{"id":"https://openalex.org/W150638804","doi":"https://doi.org/10.4049/jimmunol.178.supp.53.4","title":"Complement-mediated hemolytic anemia and platelet activation in mCd59a and mCd59b double knockout mice (53.4)","display_name":"Complement-mediated hemolytic anemia and platelet activation in mCd59a and mCd59b double knockout mice (53.4)","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W150638804","doi":"https://doi.org/10.4049/jimmunol.178.supp.53.4","mag":"150638804"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.178.supp.53.4","doi":"https://doi.org/10.4049/jimmunol.178.supp.53.4","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.53.4","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002075826","display_name":"Xuebin Qin","orcid":"https://orcid.org/0000-0001-9875-983X","observed_orcids":["https://orcid.org/0000-0001-9875-983X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuebin Qin","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082227068","display_name":"Weiguo Hu","orcid":"https://orcid.org/0000-0002-7397-6800","observed_orcids":["https://orcid.org/0000-0002-7397-6800"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiguo Hu","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034524873","display_name":"Wenping Song","orcid":"https://orcid.org/0000-0002-1171-4266","observed_orcids":["https://orcid.org/0000-0002-1171-4266"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenping Song","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036959261","display_name":"Luciano Grubissich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luciano Grubissich","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108729472","display_name":"Yanli Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanli Song","raw_affiliation_strings":["Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115","2Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102051693","display_name":"Gongxiong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gongxiong Wu","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031892713","display_name":"Xuemei Hu","orcid":"https://orcid.org/0000-0001-9009-0983","observed_orcids":["https://orcid.org/0000-0001-9009-0983"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuemei Hu","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029311054","display_name":"Sean P. Ferris","orcid":"https://orcid.org/0000-0001-5407-7212","observed_orcids":["https://orcid.org/0000-0001-5407-7212"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Ferris","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087190567","display_name":"Martin Dobarro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Dobarro","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072613124","display_name":"Selena M. Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selena Bauer","raw_affiliation_strings":["Whitaker Cardiovascular Institute, Boston University School of Medicine , 650 Albany Street, Boston, MA, 02118","3Whitaker Cardiovascular Institute, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitaker Cardiovascular Institute, Boston University School of Medicine , 650 Albany Street, Boston, MA, 02118","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"3Whitaker Cardiovascular Institute, Boston University School of Medicine, 650 Albany Street, Boston, MA, 02118","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036280404","display_name":"Martin Feelisch","orcid":"https://orcid.org/0000-0003-2320-1158","observed_orcids":["https://orcid.org/0000-0003-2320-1158"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Feelisch","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061025856","display_name":"Jane A. Leopold","orcid":"https://orcid.org/0000-0003-0598-8882","observed_orcids":["https://orcid.org/0000-0003-0598-8882"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane A Leopold","raw_affiliation_strings":["Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115","2Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028396638","display_name":"Joseph Loscalzo","orcid":"https://orcid.org/0000-0002-1153-8047","observed_orcids":["https://orcid.org/0000-0002-1153-8047"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Loscalzo","raw_affiliation_strings":["Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115","2Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"2Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, NRB Room 654, 77 Avenue Louis Pasteur, Boston, MA, 02115,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086918952","display_name":"Jos\u00e9 A. Halperin","orcid":"https://orcid.org/0000-0003-4749-5285","observed_orcids":["https://orcid.org/0000-0003-4749-5285"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose A Halperin","raw_affiliation_strings":["Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School , One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"1Medicine-Brigham and Women\u2019s Hospital, Harvard Medical School, One Kendall Square, Building# 600, 3rd Floor, Cambridge, MA, 02139,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"178","issue":"1_Supplement","first_page":"S104","last_page":"S104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd59","display_name":"CD59","score":0.9259999990463257},{"id":"https://openalex.org/keywords/complement-regulatory-proteins","display_name":"complement regulatory proteins","score":0.7250000238418579},{"id":"https://openalex.org/keywords/membrane-attack-complex","display_name":"membrane attack complex","score":0.7570000290870667},{"id":"https://openalex.org/keywords/paroxysmal-nocturnal-hemoglobinuria","display_name":"paroxysmal nocturnal hemoglobinuria","score":0.9340000152587891},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8930000066757202},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/c3-deficiency","display_name":"C3 deficiency","score":0.753000020980835},{"id":"https://openalex.org/keywords/free-hemoglobin","display_name":"free hemoglobin","score":0.6990000009536743},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.6700000166893005},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C2777346216","wikidata":"https://www.wikidata.org/wiki/Q1479494","display_name":"Paroxysmal nocturnal hemoglobinuria","level":2,"score":0.9260072708129883},{"id":"https://openalex.org/C184404459","wikidata":"https://www.wikidata.org/wiki/Q5009828","display_name":"CD59","level":4,"score":0.9134839773178101},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.7669761180877686},{"id":"https://openalex.org/C79196540","wikidata":"https://www.wikidata.org/wiki/Q14905298","display_name":"Complement membrane attack complex","level":4,"score":0.6192228198051453},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5232899785041809},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.47403526306152344},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.467926025390625},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4580605626106262},{"id":"https://openalex.org/C71318922","wikidata":"https://www.wikidata.org/wiki/Q426181","display_name":"Complement component 5","level":4,"score":0.4445562958717346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41856786608695984},{"id":"https://openalex.org/C2777991916","wikidata":"https://www.wikidata.org/wiki/Q421617","display_name":"Eculizumab","level":4,"score":0.4180489778518677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37715864181518555},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.14424672722816467},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0759703516960144}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.178.supp.53.4","doi":"https://doi.org/10.4049/jimmunol.178.supp.53.4","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.178.supp.53.4","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079112439","https://openalex.org/W2120080258","https://openalex.org/W2053613707","https://openalex.org/W2070729260","https://openalex.org/W2111884217","https://openalex.org/W2171235572","https://openalex.org/W1993136765","https://openalex.org/W2111733466","https://openalex.org/W4383755169","https://openalex.org/W4205594699"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"complement":[2,10,69,108,111,120],"regulatory":[3],"protein":[4],"CD59":[5,56],"inhibits":[6],"formation":[7],"of":[8,43,53,60,79,91,104,119,124,158,178,186],"the":[9,51,77,88,102,117,122,133,151,183],"membrane":[11,81],"attack":[12],"complex":[13],"(MAC).":[14],"Humans":[15],"express":[16,21],"only":[17],"one":[18],"while":[19],"mice":[20,106],"two":[22,29],"Cd59":[23],"genes;":[24],"each":[25],"mCd59":[26,44,93],"gene":[27],"contains":[28],"promoters":[30],"that":[31],"control":[32],"its":[33],"expression":[34],"in":[35,57,95,107,121,127,132,141,164,170,182,200],"a":[36,68,174,194],"tissue":[37],"specific":[38],"manner.":[39],"Thus,":[40],"total":[41],"deficiency":[42],"activity":[45],"is":[46],"required":[47],"to":[48,76,115,136,148,150],"study":[49],"unambiguously":[50],"role":[52,118,197],"MAC":[54],"and":[55,101,110,154,166],"mouse":[58],"models":[59],"human":[61],"diseases":[62],"including":[63],"paroxysmal":[64],"nocturnal":[65],"hemoglobinuria":[66],"(PNH),":[67],"mediated":[70],"hemolytic":[71],"anemia":[72],"with":[73],"thrombosis":[74],"due":[75,135],"lack":[78],"GPI-linked":[80],"proteins,":[82],"especially":[83],"CD59.":[84],"Here":[85],"we":[86,172],"report":[87],"targeted":[89],"deletion":[90],"both":[92],"genes":[94],"mCd59ab\u2212/\u2212":[96,187],"mice,":[97],"their":[98,142],"PNH-like":[99,125],"phenotype,":[100],"use":[103],"these":[105],"sufficient":[109],"(C3)":[112],"deficient":[113],"background":[114],"establish":[116],"activation":[123,185],"platelets":[126],"vivo.":[128],"Low":[129],"NO":[130,168,199],"bioavailability":[131],"vasculature":[134],"increased":[137],"NO-scavenging":[138],"free":[139],"hemoglobin":[140],"blood":[143],"has":[144],"long":[145],"been":[146],"suspected":[147],"contribute":[149],"thrombotic":[152],"diathesis":[153],"smooth":[155],"muscle":[156],"dystonias":[157],"PNH-patients.":[159],"Using":[160],"an":[161,167],"NO-synthase":[162],"inhibitor":[163],"vivo":[165],"donor":[169],"vitro,":[171],"established":[173],"novel":[175],"balancing":[176,201],"effect":[177],"nitric":[179],"oxide":[180],"(NO)":[181],"complement-mediated":[184,202],"(CD59":[188],"deficient,":[189],"PNH-like).":[190],"These":[191],"results":[192],"unmask":[193],"hitherto":[195],"unrecognized":[196],"for":[198],"platelet":[203],"activation.":[204]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}