{"id":"https://openalex.org/W1504435709","doi":null,"title":"Health from Herbs? Antioxidant Studies on Selected Lamiaceae Herbs in vitro and in Humans","display_name":"Health from Herbs? Antioxidant Studies on Selected Lamiaceae Herbs in vitro and in Humans","publication_year":2008,"publication_date":"2008-03-29","ids":{"openalex":"https://openalex.org/W1504435709","mag":"1504435709"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/19109","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/19109","pdf_url":"http://hdl.handle.net/10138/19109","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/19109","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Anna Nurmi","orcid":"https://orcid.org/0000-0003-2235-1752","observed_orcids":["https://orcid.org/0000-0003-2235-1752"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna Nurmi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2235-1752","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10909","display_name":"Edible Oils Quality and Analysis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sage","display_name":"sage","score":0.6259999871253967},{"id":"https://openalex.org/keywords/thyme","display_name":"thyme","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rosemary","display_name":"Rosmarinus officinalis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oregano","display_name":"oregano","score":0.9980000257492065},{"id":"https://openalex.org/keywords/origanum-onites","display_name":"Origanum onites","score":0.8429999947547913},{"id":"https://openalex.org/keywords/salvia-officinalis","display_name":"Salvia officinalis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.7760000228881836},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.7670000195503235},{"id":"https://openalex.org/keywords/ldl-oxidation","display_name":"LDL oxidation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2777143434","wikidata":"https://www.wikidata.org/wiki/Q53476","display_name":"Lamiaceae","level":2,"score":0.8062366247177124},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5926656723022461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46910175681114197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3067589998245239}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/19109","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/19109","pdf_url":"http://hdl.handle.net/10138/19109","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1504435709","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/19109/2/healthfr.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/19109","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/19109","pdf_url":"http://hdl.handle.net/10138/19109","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320322305","display_name":"Juho Vainion S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/05jf66d94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1504435709.pdf","grobid_xml":"https://content.openalex.org/works/W1504435709.grobid-xml"},"referenced_works_count":197,"referenced_works":["https://openalex.org/W10099940","https://openalex.org/W88937860","https://openalex.org/W103953941","https://openalex.org/W126725029","https://openalex.org/W151105143","https://openalex.org/W1223905092","https://openalex.org/W1238349098","https://openalex.org/W1261198562","https://openalex.org/W1536161802","https://openalex.org/W1543197883","https://openalex.org/W1559903407","https://openalex.org/W1567600191","https://openalex.org/W1574544450","https://openalex.org/W1596181788","https://openalex.org/W1614231230","https://openalex.org/W1734082729","https://openalex.org/W1748275413","https://openalex.org/W1848118980","https://openalex.org/W1853889911","https://openalex.org/W1857052429","https://openalex.org/W1907068960","https://openalex.org/W1914622032","https://openalex.org/W1938228961","https://openalex.org/W1938528378","https://openalex.org/W1946815265","https://openalex.org/W1952954894","https://openalex.org/W1955371799","https://openalex.org/W1963554650","https://openalex.org/W1965245141","https://openalex.org/W1965559891","https://openalex.org/W1966112269","https://openalex.org/W1967478570","https://openalex.org/W1971154691","https://openalex.org/W1971485602","https://openalex.org/W1974277761","https://openalex.org/W1976616659","https://openalex.org/W1976911231","https://openalex.org/W1978773061","https://openalex.org/W1979189704","https://openalex.org/W1981184057","https://openalex.org/W1981755605","https://openalex.org/W1982059829","https://openalex.org/W1983352396","https://openalex.org/W1985655598","https://openalex.org/W1986254796","https://openalex.org/W1987037049","https://openalex.org/W1990106417","https://openalex.org/W1992214779","https://openalex.org/W1992912400","https://openalex.org/W1992935214","https://openalex.org/W1993851201","https://openalex.org/W1999055613","https://openalex.org/W2000118672","https://openalex.org/W2000783941","https://openalex.org/W2000922483","https://openalex.org/W2000967440","https://openalex.org/W2001795223","https://openalex.org/W2002797577","https://openalex.org/W2003471941","https://openalex.org/W2004126708","https://openalex.org/W2005868430","https://openalex.org/W2008566131","https://openalex.org/W2009760859","https://openalex.org/W2010201651","https://openalex.org/W2010311619","https://openalex.org/W2010821874","https://openalex.org/W2010837696","https://openalex.org/W2013292119","https://openalex.org/W2013575591","https://openalex.org/W2014110381","https://openalex.org/W2014946840","https://openalex.org/W2017419560","https://openalex.org/W2019000940","https://openalex.org/W2020984555","https://openalex.org/W2022694430","https://openalex.org/W2024716555","https://openalex.org/W2025874056","https://openalex.org/W2028876385","https://openalex.org/W2029314163","https://openalex.org/W2033656939","https://openalex.org/W2033670414","https://openalex.org/W2035270181","https://openalex.org/W2036490839","https://openalex.org/W2037188360","https://openalex.org/W2038013490","https://openalex.org/W2038246208","https://openalex.org/W2038306581","https://openalex.org/W2039398380","https://openalex.org/W2041822519","https://openalex.org/W2042678998","https://openalex.org/W2042856747","https://openalex.org/W2050167455","https://openalex.org/W2050567297","https://openalex.org/W2052570683","https://openalex.org/W2055339187","https://openalex.org/W2056792558","https://openalex.org/W2056802141","https://openalex.org/W2057000237","https://openalex.org/W2057476398","https://openalex.org/W2057902127","https://openalex.org/W2058974685","https://openalex.org/W2059413874","https://openalex.org/W2060547549","https://openalex.org/W2061142443","https://openalex.org/W2061242359","https://openalex.org/W2061799142","https://openalex.org/W2063765017","https://openalex.org/W2063950428","https://openalex.org/W2065853716","https://openalex.org/W2067638587","https://openalex.org/W2068303130","https://openalex.org/W2069584550","https://openalex.org/W2070203351","https://openalex.org/W2070882338","https://openalex.org/W2070944006","https://openalex.org/W2071547862","https://openalex.org/W2072348601","https://openalex.org/W2072894291","https://openalex.org/W2074318467","https://openalex.org/W2074581135","https://openalex.org/W2076207476","https://openalex.org/W2078317560","https://openalex.org/W2078711357","https://openalex.org/W2080312876","https://openalex.org/W2080475924","https://openalex.org/W2082010159","https://openalex.org/W2083035247","https://openalex.org/W2085290726","https://openalex.org/W2085589102","https://openalex.org/W2086959952","https://openalex.org/W2087724955","https://openalex.org/W2088538490","https://openalex.org/W2092978093","https://openalex.org/W2094844123","https://openalex.org/W2095680342","https://openalex.org/W2098665066","https://openalex.org/W2100022178","https://openalex.org/W2105234557","https://openalex.org/W2109119392","https://openalex.org/W2111379380","https://openalex.org/W2112220469","https://openalex.org/W2112795697","https://openalex.org/W2114004260","https://openalex.org/W2114487906","https://openalex.org/W2117934439","https://openalex.org/W2118447955","https://openalex.org/W2119582385","https://openalex.org/W2122576275","https://openalex.org/W2122694669","https://openalex.org/W2124058238","https://openalex.org/W2124070640","https://openalex.org/W2124342337","https://openalex.org/W2124557334","https://openalex.org/W2125288624","https://openalex.org/W2126682311","https://openalex.org/W2129133439","https://openalex.org/W2129453439","https://openalex.org/W2131691081","https://openalex.org/W2136198185","https://openalex.org/W2138412449","https://openalex.org/W2139937589","https://openalex.org/W2140230248","https://openalex.org/W2140957970","https://openalex.org/W2140990894","https://openalex.org/W2141904912","https://openalex.org/W2142576035","https://openalex.org/W2145562618","https://openalex.org/W2145978854","https://openalex.org/W2147370212","https://openalex.org/W2150740780","https://openalex.org/W2153473625","https://openalex.org/W2153801889","https://openalex.org/W2154084384","https://openalex.org/W2155832294","https://openalex.org/W2156575623","https://openalex.org/W2156716051","https://openalex.org/W2158828238","https://openalex.org/W2158846505","https://openalex.org/W2160641284","https://openalex.org/W2163624012","https://openalex.org/W2163746941","https://openalex.org/W2168775710","https://openalex.org/W2169524495","https://openalex.org/W2170251534","https://openalex.org/W2172018104","https://openalex.org/W2207015025","https://openalex.org/W2212323528","https://openalex.org/W2290967234","https://openalex.org/W2315512556","https://openalex.org/W2334639039","https://openalex.org/W2429246468","https://openalex.org/W2465143030","https://openalex.org/W2599555230","https://openalex.org/W2606226734","https://openalex.org/W3139427245","https://openalex.org/W4246734780","https://openalex.org/W4317523496"],"related_works":["https://openalex.org/W6982903525","https://openalex.org/W2201039408","https://openalex.org/W7212932443","https://openalex.org/W1594142954","https://openalex.org/W2037740057","https://openalex.org/W2044638222","https://openalex.org/W2012890500","https://openalex.org/W7096872669","https://openalex.org/W2109561041","https://openalex.org/W4404716929"],"abstract_inverted_index":{"High":[0],"dietary":[1,44,149],"intake":[2,510],"of":[3,15,24,29,42,93,96,127,141,153,181,200,207,230,264,279,286,300,309,321,328,342,348,368,378,384,388,400,409,442,476,511,521,533],"fruits":[4,514],"and":[5,49,52,65,113,156,159,237,252,284,325,345,355,375,412,450,459,479,515,517],"vegetables":[6,516],"has":[7],"been":[8],"linked":[9],"to":[10,124,164,204,334,463],"protection":[11],"against":[12],"chronic":[13],"diseases,":[14],"which":[16],"cardiovascular":[17],"diseases":[18],"(CVD)":[19],"are":[20,56,135,460,495],"the":[21,30,33,39,81,90,97,125,174,182,187,197,208,271,274,297,326,372,385,398,427,439,468,503,508,518,536],"major":[22],"cause":[23],"death":[25],"in":[26,58,61,71,131,220,226,291,312,338,353,371,417,457,467,483,527],"Finland.":[27],"One":[28],"hypotheses":[31],"underlying":[32],"mechanism":[34],"behind":[35],"this":[36],"effect":[37],"is":[38],"antioxidant":[40,69,91,228,280,340,369,410,428,455,480,500],"action":[41],"several":[43,436,531],"factors,":[45],"including":[46],"vitamins":[47],"C":[48],"E,":[50],"carotenoids":[51],"polyphenolic":[53],"compounds.":[54],"Polyphenols":[55],"consumed":[57],"large":[59],"quantities":[60],"plant":[62,98],"rich":[63,513],"diets":[64],"observations":[66],"on":[67,173,270,406,426,438,444,473,493,530,544],"their":[68,389,451,489],"potency":[70],"vitro":[72,227,339,458,528],"have":[73,541],"made":[74],"them":[75],"a":[76,138,221,248,253,318,366,393],"hot":[77],"research":[78],"topic":[79],"during":[80],"past":[82],"twenty":[83],"years.":[84],"The":[85,151,191,214,225,260,282,307,337,359,485],"present":[86],"study":[87,201],"deals":[88],"with":[89,145],"activity":[92,180,341,370,379],"selected":[94],"members":[95],"family":[99],"Lamiaceae":[100],"sage":[101,169],"(Salvia":[102],"officinalis":[103,111],"L.),":[104,108],"thyme":[105,236],"(Thymus":[106],"vulgaris":[107],"rosemary":[109],"(Rosmarinus":[110],"L.)":[112],"two":[114],"oregano":[115,238,287,401],"species":[116],"(Origanum":[117],"vulgare":[118],"L.,":[119],"Origanum":[120],"onites":[121,323,350,364],"L.).":[122],"Due":[123],"abundance":[126],"various":[128],"phenolic":[129,166,262,301,310,343,360],"compounds":[130],"these":[132,265,448],"herbs,":[133],"they":[134,470],"considered":[136],"as":[137,147,523,525],"potential":[139,490],"source":[140],"health-beneficial":[142,491],"natural":[143],"components":[144],"usage":[146],"health-promoting":[148],"supplements.":[150],"applicability":[152],"hydrodistillation,":[154],"methanolic":[155],"ethanolic":[157],"extraction,":[158],"pressurised":[160],"hot-water":[161],"extraction":[162],"(PHWE)":[163],"extract":[165,290,404],"antioxidants":[167],"from":[168,233,362],"was":[170,186,194,216,267,293,314,380],"studied.":[171],"Based":[172],"1,1-diphenyl-2-picrylhydrazyl":[175],"radical":[176,245],"(DPPH":[177],")":[178],"scavenging":[179,246],"different":[183,407],"extracts,":[184],"PHWE":[185],"most":[188],"effective":[189,332],"technique.":[190],"hydrodistillation":[192],"method":[193,272],"chosen":[195],"for":[196,211,382],"further":[198],"production":[199],"extracts":[202,209,232,266,275,449],"due":[203],"sensory":[205],"properties":[206,229],"suitable":[210],"human":[212,254,346,390,545],"consumption.":[213],"technique":[215],"also":[217],"easily":[218],"applicable":[219],"larger":[222],"scale":[223],"production.":[224],"water":[231],"sage,":[234],"rosemary,":[235],"(O.":[239,288,402],"vulgare)":[240,403],"were":[241,351,415,431],"characterised":[242],"using":[243,303],"three":[244],"assays,":[247],"reductive":[249],"capacity":[250,411,481],"assay":[251],"low-density":[255],"lipoprotein":[256],"(LDL)":[257],"oxidation":[258,357],"assay.":[259],"total":[261],"content":[263],"determined.":[268],"Depending":[269],"used,":[273,374],"showed":[276,365],"varying":[277],"degrees":[278],"activity.":[281],"absorption":[283],"metabolism":[285,333],"onites)":[289],"humans":[292,494],"evaluated":[294],"by":[295],"analysing":[296],"urinary":[298,329],"excretion":[299,308],"metabolites":[302,311,330,347],"liquid":[304],"chromatographic":[305],"methods.":[306],"urine":[313],"markedly":[315],"increased":[316],"following":[317],"single":[319],"ingestion":[320],"O.":[322,349,363],"extract,":[324],"pattern":[327],"suggested":[331],"take":[335],"place.":[336],"constituents":[344,452],"studied":[352,416],"DPPH":[354],"LDL":[356],"assays.":[358],"acids":[361],"range":[367],"assays":[373],"some":[376,464,549],"degree":[377],"observed":[381],"many":[383],"aglycone":[386],"forms":[387],"metabolites.":[391],"In":[392],"double-blinded,":[394],"placebo-controlled":[395],"clinical":[396],"trial,":[397],"effects":[399,425,472,492,543],"consumption":[405],"biomarkers":[408],"lipid":[413,477],"peroxidation":[414,478],"healthy":[418],"men.":[419],"No":[420],"short-":[421],"or":[422],"long":[423],"term":[424],"parameters":[429,482],"followed":[430],"observed.":[432],"This":[433],"work":[434],"revealed":[435],"aspects":[437],"problematic":[440],"nature":[441],"studies":[443],"antioxidants.":[445],"Even":[446],"though":[447],"seem":[453],"promising":[454],"candidates":[456],"at":[461],"least":[462],"extent":[465],"available":[466],"body,":[469],"lack":[471],"an":[474],"array":[475],"vivo.":[484],"findings":[486],"suggest":[487],"that":[488,538],"not":[496],"mediated":[497,547],"via":[498,548],"direct":[499],"action.":[501],"However,":[502],"epidemiologically":[504],"observd":[505],"association":[506],"between":[507],"high":[509],"polyphenol":[512],"decreased":[519],"risk":[520],"CVD,":[522],"well":[524],"accumulating":[526],"evidence":[529],"bioactivities":[532],"polyphenols":[534,539],"support":[535],"theory":[537],"may":[540],"favourable":[542],"health":[546],"other":[550],"mechanisms.":[551]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}