{"id":"https://openalex.org/W1506636656","doi":"https://doi.org/10.1111/j.1365-2141.2011.08612.x","title":"Comparative proteomics reveals deficiency of SLC9A1 (sodium/hydrogen exchanger NHE1) in \u03b2\u2010adducin null red cells","display_name":"Comparative proteomics reveals deficiency of SLC9A1 (sodium/hydrogen exchanger NHE1) in \u03b2\u2010adducin null red cells","publication_year":2011,"publication_date":"2011-06-21","ids":{"openalex":"https://openalex.org/W1506636656","doi":"https://doi.org/10.1111/j.1365-2141.2011.08612.x","mag":"1506636656","pmid":"https://pubmed.ncbi.nlm.nih.gov/21689084","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4515348"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2141.2011.08612.x","doi":"https://doi.org/10.1111/j.1365-2141.2011.08612.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2011.08612.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.2011.08612.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.2011.08612.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044800579","display_name":"Jason M. Wooden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799735646","display_name":"Bloodworks Northwest","ror":"https://ror.org/00ek9j693","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799735646"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason M. Wooden","raw_affiliation_strings":["Puget Sound Blood Center, Seattle, WA 98104, USA. jasonw@psbc.org","Department of Medicine, Hematology Division, University of Washington School of Medicine","Puget Sound Blood Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Puget Sound Blood Center, Seattle, WA 98104, USA. jasonw@psbc.org","institution_ids":["https://openalex.org/I2799735646"]},{"raw_affiliation_string":"Department of Medicine, Hematology Division, University of Washington School of Medicine","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Puget Sound Blood Center","institution_ids":["https://openalex.org/I2799735646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111650151","display_name":"Greg L. Finney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg L. Finney","raw_affiliation_strings":["Genome Sciences, University of Washington School of Medicine, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Sciences, University of Washington School of Medicine, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088660764","display_name":"Eric Rynes","orcid":"https://orcid.org/0000-0003-0620-631X","observed_orcids":["https://orcid.org/0000-0003-0620-631X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Rynes","raw_affiliation_strings":["Genome Sciences, University of Washington School of Medicine, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Sciences, University of Washington School of Medicine, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043959168","display_name":"Michael J. MacCoss","orcid":"https://orcid.org/0000-0003-1853-0256","observed_orcids":["https://orcid.org/0000-0003-1853-0256"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. MacCoss","raw_affiliation_strings":["Genome Sciences, University of Washington School of Medicine, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Sciences, University of Washington School of Medicine, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102972301","display_name":"Amy J. Lambert","orcid":"https://orcid.org/0000-0002-1481-5839","observed_orcids":["https://orcid.org/0000-0002-1481-5839"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy J. Lambert","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076720751","display_name":"Raymond F. Robledo","orcid":"https://orcid.org/0000-0003-3606-3073","observed_orcids":["https://orcid.org/0000-0003-3606-3073"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond F. Robledo","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036956129","display_name":"Luanne L. Peters","orcid":"https://orcid.org/0000-0002-0784-0534","observed_orcids":["https://orcid.org/0000-0002-0784-0534"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luanne L. Peters","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009668677","display_name":"Diana M. Gilligan","orcid":"https://orcid.org/0000-0003-4773-6069","observed_orcids":["https://orcid.org/0000-0003-4773-6069"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2799735646","display_name":"Bloodworks Northwest","ror":"https://ror.org/00ek9j693","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799735646"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana M. Gilligan","raw_affiliation_strings":["Department of Medicine, Hematology Division, University of Washington School of Medicine","Puget Sound Blood Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hematology Division, University of Washington School of Medicine","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Puget Sound Blood Center","institution_ids":["https://openalex.org/I2799735646"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5044800579"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I2799735646"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.2377,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77183205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"154","issue":"4","first_page":"492","last_page":"501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nhe1","display_name":"NHE1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.9100000262260437},{"id":"https://openalex.org/keywords/beta-adducin","display_name":"beta-adducin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/alpha-adducin","display_name":"alpha-adducin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hereditary-spherocytosis","display_name":"hereditary spherocytosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hemolytic-anemia","display_name":"hemolytic anemia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/reticulocytes","display_name":"reticulocytes","score":0.8299999833106995},{"id":"https://openalex.org/keywords/erythrocyte-ghosts","display_name":"erythrocyte ghosts","score":0.75},{"id":"https://openalex.org/keywords/reticulocytosis","display_name":"reticulocytosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/phenylhydrazine","display_name":"phenylhydrazine","score":0.8080000281333923},{"id":"https://openalex.org/keywords/red-blood-cell-fragility","display_name":"red blood cell fragility","score":0.6389999985694885},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C2776952295","wikidata":"https://www.wikidata.org/wiki/Q541244","display_name":"Hereditary spherocytosis","level":2,"score":0.9217585325241089},{"id":"https://openalex.org/C2777799521","wikidata":"https://www.wikidata.org/wiki/Q2320954","display_name":"Reticulocytosis","level":3,"score":0.8494709134101868},{"id":"https://openalex.org/C2779245863","wikidata":"https://www.wikidata.org/wiki/Q11181178","display_name":"Spherocytosis","level":4,"score":0.7942280769348145},{"id":"https://openalex.org/C2778403015","wikidata":"https://www.wikidata.org/wiki/Q1404923","display_name":"Reticulocyte","level":4,"score":0.6661473512649536},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.49706223607063293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4537229835987091},{"id":"https://openalex.org/C151666851","wikidata":"https://www.wikidata.org/wiki/Q1433921","display_name":"Heinz body","level":3,"score":0.41517600417137146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37477418780326843},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37200334668159485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34502533078193665},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.33412230014801025},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.3154914975166321},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2684601843357086},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2661464214324951},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.190720796585083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18190467357635498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1758040487766266},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.11764267086982727},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.0},{"id":"https://openalex.org/C2776309230","wikidata":"https://www.wikidata.org/wiki/Q580383","display_name":"Splenectomy","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000074082","descriptor_name":"Sodium-Hydrogen Exchanger 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099291","descriptor_name":"Adducins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D012156","descriptor_name":"Reticulocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1365-2141.2011.08612.x","doi":"https://doi.org/10.1111/j.1365-2141.2011.08612.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2011.08612.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.2011.08612.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:21689084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21689084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3490129","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4515348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4515348","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4515348","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Br J Haematol","raw_type":"Text"},{"id":"pmh:oai:mouseion.jax.org:stfb2011-1069","doi":null,"is_oa":true,"landing_page_url":"https://mouseion.jax.org/stfb2011/70","pdf_url":"http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2011.08612.x/abstract","source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2011","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2141.2011.08612.x","doi":"https://doi.org/10.1111/j.1365-2141.2011.08612.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.2011.08612.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2141.2011.08612.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2515975477","display_name":"Hereditary Hemolytic Anemia: A Proteomic Approach","funder_award_id":"5f32hl079771-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4172154150","display_name":"Comprehensive Biology: Exploiting the Yeast Genome","funder_award_id":"P41RR011823","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4174584640","display_name":null,"funder_award_id":"F32 HL079771","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4579730608","display_name":"Hereditary Hemolytic Anemia: A Proteomic Approach","funder_award_id":"5f32hl079771-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6468495162","display_name":"Adducin and the Membrane Skeleton","funder_award_id":"R01HL075714","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6929272876","display_name":"Genetic Identification of Novel Genes Critical in Erythropoiesis","funder_award_id":"R01HL088468","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000903675","display_name":"Interdisciplinary Training in Genome Sciences","funder_award_id":"T32HG000035","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1506636656.pdf","grobid_xml":"https://content.openalex.org/works/W1506636656.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W21629621","https://openalex.org/W57617629","https://openalex.org/W168728562","https://openalex.org/W1558538072","https://openalex.org/W1567378741","https://openalex.org/W1755848100","https://openalex.org/W1964299129","https://openalex.org/W1976225127","https://openalex.org/W1982989323","https://openalex.org/W1993276324","https://openalex.org/W1993930759","https://openalex.org/W1995509779","https://openalex.org/W2001806360","https://openalex.org/W2004226305","https://openalex.org/W2007456227","https://openalex.org/W2008097533","https://openalex.org/W2011196330","https://openalex.org/W2022066534","https://openalex.org/W2032564067","https://openalex.org/W2046838656","https://openalex.org/W2049237667","https://openalex.org/W2053849089","https://openalex.org/W2053943711","https://openalex.org/W2060687142","https://openalex.org/W2060739299","https://openalex.org/W2061734853","https://openalex.org/W2063692850","https://openalex.org/W2072141006","https://openalex.org/W2077039511","https://openalex.org/W2077728564","https://openalex.org/W2078005434","https://openalex.org/W2083538044","https://openalex.org/W2086508062","https://openalex.org/W2098143583","https://openalex.org/W2102934052","https://openalex.org/W2105539899","https://openalex.org/W2126768186","https://openalex.org/W2127132889","https://openalex.org/W2133424890","https://openalex.org/W2135923382","https://openalex.org/W2157561719","https://openalex.org/W2185156651","https://openalex.org/W2419512033","https://openalex.org/W2574923021"],"related_works":["https://openalex.org/W6940825253","https://openalex.org/W2587683194","https://openalex.org/W2060397682","https://openalex.org/W2577536444","https://openalex.org/W2063692850","https://openalex.org/W4239373634","https://openalex.org/W2125943336","https://openalex.org/W21629621","https://openalex.org/W2883665152","https://openalex.org/W2979466184"],"abstract_inverted_index":{"Spherocytosis":[0],"is":[1,40,161],"one":[2],"of":[3,15,37,165],"the":[4,29,33,114,130,139,146,162,175],"most":[5],"common":[6],"inherited":[7],"disorders,":[8],"yet":[9],"presents":[10],"with":[11,27,107],"a":[12,55],"wide":[13],"range":[14],"clinical":[16],"severity.":[17],"While":[18],"several":[19],"genes":[20],"have":[21],"been":[22],"found":[23],"mutated":[24],"in":[25,35,49,63,88,118,127,133,167],"patients":[26],"spherocytosis,":[28],"molecular":[30],"basis":[31],"for":[32],"variability":[34],"severity":[36],"haemolytic":[38,50,94,168],"anaemia":[39,51,169],"not":[41],"entirely":[42],"understood.":[43],"To":[44],"identify":[45],"candidate":[46],"proteins":[47,78,84,116,131],"involved":[48],"pathophysiology,":[52],"we":[53,100],"utilized":[54],"label-free":[56],"comparative":[57],"proteomic":[58],"approach":[59],"to":[60,178],"detect":[61],"differences":[62],"red":[64],"blood":[65],"cells":[66],"(RBCs)":[67],"from":[68,104,110],"normal":[69],"and":[70,82,170],"\u03b2-adducin":[71,89],"(Add2)":[72],"knock-out":[73],"mice.":[74,112],"We":[75,152],"detected":[76],"seven":[77],"that":[79,85],"were":[80,86,124],"decreased":[81,132],"48":[83,115],"increased":[87,117,126],"null":[90],"RBC":[91],"ghosts.":[92],"Since":[93],"anaemias":[95],"are":[96],"characterized":[97],"by":[98,144,158],"reticulocytosis,":[99],"compared":[101],"reticulocyte-enriched":[102],"samples":[103],"phenylhydrazine-treated":[105],"mice":[106],"mature":[108],"RBCs":[109],"untreated":[111],"Among":[113],"Add2":[119,134],"knockout":[120,135],"RBCs,":[121,136],"only":[122],"11":[123],"also":[125],"reticulocytes.":[128],"Of":[129],"\u03b1-adducin":[137],"showed":[138],"greatest":[140],"intensity":[141],"difference,":[142],"followed":[143],"SLC9A1,":[145],"sodium-hydrogen":[147],"exchanger":[148],"previously":[149],"termed":[150],"NHE1.":[151],"verified":[153],"these":[154],"mass":[155],"spectrometry":[156],"results":[157],"immunoblot.":[159],"This":[160],"first":[163],"example":[164],"SLC9A1deficiency":[166],"suggests":[171],"new":[172],"insights":[173],"into":[174],"mechanisms":[176],"leading":[177],"fragile":[179],"RBCs.":[180]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}