{"id":"https://openalex.org/W1505740490","doi":"https://doi.org/10.1016/s0021-9258(19)36533-0","title":"A liver-specific nuclear protein represses transcription of the S14 gene in vitro and in vivo.","display_name":"A liver-specific nuclear protein represses transcription of the S14 gene in vitro and in vivo.","publication_year":1993,"publication_date":"1993-09-01","ids":{"openalex":"https://openalex.org/W1505740490","doi":"https://doi.org/10.1016/s0021-9258(19)36533-0","mag":"1505740490","pmid":"https://pubmed.ncbi.nlm.nih.gov/7690031"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)36533-0","doi":"https://doi.org/10.1016/s0021-9258(19)36533-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)36533-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)36533-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070708654","display_name":"Nicholas C. Wong","orcid":"https://orcid.org/0000-0003-4393-7541","observed_orcids":["https://orcid.org/0000-0003-4393-7541"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"N.C. Wong","raw_affiliation_strings":["Department of Medicine, University of Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Raymond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Raymond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087721092","display_name":"Frances E. Carr","orcid":"https://orcid.org/0000-0001-7266-8788","observed_orcids":["https://orcid.org/0000-0001-7266-8788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F.E. Carr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.04558223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"268","issue":"26","first_page":"19431","last_page":"19435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7006999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7006999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.1469999998807907,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dnase-i-hypersensitive-sites","display_name":"DNase I hypersensitive sites","score":0.902999997138977},{"id":"https://openalex.org/keywords/hepatic-gene-expression","display_name":"hepatic gene expression","score":0.4779999852180481},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.703000009059906},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.5789999961853027},{"id":"https://openalex.org/keywords/promoter-activity","display_name":"promoter activity","score":0.5699999928474426},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6648591160774231},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.593518853187561},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.550815224647522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48934048414230347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4771518111228943},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45984116196632385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40300458669662476},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37574875354766846},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26242002844810486},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013698","descriptor_name":"Templates, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013851","descriptor_name":"Thinness","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)36533-0","doi":"https://doi.org/10.1016/s0021-9258(19)36533-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)36533-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:7690031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7690031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)36533-0","doi":"https://doi.org/10.1016/s0021-9258(19)36533-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)36533-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1513717105","https://openalex.org/W1517725951","https://openalex.org/W1559346579","https://openalex.org/W1559993597","https://openalex.org/W1565666584","https://openalex.org/W1567844845","https://openalex.org/W1567981986","https://openalex.org/W1573975307","https://openalex.org/W1578941405","https://openalex.org/W1583328345","https://openalex.org/W1965258786","https://openalex.org/W1965372133","https://openalex.org/W1981071038","https://openalex.org/W1987717903","https://openalex.org/W2017117462","https://openalex.org/W2019705832","https://openalex.org/W2020076663","https://openalex.org/W2020260652","https://openalex.org/W2030732137","https://openalex.org/W2041277420","https://openalex.org/W2085723701","https://openalex.org/W2091423718","https://openalex.org/W2109185165","https://openalex.org/W2132573692","https://openalex.org/W2149893875","https://openalex.org/W2163265131","https://openalex.org/W2416253096"],"related_works":["https://openalex.org/W1559346579","https://openalex.org/W1565666584","https://openalex.org/W141803538","https://openalex.org/W1491150547","https://openalex.org/W2020260652","https://openalex.org/W1583328345","https://openalex.org/W2075843810","https://openalex.org/W1483275313","https://openalex.org/W1967687228","https://openalex.org/W2021484069"],"abstract_inverted_index":{"P1":[0,30,68,96,104,138,146,171],"is":[1,47],"a":[2,13,50,108,173],"nuclear":[3],"protein":[4],"found":[5],"exclusively":[6],"in":[7,36,79],"rat":[8],"liver":[9],"and":[10,83,97,123,135,153],"binds":[11],"to":[12,19,31,63,81,127],"motif":[14,43],"that":[15,103],"spans":[16],"nucleotides":[17],"-310":[18],"-288":[20],"of":[21,54,67,77,86,95,99,110,131,144,175],"the":[22,41,65,93,117,129,137,142,145,154],"thyroid":[23,164],"hormone":[24],"responsive":[25],"gene,":[26],"S14.":[27],"We":[28],"expect":[29],"play":[32],"an":[33],"important":[34],"role":[35],"regulating":[37],"gene":[38,112,158,177],"expression":[39],"because":[40],"binding":[42,73,139],"for":[44],"this":[45,58],"factor":[46],"contained":[48],"within":[49],"DNase":[51],"I-hypersensitive":[52],"site":[53],"S14":[55,111,148,176],"chromatin.":[56],"In":[57,141],"report,":[59],"we":[60,115],"have":[61],"attempted":[62],"define":[64],"function":[66,106],"by":[69,163],"correlating":[70],"its":[71],"DNA":[72],"activity":[74,94,130,150],"with":[75,134,170],"levels":[76,98],"mRNA-S14":[78],"response":[80],"aging":[82],"obesity.":[84],"Results":[85],"all":[87],"studies":[88],"revealed":[89],"inverse":[90],"relationships":[91],"between":[92],"mRNA-S14,":[100],"thus":[101],"suggesting":[102],"may":[105],"as":[107],"repressor":[109,118,174],"expression.":[113],"Accordingly,":[114],"tested":[116],"hypothesis":[119],"using":[120],"cell-free":[121],"transcription":[122,159],"transient":[124],"transfection":[125],"assays":[126],"measure":[128],"reporter":[132],"constructs":[133],"without":[136],"motif.":[140],"presence":[143],"motif,":[147],"promoter":[149],"was":[151,160],"repressed":[152],"negative":[155],"effect":[156],"on":[157],"further":[161],"enhanced":[162],"hormone.":[165],"These":[166],"observations":[167],"are":[168],"consistent":[169],"being":[172],"transcription.":[178]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}