{"id":"https://openalex.org/W1506628148","doi":"https://doi.org/10.1111/j.1747-0803.2011.00504.x","title":"Liver Disease in the Patient with Fontan Circulation","display_name":"Liver Disease in the Patient with Fontan Circulation","publication_year":2011,"publication_date":"2011-03-28","ids":{"openalex":"https://openalex.org/W1506628148","doi":"https://doi.org/10.1111/j.1747-0803.2011.00504.x","mag":"1506628148","pmid":"https://pubmed.ncbi.nlm.nih.gov/21443554"},"language":"en","primary_location":{"id":"doi:10.1111/j.1747-0803.2011.00504.x","doi":"https://doi.org/10.1111/j.1747-0803.2011.00504.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1747-0803.2011.00504.x","pdf_url":null,"source":{"id":"https://openalex.org/S173391249","display_name":"Congenital Heart Disease","issn_l":"1747-079X","issn":["1747-079X","1747-0803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congenital Heart Disease","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012980105","display_name":"Fred Ming-Chieh Wu","orcid":"https://orcid.org/0000-0002-4580-8199","observed_orcids":["https://orcid.org/0000-0002-4580-8199"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fred M. Wu","raw_affiliation_strings":["Boston Adult Congenital Heart Service, Department of Cardiology, Children's Hospital Boston, Boston, MA 02115, USA. fred.wu@cardio.chboston.org","Boston Adult Congenital Heart Service, Department of Cardiology, Children's Hospital Boston, Boston, Mass","Division of Cardiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Adult Congenital Heart Service, Department of Cardiology, Children's Hospital Boston, Boston, MA 02115, USA. fred.wu@cardio.chboston.org","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Boston Adult Congenital Heart Service, Department of Cardiology, Children's Hospital Boston, Boston, Mass","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Division of Cardiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070324246","display_name":"Chinweike Ukomadu","orcid":"https://orcid.org/0000-0002-7433-0083","observed_orcids":["https://orcid.org/0000-0002-7433-0083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chinweike Ukomadu","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061079739","display_name":"Robert Daniel Odze","orcid":"https://orcid.org/0000-0001-7910-8273","observed_orcids":["https://orcid.org/0000-0001-7910-8273"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Odze","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033468696","display_name":"Anne Marie Valente","orcid":"https://orcid.org/0000-0002-8357-694X","observed_orcids":["https://orcid.org/0000-0002-8357-694X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Marie Valente","raw_affiliation_strings":["Boston Adult Congenital Heart Service, Department of Cardiology, Children's Hospital Boston, Boston, Mass","Division of Cardiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Adult Congenital Heart Service, Department of Cardiology, Children's Hospital Boston, Boston, Mass","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Division of Cardiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023064529","display_name":"John Eleanor Mayer","orcid":"https://orcid.org/0000-0002-5849-2971","observed_orcids":["https://orcid.org/0000-0002-5849-2971"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Mayer Jr.","raw_affiliation_strings":["Department of Cardiovascular Surgery, Children's Hospital Boston, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Children's Hospital Boston, Boston, Mass","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011137806","display_name":"Michael G. Earing","orcid":"https://orcid.org/0000-0001-9108-9626","observed_orcids":["https://orcid.org/0000-0001-9108-9626"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Earing","raw_affiliation_strings":["Medical College of Wisconsin, Milwaukee, Wis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, Milwaukee, Wis, USA","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012980105"],"corresponding_institution_ids":["https://openalex.org/I1288882113"],"apc_list":{"value":3100,"currency":"USD","value_usd":3100},"apc_paid":null,"fwci":1.7585,"has_fulltext":false,"cited_by_count":140,"citation_normalized_percentile":{"value":0.83346124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"6","issue":"3","first_page":"190","last_page":"201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fontan-circulation","display_name":"Fontan circulation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.9129999876022339},{"id":"https://openalex.org/keywords/fontan-failure","display_name":"Fontan failure","score":0.7170000076293945},{"id":"https://openalex.org/keywords/single-ventricle","display_name":"single ventricle","score":0.7080000042915344},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.800000011920929},{"id":"https://openalex.org/keywords/tricuspid-atresia","display_name":"tricuspid atresia","score":0.7590000033378601},{"id":"https://openalex.org/keywords/long-term-outcomes","display_name":"long-term outcomes","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.917242169380188},{"id":"https://openalex.org/C2776229447","wikidata":"https://www.wikidata.org/wiki/Q1283303","display_name":"Tricuspid atresia","level":3,"score":0.7320264577865601},{"id":"https://openalex.org/C2776974648","wikidata":"https://www.wikidata.org/wiki/Q1413554","display_name":"Fontan procedure","level":3,"score":0.7044316530227661},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.6144154667854309},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5977051258087158},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.53118896484375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5181320905685425},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4892442226409912},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4345383942127228},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.42566654086112976},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38834458589553833},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008102","descriptor_name":"Liver Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011652","descriptor_name":"Pulmonary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018729","descriptor_name":"Fontan Procedure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1747-0803.2011.00504.x","doi":"https://doi.org/10.1111/j.1747-0803.2011.00504.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1747-0803.2011.00504.x","pdf_url":null,"source":{"id":"https://openalex.org/S173391249","display_name":"Congenital Heart Disease","issn_l":"1747-079X","issn":["1747-079X","1747-0803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congenital Heart Disease","raw_type":"journal-article"},{"id":"pmid:21443554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21443554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Congenital heart disease","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W63964101","https://openalex.org/W68774111","https://openalex.org/W138424127","https://openalex.org/W1572825624","https://openalex.org/W1963562435","https://openalex.org/W1966524265","https://openalex.org/W1967655544","https://openalex.org/W1967982404","https://openalex.org/W1970361051","https://openalex.org/W1980448734","https://openalex.org/W1980508753","https://openalex.org/W1980748566","https://openalex.org/W1980944567","https://openalex.org/W1982878947","https://openalex.org/W1985825819","https://openalex.org/W1992307897","https://openalex.org/W1994261447","https://openalex.org/W1996105652","https://openalex.org/W1997644173","https://openalex.org/W1998839443","https://openalex.org/W2003678720","https://openalex.org/W2006711764","https://openalex.org/W2010111787","https://openalex.org/W2010400293","https://openalex.org/W2010828605","https://openalex.org/W2012293076","https://openalex.org/W2012929484","https://openalex.org/W2024894304","https://openalex.org/W2026801707","https://openalex.org/W2030474278","https://openalex.org/W2031723327","https://openalex.org/W2044449286","https://openalex.org/W2045836736","https://openalex.org/W2047293287","https://openalex.org/W2048080797","https://openalex.org/W2049182964","https://openalex.org/W2056536823","https://openalex.org/W2064596527","https://openalex.org/W2066007272","https://openalex.org/W2073686990","https://openalex.org/W2081438731","https://openalex.org/W2083765813","https://openalex.org/W2086529760","https://openalex.org/W2087998077","https://openalex.org/W2089553280","https://openalex.org/W2090544095","https://openalex.org/W2099835495","https://openalex.org/W2100564663","https://openalex.org/W2102446664","https://openalex.org/W2102858359","https://openalex.org/W2103457558","https://openalex.org/W2105329651","https://openalex.org/W2105390876","https://openalex.org/W2109943163","https://openalex.org/W2114731053","https://openalex.org/W2118132159","https://openalex.org/W2119398309","https://openalex.org/W2119977690","https://openalex.org/W2123764130","https://openalex.org/W2124415477","https://openalex.org/W2128535429","https://openalex.org/W2138331123","https://openalex.org/W2155520759","https://openalex.org/W2158619791","https://openalex.org/W2160219711","https://openalex.org/W2314619766","https://openalex.org/W2334361193","https://openalex.org/W2335841220","https://openalex.org/W2369411874","https://openalex.org/W2398952854","https://openalex.org/W2403339587","https://openalex.org/W2411258829","https://openalex.org/W2412144701","https://openalex.org/W2414197639","https://openalex.org/W2469016042","https://openalex.org/W2475063279","https://openalex.org/W3022029673","https://openalex.org/W3146956409","https://openalex.org/W4240543789"],"related_works":["https://openalex.org/W2169590019","https://openalex.org/W4323045024","https://openalex.org/W4320008187","https://openalex.org/W2793049704","https://openalex.org/W2934668546","https://openalex.org/W2042364259","https://openalex.org/W2102996974","https://openalex.org/W7164232194","https://openalex.org/W2913315752","https://openalex.org/W4407293981"],"abstract_inverted_index":{"The":[0,108,149],"Fontan":[1,50,89,106,120,166],"procedure":[2,24,51],"has":[3,115],"undergone":[4],"many":[5],"modifications":[6],"since":[7],"first":[8],"being":[9],"performed":[10],"on":[11],"a":[12,38,59],"patient":[13],"with":[14,30,48],"tricuspid":[15],"valve":[16],"atresia":[17],"in":[18,36,85,97,105,124,146,164],"1968.":[19],"It":[20],"is":[21,41,154],"now":[22],"the":[23,49,55,65,71,79,88,98,138,157,165],"of":[25,46,57,74,87,111,140,151],"choice":[26],"for":[27,34],"individuals":[28],"born":[29],"single-ventricle":[31],"physiology":[32,73],"or":[33,69],"those":[35],"whom":[37],"biventricular":[39],"repair":[40],"not":[42],"feasible.":[43],"Forty":[44],"years":[45],"experience":[47],"have":[52,101,122,129,174],"gradually":[53],"revealed":[54],"shortfalls":[56],"such":[58],"circulatory":[60],"arrangement.":[61],"Sequelae":[62],"related":[63],"to":[64,70,131,143,155,161,169,176],"underlying":[66],"congenital":[67],"anomaly":[68],"altered":[72],"passive,":[75],"nonpulsatile":[76],"flow":[77],"through":[78],"pulmonary":[80],"arterial":[81],"bed":[82],"can":[83],"result":[84],"failure":[86],"circulation":[90],"over":[91],"time.":[92],"Liver":[93],"abnormalities":[94,96],"including":[95],"clotting":[99],"cascade":[100],"been":[102],"well":[103],"documented":[104],"patients.":[107],"clinical":[109],"significance":[110],"these":[112],"findings,":[113],"however,":[114],"remained":[116],"poorly":[117],"understood.":[118],"As":[119],"survivors":[121],"increased":[123],"age":[125],"and":[126,137,168],"number,":[127],"we":[128],"begun":[130],"better":[132],"recognize":[133],"subclinical":[134],"hepatic":[135],"dysfunction":[136],"contribution":[139],"liver":[141,162],"disease":[142,163],"adverse":[144],"outcomes":[145],"this":[147,152],"population.":[148],"purpose":[150],"review":[153],"summarize":[156],"existing":[158],"data":[159],"pertaining":[160],"population":[167],"identify":[170],"some":[171],"questions":[172],"that":[173],"yet":[175],"be":[177],"answered.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}