{"id":"https://openalex.org/W150314743","doi":null,"title":"Studies Of Molecular Structure-Function Relationships For A Pyrrolysine-Containing Methyltransferase And Novel Rna-Cleaving Protein Nucleic Acids","display_name":"Studies Of Molecular Structure-Function Relationships For A Pyrrolysine-Containing Methyltransferase And Novel Rna-Cleaving Protein Nucleic Acids","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W150314743","mag":"150314743"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1230879583","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036381483","display_name":"Ting-Wei Patrick Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ting-Wei Patrick Kang","raw_affiliation_strings":["the Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036381483"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrrolysine","display_name":"pyrrolysine","score":0.8650000095367432},{"id":"https://openalex.org/keywords/methanosarcina-barkeri","display_name":"Methanosarcina barkeri","score":0.9210000038146973},{"id":"https://openalex.org/keywords/rna-bulge","display_name":"RNA bulge","score":0.6869999766349792},{"id":"https://openalex.org/keywords/antisense-agents","display_name":"antisense agents","score":0.6110000014305115},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.6359999775886536},{"id":"https://openalex.org/keywords/x-ray-crystal-structure","display_name":"X-ray crystal structure","score":0.6069999933242798},{"id":"https://openalex.org/keywords/homohexamer","display_name":"homohexamer","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tim-barrel","display_name":"TIM barrel","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.8437188863754272},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5835584402084351},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5721009373664856},{"id":"https://openalex.org/C126142528","wikidata":"https://www.wikidata.org/wiki/Q3771876","display_name":"Nucleic acid structure","level":4,"score":0.5349617600440979},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5150880217552185},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4924956262111664},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4749488830566406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3687319755554199},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22074952721595764},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21780771017074585},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.1377163827419281},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:osu1230879583","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","raw_type":"text"},{"id":"mag:150314743","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/4144","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1230879583","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1230879583","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W150314743.pdf","grobid_xml":"https://content.openalex.org/works/W150314743.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1562957825","https://openalex.org/W1604827622","https://openalex.org/W1678272177","https://openalex.org/W1964261732","https://openalex.org/W1964298151","https://openalex.org/W1970222550","https://openalex.org/W1971589546","https://openalex.org/W1974422933","https://openalex.org/W1982101899","https://openalex.org/W1986191025","https://openalex.org/W1988905886","https://openalex.org/W1990548509","https://openalex.org/W1993158258","https://openalex.org/W2002488710","https://openalex.org/W2002832116","https://openalex.org/W2006371454","https://openalex.org/W2012120237","https://openalex.org/W2013167593","https://openalex.org/W2015473376","https://openalex.org/W2015474185","https://openalex.org/W2015555419","https://openalex.org/W2016186767","https://openalex.org/W2020021522","https://openalex.org/W2024572699","https://openalex.org/W2033327120","https://openalex.org/W2037238732","https://openalex.org/W2038710253","https://openalex.org/W2041745266","https://openalex.org/W2045653120","https://openalex.org/W2047289660","https://openalex.org/W2050719645","https://openalex.org/W2055043387","https://openalex.org/W2055214702","https://openalex.org/W2057850916","https://openalex.org/W2057855316","https://openalex.org/W2065915823","https://openalex.org/W2072348389","https://openalex.org/W2073115409","https://openalex.org/W2074384878","https://openalex.org/W2075781213","https://openalex.org/W2076992251","https://openalex.org/W2078827877","https://openalex.org/W2079341392","https://openalex.org/W2095370301","https://openalex.org/W2105150009","https://openalex.org/W2106882534","https://openalex.org/W2110035145","https://openalex.org/W2110893691","https://openalex.org/W2111204258","https://openalex.org/W2117991391","https://openalex.org/W2122287851","https://openalex.org/W2124709562","https://openalex.org/W2130521343","https://openalex.org/W2131605171","https://openalex.org/W2136991248","https://openalex.org/W2138668121","https://openalex.org/W2144081223","https://openalex.org/W2150261148","https://openalex.org/W2160498409","https://openalex.org/W2162601736","https://openalex.org/W2163151016","https://openalex.org/W2913186510","https://openalex.org/W2949528009","https://openalex.org/W2949854783","https://openalex.org/W2952380716","https://openalex.org/W2952795063","https://openalex.org/W2953056444","https://openalex.org/W2953368008","https://openalex.org/W3024902390"],"related_works":["https://openalex.org/W2907221027","https://openalex.org/W1981768518","https://openalex.org/W2056905587","https://openalex.org/W2030311526","https://openalex.org/W7095719160","https://openalex.org/W1762132428","https://openalex.org/W2022234776","https://openalex.org/W7051830433","https://openalex.org/W2010476099","https://openalex.org/W213766460"],"abstract_inverted_index":{"Nucleic":[0],"acids":[1,26,30,46],"and":[2,78,151,173,219,340],"proteins":[3],"are":[4,153,185,234],"abundant":[5],"linear":[6],"biopolymers":[7],"in":[8,55,122,277,296,320],"living":[9],"organisms.Much":[10],"of":[11,24,33,57,67,87,100,119,147,178,182,224,242,263,280,325],"my":[12],"research":[13],"focused":[14,154,259],"on":[15,155,164,260,283],"developing":[16],"new":[17,180,265],"antisense":[18,35,91,133],"agents":[19,36],"targeting":[20],"an":[21,90,130,160,302],"important":[22],"class":[23,181],"nucleic":[25,45,62],"known":[27,186],"as":[28,89,211,213,333,363,365],"ribonucleic":[29],"(RNA).A":[31],"number":[32],"such":[34],"have":[37],"been":[38,141],"developed":[39],"over":[40],"the":[41,58,116,145,169,174,229,237,243,250,261,278,314,337,351],"years,":[42],"including":[43],"peptide":[44],"(PNAs)":[47],"-nucleic":[48],"acid":[49,63,318],"analogs":[50],"that":[51,95,239,307],"utilize":[52],"2aminoethylglycine":[53],"linkages":[54],"place":[56],"negatively":[59],"charged":[60],"phosphodiester":[61],"backbone.A":[64],"key":[65],"feature":[66],"PNAs":[68,88],"is":[69,94,102,109,129,231,289,308,329,348],"their":[70],"ability":[71],"to":[72,125,143,158,311,350],"tightly":[73],"bind":[74],"complementary":[75,203,208],"RNA":[76,107,137,148,175,187,204,209,251],"sequences":[77],"either":[79],"block":[80],"or":[81],"alter":[82],"protein":[83,331],"synthesis.One":[84],"potential":[85],"limitation":[86,128],"agent,":[92],"however,":[93],"at":[96],"least":[97],"one":[98],"equivalent":[99],"PNA":[101,135,162,191],"required":[103],"for":[104,112,200],"each":[105,341],"target":[106],"inhibited.This":[108],"particularly":[110],"problematic":[111],"translational":[113],"suppression":[114],"given":[115],"multiple":[117],"copies":[118],"RNAs":[120,225],"present":[121],"cells.One":[123],"way":[124],"overcome":[126],"this":[127,165,179,286,299],"enzymatic":[131],"degradation":[132],"strategy.Conjugating":[134],"with":[136,226,236,336],"cleavage":[138,176,188,196,223,252],"motifs":[139],"has":[140],"shown":[142],"enhance":[144,249],"rate":[146],"hydrolysis.Chapters":[149],"2":[150,167],"3":[152],"our":[156],"attempts":[157],"develop":[159],"RNA-cleaving":[161,183],"based":[163],"approach.Chapter":[166],"describes":[168],"initial":[170],"design,":[171],"synthesis,":[172],"activity":[177],"PNA.Polyamines":[184],"agents.Two":[189],"different":[190,202,216],"monomers":[192],"harboring":[193],"a":[194,240,256,264,274,334,344,366],"diamine":[195],"oligomer":[197],"was":[198],"examined":[199],"four":[201],"substrates":[205],"-a":[206],"parent":[207],"strand,":[210],"well":[212,364],"those":[214],"containing":[215,356],"A,":[217],"C,":[218],"AC":[220],"bulges.Notably,":[221],"enhanced":[222],"bulge-loops":[227],"by":[228],"PNA-diamines":[230],"observed.These":[232],"findings":[233],"consistent":[235],"hypothesis":[238],"perturbation":[241],"enzyme-substrate":[244],"ground":[245],"state":[246],"configuration":[247],"may":[248],"rate.Chapter":[253],"4":[254],"details":[255],"distinct":[257],"project":[258],"structure":[262,324,347],"proteinthe":[266],"Methanosarcina":[267],"barkeri":[268,282,359],"trimethylamine":[269,326],"methyltransferase":[270,327,361],"(MttB).The":[271],"MttB":[272,369],"plays":[273],"critical":[275],"role":[276],"growth":[279],"M.":[281,297,358],"trimethylamine.What":[284],"makes":[285],"enzyme":[287,300],"unusual":[288],"that,":[290],"like":[291],"other":[292,352],"methylamine":[293],"methyltransferases":[294],"found":[295,319],"barkeri,":[298],"contains":[301],"in-frame":[303],"UAG":[304],"(amber)":[305],"codon":[306],"ultimately":[309],"used":[310],"incorporate":[312],"pyrrolysine,":[313],"22nd":[315],"genetically-encoded":[316],"amino":[317],"nature.The":[321],"X-ray":[322],"crystal":[323],"(MttB)":[328],"reported.The":[330],"exists":[332],"homohexamer":[335],"D3":[338],"symmetry,":[339],"subunit":[342],"adopts":[343],"TIM-barrel":[345],"fold.The":[346],"compared":[349],"structurally":[353],"characterized":[354],"pyrrolysine":[355],"protein,":[357],"monomethylamine":[360],"(MtmB),":[362],"nonpyrrolysine":[367],"exhibiting":[368],"homology.":[370]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-06-24T00:00:00"}
