{"id":"https://openalex.org/W1504017313","doi":null,"title":"Designing T cells for cancer immunotherapy.","display_name":"Designing T cells for cancer immunotherapy.","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1504017313","mag":"1504017313","pmid":"https://pubmed.ncbi.nlm.nih.gov/20423673","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2931319"},"language":"en","primary_location":{"id":"pmid:20423673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20423673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"review","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2931319","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111429670","display_name":"Leslie E. Huye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie E Huye","raw_affiliation_strings":["Center for Cell and Gene Therapy, Baylor College of Medicine, Houston 77030, United States. lehuye@txccc.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston 77030, United States. lehuye@txccc.org","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023649972","display_name":"Gianpietro Dotti","orcid":"https://orcid.org/0000-0002-2639-8526","observed_orcids":["https://orcid.org/0000-0002-2639-8526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianpietro Dotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1046,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.13240629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"47","first_page":"297","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.23430000245571136,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8069999814033508},{"id":"https://openalex.org/keywords/genetically-modified-t-cells","display_name":"genetically modified T cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.699999988079071},{"id":"https://openalex.org/keywords/t-cell-persistence","display_name":"T cell persistence","score":0.902999997138977},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8830000162124634},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.672252893447876},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.6424066424369812},{"id":"https://openalex.org/C2781251061","wikidata":"https://www.wikidata.org/wiki/Q5416089","display_name":"Evasion (ethics)","level":3,"score":0.630333662033081},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.55568927526474},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5330364108085632},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.529029130935669},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5236116051673889},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.44428855180740356},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43345892429351807},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4310150742530823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38138335943222046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34967607259750366},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.32661157846450806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06646284461021423}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:20423673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20423673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2931319","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2931319","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Discov Med","raw_type":"Text"},{"id":"mag:1504017313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20423673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2931319","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2931319","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Discov Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G162310483","display_name":"ENHANCING T CELL THERAPY OF CANCER","funder_award_id":"P01CA094237","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6993546938","display_name":"Chimeric T Cell for Therpay of Hodgkin Disease","funder_award_id":"R01CA131027","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000915301","display_name":"SPORE in Lymphoma","funder_award_id":"P50CA126752","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1737344958","https://openalex.org/W1979936799","https://openalex.org/W2000725338","https://openalex.org/W2002647051","https://openalex.org/W2004345869","https://openalex.org/W2008182044","https://openalex.org/W2009709218","https://openalex.org/W2010378562","https://openalex.org/W2020099065","https://openalex.org/W2024746352","https://openalex.org/W2028984998","https://openalex.org/W2031813404","https://openalex.org/W2033210035","https://openalex.org/W2057754694","https://openalex.org/W2062361340","https://openalex.org/W2066705769","https://openalex.org/W2068890283","https://openalex.org/W2076668490","https://openalex.org/W2087055812","https://openalex.org/W2095220820","https://openalex.org/W2095610090","https://openalex.org/W2097175022","https://openalex.org/W2102859148","https://openalex.org/W2107506072","https://openalex.org/W2111740872","https://openalex.org/W2111967568","https://openalex.org/W2112016055","https://openalex.org/W2130699680","https://openalex.org/W2141550316","https://openalex.org/W2143693981","https://openalex.org/W2163062545","https://openalex.org/W2168273245","https://openalex.org/W2169329800"],"related_works":["https://openalex.org/W2076502789","https://openalex.org/W2385873697","https://openalex.org/W2017142033","https://openalex.org/W2133566973","https://openalex.org/W2399510492","https://openalex.org/W2019256546","https://openalex.org/W2063110204","https://openalex.org/W2024201273","https://openalex.org/W2135106769","https://openalex.org/W2165418191"],"abstract_inverted_index":{"Adoptive":[0],"transfer":[1,78],"of":[2,9,61,68],"T":[3,38,87],"cells":[4,11,39],"can":[5],"enhance":[6,41],"immune-mediated":[7],"elimination":[8],"tumor":[10,50],"and":[12,28,44,79],"provides":[13],"a":[14,65],"specific,":[15],"non-toxic":[16],"cancer":[17],"therapy.":[18],"This":[19],"approach":[20],"has":[21,54],"been":[22,84],"effective":[23],"in":[24,64],"treating":[25],"some":[26],"hematologic":[27],"solid":[29],"malignancies.":[30],"In":[31,70],"addition,":[32],"the":[33,55,59],"ability":[34],"to":[35,40,57,86],"genetically":[36],"modify":[37],"their":[42],"activity":[43],"persistence":[45],"as":[46,48],"well":[47],"overcome":[49],"immune":[51],"evasion":[52],"mechanisms":[53],"potential":[56],"increase":[58],"success":[60],"these":[62],"therapies":[63],"wide":[66],"range":[67],"tumors.":[69],"this":[71],"review":[72],"we":[73],"discuss":[74],"methods":[75],"for":[76],"gene":[77],"specific":[80],"modifications":[81],"that":[82],"have":[83],"made":[85],"cells.":[88]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}