{"id":"https://openalex.org/W1503497205","doi":"https://doi.org/10.1002/jor.22610","title":"A single blunt impact on cartilage promotes fibronectin fragmentation and upregulates cartilage degrading stromelysin\u20101/matrix metalloproteinase\u20103 in a bovine ex vivo model","display_name":"A single blunt impact on cartilage promotes fibronectin fragmentation and upregulates cartilage degrading stromelysin\u20101/matrix metalloproteinase\u20103 in a bovine ex vivo model","publication_year":2014,"publication_date":"2014-03-07","ids":{"openalex":"https://openalex.org/W1503497205","doi":"https://doi.org/10.1002/jor.22610","mag":"1503497205","pmid":"https://pubmed.ncbi.nlm.nih.gov/24610678","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4034576"},"language":"en","primary_location":{"id":"doi:10.1002/jor.22610","doi":"https://doi.org/10.1002/jor.22610","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.22610","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.22610","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.22610","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lei Ding","orcid":"https://orcid.org/0000-0001-6993-8273","observed_orcids":["https://orcid.org/0000-0001-6993-8273"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Ding","raw_affiliation_strings":["Department of Orthopaedics and Rehabilitation, University of Iowa, 500 Newton Road, 1182 Medical Laboratories, Iowa City, Iowa, 52242"],"raw_orcid":"https://orcid.org/0000-0001-6993-8273","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Rehabilitation, University of Iowa, 500 Newton Road, 1182 Medical Laboratories, Iowa City, Iowa, 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060990134","display_name":"Danping Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danping Guo","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of North Dakota, Grand Forks, North Dakota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of North Dakota, Grand Forks, North Dakota","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113520679","display_name":"Gene A. Homandberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gene A. Homandberg","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of North Dakota, Grand Forks, North Dakota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of North Dakota, Grand Forks, North Dakota","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064323409","display_name":"Joseph A. Buckwalter","orcid":"https://orcid.org/0000-0003-4308-7583","observed_orcids":["https://orcid.org/0000-0003-4308-7583"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210135841","display_name":"Iowa City VA Medical Center","ror":"https://ror.org/03r9k1585","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210132647","https://openalex.org/I4210135841","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Buckwalter","raw_affiliation_strings":["Department of Orthopaedics and Rehabilitation University of Iowa 500 Newton Road, 1182 Medical Laboratories Iowa City Iowa 52242","Veteran Affairs Medical Center Iowa City Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Rehabilitation University of Iowa 500 Newton Road, 1182 Medical Laboratories Iowa City Iowa 52242","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Veteran Affairs Medical Center Iowa City Iowa","institution_ids":["https://openalex.org/I4210135841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015592017","display_name":"James A. Martin","orcid":"https://orcid.org/0000-0001-5085-0108","observed_orcids":["https://orcid.org/0000-0001-5085-0108"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James A. Martin","raw_affiliation_strings":["Department of Orthopaedics and Rehabilitation University of Iowa 500 Newton Road, 1182 Medical Laboratories Iowa City Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Rehabilitation University of Iowa 500 Newton Road, 1182 Medical Laboratories Iowa City Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015592017"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":4.4222,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.93962579,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"32","issue":"6","first_page":"811","last_page":"818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-traumatic-osteoarthritis","display_name":"post-traumatic osteoarthritis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/stromelysin-1","display_name":"stromelysin-1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-3","display_name":"matrix metalloproteinase-3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-13","display_name":"matrix metalloproteinase-13","score":0.8740000128746033},{"id":"https://openalex.org/keywords/adamts5","display_name":"ADAMTS5","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.7670000195503235},{"id":"https://openalex.org/keywords/chondrolysis","display_name":"chondrolysis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/proteoglycan-depletion","display_name":"proteoglycan depletion","score":0.8519999980926514},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.7680000066757202},{"id":"https://openalex.org/keywords/osteochondral-explants","display_name":"osteochondral explants","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bovine-cartilage","display_name":"bovine cartilage","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.8866404294967651},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7650916576385498},{"id":"https://openalex.org/C2776157581","wikidata":"https://www.wikidata.org/wiki/Q4692239","display_name":"Aggrecanase","level":5,"score":0.7486475706100464},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.6653376817703247},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.5845926403999329},{"id":"https://openalex.org/C157890192","wikidata":"https://www.wikidata.org/wiki/Q2561978","display_name":"Explant culture","level":3,"score":0.5667555928230286},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5284521579742432},{"id":"https://openalex.org/C2778232976","wikidata":"https://www.wikidata.org/wiki/Q15320335","display_name":"Cartilage oligomeric matrix protein","level":4,"score":0.5187520980834961},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48628032207489014},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.47132471203804016},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.4650479555130005},{"id":"https://openalex.org/C2910007452","wikidata":"https://www.wikidata.org/wiki/Q21114943","display_name":"Matrix Metalloproteinase 3","level":3,"score":0.4574723243713379},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4533693790435791},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41834044456481934},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3856315314769745},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.35951608419418335},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.359078586101532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2897855043411255},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28338149189949036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24421179294586182},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16262000799179077},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.13259610533714294},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/jor.22610","doi":"https://doi.org/10.1002/jor.22610","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.22610","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.22610","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:24610678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24610678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3412247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4034576","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4034576","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4034576","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Orthop Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/jor.22610","doi":"https://doi.org/10.1002/jor.22610","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.22610","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.22610","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2422945419","display_name":"NIAMS: CORT Innovations to Assess and Forestall Post-Traumatic Osteoarthritis","funder_award_id":"P50AR055533","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2640199242","display_name":null,"funder_award_id":"AR055533","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7500859680","display_name":null,"funder_award_id":"P50 AR055533","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000186184","display_name":null,"funder_award_id":"AR055533","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1503497205.pdf","grobid_xml":"https://content.openalex.org/works/W1503497205.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1588094592","https://openalex.org/W1660900149","https://openalex.org/W1904364980","https://openalex.org/W1966013695","https://openalex.org/W1969182658","https://openalex.org/W1975690515","https://openalex.org/W1983968835","https://openalex.org/W1992427599","https://openalex.org/W1999860802","https://openalex.org/W2016664601","https://openalex.org/W2018285082","https://openalex.org/W2027707975","https://openalex.org/W2038415379","https://openalex.org/W2039059443","https://openalex.org/W2040522261","https://openalex.org/W2045069758","https://openalex.org/W2046753334","https://openalex.org/W2048021515","https://openalex.org/W2074582172","https://openalex.org/W2114954785","https://openalex.org/W2122802605","https://openalex.org/W2157423568","https://openalex.org/W2166518369","https://openalex.org/W2282384608","https://openalex.org/W2414683055","https://openalex.org/W4297755929"],"related_works":["https://openalex.org/W2141968343","https://openalex.org/W1983968835","https://openalex.org/W1969182658","https://openalex.org/W2046301394","https://openalex.org/W2046753334","https://openalex.org/W1552444104","https://openalex.org/W7096067893","https://openalex.org/W2066088112","https://openalex.org/W7100931286","https://openalex.org/W4416977070"],"abstract_inverted_index":{"Post-traumatic":[0],"osteoarthritis":[1],"(PTOA)":[2],"is":[3],"characterized":[4],"by":[5,36,179],"progressive":[6],"cartilage":[7,16,70,106,117,137],"degeneration":[8],"in":[9,34,39,60,101,105,162,166],"injured":[10,42],"joints.":[11],"Since":[12],"fibronectin-fragments":[13],"(Fn-fs)":[14],"degrade":[15],"mainly":[17],"through":[18,186],"up-regulating":[19,187],"matrix":[20,118],"metalloproteinases":[21],"(MMPs)":[22],"and":[23,40,57,82,104,148,165],"pro-inflammatory":[24],"cytokines,":[25],"we":[26,48],"hypothesized":[27],"that":[28,174],"Fn-fs":[29,147,180],"play":[30],"a":[31,65,72],"key":[32],"role":[33],"PTOA":[35,175],"promoting":[37],"chondrolysis":[38],"around":[41],"cartilage.":[43,168],"To":[44],"test":[45],"this":[46],"hypothesis,":[47],"profiled":[49],"the":[50],"catabolic":[51,184],"events":[52],"focusing":[53],"on":[54,69,129],"fibronectin":[55],"fragmentation":[56],"proteinase":[58],"expression":[59],"bovine":[61],"osteochondral":[62],"explants":[63,84],"following":[64],"single":[66],"blunt":[67],"impact":[68],"with":[71,109,121,134,157],"drop":[73],"tower":[74],"device":[75],"which":[76,181],"created":[77],"partial-thickness":[78],"tissue":[79],"damage.":[80],"Injured":[81],"control":[83],"were":[85],"cultured":[86],"for":[87],"up":[88],"to":[89],"14":[90],"days.":[91],"The":[92,111,124],"presence":[93],"of":[94,116,126,142,159],"Fn-fs,":[95],"MMPs":[96],"(-1,":[97],"-3,":[98],"-13),":[99],"ADAMTS-5":[100],"culture":[102,163],"media":[103,128,164],"was":[107,119,131],"determined":[108],"immunoblotting.":[110,135],"daily":[112],"proteoglycan":[113],"(PG)":[114],"depletion":[115],"assessed":[120],"DMMB":[122],"assay.":[123],"effect":[125],"explant-conditioned":[127],"chondrocytes":[130],"also":[132],"examined":[133],"Impacted":[136],"released":[138],"significantly":[139],"higher":[140],"amount":[141],"native":[143],"Fn,":[144],"three":[145],"chondrolytic":[146],"PG":[149],"than":[150],"non-impacted":[151],"controls":[152],"did.":[153],"Those":[154],"increases":[155],"coincided":[156],"up-regulation":[158],"MMP-3":[160],"both":[161],"impacted":[167],"These":[169],"findings":[170],"support":[171],"our":[172],"hypothesis":[173],"may":[176],"be":[177],"propelled":[178],"act":[182],"as":[183],"mediators":[185],"cartilage-damaging":[188],"proteinases.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}