{"id":"https://openalex.org/W1502933868","doi":"https://doi.org/10.1016/s0021-9258(18)62896-0","title":"On the Mechanisms of pH-dependent Hydrogen Exchange of Bovine Plasma Albumin in the Range of pH 5 to 8.5","display_name":"On the Mechanisms of pH-dependent Hydrogen Exchange of Bovine Plasma Albumin in the Range of pH 5 to 8.5","publication_year":1970,"publication_date":"1970-08-01","ids":{"openalex":"https://openalex.org/W1502933868","doi":"https://doi.org/10.1016/s0021-9258(18)62896-0","mag":"1502933868","pmid":"https://pubmed.ncbi.nlm.nih.gov/5531618"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)62896-0","doi":"https://doi.org/10.1016/s0021-9258(18)62896-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)62896-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)62896-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113985165","display_name":"E.S. Benson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.S. Benson","raw_affiliation_strings":["From the Departments of Laboratory Medicine and Biochemistry, University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Laboratory Medicine and Biochemistry, University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058598659","display_name":"Ben E. Hallaway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben E. Hallaway","raw_affiliation_strings":["From the Departments of Laboratory Medicine and Biochemistry, University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Laboratory Medicine and Biochemistry, University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.936,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.83713661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"245","issue":"16","first_page":"4144","last_page":"4149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.2515000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hydrogen-exchange","display_name":"hydrogen exchange","score":0.6480000019073486},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.9660000205039978},{"id":"https://openalex.org/keywords/protein-conformational-states","display_name":"protein conformational states","score":0.6439999938011169},{"id":"https://openalex.org/keywords/sodium-dodecyl-sulfate","display_name":"sodium dodecyl sulfate","score":0.7730000019073486},{"id":"https://openalex.org/keywords/glycerol","display_name":"glycerol","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.5963264107704163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5907489657402039},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.48669177293777466},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.48669105768203735},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.44795501232147217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42236992716789246},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3658962547779083},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1305883824825287},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.04799965023994446},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013464","descriptor_name":"Sulfuric Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)62896-0","doi":"https://doi.org/10.1016/s0021-9258(18)62896-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)62896-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:5531618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5531618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)62896-0","doi":"https://doi.org/10.1016/s0021-9258(18)62896-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)62896-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W73415416","https://openalex.org/W1483044202","https://openalex.org/W1498587466","https://openalex.org/W1499408335","https://openalex.org/W1506038615","https://openalex.org/W1907732933","https://openalex.org/W1976581217","https://openalex.org/W1986992365","https://openalex.org/W1998143928","https://openalex.org/W2006761222","https://openalex.org/W2012931747","https://openalex.org/W2015745360","https://openalex.org/W2017449676","https://openalex.org/W2017606481","https://openalex.org/W2030743236","https://openalex.org/W2052857752","https://openalex.org/W2083523676","https://openalex.org/W2092206937","https://openalex.org/W2319565192","https://openalex.org/W2326609729","https://openalex.org/W2328056030","https://openalex.org/W2335377065"],"related_works":["https://openalex.org/W1498587466","https://openalex.org/W1511651884","https://openalex.org/W1507873833","https://openalex.org/W2088421308","https://openalex.org/W2070022064","https://openalex.org/W2046610247","https://openalex.org/W7029051924","https://openalex.org/W2054118102","https://openalex.org/W2127722744","https://openalex.org/W2331076184"],"abstract_inverted_index":{"Hydrogen":[0],"exchange":[1,41,142,232],"rates":[2],"of":[3,11,23,32,40,42,44,106,113,152,154,158,167,200,202,221,231,233,248],"bovine":[4,203],"plasma":[5,204],"albumin":[6],"vary":[7],"over":[8],"the":[9,17,21,30,45,104,114,129,150,155,218,228,246],"range":[10,105],"pH":[12,18,51,56,59,62,80,107,130,145,180],"5":[13,52,108,181],"to":[14,61,92,109,117,147],"8.5.":[15,63],"As":[16],"is":[19,71,131],"raised,":[20],"number":[22,31],"very":[24,46],"slowly":[25,47],"exchanging":[26,34,48,160,223],"hydrogens":[27,35,43,89],"decreases":[28],"and":[29,82,95,172,182,225],"rapidly":[33,78],"steadily":[36],"increases.":[37],"The":[38,64,136,165,184],"rate":[39,229],"core":[49,115],"at":[50,55,79,144,179],"was":[53,241],"studied":[54,178],"values":[57],"from":[58],"5.2":[60,146],"results":[65,151,185],"obtained":[66],"suggest":[67],"that":[68,74,139,193,207,215],"this":[69,134],"protein":[70],"highly":[72,119,126],"motile;":[73],"is,":[75],"it":[76],"fluctuates":[77],"7":[81],"above":[83],"between":[84,237],"states":[85,199],"in":[86,97,141],"which":[87,98],"exchangeable":[88],"are":[90,100,149],"accessible":[91],"bulk":[93],"solvent":[94],"ones":[96],"they":[99,208,216],"not":[101,242],"accessible.":[102],"In":[103],"6.5,":[110],"no":[111],"segments":[112,123,201],"appear":[116],"be":[118,163],"motile":[120,127],"but":[121],"compact":[122,197],"may":[124],"become":[125],"as":[128],"raised":[132],"through":[133],"range.":[135],"alternative":[137],"possibility,":[138],"changes":[140,153],"behavior":[143],"6.5":[148],"local":[156,219],"environment":[157,220],"individual":[159,222],"groups,":[161],"cannot":[162],"excluded.":[164],"effects":[166],"sodium":[168],"dodecyl":[169],"sulfate,":[170],"glycerol,":[171],"changing":[173],"ionic":[174],"strength":[175],"were":[176,186],"also":[177],"7.7.":[183],"consistent":[187],"with":[188],"three":[189,239],"possible":[190,244],"explanations:":[191],"(a)":[192],"these":[194,234,238],"agents":[195],"stabilize":[196],"conformational":[198,211],"albumin;":[205],"(b)":[206],"reduce":[209],"segmental":[210],"motility;;":[212],"or":[213],"(c)":[214],"alter":[217],"groups":[224],"thus":[226],"influence":[227],"dependencies":[230],"units.":[235],"Discrimination":[236],"mechanisms":[240],"deemed":[243],"on":[245],"basis":[247],"our":[249],"experimental":[250],"data.":[251]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}