{"id":"https://openalex.org/W150568786","doi":null,"title":"Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.","display_name":"Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W150568786","mag":"150568786","pmid":"https://pubmed.ncbi.nlm.nih.gov/1716045","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886213"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886213","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886213","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886213","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037911949","display_name":"Joan M. Lemire","orcid":"https://orcid.org/0000-0002-1972-053X","observed_orcids":["https://orcid.org/0000-0002-1972-053X"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Lemire","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050629953","display_name":"Nobuyoshi Shiojiri","orcid":"https://orcid.org/0000-0002-6278-3480","observed_orcids":["https://orcid.org/0000-0002-6278-3480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Shiojiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112955282","display_name":"Nelson Fausto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Fausto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.2068,"has_fulltext":false,"cited_by_count":305,"citation_normalized_percentile":{"value":0.97644711,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"139","issue":"3","first_page":"535","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oval-cells","display_name":"oval cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/d-galactosamine-induced-liver-injury","display_name":"D-galactosamine-induced liver injury","score":0.8999999761581421},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.6370000243186951},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.7200000286102295},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bile-duct-cells","display_name":"bile duct cells","score":0.7620000243186951},{"id":"https://openalex.org/keywords/duct-like-structures","display_name":"duct-like structures","score":0.5709999799728394},{"id":"https://openalex.org/keywords/hepatocyte-differentiation","display_name":"hepatocyte differentiation","score":0.5049999952316284},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6891319751739502},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5648231506347656},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.53016597032547},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5206258296966553},{"id":"https://openalex.org/C2779777945","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile duct","level":2,"score":0.5175642371177673},{"id":"https://openalex.org/C2780788601","wikidata":"https://www.wikidata.org/wiki/Q12233655","display_name":"Intrahepatic bile ducts","level":3,"score":0.49121373891830444},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4519961178302765},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4447670578956604},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4345702528953552},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.42367294430732727},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35376912355422974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31280672550201416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20558035373687744},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.19246715307235718},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19016340374946594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09606698155403137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08512672781944275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07654577493667603},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07458463311195374}],"mesh":[{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001652","descriptor_name":"Bile Ducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005688","descriptor_name":"Galactosamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019887","descriptor_name":"Peanut Agglutinin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1886213","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886213","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:1716045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1716045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:150568786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1716045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886213","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886213","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3580549657","display_name":"PROTO-ONCOGENES &CELL LINEAGES IN LIVER CARCINOGENESIS","funder_award_id":"R01CA035249","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W23438480","https://openalex.org/W61122441","https://openalex.org/W63500506","https://openalex.org/W155790071","https://openalex.org/W1492352384","https://openalex.org/W1506860172","https://openalex.org/W1533476609","https://openalex.org/W1593105968","https://openalex.org/W1780966588","https://openalex.org/W1911914287","https://openalex.org/W1973654506","https://openalex.org/W1991501430","https://openalex.org/W2006124658","https://openalex.org/W2009921251","https://openalex.org/W2016693266","https://openalex.org/W2017953073","https://openalex.org/W2032696875","https://openalex.org/W2037720761","https://openalex.org/W2040010364","https://openalex.org/W2051172626","https://openalex.org/W2059401136","https://openalex.org/W2060333964","https://openalex.org/W2062521096","https://openalex.org/W2066644227","https://openalex.org/W2072891772","https://openalex.org/W2074260855","https://openalex.org/W2077077811","https://openalex.org/W2094133811","https://openalex.org/W2104428993","https://openalex.org/W2111367456","https://openalex.org/W2144967340","https://openalex.org/W2154352985","https://openalex.org/W2154954577","https://openalex.org/W2253293478","https://openalex.org/W2277261569","https://openalex.org/W2308574337","https://openalex.org/W2416575825","https://openalex.org/W2424673444","https://openalex.org/W2425060694"],"related_works":["https://openalex.org/W1934687459","https://openalex.org/W2315457571","https://openalex.org/W1973650218","https://openalex.org/W2025388733","https://openalex.org/W1525130584","https://openalex.org/W1999289059","https://openalex.org/W2351065543","https://openalex.org/W2622962898","https://openalex.org/W1606465625","https://openalex.org/W1986763561"],"abstract_inverted_index":{"Oval":[0,56],"cells":[1,8,20,42,57,126,137,142],"may":[2],"function":[3],"as":[4],"facultative":[5],"liver":[6,13,35],"stem":[7],"and":[9,22,65,89,117,143],"tumor":[10],"progenitors":[11,32],"in":[12,33,47,51,87,146],"carcinogenesis.":[14],"The":[15,37],"authors":[16,38,133],"determined":[17],"whether":[18],"oval":[19,41,111,141],"proliferate":[21,50],"if":[23],"small":[24,78,144],"hepatocytes":[25,73,79,90,145],"might":[26],"be":[27],"generated":[28],"from":[29],"epithelial":[30,125],"cell":[31],"noncarcinogenic":[34],"injury.":[36],"found":[39],"that":[40,100,135],"similar":[43],"to":[44,53,84,148],"those":[45],"detected":[46],"early":[48,128],"carcinogenesis":[49],"response":[52,147],"D-galactosamine":[54],"(GaIN).":[55],"expressed":[58,108],"gamma-glutamyl":[59],"transpeptidase":[60],"activity,":[61],"bile":[62,114],"duct-type":[63],"cytokeratins":[64],"peanut":[66],"agglutinin":[67],"binding.":[68],"Two":[69],"unusual":[70],"types":[71],"of":[72,104,124],"also":[74],"appeared":[75],"after":[76,129],"injury:":[77],"(less":[80],"than":[81],"or":[82],"equal":[83],"16":[85],"microns":[86],"diameter)":[88],"lining":[91],"atypical":[92],"ductlike":[93],"structures.":[94],"In":[95],"situ":[96],"hybridization":[97],"studies":[98],"showed":[99],"the":[101,122,132],"fetal":[102],"form":[103],"alphafetoprotein":[105],"mRNA":[106],"was":[107],"by":[109],"many":[110],"cells,":[112,116],"some":[113],"duct":[115,136],"occasional":[118],"hepatocytes.":[119],"By":[120],"following":[121],"fate":[123],"labeled":[127],"GaIN":[130],"administration,":[131],"conclude":[134],"can":[138],"generate":[139],"both":[140],"GaIN.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
