{"id":"https://openalex.org/W1505314282","doi":null,"title":"Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors.","display_name":"Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W1505314282","mag":"1505314282","pmid":"https://pubmed.ncbi.nlm.nih.gov/2513994","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1807786"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1807786","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1807786","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bull N Y Acad Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1807786","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108874139","display_name":"J. Wasserman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wasserman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036933927","display_name":"Henric Blomgren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Blomgren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109565102","display_name":"S Rotstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rotstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113760629","display_name":"B Petrini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Petrini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109074706","display_name":"Sven Hammarstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Hammarstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.06705767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"65","issue":"1","first_page":"36","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6549999713897705},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibitors","display_name":"cyclooxygenase inhibitors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9200000166893005},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.7390000224113464},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mitogenic-response","display_name":"mitogen response","score":0.699999988079071},{"id":"https://openalex.org/keywords/phytohemagglutinin","display_name":"phytohemagglutinin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7400000095367432},{"id":"https://openalex.org/keywords/diclofenac-sodium","display_name":"diclofenac sodium","score":0.9480000138282776},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/meclofenamic-acid","display_name":"meclofenamic acid","score":0.9459999799728394},{"id":"https://openalex.org/keywords/radiation-induced-immunosuppression","display_name":"radiation-induced immunosuppression","score":0.7820000052452087},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.6541552543640137},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6268289089202881},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5311426520347595},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5143307447433472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5141497254371643},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4856325685977936},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4259638488292694},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4193597435951233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39200836420059204},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38212770223617554},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3773508667945862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27036941051483154},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1834404170513153},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10766273736953735}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1807786","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1807786","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bull N Y Acad Med","raw_type":"Text"},{"id":"pmid:2513994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2513994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the New York Academy of Medicine","raw_type":"Journal Article"},{"id":"mag:1505314282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2513994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1807786","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1807786","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bull N Y Acad Med","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1969746555","https://openalex.org/W1973424648","https://openalex.org/W1975645818","https://openalex.org/W1982262600","https://openalex.org/W2003621377","https://openalex.org/W2004238189","https://openalex.org/W2045900255","https://openalex.org/W2117939610","https://openalex.org/W2135434982","https://openalex.org/W2400572958"],"related_works":["https://openalex.org/W1987020532","https://openalex.org/W1975645818","https://openalex.org/W2019158946","https://openalex.org/W2171748300","https://openalex.org/W1974386988","https://openalex.org/W2288499705","https://openalex.org/W2401505319","https://openalex.org/W2135434982","https://openalex.org/W1992001453","https://openalex.org/W2023966914"],"abstract_inverted_index":{"We":[0],"have":[1],"documented":[2],"in":[3,82,95,148,172,182,186,285,291,302],"previous":[4],"studies":[5],"that":[6,108,139,195,296],"local":[7],"irradiation":[8,78,245],"therapy":[9],"for":[10],"breast":[11,189],"cancer":[12,190],"caused":[13,102],"severe":[14],"lymphopenia":[15],"with":[16,84,288],"reduction":[17],"of":[18,37,67,118,129,170,181,222,244,260,268],"both":[19,209],"T":[20,38],"and":[21,63,88,137,143,160,202,211,238],"non-T":[22],"lymphocytes.":[23],"Non-T":[24],"cells":[25],"were":[26,53],"relatively":[27],"more":[28],"depressed":[29],"but":[30],"recovered":[31],"within":[32],"six":[33],"months.":[34],"The":[35,91,162,240],"recovery":[36],"cells,":[39],"on":[40,133,252],"the":[41,109,127,253,258],"other":[42],"hand,":[43],"remained":[44],"incomplete":[45],"10-11":[46],"years":[47,76],"after":[48,77,212],"irradiation.":[49,223],"Several":[50],"lymphocyte":[51,135,269],"functions":[52,136],"also":[54,155,301],"severely":[55],"impaired.":[56],"An":[57],"association":[58],"was":[59,79,154,165,193,217,230],"found":[60,138],"between":[61],"prognosis":[62],"postirradiation":[64,86],"mitogen":[65,184,207],"reactivity":[66],"lymphocytes":[68,187],"from":[69,188],"these":[70,286],"patients.":[71,191],"Mortality":[72],"up":[73],"to":[74,100,166,174,177,274],"eight":[75],"significantly":[80],"higher":[81],"patients":[83,287],"low":[85],"phytohemagglutinin":[87,146],"PPD":[89],"reactivity.":[90],"radiation":[92,213],"induced":[93],"decrease":[94],"mitogenic":[96],"response":[97,147,185],"seemed":[98],"mainly":[99],"be":[101,113,247,263,283,299],"by":[103,115,120,157,234,249],"immunosuppressive":[104],"monocytes,":[105],"which":[106,271],"suggests":[107],"underlying":[110],"mechanism":[111],"might":[112,246],"mediated":[114],"increased":[116],"production":[117],"prostaglandins":[119,140,158],"monocytes.":[121],"For":[122],"this":[123],"reason":[124],"we":[125],"examined":[126],"effect":[128,216,281],"some":[130],"cyclooxygenase":[131,171,289],"products":[132],"different":[134],"A2,":[141],"D2,":[142],"E2":[144],"inhibited":[145],"vitro.":[149],"Natural":[150],"killer":[151],"cell":[152],"activity":[153],"reduced":[156],"D2":[159],"E2.":[161],"next":[163],"step":[164],"examine":[167],"various":[168],"inhibitors":[169,290],"respect":[173],"their":[175],"capacity":[176],"revert":[178],"irradiation-induced":[179],"suppression":[180,267],"vitro":[183,292],"It":[192],"demonstrated":[194],"Diclofenac":[196,228],"Na":[197,229],"(Voltaren),":[198],"Meclofenamic":[199,236],"acid,":[200,237],"Indomethacin,":[201,235],"lysin-mono-acetylsalicylate":[203],"(Aspisol)":[204],"could":[205,262],"enhance":[206],"responses":[208],"before":[210],"therapy.":[214],"This":[215],"most":[218,231],"pronounced":[219],"at":[220],"completion":[221],"On":[224],"a":[225],"molar":[226],"basis,":[227],"effective":[232],"followed":[233],"lysin-monoacetylsalicylate.":[239],"clinically":[241],"beneficial":[242],"effects":[243,251],"overshadowed":[248],"its":[250],"immune":[254],"system.":[255],"If":[256],"true,":[257],"value":[259],"treatment":[261],"improved":[264],"if":[265],"radiation-induced":[266],"response,":[270],"correlates":[272],"inversely":[273],"survival,":[275],"is":[276,294],"reduced.":[277],"Since":[278],"such":[279],"an":[280],"can":[282,298],"achieved":[284,300],"it":[293,297],"possible":[295],"vivo.":[303]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
