{"id":"https://openalex.org/W1506126972","doi":null,"title":"Immunogenicity of meningococcal PorA antigens in OMV vaccines","display_name":"Immunogenicity of meningococcal PorA antigens in OMV vaccines","publication_year":2006,"publication_date":"2006-06-08","ids":{"openalex":"https://openalex.org/W1506126972","mag":"1506126972"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/19931","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/19931","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/19931","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036042187","display_name":"Thomas A. Luijkx","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas A. Luijkx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036042187"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/outer-membrane-vesicle-vaccine","display_name":"outer membrane vesicle vaccine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.45399999618530273},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.6959999799728394},{"id":"https://openalex.org/keywords/t-cell-hybridomas","display_name":"T cell hybridomas","score":0.625},{"id":"https://openalex.org/keywords/serogroup-b-meningococcal-disease","display_name":"serogroup B meningococcal disease","score":0.6230000257492065},{"id":"https://openalex.org/keywords/vaccination-schedule","display_name":"vaccination schedule","score":0.7409999966621399},{"id":"https://openalex.org/keywords/intranasal-exposure","display_name":"intranasal exposure","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2779909307","wikidata":"https://www.wikidata.org/wiki/Q1660181","display_name":"Immunogen","level":4,"score":0.9555548429489136},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8120607137680054},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6676665544509888},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6542322635650635},{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.5442644953727722},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5296931862831116},{"id":"https://openalex.org/C2780454893","wikidata":"https://www.wikidata.org/wiki/Q6817090","display_name":"Meningococcal vaccine","level":4,"score":0.4700317084789276},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46041613817214966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43167638778686523},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40078943967819214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37473708391189575},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.27604496479034424},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.19186967611312866},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.06373763084411621}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/19931","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/19931","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/19931","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/19931","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:1506126972","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/1874/19931/1/woord.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/19931","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/19931","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W43534825","https://openalex.org/W75913038","https://openalex.org/W1499589601","https://openalex.org/W1510773753","https://openalex.org/W1522434856","https://openalex.org/W1531148794","https://openalex.org/W1538652950","https://openalex.org/W1566165411","https://openalex.org/W1567037104","https://openalex.org/W1572881837","https://openalex.org/W1576152613","https://openalex.org/W1576377498","https://openalex.org/W1589591129","https://openalex.org/W1590830087","https://openalex.org/W1622088669","https://openalex.org/W1734385177","https://openalex.org/W1851989560","https://openalex.org/W1911780585","https://openalex.org/W1934670278","https://openalex.org/W1935940544","https://openalex.org/W1945802002","https://openalex.org/W1966756198","https://openalex.org/W1967828810","https://openalex.org/W1969184830","https://openalex.org/W1969623216","https://openalex.org/W1971350415","https://openalex.org/W1971569916","https://openalex.org/W1974423506","https://openalex.org/W1975355256","https://openalex.org/W1976230577","https://openalex.org/W1976422965","https://openalex.org/W1976546346","https://openalex.org/W1979986360","https://openalex.org/W1981797020","https://openalex.org/W1982573460","https://openalex.org/W1987016144","https://openalex.org/W1988247082","https://openalex.org/W1991844560","https://openalex.org/W1993198059","https://openalex.org/W1995379601","https://openalex.org/W1996141674","https://openalex.org/W1996256410","https://openalex.org/W1998179482","https://openalex.org/W1998558781","https://openalex.org/W2003709444","https://openalex.org/W2004908118","https://openalex.org/W2007950400","https://openalex.org/W2012163630","https://openalex.org/W2012433731","https://openalex.org/W2012619809","https://openalex.org/W2017835421","https://openalex.org/W2020870088","https://openalex.org/W2025309434","https://openalex.org/W2028960154","https://openalex.org/W2031812411","https://openalex.org/W2034293576","https://openalex.org/W2037308991","https://openalex.org/W2038042144","https://openalex.org/W2038494844","https://openalex.org/W2039033277","https://openalex.org/W2041659749","https://openalex.org/W2042369282","https://openalex.org/W2044099387","https://openalex.org/W2044342990","https://openalex.org/W2044418935","https://openalex.org/W2045221557","https://openalex.org/W2046267384","https://openalex.org/W2049294116","https://openalex.org/W2057692835","https://openalex.org/W2057809738","https://openalex.org/W2058541383","https://openalex.org/W2059783102","https://openalex.org/W2059865176","https://openalex.org/W2060694962","https://openalex.org/W2060696129","https://openalex.org/W2064474732","https://openalex.org/W2067488232","https://openalex.org/W2069285405","https://openalex.org/W2069469281","https://openalex.org/W2070553347","https://openalex.org/W2073533707","https://openalex.org/W2073678729","https://openalex.org/W2074792304","https://openalex.org/W2078598660","https://openalex.org/W2078791944","https://openalex.org/W2080332703","https://openalex.org/W2080885816","https://openalex.org/W2080957576","https://openalex.org/W2086071384","https://openalex.org/W2086566503","https://openalex.org/W2086909360","https://openalex.org/W2089800576","https://openalex.org/W2091046293","https://openalex.org/W2091085026","https://openalex.org/W2093512259","https://openalex.org/W2094682437","https://openalex.org/W2100713536","https://openalex.org/W2100761378","https://openalex.org/W2101304791","https://openalex.org/W2102186420","https://openalex.org/W2103097055","https://openalex.org/W2103386460","https://openalex.org/W2103425201","https://openalex.org/W2103980159","https://openalex.org/W2105443212","https://openalex.org/W2107928905","https://openalex.org/W2110807103","https://openalex.org/W2116458521","https://openalex.org/W2117761762","https://openalex.org/W2118396981","https://openalex.org/W2118998615","https://openalex.org/W2119297049","https://openalex.org/W2119514683","https://openalex.org/W2123686037","https://openalex.org/W2125701224","https://openalex.org/W2127335580","https://openalex.org/W2129245598","https://openalex.org/W2129319296","https://openalex.org/W2130460485","https://openalex.org/W2133946487","https://openalex.org/W2134976915","https://openalex.org/W2135720956","https://openalex.org/W2139425926","https://openalex.org/W2140247005","https://openalex.org/W2141603824","https://openalex.org/W2146028208","https://openalex.org/W2147483877","https://openalex.org/W2148759300","https://openalex.org/W2150102406","https://openalex.org/W2151921752","https://openalex.org/W2153683760","https://openalex.org/W2154202775","https://openalex.org/W2154778711","https://openalex.org/W2156961356","https://openalex.org/W2157311203","https://openalex.org/W2159984475","https://openalex.org/W2160667051","https://openalex.org/W2160879811","https://openalex.org/W2161291046","https://openalex.org/W2161637923","https://openalex.org/W2162997333","https://openalex.org/W2163829208","https://openalex.org/W2164144611","https://openalex.org/W2164620232","https://openalex.org/W2165157598","https://openalex.org/W2165608602","https://openalex.org/W2166821544","https://openalex.org/W2168608625","https://openalex.org/W2169994668","https://openalex.org/W2170736102","https://openalex.org/W2171179852","https://openalex.org/W2171240083","https://openalex.org/W2214363391"],"related_works":["https://openalex.org/W1988247082","https://openalex.org/W2157311203","https://openalex.org/W1979986360","https://openalex.org/W1951352399","https://openalex.org/W2044128581","https://openalex.org/W1497203788","https://openalex.org/W2132984510","https://openalex.org/W2056448686","https://openalex.org/W1998169551","https://openalex.org/W2148376394"],"abstract_inverted_index":{"For":[0],"the":[1,11,38,42,50,53,61,75,86,121,129,143,149,153,218,228,252,255,331,341,348,353,385,393,412,438,441,450,460],"prevention":[2],"of":[3,52,63,120,123,142,180,210,240,279,333,343,355,395,435],"meningococcal":[4,418],"infection":[5],"caused":[6,138,431],"by":[7,139,177,237,352,432,458],"group":[8],"B":[9,64,223,242,258,283,297,322],"meningococci,":[10],"Netherlands":[12],"Vaccine":[13],"Institute":[14],"(NVI)":[15],"has":[16],"developed":[17],"a":[18,99,102,112,124,193,197,207,238,290,356,369,404],"hexavalent":[19,79],"Porin":[20],"A":[21,221],"(PorA)":[22],"based":[23],"Outer":[24],"Membrane":[25],"Vesicle":[26],"(OMV)":[27],"vaccine":[28,127,408,414],"(Hexamen).":[29],"In":[30,402],"various":[31],"clinical":[32],"studies":[33,93,447],"with":[34,163,170,372,440],"HexaMen,":[35,181],"differences":[36],"in":[37,49,330,347,368,420,425],"immune":[39,56,87,130,154,190,428,443,453],"responses":[40,184,191,429,454],"to":[41,84,151,262,271,315,327,410,415],"individual":[43],"PorAs":[44,159,175],"were":[45,58,82,94,234,248,299,307],"observed.":[46],"Factors":[47],"involved":[48],"development":[51],"PorA":[54,105,115,125,144,199,334,349,357,396,406,426,436,451],"specific":[55,241,257,281,335,350,359,397,427,452],"response":[57,131,155,351],"studied,":[59],"including":[60],"role":[62],"and":[65,78,167,196,214,231,267,306,312,437],"T":[66,345,360,387,399],"cells.":[67],"Also,":[68],"alternative":[69],"formulations":[70],"or":[71,244,383],"immunization":[72,161,311],"schedules":[73,162],"using":[74,96,160],"available":[76],"monovalent":[77,165,204],"candidate":[80],"vaccines":[81],"investigated":[83,148],"optimize":[85,152],"response.":[88],"To":[89],"address":[90],"these":[91,136],"issues,":[92],"undertaken":[95],"P1.7-2,4":[97,256,280],"as":[98,111],"model":[100,116],"for":[101,217,288],"weakly":[103,157,173],"immunogenic":[104,114,158,174],"antigen,":[106],"while":[107],"P1.5-1,2-2":[108],"was":[109,132,366],"used":[110],"strongly":[113],"antigen.":[117],"The":[118,188,363],"influence":[119],"composition":[122],"OMV":[126,407],"on":[128],"limited,":[133],"indicating":[134,318],"that":[135,227,295,319,449],"are":[137,430],"intrinsic":[140,433],"properties":[141,434],"antigen":[145],"itself.":[146],"We":[147,292],"possibility":[150],"against":[156,185,192,417],"both":[164,310],"OMVs":[166],"HexaMen.":[168],"Priming":[169],"two":[171,178],"different":[172],"followed":[176],"doses":[179],"induced":[182,300],"good":[183],"all":[186],"serosubtypes.":[187],"early":[189],"strong":[194],"(P1.5-1,2-2)":[195,358],"weak":[198,219],"immunogen":[200],"(P1.7-,2":[201],"4)":[202],"after":[203,251,302],"immunization,":[205,305],"revealed":[206],"delayed":[208],"onset":[209],"high":[211,264],"affinity":[212,265],"IgG":[213,230],"SBA":[215,232],"titers":[216,233],"immunogen.":[220],"PorA-specific":[222],"cell":[224,284,323,361,388,400],"ELISPOT":[225],"showed":[226,448],"lower":[229],"not":[235],"reflected":[236],"lack":[239],"cells":[243,259,298,346],"plasma":[245],"cells,":[246],"but":[247],"instead":[249],"higher":[250,277],"boost.":[253],"Apparently,":[254],"have":[260],"difficulties":[261],"generate":[263],"antibodies":[266],"require":[268],"more":[269],"proliferation":[270],"obtain":[272],"sufficient":[273],"antibody":[274],"production.":[275],"This":[276],"number":[278],"memory":[282,296,321],"pool":[285,324],"remained":[286],"constant":[287],"over":[289],"year.":[291],"also":[293],"found":[294],"already":[301],"one":[303,377],"HexaMen":[304],"reactive":[308],"upon":[309],"intranasal":[313],"exposure":[314],"live":[316],"bacteria,":[317],"this":[320],"may":[325,455],"contribute":[326],"vaccine-induced":[328],"protection":[329],"absence":[332],"bactericidal":[336],"titers.":[337],"Finally,":[338],"we":[339],"studied":[340],"involvement":[342],"CD4":[344,386,398],"generation":[354],"hybridoma.":[362],"recognized":[364],"epitope":[365,389],"located":[367],"transmembrane":[370],"region":[371],"limited":[373],"strain":[374],"variation.":[375],"Still,":[376],"amino":[378],"acid":[379],"variation":[380],"either":[381],"inside":[382],"outside":[384],"could":[390],"greatly":[391],"reduce":[392],"efficiency":[394],"activation.":[401],"conclusion,":[403],"multivalent":[405],"is":[409],"date":[411],"best":[413],"protect":[416],"disease":[419],"an":[421],"endemic":[422],"situation.":[423],"Differences":[424],"interaction":[439],"complete":[442],"system.":[444],"Furthermore,":[445],"our":[446],"be":[456],"enhanced":[457],"optimizing":[459],"vaccination":[461],"schedule.":[462]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}