{"id":"https://openalex.org/W1505127875","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1080.10","title":"Targeting inflammatory serine proteases for cardiac repair after Ischemia Reperfusion injury (1080.10)","display_name":"Targeting inflammatory serine proteases for cardiac repair after Ischemia Reperfusion injury (1080.10)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1505127875","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1080.10","mag":"1505127875"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.1080.10","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1080.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1080.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071356913","display_name":"Bahman Hooshdaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bahman Hooshdaran","raw_affiliation_strings":["physiology Temple University PHILADELPHIA PA United States","2physiology Temple University philadelphia PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"physiology Temple University PHILADELPHIA PA United States","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"2physiology Temple University philadelphia PA United States","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041867835","display_name":"Mikhail A. Kolpakov","orcid":"https://orcid.org/0000-0001-6448-2094","observed_orcids":["https://orcid.org/0000-0001-6448-2094"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikhail Kolpakov","raw_affiliation_strings":["physiology Temple University PHILADELPHIA PA United States","2physiology Temple University philadelphia PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"physiology Temple University PHILADELPHIA PA United States","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"2physiology Temple University philadelphia PA United States","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082964755","display_name":"Khadija Rafiq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khadija Rafiq","raw_affiliation_strings":["physiology Temple University PHILADELPHIA PA United States","2physiology Temple University philadelphia PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"physiology Temple University PHILADELPHIA PA United States","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"2physiology Temple University philadelphia PA United States","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055715202","display_name":"Xinji Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinji Guo","raw_affiliation_strings":["physiology Temple University PHILADELPHIA PA United States","2physiology Temple University philadelphia PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"physiology Temple University PHILADELPHIA PA United States","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"2physiology Temple University philadelphia PA United States","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011547126","display_name":"Mohammad F. Kiani","orcid":"https://orcid.org/0000-0003-1533-0179","observed_orcids":["https://orcid.org/0000-0003-1533-0179"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Kiani","raw_affiliation_strings":["engineering Temple University PHILADELPHIA PA United States","1engineering Temple University philadelphia PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"engineering Temple University PHILADELPHIA PA United States","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"1engineering Temple University philadelphia PA United States","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051015751","display_name":"Abdelkarim Sabri","orcid":"https://orcid.org/0000-0003-0553-790X","observed_orcids":["https://orcid.org/0000-0003-0553-790X"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdelkarim Sabri","raw_affiliation_strings":["physiology Temple University PHILADELPHIA PA United States","2physiology Temple University philadelphia PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"physiology Temple University PHILADELPHIA PA United States","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"2physiology Temple University philadelphia PA United States","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05518421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.30149999260902405,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cathepsin-g","display_name":"cathepsin G","score":0.8309999704360962},{"id":"https://openalex.org/keywords/chymase","display_name":"chymase","score":0.996999979019165},{"id":"https://openalex.org/keywords/tryptase","display_name":"tryptase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/serine-protease-inhibitors","display_name":"serine protease inhibitors","score":0.7710000276565552},{"id":"https://openalex.org/keywords/immunoliposomes","display_name":"immunoliposomes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.8130000233650208},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.9539999961853027},{"id":"https://openalex.org/keywords/myocyte-apoptosis","display_name":"myocyte apoptosis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7879999876022339},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cardiac-repair","display_name":"cardiac repair","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5683334469795227},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5673832893371582},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.542332649230957},{"id":"https://openalex.org/C2780614898","wikidata":"https://www.wikidata.org/wiki/Q5118578","display_name":"Chymase","level":3,"score":0.5294337272644043},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5063008069992065},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47176674008369446},{"id":"https://openalex.org/C3018686881","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac myocyte","level":3,"score":0.4278906583786011},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.42614224553108215},{"id":"https://openalex.org/C2777132095","wikidata":"https://www.wikidata.org/wiki/Q14906548","display_name":"Cathepsin G","level":4,"score":0.4212183952331543},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3573603332042694},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26872771978378296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2432149350643158},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2396312654018402},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.13573595881462097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08173671364784241},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.1080.10","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1080.10","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1080.10","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3728926910","display_name":null,"funder_award_id":"R01360998","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2624284676","https://openalex.org/W7613878","https://openalex.org/W2755179889","https://openalex.org/W2955978012","https://openalex.org/W2017534437","https://openalex.org/W3043511381","https://openalex.org/W2779904377","https://openalex.org/W3135389411","https://openalex.org/W1996462600","https://openalex.org/W4387114395"],"abstract_inverted_index":{"Background:":[0],"Chronic":[1],"inflammation":[2,19],"predisposes":[3],"tissue":[4],"to":[5,11,62,141,165,180,196,243],"adverse":[6,50],"cardiac":[7,21,51,102,161,227,246],"remodeling":[8,22,52,247],"and":[9,34,43,49,57,75,94,101,134,159,169,209,226,230,248],"contributes":[10],"heart":[12],"failure":[13],"(HF)":[14],"progression.":[15],"The":[16],"mechanisms":[17],"whereby":[18],"affect":[20],"after":[23,109,138],"injury":[24],"has":[25],"largely":[26,54],"focused":[27],"on":[28,96,205],"action":[29],"of":[30,79,90,149,172,175,186,202,218,223,235],"reactive":[31],"oxygen":[32],"species":[33],"cytokines/chemokines.":[35],"However,":[36],"inflammatory":[37,80],"cells":[38],"also":[39,152],"release":[40],"serine":[41,81],"proteases":[42],"their":[44],"role":[45,217],"in":[46,118,163],"myocyte":[47,97,154,224],"loss":[48],"remains":[53],"unknown.":[55],"Methods":[56],"Results:":[58],"We":[59],"subjected":[60],"mice":[61,142],"myocardial":[63,252],"ischemia":[64],"for":[65,71],"30":[66],"minutes":[67],"followed":[68],"by":[69],"reperfusion":[70,110],"24":[72],"hours":[73],"(IRI)":[74],"assessed":[76],"the":[77,194,216],"effect":[78],"protease":[82],"(ISP)":[83],"inhibitor,":[84],"a":[85,241],"potent":[86],"non":[87],"peptide":[88],"inhibitor":[89,105,128,151,177,188],"cathepsin":[91,132],"G,":[92],"chymase":[93,135],"tryptase,":[95],"apoptosis,":[98,155],"infarct":[99,157],"size":[100,158],"function.":[103],"ISP":[104,127,150,176,187,203],"was":[106],"delivered":[107],"just":[108],"either":[111],"systemically":[112],"(10":[113],"mg/kg,":[114,123],"i.v.)":[115],"or":[116],"encapsulated":[117],"anti\u2010P\u2010selectin":[119],"conjugated":[120],"immunoliposomes":[121,130],"(2":[122],"i.v.).":[124],"Treatment":[125],"with":[126,144,183,251],"loaded":[129],"reduced":[131,153],"G":[133],"activity":[136],"induced":[137],"IRI":[139],"compared":[140],"treated":[143],"empty":[145],"immunoliposomes.":[146],"Targeted":[147],"delivery":[148,174,185],"limited":[156],"improved":[160],"function":[162],"response":[164],"IRI.":[166],"These":[167,213],"structural":[168],"functional":[170],"improvements":[171],"targeted":[173,233],"were":[178],"similar":[179],"those":[181],"obtained":[182],"systemic":[184],"at":[189],"higher":[190],"dose,":[191],"but":[192],"have":[193],"advantage":[195],"occur":[197],"without":[198],"detectable":[199],"side":[200],"effects":[201],"inhibition":[204,234],"spleen,":[206],"bone":[207],"marrow":[208],"circulating":[210],"leukocytes.":[211],"Conclusions:":[212],"findings":[214],"reveal":[215],"ISPs":[219,236],"as":[220,240],"key":[221],"mediators":[222],"apoptosis":[225],"dysfunction":[228,249],"post\u2010IRI":[229],"show":[231],"that":[232],"could":[237],"be":[238],"used":[239],"therapy":[242],"reduce":[244],"pathological":[245],"associated":[250],"infarction.":[253],"Grant":[254],"Funding":[255],"Source":[256],":":[257],"NIH":[258],"R01360998":[259]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}
