{"id":"https://openalex.org/W1505268812","doi":null,"title":"[Depression and neuroplasticity. Interaction of nervous, endocrine and immune systems].","display_name":"[Depression and neuroplasticity. Interaction of nervous, endocrine and immune systems].","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1505268812","mag":"1505268812","pmid":"https://pubmed.ncbi.nlm.nih.gov/20447905"},"language":"es","primary_location":{"id":"pmid:20447905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20447905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11336/53711","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016666551","display_name":"Paola Cassano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802359038","display_name":"Hospital Italiano de Buenos Aires","ror":"https://ror.org/00bq4rw46","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I2802359038"]},{"id":"https://openalex.org/I4210163230","display_name":"Universidad Hospital Italiano","ror":"https://ror.org/05x6bj397","country_code":"AR","type":"education","lineage":["https://openalex.org/I4210163230"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Paola Cassano","raw_affiliation_strings":["Instituto de Ciencias B\u00e1sicas y Medicina Experimental, Instituto Universitario-Escuela de Medicina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. paola.cassano@hospitalitaliano.org.ar","Hospital Italiano de Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Ciencias B\u00e1sicas y Medicina Experimental, Instituto Universitario-Escuela de Medicina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. paola.cassano@hospitalitaliano.org.ar","institution_ids":["https://openalex.org/I2802359038","https://openalex.org/I4210163230"]},{"raw_affiliation_string":"Hospital Italiano de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2802359038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032801196","display_name":"Pablo Francisco Argibay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802359038","display_name":"Hospital Italiano de Buenos Aires","ror":"https://ror.org/00bq4rw46","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I2802359038"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Pablo Argibay","raw_affiliation_strings":["Hospital Italiano de Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Italiano de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I2802359038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2188,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58289801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"70","issue":"2","first_page":"185","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8619999885559082},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.6759999990463257},{"id":"https://openalex.org/keywords/monoamine-hypothesis","display_name":"monoamine hypothesis","score":0.734000027179718},{"id":"https://openalex.org/keywords/neuroendocrine-immune-interaction","display_name":"neuroendocrine-immune interaction","score":0.722000002861023},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.7839999794960022},{"id":"https://openalex.org/keywords/genetic-and-environmental-factors","display_name":"genetic and environmental factors","score":0.6499999761581421},{"id":"https://openalex.org/keywords/brain-reorganization","display_name":"brain reorganization","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.6422057151794434},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.1877785325050354}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015306","descriptor_name":"Biogenic Monoamines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:20447905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20447905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"English Abstract"},{"id":"pmh:oai:americanae.aecid.es:3883731","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/53711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/53711","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/53711","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:1505268812","doi":null,"is_oa":false,"landing_page_url":"http://scielo.org.ar/scielo.php?script=sci_abstract&pid=S0025-76802010000200015&lng=es","pdf_url":null,"source":{"id":"https://openalex.org/S1032365090","display_name":"Medicina-buenos Aires","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4320800550","host_organization_name":"Fundaci\u00f3n Revista Medicina","host_organization_lineage":["https://openalex.org/P4320800550"],"host_organization_lineage_names":["Fundaci\u00f3n Revista Medicina"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Medicina-buenos Aires","raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3883731","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/53711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W54111966","https://openalex.org/W70197799","https://openalex.org/W99296762","https://openalex.org/W143896206","https://openalex.org/W1016442247","https://openalex.org/W1509310965","https://openalex.org/W1551014807","https://openalex.org/W1596332459","https://openalex.org/W1804267428","https://openalex.org/W1920894533","https://openalex.org/W1973079557","https://openalex.org/W1979020501","https://openalex.org/W1981724466","https://openalex.org/W1981964751","https://openalex.org/W1987604172","https://openalex.org/W1989699877","https://openalex.org/W1993636230","https://openalex.org/W1999407262","https://openalex.org/W2008050722","https://openalex.org/W2018865313","https://openalex.org/W2019316537","https://openalex.org/W2019455566","https://openalex.org/W2028084470","https://openalex.org/W2030772288","https://openalex.org/W2036589524","https://openalex.org/W2041663965","https://openalex.org/W2045510308","https://openalex.org/W2052500168","https://openalex.org/W2053298567","https://openalex.org/W2057518072","https://openalex.org/W2059565695","https://openalex.org/W2060590717","https://openalex.org/W2061794524","https://openalex.org/W2065089135","https://openalex.org/W2071070948","https://openalex.org/W2071783417","https://openalex.org/W2073216156","https://openalex.org/W2074802748","https://openalex.org/W2078660110","https://openalex.org/W2079806280","https://openalex.org/W2084691692","https://openalex.org/W2088249994","https://openalex.org/W2092305254","https://openalex.org/W2093052211","https://openalex.org/W2093541378","https://openalex.org/W2095491277","https://openalex.org/W2096582296","https://openalex.org/W2097408153","https://openalex.org/W2098630015","https://openalex.org/W2101585433","https://openalex.org/W2104012185","https://openalex.org/W2106623141","https://openalex.org/W2110248451","https://openalex.org/W2113354422","https://openalex.org/W2115430420","https://openalex.org/W2116629441","https://openalex.org/W2121358117","https://openalex.org/W2132539548","https://openalex.org/W2133518193","https://openalex.org/W2133565799","https://openalex.org/W2141451099","https://openalex.org/W2148239264","https://openalex.org/W2162196924","https://openalex.org/W2168558569","https://openalex.org/W2171238991","https://openalex.org/W2325380932","https://openalex.org/W2405043795","https://openalex.org/W2471814287"],"related_works":["https://openalex.org/W2992944318","https://openalex.org/W7061582663","https://openalex.org/W2007904965","https://openalex.org/W2309339129","https://openalex.org/W1972396616","https://openalex.org/W2095618681","https://openalex.org/W2183217452","https://openalex.org/W2474166533","https://openalex.org/W2038128888","https://openalex.org/W7205015462"],"abstract_inverted_index":{"Clinical":[0],"depression":[1],"is":[2,19,23,36,108,157],"a":[3,26],"physical":[4],"and":[5,50,60,123,149],"psychic":[6],"disease":[7],"that":[8,115,159],"has":[9],"neuropathological":[10],"basis,":[11],"although":[12],"the":[13,32,44,51,54,58,70,79,90,94,104,109,116,133,141,144,166],"clear":[14],"understanding":[15],"of":[16,25,34,46,53,69,72,81,89,96,106,118,143,168],"its":[17],"ethiopathology":[18],"still":[20],"missing.":[21],"There":[22],"evidence":[24],"genetic":[27],"component":[28],"in":[29,43,65,93,132,165],"depression,":[30],"however,":[31],"participation":[33],"environment":[35],"crucial.":[37],"Stress":[38],"plays":[39],"an":[40],"essential":[41],"role":[42],"onset":[45],"depression.":[47,66],"The":[48,67,98,135],"interaction":[49],"response":[52],"endocrine":[55,124],"system":[56,62],"with":[57],"immune":[59,122],"nervous":[61],"are":[63,126],"altered":[64],"observation":[68],"effect":[71],"antidepressants":[73,119,160],"on":[74,120],"monoaminergic":[75],"transmitters":[76],"leads":[77],"to":[78,102,128,146],"hypothesis":[80,85,100,113],"monoamines.":[82],"However":[83],"this":[84,169],"cannot":[86],"explain":[87,103],"many":[88],"mechanisms":[91],"involved":[92],"action":[95,105],"antidepressants.":[97],"new":[99,151],"proposed":[101,158],"antidepressant":[107],"neuro-plasticity":[110],"hypothesis.":[111],"This":[112],"suggests":[114],"effects":[117],"nervous,":[121],"systems":[125],"able":[127],"induce":[129],"neuroadaptative":[130],"changes":[131],"brain.":[134],"neuroplasticity":[136,162],"have":[137],"been":[138],"described":[139],"as":[140],"ability":[142],"brain":[145],"reorganize":[147],"itself":[148],"form":[150],"neuronal":[152],"connections":[153],"throughout":[154],"life.":[155],"It":[156],"influence":[161],"inducing":[163],"improvements":[164],"symptoms":[167],"illness.":[170]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
