{"id":"https://openalex.org/W1504092627","doi":null,"title":"Review: Negative regulation of leptin receptor signalling.","display_name":"Review: Negative regulation of leptin receptor signalling.","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W1504092627","mag":"1504092627","pmid":"https://pubmed.ncbi.nlm.nih.gov/17194642"},"language":"en","primary_location":{"id":"pmid:17194642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17194642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078953900","display_name":"Delphine Lavens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Delphine Lavens","raw_affiliation_strings":["Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology, VIB09, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology, VIB09, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent","institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028859507","display_name":"Julie Piessevaux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Piessevaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054994879","display_name":"Jan H. Tavernier","orcid":"https://orcid.org/0000-0002-7609-6462","observed_orcids":["https://orcid.org/0000-0002-7609-6462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Tavernier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6785,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.6188764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"3","first_page":"211","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/leptin-receptor","display_name":"leptin receptor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/negative-regulation","display_name":"negative regulation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.937393844127655},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.7249225974082947},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.6420586705207825},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.6341227889060974},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5728440880775452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5529961585998535},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5413823127746582},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5151137709617615},{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.4540385603904724},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4397073984146118},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40768569707870483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38084372878074646},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2608012855052948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23951485753059387},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.22582849860191345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1842862069606781},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08441346883773804}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:17194642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17194642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.909.1556","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.909.1556","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jle.com/download/ecn-272083-review_negative_regulation_of_leptin_receptor_signalling--VzTo%40H8AAQEAACB31j4AAAAK-a.pdf","raw_type":"text"},{"id":"pmh:oai:archive.ugent.be:360714","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/360714","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1148-5493","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1504092627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17194642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1487264337","https://openalex.org/W1512072195","https://openalex.org/W1551216731","https://openalex.org/W1590709474","https://openalex.org/W1600880434","https://openalex.org/W1639930240","https://openalex.org/W1668039320","https://openalex.org/W1963705072","https://openalex.org/W1964778321","https://openalex.org/W1965408498","https://openalex.org/W1967850325","https://openalex.org/W1970804941","https://openalex.org/W1972750645","https://openalex.org/W1976630549","https://openalex.org/W1983089513","https://openalex.org/W1990819309","https://openalex.org/W1996713062","https://openalex.org/W2010784970","https://openalex.org/W2012496594","https://openalex.org/W2015045770","https://openalex.org/W2016994959","https://openalex.org/W2028196750","https://openalex.org/W2032969323","https://openalex.org/W2034014949","https://openalex.org/W2038468714","https://openalex.org/W2039242473","https://openalex.org/W2042893069","https://openalex.org/W2044153433","https://openalex.org/W2049847654","https://openalex.org/W2052743140","https://openalex.org/W2053544216","https://openalex.org/W2056383195","https://openalex.org/W2062570379","https://openalex.org/W2063175358","https://openalex.org/W2068968795","https://openalex.org/W2070160790","https://openalex.org/W2070582535","https://openalex.org/W2074303577","https://openalex.org/W2076146140","https://openalex.org/W2081876438","https://openalex.org/W2087482176","https://openalex.org/W2088001545","https://openalex.org/W2088062021","https://openalex.org/W2088666203","https://openalex.org/W2094481749","https://openalex.org/W2098859298","https://openalex.org/W2103270369","https://openalex.org/W2108033183","https://openalex.org/W2119733834","https://openalex.org/W2121133160","https://openalex.org/W2123229219","https://openalex.org/W2125510262","https://openalex.org/W2131636785","https://openalex.org/W2135217300","https://openalex.org/W2136226444","https://openalex.org/W2143578581","https://openalex.org/W2144299243","https://openalex.org/W2147875815","https://openalex.org/W2148161631","https://openalex.org/W2150316152","https://openalex.org/W2155854462","https://openalex.org/W2157273158","https://openalex.org/W2158902159","https://openalex.org/W2166917491","https://openalex.org/W2167786713","https://openalex.org/W2168692939","https://openalex.org/W2171967754","https://openalex.org/W2334337188"],"related_works":["https://openalex.org/W1695738350","https://openalex.org/W262892949","https://openalex.org/W2293422499","https://openalex.org/W1982167713","https://openalex.org/W1988816676","https://openalex.org/W4247302633","https://openalex.org/W31010998","https://openalex.org/W2771442536","https://openalex.org/W2095245001","https://openalex.org/W2072367079"],"abstract_inverted_index":{"Leptin":[0,42],"was":[1],"discovered":[2],"as":[3,19],"an":[4],"adipostat,":[5],"regulating":[6],"body":[7],"weight":[8],"by":[9],"balancing":[10],"food":[11],"intake":[12],"and":[13,40],"energy":[14],"expenditure.":[15],"Recently,":[16],"leptin":[17,71],"emerged":[18],"a":[20,25,29,58],"pleiotropic":[21],"cytokine.":[22],"It":[23],"plays":[24],"substantial":[26],"role":[27],"in":[28,57],"wide":[30],"spectrum":[31],"of":[32,49,60],"other":[33],"functions":[34],"including":[35],"immune":[36],"regulation,":[37],"bone":[38],"formation":[39],"fertility.":[41],"signalling":[43],"is":[44],"under":[45],"tight":[46],"control.":[47],"Aberrations":[48],"this":[50],"stringent":[51],"control":[52,69],"system":[53],"may":[54],"be":[55],"implicated":[56],"variety":[59],"pathologies.":[61],"Here,":[62],"we":[63],"review":[64],"the":[65],"various":[66],"mechanisms":[67],"that":[68],"cellular":[70],"receptor":[72],"signalling.":[73]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}