{"id":"https://openalex.org/W1504361237","doi":"https://doi.org/10.4049/jimmunol.175.8.5532","title":"IL-13 Acutely Augments HIV-Specific and Recall Responses from HIV-1-Infected Subjects In Vitro by Modulating Monocytes","display_name":"IL-13 Acutely Augments HIV-Specific and Recall Responses from HIV-1-Infected Subjects In Vitro by Modulating Monocytes","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W1504361237","doi":"https://doi.org/10.4049/jimmunol.175.8.5532","mag":"1504361237","pmid":"https://pubmed.ncbi.nlm.nih.gov/16210662"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.175.8.5532","doi":"https://doi.org/10.4049/jimmunol.175.8.5532","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.175.8.5532","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057398938","display_name":"Emmanouil Papasavvas","orcid":"https://orcid.org/0009-0005-2794-3361","observed_orcids":["https://orcid.org/0009-0005-2794-3361"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanouil Papasavvas","raw_affiliation_strings":["The Wistar Institute , Philadelphia, PA 19104","*The Wistar Institute, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"*The Wistar Institute, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058764792","display_name":"Junwei Sun","orcid":"https://orcid.org/0000-0003-2532-0361","observed_orcids":["https://orcid.org/0000-0003-2532-0361"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junwei Sun","raw_affiliation_strings":["The Wistar Institute , Philadelphia, PA 19104","*The Wistar Institute, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"*The Wistar Institute, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101662100","display_name":"Qi Luo","orcid":"https://orcid.org/0000-0002-8942-5405","observed_orcids":["https://orcid.org/0000-0002-8942-5405"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Luo","raw_affiliation_strings":["The Wistar Institute , Philadelphia, PA 19104","*The Wistar Institute, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"*The Wistar Institute, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024496399","display_name":"Elizabeth C. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth C Moore","raw_affiliation_strings":["The Wistar Institute , Philadelphia, PA 19104","*The Wistar Institute, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"*The Wistar Institute, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010983756","display_name":"Brian D. Thiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Thiel","raw_affiliation_strings":["The Wistar Institute , Philadelphia, PA 19104","*The Wistar Institute, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"*The Wistar Institute, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066872572","display_name":"Rob Roy MacGregor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rob Roy MacGregor","raw_affiliation_strings":["Infectious Diseases Division, University of Pennsylvania , Philadelphia, PA 19104","\u2020Infectious Diseases Division, University of Pennsylvania, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Division, University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"\u2020Infectious Diseases Division, University of Pennsylvania, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022090192","display_name":"Adrian J. Minty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]}],"countries":["FR","TR"],"is_corresponding":false,"raw_author_name":"Adrian Minty","raw_affiliation_strings":["Molecular and Functional Genomics Department, Sanofi-Synthelabo Recherche , Labege ,","\u2021Molecular and Functional Genomics Department, Sanofi-Synthelabo Recherche, Labege, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Functional Genomics Department, Sanofi-Synthelabo Recherche , Labege ,","institution_ids":["https://openalex.org/I4210139898"]},{"raw_affiliation_string":"\u2021Molecular and Functional Genomics Department, Sanofi-Synthelabo Recherche, Labege, France; and","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013318234","display_name":"Karam Mounzer","orcid":"https://orcid.org/0000-0001-8537-7103","observed_orcids":["https://orcid.org/0000-0001-8537-7103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karam Mounzer","raw_affiliation_strings":["Philadelphia Field Initiating Group for HIV-1 Trials , Philadelphia, PA 19107","\u00a7Philadelphia Field Initiating Group for HIV-1 Trials, Philadelphia, PA 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philadelphia Field Initiating Group for HIV-1 Trials , Philadelphia, PA 19107","institution_ids":[]},{"raw_affiliation_string":"\u00a7Philadelphia Field Initiating Group for HIV-1 Trials, Philadelphia, PA 19107","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036887186","display_name":"Jay R. Kostman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay R Kostman","raw_affiliation_strings":["Infectious Diseases Division, University of Pennsylvania , Philadelphia, PA 19104","Philadelphia Field Initiating Group for HIV-1 Trials , Philadelphia, PA 19107","\u00a7Philadelphia Field Initiating Group for HIV-1 Trials, Philadelphia, PA 19107","\u2020Infectious Diseases Division, University of Pennsylvania, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Division, University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Philadelphia Field Initiating Group for HIV-1 Trials , Philadelphia, PA 19107","institution_ids":[]},{"raw_affiliation_string":"\u00a7Philadelphia Field Initiating Group for HIV-1 Trials, Philadelphia, PA 19107","institution_ids":[]},{"raw_affiliation_string":"\u2020Infectious Diseases Division, University of Pennsylvania, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069209710","display_name":"Luis J. Montaner","orcid":"https://orcid.org/0000-0001-5799-6759","observed_orcids":["https://orcid.org/0000-0001-5799-6759"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis J Montaner","raw_affiliation_strings":["The Wistar Institute , Philadelphia, PA 19104","*The Wistar Institute, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"*The Wistar Institute, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.3299,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.50497576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"175","issue":"8","first_page":"5532","last_page":"5540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.9580000042915344},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cd14-monocytes","display_name":"CD14+ monocytes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/antigen-presenting-cell-function","display_name":"antigen-presenting cell function","score":0.8090000152587891},{"id":"https://openalex.org/keywords/t-cell-recall-response","display_name":"T cell recall response","score":0.6570000052452087},{"id":"https://openalex.org/keywords/hiv-p24","display_name":"HIV p24","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cd4-t-cell-proliferation","display_name":"CD4+ T cell proliferation","score":0.621999979019165},{"id":"https://openalex.org/keywords/cd86-expression","display_name":"CD86 expression","score":0.9330000281333923},{"id":"https://openalex.org/keywords/monocyte-apoptosis","display_name":"monocyte apoptosis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronic-hiv-infection","display_name":"chronic HIV infection","score":0.675000011920929},{"id":"https://openalex.org/keywords/lymphoproliferation","display_name":"lymphoproliferation","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.7601594924926758},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6141910552978516},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5596677660942078},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5250461101531982},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49793004989624023},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4968474209308624},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.4354569613933563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39999106526374817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3474240303039551},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.34575194120407104},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3336940407752991},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.175.8.5532","doi":"https://doi.org/10.4049/jimmunol.175.8.5532","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.175.8.5532","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16210662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16210662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3071480874","display_name":null,"funder_award_id":"AI40379","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G953630735","display_name":"ANTIHIV-1 EFFECTS OF IL 13 ON MACROPHAGES AND T CELLS","funder_award_id":"5r29ai040379-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1493216","https://openalex.org/W17651894","https://openalex.org/W108311815","https://openalex.org/W176891138","https://openalex.org/W1565411191","https://openalex.org/W1570171227","https://openalex.org/W1805248875","https://openalex.org/W1837576575","https://openalex.org/W1925985183","https://openalex.org/W1963559980","https://openalex.org/W1970555184","https://openalex.org/W1976493250","https://openalex.org/W1984999783","https://openalex.org/W1999396723","https://openalex.org/W2006266678","https://openalex.org/W2010603430","https://openalex.org/W2023198484","https://openalex.org/W2023914649","https://openalex.org/W2059147865","https://openalex.org/W2063650456","https://openalex.org/W2068993874","https://openalex.org/W2076120354","https://openalex.org/W2081559306","https://openalex.org/W2099948570","https://openalex.org/W2100740302","https://openalex.org/W2101835477","https://openalex.org/W2104439753","https://openalex.org/W2106447712","https://openalex.org/W2119197572","https://openalex.org/W2121697569","https://openalex.org/W2132403618","https://openalex.org/W2133525640","https://openalex.org/W2134500402","https://openalex.org/W2145508988","https://openalex.org/W2149492547","https://openalex.org/W2152958369","https://openalex.org/W2154916884","https://openalex.org/W2156672979","https://openalex.org/W2182616274","https://openalex.org/W2203531970","https://openalex.org/W2258639618","https://openalex.org/W2259673668","https://openalex.org/W4250189922","https://openalex.org/W4313305965","https://openalex.org/W4313377050"],"related_works":["https://openalex.org/W2368671469","https://openalex.org/W2476067827","https://openalex.org/W2562018129","https://openalex.org/W4378745089","https://openalex.org/W272206334","https://openalex.org/W3185397586","https://openalex.org/W2420872905","https://openalex.org/W2966345944","https://openalex.org/W3153646899","https://openalex.org/W2190014693"],"abstract_inverted_index":{"We":[0],"show":[1,186],"in":[2,17,66,103,128,179,206],"this":[3],"study":[4],"that":[5,61,187],"acute":[6],"exposure":[7,139,170],"of":[8,76,83,107,144,149,169,196],"PBMCs":[9],"derived":[10],"from":[11],"HIV-infected":[12],"subjects":[13],"to":[14,58,97,191],"IL-13":[15,98,138,188],"results":[16],"increased":[18],"recall":[19,35],"T":[20,78,92],"cell":[21,79,182,199],"lymphoproliferative":[22],"responses":[23,80,205],"against":[24],"HIV-1":[25,208],"p24":[26],"(n":[27,110,118,131,152,160],"=":[28,39,49,52,111,114,119,122,132,135,153,161],"30,":[29],"p":[30,41,51,113,121,134,155,163],"<":[31,42,156,164],"0.0001)":[32],"and":[33,94,124,158],"other":[34],"Ags":[36],"(influenza,":[37],"n":[38,48],"43,":[40],"0.0001;":[43],"purified":[44],"protein":[45],"derivative":[46],"tuberculin,":[47],"6,":[50],"0.0299).":[53],"This":[54],"effect":[55],"is":[56,189],"due":[57],"a":[59,104,125,141],"mechanism":[60],"acutely":[62,192],"targets":[63],"APC":[64],"function":[65,195],"the":[67,74,180,194,197],"adherent":[68,181],"monocyte":[69,108],"subset,":[70],"as":[71],"shown":[72],"by":[73,175],"expansion":[75],"CD4(+)":[77,91],"following":[81],"coculture":[82],"IL-13-treated":[84],"enriched":[85,90],"CD14(+)":[86,198],"monocytes":[87],"with":[88],"donor-matched":[89],"cells":[93],"Ag.":[95],"Exposure":[96],"over":[99],"18-72":[100],"h":[101,168],"resulted":[102],"significant":[105,126,142],"enhancement":[106],"endocytosis":[109],"11,":[112],"0.0005),":[115],"CD86":[116],"expression":[117,178],"12,":[120],"0.001),":[123],"decrease":[127,143],"spontaneous":[129],"apoptosis":[130],"8,":[133],"0.008).":[136],"Moreover,":[137],"induced":[140],"significantly":[145],"elevated":[146],"constitutive":[147],"levels":[148],"PBMC-secreted":[150],"TNF-alpha":[151],"14,":[154],"0.001)":[157,165],"IL-10":[159],"29,":[162],"within":[166],"18":[167],"ex":[171],"vivo,":[172],"also":[173],"reflected":[174],"decreased":[176],"gene":[177],"population.":[183],"Our":[184],"data":[185],"able":[190],"enhance":[193],"subset":[200],"toward":[201],"supporting":[202],"Ag-specific":[203],"cell-mediated":[204],"chronic":[207],"infection.":[209]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}