{"id":"https://openalex.org/W1504380227","doi":null,"title":"Tau and neurofilament proteins in Alzheimer's disease and related cell models","display_name":"Tau and neurofilament proteins in Alzheimer's disease and related cell models","publication_year":2007,"publication_date":"2007-11-23","ids":{"openalex":"https://openalex.org/W1504380227","mag":"1504380227"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26906707","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Tau_and_neurofilament_proteins_in_Alzheimer_s_disease_and_related_cell_models/26906707","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38463","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017442408","display_name":"Cecilia Bj\u00f6rkdahl","orcid":"https://orcid.org/0000-0002-0338-5909","observed_orcids":["https://orcid.org/0000-0002-0338-5909"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cecilia Bj\u00f6rkdahl","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0338-5909","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017442408"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.8460000157356262},{"id":"https://openalex.org/keywords/neurofilament-proteins","display_name":"neurofilament proteins","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8870000243186951},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.800000011920929},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.925000011920929},{"id":"https://openalex.org/keywords/p70s6k","display_name":"p70S6K","score":0.949999988079071},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cell-cycle-markers","display_name":"cell cycle markers","score":0.460999995470047},{"id":"https://openalex.org/keywords/braak-staging","display_name":"Braak staging","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.627355694770813},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6244190335273743},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5658896565437317},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5344091653823853},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5298033952713013},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5119220018386841},{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.49805140495300293},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4931153953075409},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.4924560487270355},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4804810583591461},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.4495944082736969},{"id":"https://openalex.org/C121738310","wikidata":"https://www.wikidata.org/wiki/Q18248262","display_name":"Cyclin-dependent kinase 5","level":5,"score":0.4401475191116333},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4359561800956726},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41431209444999695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4118489623069763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3850431442260742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3473520278930664},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3268303871154785},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.12413865327835083},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0959586501121521}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26906707","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Tau_and_neurofilament_proteins_in_Alzheimer_s_disease_and_related_cell_models/26906707","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38463","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38463","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1504380227","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/38463/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38463","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38463","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":226,"referenced_works":["https://openalex.org/W3668970","https://openalex.org/W10604852","https://openalex.org/W41425367","https://openalex.org/W134536487","https://openalex.org/W186935322","https://openalex.org/W283353572","https://openalex.org/W328531019","https://openalex.org/W1456573927","https://openalex.org/W1481540262","https://openalex.org/W1483229283","https://openalex.org/W1519600605","https://openalex.org/W1525169050","https://openalex.org/W1528790659","https://openalex.org/W1531522492","https://openalex.org/W1545362848","https://openalex.org/W1556008598","https://openalex.org/W1567624342","https://openalex.org/W1573139030","https://openalex.org/W1577397450","https://openalex.org/W1577877616","https://openalex.org/W1581358998","https://openalex.org/W1592716123","https://openalex.org/W1601433695","https://openalex.org/W1603046163","https://openalex.org/W1611407165","https://openalex.org/W1620905250","https://openalex.org/W1624844572","https://openalex.org/W1646952712","https://openalex.org/W1708445842","https://openalex.org/W1773591497","https://openalex.org/W1822372593","https://openalex.org/W1908612571","https://openalex.org/W1934937165","https://openalex.org/W1935951477","https://openalex.org/W1954244449","https://openalex.org/W1956314911","https://openalex.org/W1963723155","https://openalex.org/W1964597381","https://openalex.org/W1966242095","https://openalex.org/W1966308573","https://openalex.org/W1968937229","https://openalex.org/W1969209100","https://openalex.org/W1970452111","https://openalex.org/W1970458627","https://openalex.org/W1971614735","https://openalex.org/W1975040221","https://openalex.org/W1976108141","https://openalex.org/W1976462601","https://openalex.org/W1977002082","https://openalex.org/W1977206425","https://openalex.org/W1978254707","https://openalex.org/W1979268652","https://openalex.org/W1980398713","https://openalex.org/W1981756966","https://openalex.org/W1983010354","https://openalex.org/W1984909573","https://openalex.org/W1985043600","https://openalex.org/W1985446942","https://openalex.org/W1985703940","https://openalex.org/W1986458417","https://openalex.org/W1986953518","https://openalex.org/W1987012898","https://openalex.org/W1987084487","https://openalex.org/W1987105275","https://openalex.org/W1991647860","https://openalex.org/W1993292386","https://openalex.org/W1996175518","https://openalex.org/W1997874814","https://openalex.org/W1998440070","https://openalex.org/W1999008576","https://openalex.org/W1999086610","https://openalex.org/W1999339491","https://openalex.org/W2000706612","https://openalex.org/W2002021660","https://openalex.org/W2002855119","https://openalex.org/W2002896646","https://openalex.org/W2003772355","https://openalex.org/W2004190833","https://openalex.org/W2005199015","https://openalex.org/W2005809709","https://openalex.org/W2006345162","https://openalex.org/W2007472518","https://openalex.org/W2007961618","https://openalex.org/W2008205044","https://openalex.org/W2008359273","https://openalex.org/W2008859668","https://openalex.org/W2010958261","https://openalex.org/W2011238785","https://openalex.org/W2011451688","https://openalex.org/W2011783950","https://openalex.org/W2012341420","https://openalex.org/W2014566379","https://openalex.org/W2014898742","https://openalex.org/W2015239901","https://openalex.org/W2015600776","https://openalex.org/W2015675204","https://openalex.org/W2019175855","https://openalex.org/W2021280880","https://openalex.org/W2021933220","https://openalex.org/W2023193162","https://openalex.org/W2023296859","https://openalex.org/W2023610686","https://openalex.org/W2025869353","https://openalex.org/W2027150462","https://openalex.org/W2027642546","https://openalex.org/W2027771129","https://openalex.org/W2028488410","https://openalex.org/W2030223062","https://openalex.org/W2031065479","https://openalex.org/W2031864556","https://openalex.org/W2032009532","https://openalex.org/W2032115754","https://openalex.org/W2034713237","https://openalex.org/W2034792033","https://openalex.org/W2036011584","https://openalex.org/W2036755018","https://openalex.org/W2037387044","https://openalex.org/W2037426179","https://openalex.org/W2039069312","https://openalex.org/W2039468514","https://openalex.org/W2041058051","https://openalex.org/W2041857757","https://openalex.org/W2042929078","https://openalex.org/W2043748431","https://openalex.org/W2045430710","https://openalex.org/W2045790905","https://openalex.org/W2046031602","https://openalex.org/W2047427096","https://openalex.org/W2047514208","https://openalex.org/W2048667586","https://openalex.org/W2049628649","https://openalex.org/W2050123272","https://openalex.org/W2050373702","https://openalex.org/W2052537022","https://openalex.org/W2052742260","https://openalex.org/W2054430629","https://openalex.org/W2054546547","https://openalex.org/W2054619408","https://openalex.org/W2055649795","https://openalex.org/W2058012673","https://openalex.org/W2058570072","https://openalex.org/W2060046173","https://openalex.org/W2060289280","https://openalex.org/W2060792213","https://openalex.org/W2060792845","https://openalex.org/W2061909885","https://openalex.org/W2064587868","https://openalex.org/W2065450424","https://openalex.org/W2065572957","https://openalex.org/W2065691470","https://openalex.org/W2066068917","https://openalex.org/W2066187882","https://openalex.org/W2068409938","https://openalex.org/W2068574115","https://openalex.org/W2068967976","https://openalex.org/W2069158867","https://openalex.org/W2072565746","https://openalex.org/W2072780644","https://openalex.org/W2074725734","https://openalex.org/W2077435537","https://openalex.org/W2083040356","https://openalex.org/W2083500052","https://openalex.org/W2083715632","https://openalex.org/W2084555860","https://openalex.org/W2085495204","https://openalex.org/W2086834321","https://openalex.org/W2087745495","https://openalex.org/W2089376683","https://openalex.org/W2089789496","https://openalex.org/W2090060333","https://openalex.org/W2090150925","https://openalex.org/W2093386623","https://openalex.org/W2094808560","https://openalex.org/W2096410114","https://openalex.org/W2100359559","https://openalex.org/W2101330413","https://openalex.org/W2101672833","https://openalex.org/W2102369205","https://openalex.org/W2103993711","https://openalex.org/W2106142655","https://openalex.org/W2106931873","https://openalex.org/W2110924006","https://openalex.org/W2111982828","https://openalex.org/W2116876598","https://openalex.org/W2117513966","https://openalex.org/W2118997136","https://openalex.org/W2125420609","https://openalex.org/W2125904354","https://openalex.org/W2130118447","https://openalex.org/W2130285871","https://openalex.org/W2131579032","https://openalex.org/W2132104987","https://openalex.org/W2134573238","https://openalex.org/W2135947516","https://openalex.org/W2136750984","https://openalex.org/W2137337037","https://openalex.org/W2138403763","https://openalex.org/W2139044196","https://openalex.org/W2144929560","https://openalex.org/W2146729934","https://openalex.org/W2146808436","https://openalex.org/W2147740755","https://openalex.org/W2147958725","https://openalex.org/W2148570557","https://openalex.org/W2148628103","https://openalex.org/W2149150386","https://openalex.org/W2150123812","https://openalex.org/W2151448727","https://openalex.org/W2151498829","https://openalex.org/W2152058429","https://openalex.org/W2153317360","https://openalex.org/W2153371047","https://openalex.org/W2154111513","https://openalex.org/W2154566941","https://openalex.org/W2156021708","https://openalex.org/W2158898828","https://openalex.org/W2162956805","https://openalex.org/W2164136371","https://openalex.org/W2166617413","https://openalex.org/W2168787545","https://openalex.org/W2186126235","https://openalex.org/W2309773444","https://openalex.org/W2417105776","https://openalex.org/W2467607972","https://openalex.org/W2605346087","https://openalex.org/W3106378404"],"related_works":["https://openalex.org/W2504112076","https://openalex.org/W2062932176","https://openalex.org/W2032009532","https://openalex.org/W1497358360","https://openalex.org/W1608295855","https://openalex.org/W2162771368","https://openalex.org/W2322126472","https://openalex.org/W1535116242","https://openalex.org/W2473042508","https://openalex.org/W2089376683"],"abstract_inverted_index":{"Background":[0],"and":[1,29,60,63,119,130,136,145,159,169,174,222,232,265,310,312,349,375,448,456,463,469,494,505,528,534,563,634,644,674,738,746],"aims:":[2],"Among":[3],"those":[4],"afflicted":[5],"with":[6,57,248,269,331,381,394,407,466],"dementia":[7],"more":[8,103,510],"than":[9,96],"half":[10],"suffer":[11],"from":[12],"Alzheimer\u2019s":[13],"disease":[14,20,80,106],"(AD).":[15],"Pathological":[16],"hallmarks":[17],"of":[18,23,35,52,117,125,155,199,207,229,243,253,272,327,356,372,574,590,596,601,627,631,642,667,670,703,742,749],"the":[19,49,86,92,105,108,126,137,153,156,179,197,205,251,254,258,273,325,353,409,415,418,431,500,506,513,517,546,560,565,572,597,628,638,739],"include":[21],"aggregates":[22],"Abeta,":[24,200],"so":[25,564],"called":[26],"amyloid":[27,632],"plaques,":[28],"neurofibrillary":[30,743],"tangles":[31],"(NFTs)":[32],"made":[33],"up":[34],"hyperphosphorylated":[36,133,635],"cytoskeletal":[37],"proteins.":[38],"So":[39],"far,":[40],"no":[41,64],"single":[42],"pathological":[43],"lesion":[44],"has":[45,521],"proven":[46],"to":[47,82,164,211,294,303,478,585],"be":[48,76,83,89,165,187,285,540],"sole":[50],"cause":[51],"this":[53,79,112,182,464],"slowly":[54],"progressive":[55],"disorder,":[56],"declining":[58],"memory":[59],"cognitive":[61],"deficits,":[62],"curative":[65],"treatment":[66,87,301,577],"exists":[67],"for":[68,537,579],"AD,":[69,168],"even":[70,509],"though":[71],"some":[72],"clinical":[73,98],"symptoms":[74],"can":[75,284,343],"alleviated.":[77],"If":[78],"is":[81,140,362,583],"defeated,":[84],"probably":[85,482],"must":[88,426],"directed":[90],"against":[91],"disease-causing":[93],"proteins,":[94,444],"rather":[95],"downstream":[97],"manifestations.":[99],"To":[100],"find":[101],"out":[102],"about":[104],"mechanisms,":[107],"studies":[109,180],"included":[110],"in":[111,134,149,167,178,181,196,218,238,288,316,329,335,383,388,398,430,460,474,491,512,552,637,679,707],"thesis":[113],"focused":[114],"on":[115,142,172,257,346,363,557],"regulation":[116],"tau":[118,129,173,234,260,266,282,317,333,345,364,367,447,468,493,543,558,636,745],"neurofilament":[120,700],"proteins":[121,734],"(NFs),":[122],"both":[123,215,347,454,532],"part":[124,589],"NFTs.":[127],"Both":[128,263],"NFs":[131,175],"are":[132,369],"NFTs":[135],"abnormal":[138],"phosphorylation":[139,261,374,411,429,669,701],"dependent":[141],"dysregulated":[143],"kinase":[144,305,673,677,706],"phosphatase":[146],"activities":[147],"found":[148,163],"AD.":[150],"For":[151],"example,":[152,538],"activity":[154,185,390,404,420],"kinases":[157,191,368],"GSK-3beta":[158],"p70S6K":[160,309,342,389,403,419],"have":[161,554],"been":[162],"increased":[166,201,304,323,332,467,479],"their":[170],"effects":[171,556],"were":[176,236,379,458],"investigated":[177,217],"thesis.":[183],"Kinase":[184],"may":[186,445,539,551],"regulated":[188,483],"by":[189,193,484,542],"other":[190,357,435],"or":[192,204,275,545,559,736],"AD":[194,239,289,336,461,580],"pathology":[195],"form":[198],"zinc":[202,300,425],"concentrations":[203],"reoccurrence":[206],"cell":[208,547,561],"cycle":[209],"markers":[210],"name":[212],"a":[213,292,313,395],"few,":[214],"also":[216,322,370,520],"these":[219],"studies.":[220],"Results":[221],"discussion:":[223],"In":[224,297,451],"Study":[225,298,384,452],"I,":[226,614,618],"sequential":[227],"accumulation":[228,629],"Abeta":[230,244,264],"variants":[231],"phosphorylated":[233,249],"epitopes":[235],"demonstrated":[237],"brains.":[240,337],"The":[241],"levels":[242,334],"showed":[245],"good":[246],"correlation":[247,255],"tau;":[250],"strength":[252],"depending":[256],"specific":[259,588],"epitopes.":[262],"correlated":[267,465],"well":[268],"different":[270],"stages":[271],"Braak":[274],"CERAD":[276],"staging":[277],"systems,":[278],"which":[279],"suggests":[280],"that":[281,341,417],"antibodies":[283],"used":[286],"selectively":[287],"diagnosis":[290],"as":[291,360,440],"complement":[293],"morphological":[295],"evaluations.":[296],"II,":[299],"led":[302,477],"activities,":[306],"among":[307],"them":[308],"GSK-3beta,":[311,361],"subsequent":[314],"increase":[315,387,397],"phosphorylation.":[318,365,400,471,496],"Tau":[319],"translation":[320],"was":[321,391,405,421],"through":[324,434],"activation":[326],"p70S6K,":[328,485],"accordance":[330],"These":[338,497],"results":[339],"indicate":[340],"regulate":[344],"translational":[348],"post-translational":[350],"levels,":[351,481],"while":[352,486],"main":[354],"effect":[355],"kinases,":[358],"such":[359,439],"Many":[366],"capable":[371],"NF":[373,399,410,428,449,470,495],"when":[376,402],"N2a":[377,432,475,708],"cells":[378,433,476],"treated":[380],"zinc,":[382],"III,":[385],"an":[386,522],"observed,":[392],"together":[393],"concomitant":[396],"However,":[401],"blocked":[406],"rapamycin,":[408],"remained":[412],"unchanged,":[413],"despite":[414],"fact":[416],"significantly":[422],"decreased.":[423],"Thus,":[424],"induce":[427],"kinases.":[436],"Other":[437],"factors,":[438],"small":[441,731],"heat":[442,732],"shock":[443,733],"influence":[446],"regulation.":[450],"IV,":[453],"Hsp27":[455,472,735],"alphaB-crystallin":[457,487],"up-regulated":[459],"brains,":[462],"overexpression":[473,488],"pSer262-tau":[480],"actually":[489],"resulted":[490],"decreased":[492],"differences":[498],"reflect":[499],"complexity":[501,569],"behind":[502],"cellular":[503],"regulation,":[504],"picture":[507],"gets":[508],"complicated":[511],"human":[514],"brain,":[515],"where":[516],"surrounding":[518],"environment":[519],"effect.":[523],"Since":[524],"many":[525],"pathways":[526],"intertwine":[527],"affect":[529,571],"each":[530],"other,":[531],"directly":[533],"indirectly,":[535],"sHSPs,":[536],"activated":[541],"hyperphosphorylation":[544],"cycle.":[548],"And":[549],"they":[550],"turn":[553],"reciprocal":[555],"cycle,":[562],"circle":[566],"continues.":[567],"This":[568],"will":[570],"choice":[573],"possible":[575],"future":[576],"strategies":[578],"since":[581],"it":[582],"difficult":[584],"isolate":[586],"one":[587,591],"pathway,":[592],"without":[593],"affecting":[594],"any":[595],"others":[598],"detrimentally.":[599],"List":[600],"scientific":[602],"papers":[603],"I.":[604],"Zhou":[605,719],"XW,":[606],"Li":[607],"X,":[608,720],"Bjorkdahl":[609,655],"C,":[610,656,690,716],"Sjogren":[611],"MJ,":[612,692,718],"Alafuzoff":[613],"Soininen":[615],"H,":[616,722],"Grundke-Iqbal":[617],"Iqbal":[619],"K,":[620],"Winblad":[621,661,693,725],"B,":[622,662,694,726],"Pei":[623,663,695,727],"JJ":[624,664,696],"(2006).":[625],"\"Assessments":[626],"severities":[630],"beta-protein":[633],"medial":[639],"temporal":[640],"cortex":[641],"control":[643],"Alzheimers":[645],"brains.\"":[646],"Neurobiol":[647],"Dis":[648],"22(3):":[649],"657-68.":[650],"https://doi.org/10.1016/j.nbd.2006.01.006":[651],"II.":[652],"An":[653],"WL,":[654],"Liu":[657],"R,":[658],"Cowburn":[659],"RF,":[660],"(2005).":[665,697],"\"Mechanism":[666],"zinc-induced":[668],"p70":[671,704],"S6":[672,705],"glycogen":[675],"synthase":[676],"3beta":[678],"SH-SY5Y":[680],"neuroblastoma":[681],"cells.\"":[682,709],"J":[683],"Neurochem":[684],"92(5):":[685],"1104-15.":[686],"https://doi.org/10.1111/j.1471-4159.2004.02948.x":[687],"III.":[688],"Bj\u00f6rkdahl":[689,715],"Sj\u00f6gren":[691,717],"\"Zinc":[698],"induces":[699],"independent":[702],"Neuroreport":[710],"16(6):":[711],"591-5.":[712],"https://pubmed.ncbi.nlm.nih.gov/15812314":[713],"IV.":[714],"Concha":[721],"Avila":[723],"J,":[724],"J-J":[728],"(2007).":[729],"\"The":[730],"\u00d1B-crystallin":[737],"protein":[740],"components":[741],"tangles:":[744],"neurofilaments.\"":[747],"Journal":[748],"Neuroscience":[750],"Research.":[751],"[Accepted]":[752],"https://doi.org/10.1002/jnr.21589":[753]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
