{"id":"https://openalex.org/W1502641732","doi":"https://doi.org/10.4049/jimmunol.155.11.5268","title":"Mouse VH7183 recombination signal sequences mediate recombination more frequently than those of VHJ558","display_name":"Mouse VH7183 recombination signal sequences mediate recombination more frequently than those of VHJ558","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W1502641732","doi":"https://doi.org/10.4049/jimmunol.155.11.5268","mag":"1502641732","pmid":"https://pubmed.ncbi.nlm.nih.gov/7594539"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.155.11.5268","doi":"https://doi.org/10.4049/jimmunol.155.11.5268","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.155.11.5268","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113580025","display_name":"Alison M. Connor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A M Connor","raw_affiliation_strings":["Wellesley Hospital Research Institute, University of Toronto , Ontario,","Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto , Ontario,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025060240","display_name":"Liam J. Fanning","orcid":"https://orcid.org/0000-0001-6629-8418","observed_orcids":["https://orcid.org/0000-0001-6629-8418"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L J Fanning","raw_affiliation_strings":["Wellesley Hospital Research Institute, University of Toronto , Ontario,","Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto , Ontario,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082278394","display_name":"Jakub W. Celler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J W Celler","raw_affiliation_strings":["Wellesley Hospital Research Institute, University of Toronto , Ontario,","Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto , Ontario,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070115729","display_name":"Lisa K. Hicks","orcid":"https://orcid.org/0000-0003-1858-7420","observed_orcids":["https://orcid.org/0000-0003-1858-7420"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L K Hicks","raw_affiliation_strings":["Wellesley Hospital Research Institute, University of Toronto , Ontario,","Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto , Ontario,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076234244","display_name":"Dale A. Ramsden","orcid":"https://orcid.org/0000-0003-1575-4748","observed_orcids":["https://orcid.org/0000-0003-1575-4748"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D A Ramsden","raw_affiliation_strings":["Wellesley Hospital Research Institute, University of Toronto , Ontario,","Biochemistry and Biophysics","Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto , Ontario,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Biochemistry and Biophysics","institution_ids":[]},{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079481552","display_name":"G E Wu","orcid":"https://orcid.org/0009-0001-6829-7811","observed_orcids":["https://orcid.org/0009-0001-6829-7811"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G E Wu","raw_affiliation_strings":["Wellesley Hospital Research Institute, University of Toronto , Ontario,","Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto , Ontario,","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Wellesley Hospital Research Institute, University of Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.7148,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.68182149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"155","issue":"11","first_page":"5268","last_page":"5272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.15649999678134918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.09610000252723694,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombination-signal-sequences","display_name":"recombination signal sequences","score":0.796999990940094},{"id":"https://openalex.org/keywords/immunoglobulin-variable-region-genes","display_name":"immunoglobulin variable region genes","score":0.6079999804496765},{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.6980000138282776},{"id":"https://openalex.org/keywords/strain-differences","display_name":"strain differences","score":0.6050000190734863},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.9480000138282776},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vh-gene-families","display_name":"VH gene families","score":0.46299999952316284},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.7218140363693237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6365543603897095},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5755971074104309},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5710589289665222},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4895423352718353},{"id":"https://openalex.org/C157402786","wikidata":"https://www.wikidata.org/wiki/Q7302710","display_name":"Recombination signal sequences","level":5,"score":0.4350701570510864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4136534035205841},{"id":"https://openalex.org/C113646796","wikidata":"https://www.wikidata.org/wiki/Q50263283","display_name":"Recombination-activating gene","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007143","descriptor_name":"Immunoglobulin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015326","descriptor_name":"Gene Rearrangement, B-Lymphocyte, Heavy Chain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.155.11.5268","doi":"https://doi.org/10.4049/jimmunol.155.11.5268","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.155.11.5268","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:7594539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7594539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032414205","https://openalex.org/W1496680764","https://openalex.org/W2071761559","https://openalex.org/W7098765663","https://openalex.org/W2058660996","https://openalex.org/W2028633864","https://openalex.org/W2031397199","https://openalex.org/W1580710981","https://openalex.org/W1598449725","https://openalex.org/W2117789925"],"abstract_inverted_index":{"Mouse":[0],"VH":[1,47,93],"gene":[2],"segments":[3,94],"are":[4],"conventionally":[5],"classified":[6],"into":[7,109],"13":[8],"families":[9,67],"on":[10],"the":[11,22,26,36,42,46,62,65,71,76,87,127,138,156,160,171],"basis":[12],"of":[13,25,45,61,73,79,92,148],"sequence":[14],"similarity.":[15],"The":[16],"7183":[17,74,95,128,139],"family":[18],"lies":[19,39],"close":[20,40],"to":[21,41,70,132],"3'":[23],"end":[24,44],"locus":[27],"and":[28,49,96,117,150],"is":[29,50],"preferentially":[30,51,134],"used":[31,52,135],"in":[32,53,64,75,85,170],"BALB/c":[33,122],"mice;":[34],"J558,":[35,149],"largest":[37],"family,":[38],"5'":[43],"stretch":[48],"C57BL/6":[54,116],"mice.":[55,123],"To":[56],"investigate":[57],"whether":[58],"differential":[59],"effectiveness":[60],"RSSs":[63],"two":[66,110,118],"might":[68],"contribute":[69],"overusage":[72],"primary":[77,157],"repertoire":[78],"BALB/c,":[80],"we":[81],"constructed":[82],"recombination":[83,88,142],"substrates":[84],"which":[86],"signal":[89],"sequences":[90],"(RSSs)":[91],"J558":[97],"compete":[98],"with":[99],"each":[100],"other":[101],"for":[102,166],"a":[103,168],"single":[104],"RSS,":[105],"DFL16.1,":[106],"after":[107],"transfection":[108],"transformed":[111],"cell":[112,119],"lines":[113,120],"derived":[114],"from":[115,121],"In":[124],"both":[125],"strains,":[126],"RSS":[129,140],"was":[130],"found":[131],"be":[133,164],"(83%).":[136],"Thus,":[137],"mediates":[141],"more":[143],"frequently":[144],"than":[145],"does":[146],"that":[147],"this":[151],"preference":[152],"must":[153],"thereby":[154],"influence":[155],"repertoire,":[158],"but":[159],"strain":[161],"difference":[162,169],"cannot":[163],"accounted":[165],"by":[167],"RSSs.":[172]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
