Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center Hospital and Research Institute","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108294884","display_name":"Takahiko Sugiura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Sugiura","raw_affiliation_strings":["Aichi Cancer Center Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center Hospital and Research Institute","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090236371","display_name":"Takashi Takahashi","orcid":"https://orcid.org/0000-0003-0615-7001","observed_orcids":["https://orcid.org/0000-0003-0615-7001"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Takahashi","raw_affiliation_strings":["Aichi Cancer Center Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center Hospital and Research Institute","institution_ids":["https://openalex.org/I4210133851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":20.2837,"has_fulltext":false,"cited_by_count":815,"citation_normalized_percentile":{"value":0.99575912,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"58","issue":"17","first_page":"3761","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7710000276565552},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/atypical-adenomatous-hyperplasia","display_name":"atypical adenomatous hyperplasia","score":0.949999988079071},{"id":"https://openalex.org/keywords/carcinoma-in-situ","display_name":"carcinoma in situ","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/small-cell-carcinoma","display_name":"small cell carcinoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5239999890327454},{"id":"https://openalex.org/keywords/metastatic-phenotype","display_name":"metastatic phenotype","score":0.6359999775886536},{"id":"https://openalex.org/keywords/premalignant-lung-lesions","display_name":"premalignant lung lesions","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.814886212348938},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6868793368339539},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5922954082489014},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.5399603247642517},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5227482318878174},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46527430415153503},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.45015332102775574},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.441759318113327},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4306243062019348},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41872477531433105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3902820348739624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30096763372421265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16828271746635437},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1519031524658203},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9731479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9731479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1506887248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9731479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2012890445","https://openalex.org/W2392740958","https://openalex.org/W2165494849","https://openalex.org/W1967257081","https://openalex.org/W1966345401","https://openalex.org/W1989919135","https://openalex.org/W2382902704","https://openalex.org/W2050310941","https://openalex.org/W2008689448","https://openalex.org/W2138149687"],"abstract_inverted_index":{"Cyclooxygenase":[0],"(COX)-2":[1],"expression":[2,36,57,75,115],"was":[3,37,58,76],"immunohistochemically":[4],"examined":[5],"in":[6,14,27,39,48,55,60,79,84,113],"59":[7],"human":[8],"lung":[9,18],"cancers":[10],"as":[11,13],"well":[12],"normal":[15,28],"and":[16,46,51,98,104,124,131],"premalignant":[17],"specimens.":[19],"In":[20,89],"contrast":[21],"to":[22],"scattered":[23],"weak":[24],"reactivity":[25],"seen":[26],"peripheral":[29],"airway":[30],"epithelial":[31],"cells,":[32],"markedly":[33],"up-regulated":[34],"COX-2":[35,56,74,114],"detected":[38],"about":[40],"one-third":[41],"of":[42,62,69,122,128],"atypical":[43],"adenomatous":[44],"hyperplasias":[45],"carcinoma":[47],"situ":[49],"specimens,":[50],"a":[52],"significant":[53],"increase":[54,112],"observed":[59],"70%":[61],"invasive":[63,130],"adenocarcinoma":[64,70],"cases.":[65],"Interestingly,":[66],"the":[67,85,120],"proportion":[68],"cells":[71],"with":[72,119,126],"marked":[73],"much":[77],"greater":[78],"lymph":[80],"node":[81],"metastases":[82],"than":[83],"corresponding":[86],"primary":[87],"tumors.":[88],"contrast,":[90],"small":[91],"cell":[92,100],"carcinomas":[93,101],"showed":[94,102],"virtually":[95],"negligible":[96],"expression,":[97],"squamous":[99],"infrequent":[103],"low":[105],"expression.":[106],"These":[107],"findings":[108],"suggest":[109],"that":[110],"an":[111,129],"may":[116],"be":[117],"associated":[118],"development":[121],"adenocarcinomas":[123],"possibly":[125],"acquisition":[127],"metastatic":[132],"phenotype.":[133]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":36},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
