{"id":"https://openalex.org/W150602832","doi":null,"title":"Prognostic and therapeutic role of nuclear factor-kappa B (NF-kappaB) in breast cancer.","display_name":"Prognostic and therapeutic role of nuclear factor-kappa B (NF-kappaB) in breast cancer.","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W150602832","mag":"150602832","pmid":"https://pubmed.ncbi.nlm.nih.gov/22338460"},"language":"en","primary_location":{"id":"pmid:22338460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22338460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College, Abbottabad : JAMC","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001901048","display_name":"Ayesha M. Ahmed","orcid":"https://orcid.org/0000-0002-2036-7067","observed_orcids":["https://orcid.org/0000-0002-2036-7067"]},"institutions":[{"id":"https://openalex.org/I76571253","display_name":"Imam Abdulrahman Bin Faisal University","ror":"https://ror.org/038cy8j79","country_code":"SA","type":"education","lineage":["https://openalex.org/I76571253"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Ayesha Ahmed","raw_affiliation_strings":["Department of Pathology, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia. ayesash@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia. ayesash@hotmail.com","institution_ids":["https://openalex.org/I76571253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001901048"],"corresponding_institution_ids":["https://openalex.org/I76571253"],"apc_list":null,"apc_paid":null,"fwci":0.3902,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.60670599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"3","first_page":"218","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8980000019073486},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9869999885559082},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6679999828338623},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/lymphangiogenesis","display_name":"lymphangiogenesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7110000252723694},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.9350000023841858},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/inflammatory-breast-cancer","display_name":"inflammatory breast cancer","score":0.9150000214576721},{"id":"https://openalex.org/keywords/constitutive-activation","display_name":"constitutive activation","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8901512026786804},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.6654655337333679},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6620956659317017},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5826494097709656},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5463108420372009},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5197945833206177},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.49906086921691895},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4975145161151886},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4406081736087799},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4347509443759918},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3475619852542877},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3443078100681305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24777209758758545},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.10275110602378845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09421351552009583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22338460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22338460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ayub Medical College, Abbottabad : JAMC","raw_type":"Journal Article"},{"id":"mag:150602832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22338460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W20888715","https://openalex.org/W306915739","https://openalex.org/W1487939040","https://openalex.org/W1836453327","https://openalex.org/W1969044500","https://openalex.org/W1973489125","https://openalex.org/W1975527161","https://openalex.org/W1976447688","https://openalex.org/W1976457453","https://openalex.org/W1980188722","https://openalex.org/W1980790180","https://openalex.org/W1981835430","https://openalex.org/W1981876883","https://openalex.org/W1981884734","https://openalex.org/W1992889151","https://openalex.org/W1995747121","https://openalex.org/W1998253936","https://openalex.org/W2007456673","https://openalex.org/W2013810114","https://openalex.org/W2014435531","https://openalex.org/W2031375858","https://openalex.org/W2032004961","https://openalex.org/W2032531389","https://openalex.org/W2038890616","https://openalex.org/W2050861484","https://openalex.org/W2052908553","https://openalex.org/W2053475175","https://openalex.org/W2058391882","https://openalex.org/W2074150439","https://openalex.org/W2085049920","https://openalex.org/W2088094960","https://openalex.org/W2096694106","https://openalex.org/W2106877484","https://openalex.org/W2113137803","https://openalex.org/W2130690901","https://openalex.org/W2133415120","https://openalex.org/W2135753689","https://openalex.org/W2136179374","https://openalex.org/W2141290206","https://openalex.org/W2148119611","https://openalex.org/W2149835039","https://openalex.org/W2160679814","https://openalex.org/W2165214050","https://openalex.org/W2166463482","https://openalex.org/W2166781237","https://openalex.org/W2171865516","https://openalex.org/W2331176038","https://openalex.org/W2335925695","https://openalex.org/W4296759770"],"related_works":["https://openalex.org/W2329609661","https://openalex.org/W2782832253","https://openalex.org/W2160679814","https://openalex.org/W2034872538","https://openalex.org/W2792350114","https://openalex.org/W2146373235","https://openalex.org/W2133415120","https://openalex.org/W3028712314","https://openalex.org/W2092460415","https://openalex.org/W1981876883"],"abstract_inverted_index":{"Nuclear":[0],"Factor-":[1],"kappa":[2],"B":[3],"(NF-kappaB)":[4],"is":[5],"an":[6],"essential":[7],"transcription":[8],"factor":[9],"that":[10],"not":[11],"only":[12],"modulates":[13],"cellular":[14,41],"responses":[15],"to":[16,37],"stress":[17],"but":[18],"also":[19],"plays":[20],"a":[21,87],"pivotal":[22],"role":[23],"in":[24,40,59,65],"inflammation,":[25],"immunity,":[26],"cell":[27],"cycle":[28],"growth":[29],"and":[30,43,50,69,75,90],"survival.":[31],"NF-kappaB-regulated":[32],"genes":[33],"have":[34],"been":[35],"documented":[36],"be":[38],"involved":[39],"proliferation":[42],"invasion":[44],"along":[45],"with":[46],"tumour":[47],"related":[48],"angiogenesis":[49],"lymphangiogenesis.":[51],"Dysregulation":[52],"of":[53],"NF-kappaB":[54],"associated":[55],"pathways":[56],"are":[57],"seen":[58],"multiple":[60],"malignancies.":[61],"Its":[62],"constitutive":[63],"activation":[64],"the":[66,81],"clinically":[67],"aggressive":[68],"prognostically":[70],"poor":[71],"ER-negative,":[72],"Her2-neu":[73],"positive":[74],"inflammatory":[76],"breast":[77],"cancer":[78],"could":[79],"formulate":[80],"basis":[82],"for":[83],"its":[84],"evolution":[85],"as":[86],"potential":[88],"prognostic":[89],"therapeutic":[91],"target.":[92]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
