{"id":"https://openalex.org/W150397219","doi":null,"title":"Characterization of the glutametergic system in MG-63 osteoblast-like osteosarcoma cells.","display_name":"Characterization of the glutametergic system in MG-63 osteoblast-like osteosarcoma cells.","publication_year":2004,"publication_date":"2004-11-01","ids":{"openalex":"https://openalex.org/W150397219","mag":"150397219","pmid":"https://pubmed.ncbi.nlm.nih.gov/15736433"},"language":"en","primary_location":{"id":"pmid:15736433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15736433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019061970","display_name":"Niki Kalariti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Niki Kalariti","raw_affiliation_strings":["Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Physiology, Medical School, University of Athens, Goudi-Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057775787","display_name":"Peter Lembessis","orcid":"https://orcid.org/0000-0001-8972-3499","observed_orcids":["https://orcid.org/0000-0001-8972-3499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Lembessis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038410281","display_name":"Michael Koutsilieris","orcid":"https://orcid.org/0000-0002-3340-9916","observed_orcids":["https://orcid.org/0000-0002-3340-9916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Koutsilieris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5432,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.54218387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"6","first_page":"3923","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.22679999470710754,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamatergic-system","display_name":"glutamatergic system","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mg-63-cells","display_name":"MG-63 cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/osteoblast-like-cells","display_name":"osteoblast-like cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.7799999713897705},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptors","display_name":"metabotropic glutamate receptors","score":0.984000027179718},{"id":"https://openalex.org/keywords/glutamine-synthetase","display_name":"glutamine synthetase","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.7028015851974487},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.6652858853340149},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.602279782295227},{"id":"https://openalex.org/C115955781","wikidata":"https://www.wikidata.org/wiki/Q6063798","display_name":"Ionotropic effect","level":4,"score":0.5954020023345947},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5577516555786133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.518960177898407},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.500645637512207},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.42095452547073364},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.42032793164253235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35397934913635254},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30661076307296753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14921244978904724},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.14829441905021667}],"mesh":[{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005974","descriptor_name":"Glutamate-Ammonia Ligase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005974","descriptor_name":"Glutamate-Ammonia Ligase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027341","descriptor_name":"Excitatory Amino Acid Transporter 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D027981","descriptor_name":"Symporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050491","descriptor_name":"Glutamate Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15736433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15736433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:150397219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15736433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1502333075","https://openalex.org/W1503507021","https://openalex.org/W1594111906","https://openalex.org/W1608934724","https://openalex.org/W1868834139","https://openalex.org/W1969400861","https://openalex.org/W1983197885","https://openalex.org/W1991701465","https://openalex.org/W1994741987","https://openalex.org/W2011767937","https://openalex.org/W2014577644","https://openalex.org/W2022039597","https://openalex.org/W2035339470","https://openalex.org/W2040456704","https://openalex.org/W2044146387","https://openalex.org/W2049953991","https://openalex.org/W2059334396","https://openalex.org/W2066439205","https://openalex.org/W2068721214","https://openalex.org/W2072774318","https://openalex.org/W2092151126","https://openalex.org/W2092358916","https://openalex.org/W2094673798","https://openalex.org/W2100040827","https://openalex.org/W2111179284","https://openalex.org/W2129108032","https://openalex.org/W2163309923","https://openalex.org/W2185203644","https://openalex.org/W2187670227","https://openalex.org/W2269458787","https://openalex.org/W2308466324","https://openalex.org/W2486131164"],"related_works":["https://openalex.org/W1985244216","https://openalex.org/W2086884440","https://openalex.org/W2093995681","https://openalex.org/W2040081058","https://openalex.org/W2131601310","https://openalex.org/W2049382869","https://openalex.org/W2011767937","https://openalex.org/W2055842467","https://openalex.org/W1981209225","https://openalex.org/W2058675779"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"glutamate":[2,31],"system":[3],"is":[4],"a":[5,146],"fairly":[6],"complex":[7],"bioregulation":[8],"pathway,":[9],"consisting":[10],"of":[11,50,55,80,88,91,108,128,153],"several":[12],"ionotropic":[13],"Glu":[14,19,22,154],"receptors":[15,20],"(iGlu.Rs),":[16],"the":[17,39,51,77,81,102,105,109,125,150],"metabotropic":[18],"(mGlu.Rs),":[21],"transporters":[23],"(EAATs)":[24],"and":[25,62,85,90,117,132],"glutamine":[26],"synthetase":[27],"(GS),":[28],"which":[29],"metabolizes":[30],"to":[32,47],"glutamine.":[33],"MATERIALS":[34],"AND":[35],"METHODS:":[36],"We":[37],"characterized":[38],"MG-63":[40,95,140],"human":[41],"osteoblast-like":[42],"osteosarcoma":[43],"cells":[44,141],"with":[45],"regards":[46],"mRNA":[48,78,93,106,126],"expression":[49,79,107,127],"(a)":[52],"NMDA.R":[53,89],"group":[54],"iGlu.Rs,":[56],"(b)":[57],"mGlu.Rs,":[58],"(c)":[59],"EAAT1":[60],"transporter,":[61],"(d)":[63],"GS,":[64],"using":[65],"specific":[66],"primers":[67],"for":[68,101,148],"their":[69],"detection":[70],"by":[71],"RT-PCR.":[72],"RESULTS:":[73],"Our":[74,136],"data":[75,137],"confirm":[76],"NR1,":[82],"NR2A,":[83],"NR2B":[84],"NR2D":[86],"subunits":[87],"GS":[92],"in":[94],"cells.":[96],"In":[97],"addition,":[98],"we":[99,121],"documented,":[100],"first":[103],"time,":[104],"NR3A,":[110],"EAAT1,":[111],"mGlu.R1,":[112],"mGlu.R2,":[113],"mGlu.R3,":[114],"mGluR.4,":[115],"mGlu.R5":[116],"mGlu.R8":[118],"mRNA.":[119,134],"However,":[120],"did":[122],"not":[123],"detect":[124],"NR2C,":[129],"NR3B,":[130],"mGlu.R6":[131],"mGlu.R7":[133],"CONCLUSION:":[135],"suggest":[138],"that":[139],"can":[142],"be":[143],"used":[144],"as":[145],"model":[147],"studying":[149],"possible":[151],"role":[152],"beyond":[155],"CNS.":[156]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
