{"id":"https://openalex.org/W150288523","doi":"https://doi.org/10.1186/1479-5876-13-s1-p3","title":"The relevance of BRAF G469A mutation in determining the response to therapy in metastatic melanoma","display_name":"The relevance of BRAF G469A mutation in determining the response to therapy in metastatic melanoma","publication_year":2015,"publication_date":"2015-01-15","ids":{"openalex":"https://openalex.org/W150288523","doi":"https://doi.org/10.1186/1479-5876-13-s1-p3","mag":"150288523"},"language":"en","primary_location":{"id":"doi:10.1186/1479-5876-13-s1-p3","doi":"https://doi.org/10.1186/1479-5876-13-s1-p3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-13-s1-p3","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-13-S1-P3","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-13-S1-P3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029535504","display_name":"Letizia Porcelli","orcid":"https://orcid.org/0000-0003-0175-9716","observed_orcids":["https://orcid.org/0000-0003-0175-9716"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Letizia Porcelli","raw_affiliation_strings":["Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057411067","display_name":"Gabriella Guida","orcid":"https://orcid.org/0000-0003-2345-2838","observed_orcids":["https://orcid.org/0000-0003-2345-2838"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriella Guida","raw_affiliation_strings":["Dept. of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'A. Moro', 70124, Bari, Italy","Department of Basic Medical Sciences, Neurosciences and Sense Organs; University of Bari \u201cA. Moro\u201d; Bari Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'A. Moro', 70124, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Department of Basic Medical Sciences, Neurosciences and Sense Organs; University of Bari \u201cA. Moro\u201d; Bari Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082787097","display_name":"Tiziana Cocco","orcid":"https://orcid.org/0000-0001-7171-3460","observed_orcids":["https://orcid.org/0000-0001-7171-3460"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tiziana Cocco","raw_affiliation_strings":["Department of Medical Biochemistry, Biology & Physics, University of Bari 'A. Moro', 70124, Bari, Italy","Department of Medical Biochemistry, Biology & Physics, University of Bari 'A. Moro', Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Biology & Physics, University of Bari 'A. Moro', 70124, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Department of Medical Biochemistry, Biology & Physics, University of Bari 'A. Moro', Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113619540","display_name":"Anna Elisa Quatrale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna E. Quatrale","raw_affiliation_strings":["Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011081585","display_name":"Rosa Maria Iacobazzi","orcid":"https://orcid.org/0000-0002-0737-6591","observed_orcids":["https://orcid.org/0000-0002-0737-6591"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosa M Iacobazzi","raw_affiliation_strings":["Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018281862","display_name":"Diana A. Stolfa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diana A Stolfa","raw_affiliation_strings":["Dept. of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'A. Moro', 70124, Bari, Italy","Department of Basic Medical Sciences, Neurosciences and Sense Organs; University of Bari \u201cA. Moro\u201d; Bari Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'A. Moro', 70124, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Department of Basic Medical Sciences, Neurosciences and Sense Organs; University of Bari \u201cA. Moro\u201d; Bari Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015737167","display_name":"Immacolata Maida","orcid":"https://orcid.org/0000-0002-2106-3313","observed_orcids":["https://orcid.org/0000-0002-2106-3313"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Imma Maida","raw_affiliation_strings":["Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045329191","display_name":"Anna Ferretta","orcid":"https://orcid.org/0000-0003-2279-9557","observed_orcids":["https://orcid.org/0000-0003-2279-9557"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Ferretta","raw_affiliation_strings":["Department of Medical Biochemistry, Biology & Physics, University of Bari 'A. Moro', 70124, Bari, Italy","Department of Medical Biochemistry, Biology & Physics, University of Bari 'A. Moro', Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Biology & Physics, University of Bari 'A. Moro', 70124, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Department of Medical Biochemistry, Biology & Physics, University of Bari 'A. Moro', Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083495765","display_name":"Claudia Grieco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Grieco","raw_affiliation_strings":["Dept. of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'A. Moro', 70124, Bari, Italy","Department of Basic Medical Sciences, Neurosciences and Sense Organs; University of Bari \u201cA. Moro\u201d; Bari Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'A. Moro', 70124, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Department of Basic Medical Sciences, Neurosciences and Sense Organs; University of Bari \u201cA. Moro\u201d; Bari Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036080562","display_name":"Stefania Guida","orcid":"https://orcid.org/0000-0002-8221-6694","observed_orcids":["https://orcid.org/0000-0002-8221-6694"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Guida","raw_affiliation_strings":["Dept. of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'A. Moro', 70124, Bari, Italy","Department of Basic Medical Sciences, Neurosciences and Sense Organs; University of Bari \u201cA. Moro\u201d; Bari Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari 'A. Moro', 70124, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Department of Basic Medical Sciences, Neurosciences and Sense Organs; University of Bari \u201cA. Moro\u201d; Bari Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071490805","display_name":"Sabino Strippoli","orcid":"https://orcid.org/0000-0001-7982-7788","observed_orcids":["https://orcid.org/0000-0001-7982-7788"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabino Strippoli","raw_affiliation_strings":["Medical Oncology Department, Istituto Tumori Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Istituto Tumori Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014032423","display_name":"Stefania Tommasi","orcid":"https://orcid.org/0000-0002-2157-2978","observed_orcids":["https://orcid.org/0000-0002-2157-2978"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Tommasi","raw_affiliation_strings":["Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057828080","display_name":"Michele Guida","orcid":"https://orcid.org/0000-0001-8411-0319","observed_orcids":["https://orcid.org/0000-0001-8411-0319"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Guida","raw_affiliation_strings":["Medical Oncology Department, Istituto Tumori Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Istituto Tumori Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050514750","display_name":"Amalia Azzariti","orcid":"https://orcid.org/0000-0002-6149-5049","observed_orcids":["https://orcid.org/0000-0002-6149-5049"]},"institutions":[{"id":"https://openalex.org/I4210131058","display_name":"Istituto Tumori Bari","ror":"https://ror.org/03jxkz251","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210131058","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Amalia Azzariti","raw_affiliation_strings":["Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Experimental Oncology Laboratory, Istituto Tumori Giovanni Paolo II, Bari, Italy","institution_ids":["https://openalex.org/I4210131058"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050514750"],"corresponding_institution_ids":["https://openalex.org/I4210131058"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.1154,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.43432672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"13","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/vemurafenib","display_name":"vemurafenib","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6159999966621399},{"id":"https://openalex.org/keywords/braf-v600-mutation","display_name":"BRAF V600 mutation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.5989999771118164},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7630000114440918},{"id":"https://openalex.org/keywords/fotemustine","display_name":"fotemustine","score":0.8360000252723694},{"id":"https://openalex.org/keywords/melanoma-cell-lines","display_name":"melanoma cell lines","score":0.7789999842643738},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.8649144172668457},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.640451192855835},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5711151957511902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.533917248249054},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.5015945434570312},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48062390089035034},{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.47673189640045166},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39235955476760864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2567388415336609},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15055370330810547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06617507338523865},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/1479-5876-13-s1-p3","doi":"https://doi.org/10.1186/1479-5876-13-s1-p3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-13-s1-p3","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-13-S1-P3","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3291371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4315283","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4315283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4315283","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmh:oai:ricerca.uniba.it:11586/139865","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11586/139865","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1479-5876-13-s1-p3","doi":"https://doi.org/10.1186/1479-5876-13-s1-p3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1479-5876-13-s1-p3","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/1479-5876-13-S1-P3","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W150288523.pdf","grobid_xml":"https://content.openalex.org/works/W150288523.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W637873005","https://openalex.org/W1983939403","https://openalex.org/W2167202878","https://openalex.org/W2313037686","https://openalex.org/W2946779737","https://openalex.org/W2344670011","https://openalex.org/W2976422870","https://openalex.org/W2011042089","https://openalex.org/W3027281882","https://openalex.org/W2116978375"],"abstract_inverted_index":{"Background":[0],"BRAF":[1,12,33,55,79,137,151],"G469A":[2,34,56],"is":[3,41,47,58,164],"a":[4,16,51,87,104,157],"missense":[5],"mutation":[6,57],"within":[7],"exon":[8],"11":[9],"of":[10,20,121,134],"the":[11,21,26,30,98,119,132,160],"gene":[13],"resulting":[14],"in":[15,38,43,75,145,154],"constitutively":[17],"active":[18],"state":[19],"enzyme":[22],"responsible":[23],"also":[24],"for":[25,131,150,159],"protein":[27],"localization":[28],"to":[29,61,78,124,162],"mitochondria.":[31],"The":[32],"mutation,":[35],"frequently":[36,59],"recovers":[37],"lung":[39],"cancer,":[40],"rare":[42],"melanoma":[44,91,107,135],"and":[45,113,126],"uncertain":[46],"its":[48,73],"association":[49],"with":[50,89,95,142],"more":[52],"aggressive":[53],"disease.":[54],"associated":[60],"MAP":[62],"kinase":[63],"cascade":[64],"signaling":[65],"activation,":[66],"however":[67,97],"no":[68],"evidence":[69],"currently":[70],"exists":[71],"about":[72],"role":[74],"determining":[76],"sensitivity/resistance":[77],"inhibitors":[80],"vemurafenib":[81,125],"or":[82,152],"dabrafenib.":[83],"In":[84],"our":[85],"Institute,":[86],"patient":[88,102],"metastatic":[90,106],"(MM)":[92],"was":[93],"treated":[94],"fotemustine,":[96],"disease":[99],"progressed.":[100],"From":[101],"biopsy,":[103],"new":[105],"cell":[108],"line":[109],"has":[110],"been":[111],"established":[112],"named":[114],"Mo-1.":[115],"Here,":[116],"we":[117],"investigated":[118],"sensitivity":[120],"Mo-1":[122],"cells":[123,147],"abraxane,":[127],"both":[128],"already":[129],"approved":[130],"treatment":[133],"carrying":[136],"V600":[138],"mutations,":[139],"comparing":[140],"it":[141],"that":[143],"found":[144],"MM":[146],"wild":[148],"type":[149],"mutated":[153],"V600.":[155],"Furthermore,":[156],"biomarker":[158],"response":[161],"abraxane":[163],"hypothesized.":[165]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}