{"id":"https://openalex.org/W150228992","doi":"https://doi.org/10.1007/978-1-4615-4811-9_18","title":"Both Pgp and MRP1 Activities Using Calcein-AM Contribute to Drug Resistance in AML","display_name":"Both Pgp and MRP1 Activities Using Calcein-AM Contribute to Drug Resistance in AML","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W150228992","doi":"https://doi.org/10.1007/978-1-4615-4811-9_18","mag":"150228992","pmid":"https://pubmed.ncbi.nlm.nih.gov/10500791"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4615-4811-9_18","doi":"https://doi.org/10.1007/978-1-4615-4811-9_18","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-4811-9_18","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1583876657","display_name":"Drug Resistance in Leukemia and Lymphoma III"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043175279","display_name":"Ollivier Legrand","orcid":"https://orcid.org/0000-0003-1804-6392","observed_orcids":["https://orcid.org/0000-0003-1804-6392"]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ollivier Legrand","raw_affiliation_strings":["EA1529, Universit\u00e9 Paris VI, Formation de Recherche Claude Bernard, France","Formation de Recherche Claude Bernard and Service d'h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA1529, Universit\u00e9 Paris VI, Formation de Recherche Claude Bernard, France","institution_ids":["https://openalex.org/I4405264447"]},{"raw_affiliation_string":"Formation de Recherche Claude Bernard and Service d'h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016895917","display_name":"Ghislaine Simonin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ghislaine Simonin","raw_affiliation_strings":["Formation de Recherche Claude Bernard and Service d\u2019h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formation de Recherche Claude Bernard and Service d\u2019h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077341645","display_name":"Jean\u2010Yves Perrot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Yves Perrot","raw_affiliation_strings":["Formation de Recherche Claude Bernard and Service d\u2019h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formation de Recherche Claude Bernard and Service d\u2019h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078885918","display_name":"R Zittoun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Robert Zittoun","raw_affiliation_strings":["Formation de Recherche Claude Bernard and Service d\u2019h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formation de Recherche Claude Bernard and Service d\u2019h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112233576","display_name":"Jean\u2010Pierre Marie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133078","display_name":"H\u00f4tel-Dieu de Paris","ror":"https://ror.org/03jmjy508","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210124464","https://openalex.org/I4210133078"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Marie","raw_affiliation_strings":["Formation de Recherche Claude Bernard and Service d\u2019h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formation de Recherche Claude Bernard and Service d\u2019h\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, EA1529, Universit\u00e9 Paris VI, Paris, France","institution_ids":["https://openalex.org/I4210133078","https://openalex.org/I4405264447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4565,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.68092692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"457","issue":null,"first_page":"161","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.5820000171661377},{"id":"https://openalex.org/keywords/pgp","display_name":"PGP","score":0.5669999718666077},{"id":"https://openalex.org/keywords/mrp1","display_name":"MRP1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/calcein-am","display_name":"calcein-AM","score":0.9210000038146973},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8199999928474426},{"id":"https://openalex.org/keywords/probenecid","display_name":"probenecid","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9089999794960022},{"id":"https://openalex.org/keywords/calcein-efflux","display_name":"calcein efflux","score":0.7490000128746033},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.8389999866485596},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9309999942779541},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"myeloid leukemia","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2776872141","wikidata":"https://www.wikidata.org/wiki/Q413006","display_name":"Calcein","level":3,"score":0.8568805456161499},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5355199575424194},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5079808831214905},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.46617579460144043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41109657287597656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3733100891113281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20780441164970398},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1113603413105011},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09727925062179565},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.03862842917442322}],"mesh":[{"descriptor_ui":"D000074081","descriptor_name":"MutS Homolog 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018432","descriptor_name":"Drug Resistance, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019450","descriptor_name":"Genes, MDR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020137","descriptor_name":"Base Pair Mismatch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-4615-4811-9_18","doi":"https://doi.org/10.1007/978-1-4615-4811-9_18","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-4811-9_18","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:10500791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10500791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W76595895","https://openalex.org/W225277523","https://openalex.org/W1594196316","https://openalex.org/W1595506167","https://openalex.org/W1967087238","https://openalex.org/W1981517333","https://openalex.org/W2000980801","https://openalex.org/W2009396840","https://openalex.org/W2028962524","https://openalex.org/W2075861079","https://openalex.org/W2076623448","https://openalex.org/W2081538957","https://openalex.org/W2093172276","https://openalex.org/W2103003264","https://openalex.org/W2125205754","https://openalex.org/W2149994120","https://openalex.org/W2150113701","https://openalex.org/W2152057741","https://openalex.org/W2168070336","https://openalex.org/W2168095256","https://openalex.org/W2288226674","https://openalex.org/W2419542593","https://openalex.org/W2431955049"],"related_works":["https://openalex.org/W77471785","https://openalex.org/W1706395004","https://openalex.org/W2041862718","https://openalex.org/W7061197753","https://openalex.org/W2140847482","https://openalex.org/W3030623977","https://openalex.org/W2390434224","https://openalex.org/W2048576022","https://openalex.org/W2418439844","https://openalex.org/W2950475255"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
