{"id":"https://openalex.org/W1505741973","doi":"https://doi.org/10.1542/peds.75.2.329","title":"Oral Dexamethasone for Treatment of Persistent Middle Ear Effusion","display_name":"Oral Dexamethasone for Treatment of Persistent Middle Ear Effusion","publication_year":1985,"publication_date":"1985-02-01","ids":{"openalex":"https://openalex.org/W1505741973","doi":"https://doi.org/10.1542/peds.75.2.329","mag":"1505741973","pmid":"https://pubmed.ncbi.nlm.nih.gov/4038553"},"language":"en","primary_location":{"id":"doi:10.1542/peds.75.2.329","doi":"https://doi.org/10.1542/peds.75.2.329","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.75.2.329","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026578355","display_name":"Michael L. Macknin","orcid":"https://orcid.org/0000-0002-7492-0067","observed_orcids":["https://orcid.org/0000-0002-7492-0067"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Macknin","raw_affiliation_strings":["From the Departments of Pediatrics and Biometry, Case Western Reserve University, Cleveland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics and Biometry, Case Western Reserve University, Cleveland","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050757017","display_name":"Paul K. Jones","orcid":"https://orcid.org/0000-0001-5260-8550","observed_orcids":["https://orcid.org/0000-0001-5260-8550"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul K. Jones","raw_affiliation_strings":["From the Departments of Pediatrics and Biometry, Case Western Reserve University, Cleveland","Epidemiology & Biostatistics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics and Biometry, Case Western Reserve University, Cleveland","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Epidemiology & Biostatistics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":4.544,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.94,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"75","issue":"2","first_page":"329","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9539999961853027},{"id":"https://openalex.org/keywords/middle-ear-effusion","display_name":"middle ear effusion","score":0.9599999785423279},{"id":"https://openalex.org/keywords/otitis-media-with-effusion","display_name":"otitis media with effusion","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.847000002861023},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/hearing-improvement","display_name":"hearing improvement","score":0.6520000100135803},{"id":"https://openalex.org/keywords/tympanometry","display_name":"tympanometry","score":0.7940000295639038},{"id":"https://openalex.org/keywords/myringotomy","display_name":"myringotomy","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9820832014083862},{"id":"https://openalex.org/C2776408402","wikidata":"https://www.wikidata.org/wiki/Q2378102","display_name":"Myringotomy","level":3,"score":0.8570424318313599},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.7830753922462463},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6439279913902283},{"id":"https://openalex.org/C2780283655","wikidata":"https://www.wikidata.org/wiki/Q1671504","display_name":"Tympanometry","level":4,"score":0.6337239742279053},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6144455075263977},{"id":"https://openalex.org/C163430725","wikidata":"https://www.wikidata.org/wiki/Q424532","display_name":"Effusion","level":2,"score":0.6072256565093994},{"id":"https://openalex.org/C2777846895","wikidata":"https://www.wikidata.org/wiki/Q501553","display_name":"Middle ear","level":2,"score":0.5236701369285583},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.514444887638092},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3728891611099243},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33677759766578674},{"id":"https://openalex.org/C2780554537","wikidata":"https://www.wikidata.org/wiki/Q758881","display_name":"Audiometry","level":3,"score":0.27707988023757935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2578755021095276},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.19309654831886292},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.14459118247032166},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006309","descriptor_name":"Hearing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010033","descriptor_name":"Otitis Media","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010034","descriptor_name":"Otitis Media with Effusion","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010034","descriptor_name":"Otitis Media with Effusion","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010349","descriptor_name":"Patient Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.75.2.329","doi":"https://doi.org/10.1542/peds.75.2.329","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.75.2.329","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:4038553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4038553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2292346923","https://openalex.org/W2216511317","https://openalex.org/W2417180118","https://openalex.org/W1986174267","https://openalex.org/W116021214","https://openalex.org/W2116737951","https://openalex.org/W2078300418","https://openalex.org/W1808378643","https://openalex.org/W2093022568","https://openalex.org/W2945040244"],"abstract_inverted_index":{"A":[0],"double-blind":[1],"controlled":[2],"study":[3,122],"of":[4,31,85],"oral":[5],"dexamethasone":[6,64,90,117],"(in":[7],"a":[8,46],"2-week":[9],"tapering":[10],"dose":[11],"from":[12],".15":[13],"mg/kg/d)":[14],"v":[15],"placebo":[16,70,96],"in":[17,101,120,126,132],"49":[18],"pediatric":[19],"patients":[20,62,68,88,94],"(mean":[21],"age":[22],"3.7":[23],"years)":[24],"with":[25],"persistent":[26,128],"asymptomatic":[27],"middle":[28,75,129],"ear":[29,40,76,130],"effusion":[30,41,77,131],"three":[32],"or":[33,108],"more":[34,109],"weeks":[35,56],"duration":[36],"was":[37,43,123],"conducted.":[38],"Middle":[39],"resolution":[42],"determined":[44],"by":[45,105],"myringotomy-validated":[47],"algorithm":[48],"that":[49],"combined":[50],"pneumatic":[51],"otoscopy":[52],"and":[53,65,91],"tympanometry.":[54],"Four":[55],"after":[57],"completing":[58],"treatment,":[59],"1/26":[60],"(4%)":[61],"receiving":[63,69,89,95],"2/23":[66],"(9%)":[67],"had":[71,97],"completely":[72],"cleared":[73],"their":[74,99],"(95%":[78,110],"confidence":[79,111],"interval":[80,112],"-0.05":[81],"+/-":[82,114],"0.14).":[83],"Five":[84],"26":[86],"(19%)":[87],"6/23":[92],"(26%)":[93],"improved":[98],"hearing":[100],"all":[102],"affected":[103],"ears":[104],"10":[106],"dB":[107],"-0.07":[113],"0.23).":[115],"Oral":[116],"as":[118],"used":[119],"this":[121],"not":[124],"effective":[125],"treating":[127],"children.":[133]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}