{"id":"https://openalex.org/W1504750263","doi":"https://doi.org/10.1111/j.1365-2230.2012.04441.x","title":"Safety and efficacy analysis of liposomal insulin-like growth factor-1 in a fluid gel formulation for hair-loss treatment in a hamster model","display_name":"Safety and efficacy analysis of liposomal insulin-like growth factor-1 in a fluid gel formulation for hair-loss treatment in a hamster model","publication_year":2012,"publication_date":"2012-08-27","ids":{"openalex":"https://openalex.org/W1504750263","doi":"https://doi.org/10.1111/j.1365-2230.2012.04441.x","mag":"1504750263","pmid":"https://pubmed.ncbi.nlm.nih.gov/22924775"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2230.2012.04441.x","doi":"https://doi.org/10.1111/j.1365-2230.2012.04441.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2230.2012.04441.x","pdf_url":null,"source":{"id":"https://openalex.org/S80252431","display_name":"Clinical and Experimental Dermatology","issn_l":"0307-6938","issn":["0307-6938","1365-2230"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085616940","display_name":"R. F. Castro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"R. F. Castro","raw_affiliation_strings":["Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086612734","display_name":"L\u00edgia Ajaime Azzalis","orcid":"https://orcid.org/0000-0002-5634-1221","observed_orcids":["https://orcid.org/0000-0002-5634-1221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. A. Azzalis","raw_affiliation_strings":["Departments of Exact and Earth Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Exact and Earth Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006904488","display_name":"David Feder","orcid":"https://orcid.org/0000-0002-2366-5019","observed_orcids":["https://orcid.org/0000-0002-2366-5019"]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"D. Feder","raw_affiliation_strings":["Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013887073","display_name":"F\u00e1bio Ferreira Perazzo","orcid":"https://orcid.org/0000-0001-6114-4903","observed_orcids":["https://orcid.org/0000-0001-6114-4903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. F. Perazzo","raw_affiliation_strings":["Departments of Exact and Earth Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Exact and Earth Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065776779","display_name":"Edimar Cristiano Pereira","orcid":"https://orcid.org/0000-0001-6136-3700","observed_orcids":["https://orcid.org/0000-0001-6136-3700","https://orcid.org/0000-0003-3710-5511"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"E. C. Pereira","raw_affiliation_strings":["Biological Sciences, Campus Diadema, Federal University of S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences, Campus Diadema, Federal University of S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082542787","display_name":"Virginia Berlanga Campos Junqueira","orcid":"https://orcid.org/0000-0002-7921-5682","observed_orcids":["https://orcid.org/0000-0002-7921-5682"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"V. B. C. Junqueira","raw_affiliation_strings":["Biological Sciences, Campus Diadema, Federal University of S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences, Campus Diadema, Federal University of S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060102241","display_name":"Katya Cristina Rocha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"K. C. Rocha","raw_affiliation_strings":["Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109107994","display_name":"Carlos D\u2019 Aparecida Machado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"C. D\u2019A. Machado","raw_affiliation_strings":["Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023060900","display_name":"Francisco Camargo Paschoal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F. C. Paschoal","raw_affiliation_strings":["Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087320934","display_name":"La\u00eds Angelo Gnann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143330","display_name":"Faculdade de Medicina do ABC","ror":"https://ror.org/047s7ag77","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210143330"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"L. A. Gnann","raw_affiliation_strings":["Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Dermatology, Department of Clinical Medicine, Faculty of Medicine ABC, Santo Andr\u00e9, SP, Brazil","institution_ids":["https://openalex.org/I4210143330"]}]},{"author_position":"last","author":{"id":null,"display_name":"F. L. A. Fonseca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"F. L. A. Fonseca","raw_affiliation_strings":["Biological Sciences, Campus Diadema, Federal University of S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences, Campus Diadema, Federal University of S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I88273585"],"apc_list":{"value":2543,"currency":"GBP","value_usd":3354},"apc_paid":null,"fwci":1.45,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.8035356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"37","issue":"8","first_page":"909","last_page":"912"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.968999981880188},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.8209999799728394},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.5989999771118164},{"id":"https://openalex.org/keywords/topical-gel-formulation","display_name":"topical gel formulation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hair-density","display_name":"hair density","score":0.6769999861717224},{"id":"https://openalex.org/keywords/hair-diameter","display_name":"hair diameter","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hamster-model","display_name":"hamster model","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dermoscopy","display_name":"dermoscopy","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4345756471157074},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3447943329811096},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10944315791130066}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2230.2012.04441.x","doi":"https://doi.org/10.1111/j.1365-2230.2012.04441.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2230.2012.04441.x","pdf_url":null,"source":{"id":"https://openalex.org/S80252431","display_name":"Clinical and Experimental Dermatology","issn_l":"0307-6938","issn":["0307-6938","1365-2230"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:22924775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22924775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.unifesp.br:11600/35591","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/35591","pdf_url":null,"source":{"id":"https://openalex.org/S4377196380","display_name":"UNIFESP Institutional Repository (Universidade Federal de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88273585","host_organization_name":"Universidade Federal de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I88273585"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artigo"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W113957248","https://openalex.org/W1975690556","https://openalex.org/W1992141852","https://openalex.org/W2021182524","https://openalex.org/W2054838783","https://openalex.org/W2080586246","https://openalex.org/W2168161566","https://openalex.org/W2260688232"],"related_works":["https://openalex.org/W4414328469","https://openalex.org/W2328083892","https://openalex.org/W1997415552","https://openalex.org/W2386127492","https://openalex.org/W3127415918","https://openalex.org/W2748066864","https://openalex.org/W2354293692","https://openalex.org/W54024103","https://openalex.org/W4239486617","https://openalex.org/W2017501842"],"abstract_inverted_index":{"Insulin-like":[0],"growth":[1,124],"factor":[2],"(IGF)-1":[3],"has":[4],"shown":[5,78],"some":[6],"interesting":[7],"results":[8,140],"in":[9,37,58,81,125,130,146],"studies":[10],"examining":[11],"its":[12],"use":[13],"as":[14],"a":[15,147,152],"hair-loss":[16],"treatment.":[17],"IGF-1":[18,51,145],"works":[19],"by":[20,102],"regulating":[21],"cellular":[22],"proliferation":[23],"and":[24,33,72,108,120,154],"migration":[25],"during":[26],"the":[27,45,59,70,82,126,132,136],"development":[28],"of":[29,44,61,85,105,111],"hair":[30,106,112,115,158],"follicles.":[31],"Hepatotoxicity":[32],"myelotoxicity":[34],"were":[35],"evaluated":[36],"hamsters":[38],"(Mesocricetus":[39],"auratus)":[40],"after":[41],"topical":[42],"application":[43],"liquid":[46,148],"gel":[47,149],"vehicle":[48],"(placebo),":[49],"1%":[50,133],"or":[52,64,135],"3%":[53,127],"IGF-1.":[54,86],"No":[55],"significant":[56],"difference":[57],"levels":[60],"aspartate":[62],"aminotransferase":[63,66],"alanine":[65],"was":[67,90,94,100],"found":[68,116],"between":[69],"control":[71,137],"treated":[73],"groups.":[74],"ELISA":[75],"did":[76],"not":[77,95],"any":[79],"increase":[80],"plasma":[83],"level":[84],"A":[87],"haematopoietic":[88],"niche":[89],"found,":[91],"but":[92],"it":[93],"associated":[96],"with":[97,114,121],"myelotoxicity.":[98],"Efficacy":[99],"determined":[101],"dermatoscopy":[103],"analysis":[104,110],"density":[107],"microscopy":[109],"diameter,":[113],"to":[117],"be":[118],"thicker":[119],"more":[122],"rapid":[123],"group":[128,134],"than":[129],"either":[131],"group.":[138],"These":[139],"strongly":[141],"suggest":[142],"that":[143],"liposomal":[144],"formulation":[150],"is":[151],"safe":[153],"efficient":[155],"treatment":[156],"for":[157],"loss.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
