{"id":"https://openalex.org/W1503395979","doi":"https://doi.org/10.1016/s0021-9258(19)47308-0","title":"\u03b2-bungarotoxin","display_name":"\u03b2-bungarotoxin","publication_year":1989,"publication_date":"1989-11-01","ids":{"openalex":"https://openalex.org/W1503395979","doi":"https://doi.org/10.1016/s0021-9258(19)47308-0","mag":"1503395979","pmid":"https://pubmed.ncbi.nlm.nih.gov/2808427"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)47308-0","doi":"https://doi.org/10.1016/s0021-9258(19)47308-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)47308-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)47308-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043677118","display_name":"Peter D. Kwong","orcid":"https://orcid.org/0000-0003-3560-232X","observed_orcids":["https://orcid.org/0000-0003-3560-232X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P D Kwong","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637","Department of Biochemistry and Molecular Biophysics, Columbia University, 630 W. 168th St., New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, 630 W. 168th St., New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030659071","display_name":"Wayne A. Hendrickson","orcid":"https://orcid.org/0000-0003-1412-5747","observed_orcids":["https://orcid.org/0000-0003-1412-5747"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W A Hendrickson","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, 630 W. 168th St., New York, New York 10032","Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, 630 W. 168th St., New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059655185","display_name":"Paul B. Sigler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P B Sigler","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637","Howard Hughes Medical Institute and the Dept. of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and the Dept. of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.5164,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.85939708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"264","issue":"32","first_page":"19349","last_page":"19353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-bungarotoxin","display_name":"beta-bungarotoxin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/snake-neurotoxins","display_name":"snake venom neurotoxins","score":0.8920000195503235},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7590000033378601},{"id":"https://openalex.org/keywords/rotation-function","display_name":"rotation function","score":0.46000000834465027},{"id":"https://openalex.org/keywords/d2-symmetry","display_name":"D2 symmetry","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4318516254425049},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3270370662212372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2514936327934265}],"mesh":[{"descriptor_ui":"D002038","descriptor_name":"Bungarotoxins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002852","descriptor_name":"Chromatography, Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)47308-0","doi":"https://doi.org/10.1016/s0021-9258(19)47308-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)47308-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:2808427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2808427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)47308-0","doi":"https://doi.org/10.1016/s0021-9258(19)47308-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)47308-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3100937166","display_name":"PHOSPHOLIPASIC NEUROTOXINS--STRUCTURE AND FUNCTION","funder_award_id":"R01NS025867","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W72107370","https://openalex.org/W136579853","https://openalex.org/W1547673187","https://openalex.org/W1566192162","https://openalex.org/W1926656218","https://openalex.org/W1928920289","https://openalex.org/W1964866649","https://openalex.org/W1970423878","https://openalex.org/W1987461797","https://openalex.org/W1990044831","https://openalex.org/W1997314470","https://openalex.org/W2004898625","https://openalex.org/W2013917043","https://openalex.org/W2026659382","https://openalex.org/W2031647295","https://openalex.org/W2037909798","https://openalex.org/W2062385260","https://openalex.org/W2073068631","https://openalex.org/W2102262193","https://openalex.org/W2105997907","https://openalex.org/W2172962186","https://openalex.org/W2314829291"],"related_works":["https://openalex.org/W2032797071","https://openalex.org/W1986946637","https://openalex.org/W2171980421","https://openalex.org/W2002142711","https://openalex.org/W1965746385","https://openalex.org/W2095105325","https://openalex.org/W2468759822","https://openalex.org/W1994721476","https://openalex.org/W2066877410","https://openalex.org/W2099222586"],"abstract_inverted_index":{"Phospholipases":[0],"in":[1],"some":[2],"snake":[3],"venoms":[4],"are":[5,68,134],"potent":[6],"neurotoxins":[7],"that":[8,45,171],"target":[9],"their":[10],"enzymatic":[11],"action":[12],"to":[13,32,118,151],"the":[14,21,59,97,164],"synaptic":[15],"membrane.":[16],"One":[17],"of":[18,58,96,112,156,163],"these":[19,157],"is":[20],"heterodimeric":[22],"neurotoxin,":[23],"beta-bungarotoxin,":[24],"which":[25],"binds":[26],"with":[27,41,73,136,142],"a":[28,33,42,77,103],"protease":[29],"inhibitor-like":[30],"subunit":[31,44],"presynaptic":[34],"potassium":[35],"channel":[36],"and":[37,53,89,168],"then":[38],"blocks":[39],"neurotransmission":[40],"second":[43],"has":[46],"phospholipase":[47,173],"A2":[48],"activity.":[49],"We":[50],"have":[51],"prepared":[52],"characterized":[54],"well":[55],"ordered":[56],"crystals":[57,67,158],"most":[60],"toxic":[61],"beta-bungarotoxin":[62],"isoform,":[63],"beta":[64,90],"1-bungarotoxin.":[65],"The":[66,132],"monoclinic,":[69],"space":[70],"group":[71],"C2,":[72],"unit":[74,110],"cell":[75],"parameters:":[76],"=":[78,82,86,91],"176.5":[79],"A,":[80,84,88],"b":[81],"39.3":[83],"c":[85],"92.7":[87],"114.8":[92],"degrees.":[93],"Rotation-function":[94],"analysis":[95,155],"Patterson":[98],"function,":[99],"as":[100,121],"calculated":[101],"from":[102],"2.3-A":[104],"data":[105],"set,":[106],"reveals":[107],"an":[108],"asymmetric":[109],"composed":[111],"four":[113],"heterodimers.":[114],"These":[115],"heterodimers":[116],"appear":[117],"be":[119],"associated":[120],"two":[122,133],"crystallographically":[123],"distinct":[124],"(AB)4":[125],"tetramers,":[126],"each":[127],"having":[128],"dihedral":[129],"D2":[130],"symmetry.":[131],"positioned":[135],"equivalent":[137],"molecular":[138],"2-fold":[139],"axes":[140],"coincident":[141],"crystallographic":[143],"dyads,":[144],"but":[145],"rotated":[146],"by":[147],"55":[148],"degrees":[149],"relative":[150],"one":[152],"another.":[153],"X-ray":[154],"will":[159],"permit":[160],"direct":[161],"visualization":[162],"specific":[165],"structural":[166],"motifs":[167],"chemical":[169],"features":[170],"underlie":[172],"neurotoxicity.":[174]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
