{"id":"https://openalex.org/W1504612940","doi":"https://doi.org/10.4049/jimmunol.174.9.5856","title":"CXC Chemokine Ligand 12 (Stromal Cell-Derived Factor 1\u03b1) and CXCR4-Dependent Migration of CTLs toward Melanoma Cells in Organotypic Culture","display_name":"CXC Chemokine Ligand 12 (Stromal Cell-Derived Factor 1\u03b1) and CXCR4-Dependent Migration of CTLs toward Melanoma Cells in Organotypic Culture","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W1504612940","doi":"https://doi.org/10.4049/jimmunol.174.9.5856","mag":"1504612940","pmid":"https://pubmed.ncbi.nlm.nih.gov/15843590"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.174.9.5856","doi":"https://doi.org/10.4049/jimmunol.174.9.5856","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.174.9.5856","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/174/9/5856/1200638/5856.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/174/9/5856/1200638/5856.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004021303","display_name":"Tianqian Zhang","orcid":"https://orcid.org/0000-0002-7952-5728","observed_orcids":["https://orcid.org/0000-0002-7952-5728"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianqian Zhang","raw_affiliation_strings":["The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","The Wistar Institute, Philadelphia, PA, 19104, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I2799810409"]},{"raw_affiliation_string":"The Wistar Institute, Philadelphia, PA, 19104, USA,","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012401963","display_name":"Rajasekharan Somasundaram","orcid":"https://orcid.org/0000-0002-8444-8472","observed_orcids":["https://orcid.org/0000-0002-8444-8472"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajasekharan Somasundaram","raw_affiliation_strings":["The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","*The Wistar Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I2799810409"]},{"raw_affiliation_string":"*The Wistar Institute,","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071672166","display_name":"Kl\u00e1ra Berencsi","orcid":"https://orcid.org/0000-0002-2109-6369","observed_orcids":["https://orcid.org/0000-0002-2109-6369"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Klara Berencsi","raw_affiliation_strings":["The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","*The Wistar Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I2799810409"]},{"raw_affiliation_string":"*The Wistar Institute,","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013048343","display_name":"Laura Caputo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Caputo","raw_affiliation_strings":["The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","*The Wistar Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I2799810409"]},{"raw_affiliation_string":"*The Wistar Institute,","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002657937","display_name":"Pyapalli Rani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pyapalli Rani","raw_affiliation_strings":["The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","*The Wistar Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I2799810409"]},{"raw_affiliation_string":"*The Wistar Institute,","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056828031","display_name":"DuPont Guerry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DuPont Guerry","raw_affiliation_strings":["Pigmented Lesion Clinic, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","\u2020Pigmented Lesion Clinic, Hospital of the University of Pennsylvania,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pigmented Lesion Clinic, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"\u2020Pigmented Lesion Clinic, Hospital of the University of Pennsylvania,","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042763431","display_name":"Emma Elizabeth Furth","orcid":"https://orcid.org/0000-0002-9309-985X","observed_orcids":["https://orcid.org/0000-0002-9309-985X"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Furth","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","\u2021Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"\u2021Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, and","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060446154","display_name":"Barrett J. Rollins","orcid":"https://orcid.org/0000-0003-4450-7092","observed_orcids":["https://orcid.org/0000-0003-4450-7092"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barrett J Rollins","raw_affiliation_strings":["\u00b6Dana-Farber Cancer Institute, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Dana-Farber Cancer Institute, Boston, MA 02115","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024323248","display_name":"Mary  E. Putt","orcid":"https://orcid.org/0000-0001-7954-1288","observed_orcids":["https://orcid.org/0000-0001-7954-1288","https://orcid.org/0009-0002-3631-0388"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Putt","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, University of Pennsylvania , Philadelphia, PA 19104","\u00a7Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"\u00a7Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104; and","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013962604","display_name":"Phyllis A. Gimotty","orcid":"https://orcid.org/0000-0002-3850-9799","observed_orcids":["https://orcid.org/0000-0002-3850-9799"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phyllis Gimotty","raw_affiliation_strings":["Department of Biostatistics and Epidemiology, University of Pennsylvania , Philadelphia, PA 19104","\u00a7Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Epidemiology, University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"\u00a7Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104; and","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006285859","display_name":"Rolf Swoboda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rolf Swoboda","raw_affiliation_strings":["The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","*The Wistar Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I2799810409"]},{"raw_affiliation_string":"*The Wistar Institute,","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028792712","display_name":"Meenhard Herlyn","orcid":"https://orcid.org/0000-0003-0839-0739","observed_orcids":["https://orcid.org/0000-0003-0839-0739"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meenhard Herlyn","raw_affiliation_strings":["The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","*The Wistar Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I2799810409"]},{"raw_affiliation_string":"*The Wistar Institute,","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021976445","display_name":"Dorothee Herlyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothee Herlyn","raw_affiliation_strings":["The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","*The Wistar Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute, Hospital of the University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I2799810409"]},{"raw_affiliation_string":"*The Wistar Institute,","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.3316,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.87608114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"174","issue":"9","first_page":"5856","last_page":"5863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.984000027179718},{"id":"https://openalex.org/keywords/stromal-cell-derived-factor-1alpha","display_name":"stromal cell-derived factor-1\u03b1","score":0.871999979019165},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.718999981880188},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6949999928474426},{"id":"https://openalex.org/keywords/organotypic-culture","display_name":"organotypic culture","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-cell-apoptosis","display_name":"tumor cell apoptosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cxcr4-antagonist","display_name":"CXCR4 antagonist","score":0.9210000038146973},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5699999928474426},{"id":"https://openalex.org/keywords/tumor-cell-transduction","display_name":"tumor cell transduction","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7108065485954285},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.6435135006904602},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6108139753341675},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5862681865692139},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5720790028572083},{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.5134371519088745},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4785240888595581},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.43301820755004883},{"id":"https://openalex.org/C135576274","wikidata":"https://www.wikidata.org/wiki/Q21112082","display_name":"CXCL16","level":5,"score":0.4270004630088806},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.41677045822143555},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4098796844482422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39968258142471313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3489651083946228},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3320956826210022},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29533708095550537},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2018439769744873},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.14394435286521912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.174.9.5856","doi":"https://doi.org/10.4049/jimmunol.174.9.5856","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.174.9.5856","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/174/9/5856/1200638/5856.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15843590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15843590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.174.9.5856","doi":"https://doi.org/10.4049/jimmunol.174.9.5856","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.174.9.5856","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/174/9/5856/1200638/5856.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3471318205","display_name":null,"funder_award_id":"CA-10815","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6442871445","display_name":"SPORE in Skin Cancer","funder_award_id":"P50CA093372","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000085015","display_name":null,"funder_award_id":"CA 10815","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000906427","display_name":"Consolidated Basic Cancer Research Program","funder_award_id":"P30CA010815","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308109","display_name":"Pennsylvania Department of Health","ror":"https://ror.org/00ra1fg11"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1504612940.pdf","grobid_xml":"https://content.openalex.org/works/W1504612940.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W107725474","https://openalex.org/W1499263255","https://openalex.org/W1504680408","https://openalex.org/W1519513582","https://openalex.org/W1553520538","https://openalex.org/W1751960924","https://openalex.org/W1963560035","https://openalex.org/W1963984954","https://openalex.org/W1964657187","https://openalex.org/W1964660899","https://openalex.org/W1970376873","https://openalex.org/W1970815741","https://openalex.org/W1978497275","https://openalex.org/W1993243004","https://openalex.org/W2003219276","https://openalex.org/W2007154637","https://openalex.org/W2019985934","https://openalex.org/W2032211562","https://openalex.org/W2035916624","https://openalex.org/W2037133729","https://openalex.org/W2037990739","https://openalex.org/W2038639526","https://openalex.org/W2057568338","https://openalex.org/W2062148688","https://openalex.org/W2064966614","https://openalex.org/W2070113911","https://openalex.org/W2076625163","https://openalex.org/W2076823120","https://openalex.org/W2078197336","https://openalex.org/W2079450072","https://openalex.org/W2081978192","https://openalex.org/W2092021793","https://openalex.org/W2094115571","https://openalex.org/W2095354110","https://openalex.org/W2102288149","https://openalex.org/W2107560602","https://openalex.org/W2118111815","https://openalex.org/W2120209561","https://openalex.org/W2122463890","https://openalex.org/W2125580285","https://openalex.org/W2129091609","https://openalex.org/W2129176443","https://openalex.org/W2135463621","https://openalex.org/W2138899068","https://openalex.org/W2144912209","https://openalex.org/W2150341008","https://openalex.org/W2228284268","https://openalex.org/W2401081924","https://openalex.org/W4211264883"],"related_works":["https://openalex.org/W2151617016","https://openalex.org/W2106481211","https://openalex.org/W1994793303","https://openalex.org/W2110473521","https://openalex.org/W2112248596","https://openalex.org/W7097040535","https://openalex.org/W2052322683","https://openalex.org/W1858413751","https://openalex.org/W2096522498","https://openalex.org/W2072178451"],"abstract_inverted_index":{"Studies":[0],"in":[1,29,32,35,42,64,79,137,190],"experimental":[2],"animal":[3],"models":[4],"have":[5],"demonstrated":[6],"that":[7,207],"chemokines":[8,41,60],"produced":[9],"by":[10,99,145,150,160,165,170,199],"tumor":[11,20,26,48,74,101,134,138,161,196,204,222,231],"cells":[12,49,75],"attract":[13],"chemokine":[14,146],"receptor-positive":[15],"T":[16,43,118],"lymphocytes":[17],"into":[18,221],"the":[19,38,54,57,65,126,130,151],"area,":[21],"which":[22],"may":[23,209],"lead":[24],"to":[25,172,226],"growth":[27],"inhibition":[28],"vitro":[30],"and":[31,61,117,153],"vivo.":[33],"However,":[34],"cancer":[36,217],"patients,":[37,218],"role":[39,58],"of":[40,59,67,86,90,112,167,178,194,201],"lymphocyte":[44],"trafficking":[45],"toward":[46,72,133],"human":[47],"is":[50],"relatively":[51],"unexplored.":[52],"In":[53,120],"present":[55],"study,":[56],"their":[62],"receptors":[63],"migration":[66,142,169],"a":[68,80,87,100,109],"melanoma":[69,83],"patient's":[70],"CTL":[71,123,141,152,168],"autologous":[73],"has":[76],"been":[77],"studied":[78],"novel":[81],"organotypic":[82],"culture,":[84],"consisting":[85],"bottom":[88],"layer":[89,111,128,132],"collagen":[91,113],"type":[92],"I":[93],"with":[94,114,188],"embedded":[95,115],"fibroblasts":[96,116],"followed":[97,198],"successively":[98],"cell":[102,139],"layer,":[103,106],"collagen/fibroblast":[104],"separating":[105,131],"and,":[107],"finally,":[108],"top":[110,127],"cells.":[119],"this":[121],"model,":[122],"migrated":[124],"from":[125],"through":[129],"cells,":[135,162,197,205,223],"resulting":[136],"apoptosis.":[140],"was":[143],"mediated":[144],"receptor":[147],"CXCR4":[148,183],"expressed":[149],"CXCL12":[154,173,179,208],"(stromal":[155],"cell-derived":[156],"factor":[157],"1alpha)":[158],"secreted":[159],"as":[163,212],"evidenced":[164],"blockage":[166],"Abs":[171],"or":[174,180,224,230],"CXCR4,":[175],"high":[176],"concentrations":[177],"small":[181],"molecule":[182],"antagonist.":[184],"These":[185],"studies,":[186],"together":[187],"studies":[189],"mice":[191],"indicating":[192],"regression":[193,200],"CXCL12-transduced":[195],"nontransduced":[202],"challenge":[203],"suggest":[206],"be":[210],"useful":[211],"an":[213],"immunotherapeutic":[214],"agent":[215],"for":[216],"when":[219],"transduced":[220],"fused":[225],"anti-tumor":[227],"Ag":[228],"Ab":[229],"Ag.":[232]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}