{"id":"https://openalex.org/W1506280935","doi":"https://doi.org/10.1016/j.neuroimage.2017.02.013","title":"Machine learning based compartment models with permeability for white matter microstructure imaging","display_name":"Machine learning based compartment models with permeability for white matter microstructure imaging","publication_year":2017,"publication_date":"2017-02-08","ids":{"openalex":"https://openalex.org/W1506280935","doi":"https://doi.org/10.1016/j.neuroimage.2017.02.013","mag":"1506280935","pmid":"https://pubmed.ncbi.nlm.nih.gov/28188915"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2017.02.013","doi":"https://doi.org/10.1016/j.neuroimage.2017.02.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2017.02.013","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1053811917301179/pdf","source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1053811917301179/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003559913","display_name":"Gemma L. Nedjati-Gilani","orcid":"https://orcid.org/0000-0001-5723-5028","observed_orcids":["https://orcid.org/0000-0001-5723-5028"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gemma L. Nedjati-Gilani","raw_affiliation_strings":["Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK; MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, UK","Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK","MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK; MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, UK","institution_ids":["https://openalex.org/I45129253","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060177266","display_name":"Torben Schneider","orcid":"https://orcid.org/0000-0003-4130-7220","observed_orcids":["https://orcid.org/0000-0003-4130-7220"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Torben Schneider","raw_affiliation_strings":["Department of Neuroinflammation, Institute of Neurology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroinflammation, Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027461916","display_name":"Matt G. Hall","orcid":"https://orcid.org/0000-0002-9530-5477","observed_orcids":["https://orcid.org/0000-0002-9530-5477"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matt G. Hall","raw_affiliation_strings":["Institute of Child Health, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Child Health, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065615792","display_name":"Niamh Cawley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Niamh Cawley","raw_affiliation_strings":["Department of Neuroinflammation, Institute of Neurology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroinflammation, Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051093140","display_name":"Ioana Hill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ioana Hill","raw_affiliation_strings":["Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067383775","display_name":"Olga Ciccarelli","orcid":"https://orcid.org/0000-0001-7485-1367","observed_orcids":["https://orcid.org/0000-0001-7485-1367","https://orcid.org/0000-0003-0638-1660"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olga Ciccarelli","raw_affiliation_strings":["Department of Neuroinflammation, Institute of Neurology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroinflammation, Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000738727","display_name":"Ivana Drobnjak","orcid":"https://orcid.org/0000-0002-3989-1715","observed_orcids":["https://orcid.org/0000-0002-3989-1715"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ivana Drobnjak","raw_affiliation_strings":["Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: i.drobnjak@ucl.ac.uk","Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: i.drobnjak@ucl.ac.uk","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037442059","display_name":"Claudia A. M. Gandini Wheeler\u2010Kingshott","orcid":"https://orcid.org/0000-0002-4832-1300","observed_orcids":["https://orcid.org/0000-0002-4832-1300"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210095701","display_name":"Fondazione Istituto Neurologico Nazionale Casimiro Mondino","ror":"https://ror.org/009h0v784","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210095701","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Claudia A.M. Gandini Wheeler-Kingshott","raw_affiliation_strings":["Department of Neuroinflammation, Institute of Neurology, University College London, London, UK; Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy","Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","Department of Neuroinflammation, Institute of Neurology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroinflammation, Institute of Neurology, University College London, London, UK; Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210095701","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy","institution_ids":["https://openalex.org/I4210095701"]},{"raw_affiliation_string":"Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Department of Neuroinflammation, Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033449704","display_name":"Daniel C. Alexander","orcid":"https://orcid.org/0000-0003-2439-350X","observed_orcids":["https://orcid.org/0000-0003-2439-350X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel C. Alexander","raw_affiliation_strings":["Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Image Computing and Dept of Computer Science, University College London, Gower Street, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000738727"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":{"value":2156,"currency":"EUR","value_usd":2325},"fwci":8.5978,"has_fulltext":true,"cited_by_count":108,"citation_normalized_percentile":{"value":0.98571464,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"150","issue":null,"first_page":"119","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/compartmental-model","display_name":"compartmental model","score":0.7310000061988831},{"id":"https://openalex.org/keywords/water-residence-time","display_name":"water residence time","score":0.902999997138977},{"id":"https://openalex.org/keywords/white-matter-microstructure","display_name":"white matter microstructure","score":0.9559999704360962},{"id":"https://openalex.org/keywords/diffusion-weighted-imaging","display_name":"diffusion-weighted imaging","score":0.7990000247955322},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.6470000147819519},{"id":"https://openalex.org/keywords/random-forest-regression","display_name":"random forest regression","score":0.878000020980835},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/myelin-damage","display_name":"myelin damage","score":0.8050000071525574},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.824999988079071},{"id":"https://openalex.org/keywords/corticospinal-tract","display_name":"corticospinal tract","score":0.9879999756813049},{"id":"https://openalex.org/keywords/diffusion-coefficient","display_name":"diffusion coefficient","score":0.5929999947547913},{"id":"https://openalex.org/keywords/machine-learning-parameter-estimation","display_name":"machine learning parameter estimation","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6772347092628479},{"id":"https://openalex.org/C146849305","wikidata":"https://www.wikidata.org/wiki/Q370766","display_name":"Ground truth","level":2,"score":0.6380033493041992},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.6128621101379395},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5546090006828308},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4925556778907776},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46571993827819824},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.4232010245323181},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35663747787475586},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3523319363594055},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33032119274139404},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.32685261964797974},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.28149452805519104},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.24558895826339722},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21960756182670593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21523267030715942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19507816433906555},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.14972466230392456}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017352","descriptor_name":"Echo-Planar Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.neuroimage.2017.02.013","doi":"https://doi.org/10.1016/j.neuroimage.2017.02.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2017.02.013","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1053811917301179/pdf","source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:28188915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28188915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1452526","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1452526/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: Golland, P and Hata, N and Barillot, C and Hornegger, J and Howe, R, (eds.) (Proceedings) 17th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI). (pp. pp. 257-264). SPRINGER-VERLAG BERLIN (2014)","raw_type":"Proceedings paper"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1457958","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1457958/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage , 150 pp. 119-135. (2017)","raw_type":"Article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/48363","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/48363","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"135","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2017.02.013","doi":"https://doi.org/10.1016/j.neuroimage.2017.02.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2017.02.013","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1053811917301179/pdf","source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1489617033","display_name":"Anatomy-Driven Brain Connectivity Mapping","funder_award_id":"EP/L022680/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1622632528","display_name":"EPSRC Centre for Doctoral Training in Medical Imaging","funder_award_id":"EP/L016478/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2810537366","display_name":null,"funder_award_id":"EP/M020533/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G295217152","display_name":"A biophysical simulation framework for magnetic resonance microstructure imaging","funder_award_id":"EP/N018702/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3142271793","display_name":"Direct Measurements of Microstructure from MRI","funder_award_id":"EP/G007748/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3157788177","display_name":"Medical image computing for next-generation healthcare technology","funder_award_id":"EP/M020533/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3705275509","display_name":"Cardiff University-Equipment Account","funder_award_id":"EP/M00855X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4266322423","display_name":null,"funder_award_id":"M020533/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4510347995","display_name":null,"funder_award_id":"MR/M009106/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4606663280","display_name":null,"funder_award_id":"G007748","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4714631627","display_name":null,"funder_award_id":"L022680","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G514209115","display_name":null,"funder_award_id":"EP/E064280/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5959522739","display_name":"Axon and myelin damage assessed using advanced diffusion imaging: from mathematical models to clinical applications","funder_award_id":"EP/I027084/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6194675606","display_name":"National Facility for In Vivo MR Imaging of Human Tissue Microstructure","funder_award_id":"EP/M029778/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6353617916","display_name":null,"funder_award_id":"I027084","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6783527687","display_name":null,"funder_award_id":"EP/I027084/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G68706309","display_name":null,"funder_award_id":"EP/M029778/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6956867756","display_name":null,"funder_award_id":"1763793","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G696815201","display_name":null,"funder_award_id":"EP/L016478/1","funder_id":"https://openalex.org/F4320320286","funder_display_name":"University College London"},{"id":"https://openalex.org/G7628549173","display_name":null,"funder_award_id":"EP/G007748/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G792077687","display_name":"Copy of A Monte-Carlo diffusion simulation framework for diffusion MRI","funder_award_id":"EP/E064280/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8057189669","display_name":null,"funder_award_id":"EP/N018702/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G818010940","display_name":null,"funder_award_id":"EP/M00855X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8237986818","display_name":null,"funder_award_id":"1212889","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8390508323","display_name":null,"funder_award_id":"EP/L022680/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G844244329","display_name":null,"funder_award_id":"M020533","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8662128564","display_name":null,"funder_award_id":"EP/G007748","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G902693135","display_name":null,"funder_award_id":"EP/M020533/1","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1506280935.pdf","grobid_xml":"https://content.openalex.org/works/W1506280935.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W3760100","https://openalex.org/W137456267","https://openalex.org/W278712781","https://openalex.org/W1597940528","https://openalex.org/W1953771843","https://openalex.org/W1963839205","https://openalex.org/W1975017507","https://openalex.org/W1979893109","https://openalex.org/W1999110803","https://openalex.org/W2006096283","https://openalex.org/W2007327526","https://openalex.org/W2010121004","https://openalex.org/W2011015491","https://openalex.org/W2012723154","https://openalex.org/W2013761469","https://openalex.org/W2021939133","https://openalex.org/W2022514814","https://openalex.org/W2025249109","https://openalex.org/W2029845038","https://openalex.org/W2042870963","https://openalex.org/W2044363734","https://openalex.org/W2045726965","https://openalex.org/W2050873013","https://openalex.org/W2052644075","https://openalex.org/W2054777733","https://openalex.org/W2060757311","https://openalex.org/W2066807438","https://openalex.org/W2073738917","https://openalex.org/W2074888367","https://openalex.org/W2082182286","https://openalex.org/W2087389265","https://openalex.org/W2101234009","https://openalex.org/W2102520467","https://openalex.org/W2116940908","https://openalex.org/W2122662954","https://openalex.org/W2123220620","https://openalex.org/W2127635814","https://openalex.org/W2128444449","https://openalex.org/W2130416410","https://openalex.org/W2133612938","https://openalex.org/W2133902464","https://openalex.org/W2143671152","https://openalex.org/W2148333046","https://openalex.org/W2149778524","https://openalex.org/W2168667711","https://openalex.org/W2177835590","https://openalex.org/W2213972894","https://openalex.org/W2252614221","https://openalex.org/W2460672133","https://openalex.org/W2523944554","https://openalex.org/W2791630165","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3023442766","https://openalex.org/W2076871432","https://openalex.org/W3097381347","https://openalex.org/W1571749493","https://openalex.org/W6990347884","https://openalex.org/W4385474102","https://openalex.org/W4401737335","https://openalex.org/W2894333093","https://openalex.org/W4392534347","https://openalex.org/W7212240583"],"abstract_inverted_index":{"Some":[0],"microstructure":[1,125,214],"parameters,":[2,126],"such":[3],"as":[4,76],"permeability,":[5,84],"remain":[6],"elusive":[7],"because":[8,373],"mathematical":[9],"models":[10,28],"that":[11,147,266,361],"express":[12],"their":[13],"relationship":[14],"to":[15,25,32,81,110,258],"the":[16,38,71,154,188,236,241,259,268,274,277,284,289,302,312,315,319,322,329,334,347,353,362,374,387,395,401],"MR":[17,120],"signal":[18],"accurately":[19],"are":[20],"intractable.":[21],"Here,":[22],"we":[23,247,382],"propose":[24],"use":[26],"computational":[27,93],"learned":[29],"from":[30,117,216,223,250,394],"simulations":[31,98],"estimate":[33,275,320],"these":[34],"parameters.":[35],"We":[36,90,131,264],"demonstrate":[37],"approach":[39],"in":[40,48,108,139,217,229,261,267,288,295,301,311,333,340,346,352,365,371,386],"an":[41],"example":[42],"which":[43],"estimates":[44,212,385],"water":[45,58],"residence":[46,53,175,278,323,363],"time":[47,54,279,324,364],"brain":[49,142,220],"white":[50,67,305],"matter.":[51],"The":[52,208],"\u03c4":[55,87,128],"i":[56,88,129],"of":[57,70,270,276,321,376,397,404],"inside":[59],"axons":[60],"is":[61,79,280,298,325,343],"a":[62,92,104,112,184,293,338],"potentially":[63],"important":[64],"biomarker":[65],"for":[66,172,283,328],"matter":[68,306],"pathologies":[69],"human":[72,141,219],"central":[73],"nervous":[74],"system,":[75],"myelin":[77,377],"damage":[78],"hypothesised":[80],"affect":[82],"axonal":[83],"and":[85,99,122,138,179,182,231,243,256,308,349],"thus":[86],".":[89,130],"construct":[91],"model":[94,135,193,210,238],"using":[95,136],"Monte":[96],"Carlo":[97],"machine":[100],"learning":[101],"(specifically":[102],"here":[103],"random":[105],"forest":[106],"regressor)":[107],"order":[109],"learn":[111],"mapping":[113],"between":[114],"features":[115],"derived":[116],"diffusion":[118],"weighted":[119],"signals":[121],"ground":[123,155],"truth":[124,156],"including":[127],"test":[132],"our":[133,359],"numerical":[134],"simulated":[137],"vivo":[140,218],"data.":[143],"Simulation":[144],"results":[145,356],"show":[146],"estimated":[148],"parameters":[149,157,215],"have":[150],"strong":[151],"correlations":[152],"with":[153,292,337,358,392],"(":[158,194],"R":[159,195],"2":[160,196],"=":[161,197],"{":[162,198],"0.88":[163],",":[164,166,168,200,202,204],"0.95":[165],"0.82":[167],"0.99":[169,205],"}":[170,206],")":[171],"volume":[173],"fraction,":[174],"time,":[176],"axon":[177],"radius":[178],"diffusivity":[180],"respectively),":[181],"provide":[183],"marked":[185],"improvement":[186],"over":[187],"most":[189],"widely":[190],"used":[191],"K\u00e4rger":[192,237],"0.75":[199],"0.60":[201],"0.11":[203],").":[207],"trained":[209],"also":[211],"sensible":[213],"data":[221,249],"acquired":[222],"healthy":[224,262,285,330],"controls,":[225],"matching":[226],"values":[227,260],"found":[228],"literature,":[230],"provides":[232],"better":[233],"reproducibility":[234],"than":[235,370],"on":[239],"both":[240],"voxel":[242],"ROI":[244],"level.":[245],"Finally,":[246],"acquire":[248],"two":[251,388],"Multiple":[252],"Sclerosis":[253],"(MS)":[254],"patients":[255,390],"compare":[257],"subjects.":[263],"find":[265,383],"splenium":[269],"corpus":[271],"callosum":[272],"(CC-S)":[273],"0.57\u00b10.05":[281],"s":[282,300,310,327,345,351],"subjects,":[286,331],"while":[287,332],"MS":[290,335,389,398],"patient":[291,336],"lesion":[294,339],"CC-S":[296],"it":[297,342],"0.33\u00b10.12":[299],"normal":[303],"appearing":[304],"(NAWM)":[307],"0.19\u00b10.11":[309],"lesion.":[313,354],"In":[314],"corticospinal":[316],"tracts":[317],"(CST)":[318],"0.52\u00b10.09":[326],"CST":[341],"0.56\u00b10.05":[344],"NAWM":[348,372],"0.13\u00b10.09":[350],"These":[355],"agree":[357],"expectations":[360,393],"lesions":[366,399],"would":[367],"be":[368],"lower":[369],"loss":[375],"should":[378],"increase":[379],"permeability.":[380],"Overall,":[381],"parameter":[384],"consistent":[391],"pathology":[396],"demonstrating":[400],"clinical":[402],"potential":[403],"this":[405],"new":[406],"technique.":[407]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}