{"id":"https://openalex.org/W1504486485","doi":"https://doi.org/10.1152/ajpregu.1988.254.3.r463","title":"Further evidence implicating prostaglandin E2 in the genesis of pyrogen fever","display_name":"Further evidence implicating prostaglandin E2 in the genesis of pyrogen fever","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W1504486485","doi":"https://doi.org/10.1152/ajpregu.1988.254.3.r463","mag":"1504486485","pmid":"https://pubmed.ncbi.nlm.nih.gov/3279826"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.1988.254.3.r463","doi":"https://doi.org/10.1152/ajpregu.1988.254.3.r463","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1988.254.3.r463","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012624770","display_name":"Flavio Coceani","orcid":"https://orcid.org/0000-0002-5423-983X","observed_orcids":["https://orcid.org/0000-0002-5423-983X"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4405261154","display_name":"Sickkids Research Institute","ror":"https://ror.org/04wex6338","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801317318","https://openalex.org/I4405261154"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F. Coceani","raw_affiliation_strings":["Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I4405261154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037880195","display_name":"Jodi Lees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4405261154","display_name":"Sickkids Research Institute","ror":"https://ror.org/04wex6338","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801317318","https://openalex.org/I4405261154"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Lees","raw_affiliation_strings":["Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I4405261154"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110169241","display_name":"Isis Bishai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4405261154","display_name":"Sickkids Research Institute","ror":"https://ror.org/04wex6338","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801317318","https://openalex.org/I4405261154"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"I. Bishai","raw_affiliation_strings":["Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318","https://openalex.org/I4405261154"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0323,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.94706369,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"254","issue":"3","first_page":"R463","last_page":"R469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.06440000236034393,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.996999979019165},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.7369999885559082},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/probenecid","display_name":"probenecid","score":0.8659999966621399},{"id":"https://openalex.org/keywords/fever-regulation","display_name":"fever regulation","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.6813798546791077},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.6774418950080872},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6171686053276062},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.6015965342521667},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.5885512828826904},{"id":"https://openalex.org/C2776769776","wikidata":"https://www.wikidata.org/wiki/Q900898","display_name":"Probenecid","level":2,"score":0.5554389953613281},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.535988450050354},{"id":"https://openalex.org/C2781080829","wikidata":"https://www.wikidata.org/wiki/Q3009646","display_name":"Thromboxane B2","level":3,"score":0.5353586673736572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5099695920944214},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4898216426372528},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4771242141723633},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.4203813970088959},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3450257480144501},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011458","descriptor_name":"Prostaglandins E","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D011458","descriptor_name":"Prostaglandins E","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011749","descriptor_name":"Pyrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013928","descriptor_name":"Thromboxane A2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013928","descriptor_name":"Thromboxane A2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.1988.254.3.r463","doi":"https://doi.org/10.1152/ajpregu.1988.254.3.r463","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1988.254.3.r463","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:3279826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3279826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2190113282","https://openalex.org/W2301828609","https://openalex.org/W2464222546","https://openalex.org/W2062102197","https://openalex.org/W2149323789","https://openalex.org/W2047297053","https://openalex.org/W2063496770","https://openalex.org/W2422946542","https://openalex.org/W2067473770","https://openalex.org/W7097451325"],"abstract_inverted_index":{"Conscious":[0],"cats":[1],"were":[2,38,45],"used":[3],"to":[4,169,177],"study":[5],"the":[6,34,67,83,102,106,128,149,167,181,227],"effects":[7,200],"of":[8,17,105,125,151,231,236],"endotoxin":[9,72,215],"and":[10,21,43,61,85,95,229],"interleukin":[11],"1":[12,76],"(IL":[13],"1)":[14],"on":[15,127,201],"levels":[16,162],"prostaglandin":[18],"(PG)":[19],"E2":[20],"thromboxane":[22],"(TX)":[23],"B2":[24],"(the":[25],"stable":[26],"TXA2":[27,191,206],"byproduct)":[28],"in":[29,115,133,154,175,226],"cerebrospinal":[30],"fluid":[31],"(CSF)":[32],"from":[33,117,157],"third":[35],"ventricle.":[36],"Pyrogens":[37],"given":[39],"intravenously":[40],"or":[41,74,120,141,144,194],"intraventricularly":[42],"prostanoids":[44,156],"measured":[46],"by":[47],"radioimmunoassay.":[48],"PGE2":[49,80,93,109,225],"was":[50,86,98,112,131,240],"normally":[51],"less":[52],"abundant":[53],"than":[54],"TXB2":[55,161,172],"(mean,":[56],"37":[57],"vs.":[58],"528":[59],"pg/ml),":[60],"its":[62],"level":[63],"increased":[64],"severalfold":[65],"during":[66,101,166],"sustained":[68],"fever":[69,84,168,187],"following":[70],"intravenous":[71,170],"(bolus)":[73],"IL":[75],"(bolus":[77],"plus":[78],"infusion).":[79],"elevation":[81,182],"preceded":[82],"maintained":[87],"thereafter.":[88],"Likewise,":[89],"intraventricular":[90,178],"pyrogens":[91],"promoted":[92],"formation,":[94],"their":[96],"effect":[97],"also":[99],"manifest":[100],"latent":[103],"period":[104],"fever.":[107,216,233],"The":[108],"metabolite,":[110],"13,14-dihydro-15-keto-PGE2,":[111],"not":[113,164,184,212],"measurable":[114],"CSF":[116],"either":[118],"afebrile":[119],"febrile":[121],"animals.":[122],"Basal":[123],"content":[124],"PGE2,":[126,160],"other":[129],"hand,":[130],"higher":[132],"animals":[134],"pretreated":[135],"with":[136,214],"probenecid":[137],"(30":[138],"mg/kg":[139],"ip":[140],"iv;":[142],"50":[143],"100":[145],"micrograms":[146,196,209],"ivt),":[147],"confirming":[148],"importance":[150],"transport":[152],"processes":[153],"removing":[155],"brain.":[158],"Unlike":[159],"did":[163,183,211],"change":[165],"endotoxin.":[171],"rose":[173],"instead":[174],"response":[176],"endotoxin,":[179],"although":[180],"extend":[185],"beyond":[186],"uprise.":[188],"Furthermore,":[189],"a":[190,205,221,237],"analog":[192],"(ONO-11113;2":[193],"4":[195],"ivt)":[197,210],"had":[198],"inconsistent":[199],"body":[202],"temperature,":[203],"while":[204],"antagonist":[207],"(ONO-11120;2":[208],"interfere":[213],"These":[217],"findings":[218],"strongly":[219],"support":[220],"causative":[222],"role":[223,239],"for":[224,242],"onset":[228],"progression":[230],"pyrogen":[232],"No":[234],"evidence":[235],"similar":[238],"obtained":[241],"TXA2.":[243]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
