{"id":"https://openalex.org/W1502000672","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a132738","title":"A Spin-Label Study of the Effects of Drugs on Calcium Release from Isolated Sarcoplasmic Reticulum Vesicles1","display_name":"A Spin-Label Study of the Effects of Drugs on Calcium Release from Isolated Sarcoplasmic Reticulum Vesicles1","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W1502000672","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a132738","mag":"1502000672","pmid":"https://pubmed.ncbi.nlm.nih.gov/6244262"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a132738","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a132738","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a132738","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070293932","display_name":"Kunio Takishima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunio TAKISHIMA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013596644","display_name":"Hiroshi Shimizu","orcid":"https://orcid.org/0000-0002-4869-502X","observed_orcids":["https://orcid.org/0000-0002-4869-502X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi SHIMIZU","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111634673","display_name":"Morio Setaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Morio SETAKA","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo UniversitySagamiko-cho, Tsukui-gun, Kanagawa 199-01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo UniversitySagamiko-cho, Tsukui-gun, Kanagawa 199-01","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111547621","display_name":"Takao Kwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao KWAN","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Teikyo UniversitySagamiko-cho, Tsukui-gun, Kanagawa 199-01"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Teikyo UniversitySagamiko-cho, Tsukui-gun, Kanagawa 199-01","institution_ids":["https://openalex.org/I87531838"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":1.1262,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.69789298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"87","issue":"1","first_page":"305","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12381","display_name":"Electron Spin Resonance Studies","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12381","display_name":"Electron Spin Resonance Studies","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.9869999885559082},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.9860000014305115},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.5199999809265137},{"id":"https://openalex.org/keywords/thymol","display_name":"thymol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/procaine","display_name":"procaine","score":1.0},{"id":"https://openalex.org/keywords/spin-labeling","display_name":"spin labeling","score":0.6710000038146973},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.824999988079071},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8070806264877319},{"id":"https://openalex.org/C2776515853","wikidata":"https://www.wikidata.org/wiki/Q2191895","display_name":"Iodoacetamide","level":4,"score":0.7796485424041748},{"id":"https://openalex.org/C2779828710","wikidata":"https://www.wikidata.org/wiki/Q423741","display_name":"Procaine","level":2,"score":0.7337664365768433},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6846038699150085},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6816363334655762},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.5990850329399109},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5957213640213013},{"id":"https://openalex.org/C79123411","wikidata":"https://www.wikidata.org/wiki/Q2379429","display_name":"Spin label","level":3,"score":0.541537880897522},{"id":"https://openalex.org/C2780105360","wikidata":"https://www.wikidata.org/wiki/Q6743002","display_name":"Maleimide","level":2,"score":0.4721943140029907},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42500337958335876},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3382135033607483},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3233623802661896},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.250745952129364},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2137148082256317},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14501503109931946},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08155342936515808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011343","descriptor_name":"Procaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013943","descriptor_name":"Thymol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a132738","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a132738","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a132738","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:6244262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6244262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093566267","https://openalex.org/W1512340857","https://openalex.org/W1971345696","https://openalex.org/W2068688339","https://openalex.org/W1486688825","https://openalex.org/W2147265362","https://openalex.org/W2087428862","https://openalex.org/W2053666484","https://openalex.org/W1564290312","https://openalex.org/W2064735040"],"abstract_inverted_index":{"The":[0,46,68,90],"effects":[1,177,192],"of":[2,43,49,87,92,99,106,119,122,139,154,158,193,210,223],"caffeine,":[3],"thymol,":[4],"and":[5,36,53,64,129,173,215],"procaine":[6,147,184],"on":[7,96,178,196],"calcium":[8,179,229],"release":[9,180,230],"from":[10,15,181,231],"fragmented":[11],"sarcoplasmic":[12],"reticulum":[13],"(FSR)":[14],"rabbit":[16],"skeletal":[17],"white":[18],"muscle":[19],"were":[20,38],"investigated":[21],"by":[22,110,144,166,208],"the":[23,28,41,50,62,78,93,97,100,115,120,127,136,140,155,169,191,194,197,205,211,221],"spin":[24,33,212],"label":[25,213],"method":[26],"at":[27,84,204],"organellar":[29,206],"level.":[30],"Two":[31],"thiol-directed":[32],"labels,":[34],"4-maleimide-2,2,6,6-tetramethylpiperidinooxyl":[35],"4-(2-iodoacetamide)-2,2,6,6-tetramethylpiperidinooxyl,":[37],"used":[39],"for":[40,61,228],"labeling":[42],"SR":[44,88,107,141,224],"proteins.":[45,89],"ratio":[47],"(W/S)":[48],"weakly":[51],"(W)":[52],"strongly":[54],"(S)":[55],"immobilized":[56],"ESR":[57],"signals":[58],"was":[59,133,163],"measured":[60],"maleimide":[63],"iodoacetamide":[65],"labeled":[66],"FSR.":[67,232],"two":[69,79],"labels":[70,80],"gave":[71],"different":[72,85],"W/S":[73,94],"values,":[74],"which":[75],"means":[76,209],"that":[77,103,135,190,216],"report":[81],"conformational":[82,104,137],"changes":[83,105,138,219],"loci":[86],"dependences":[91],"ratios":[95],"concentration":[98],"drugs":[101,112,195],"showed":[102,175],"proteins":[108,142,225],"induced":[109,148,165],"these":[111],"are":[113,226],"not":[114,164],"same.":[116],"From":[117],"measurements":[118],"distribution":[121],"5-doxyldecanoic":[123],"acid":[124],"methylester":[125],"between":[126],"lipid":[128],"water":[130],"phases,":[131],"it":[132],"found":[134],"caused":[143],"thymol":[145,174],"or":[146],"a":[149],"disorder":[150],"in":[151,220],"local":[152],"regions":[153],"phospholipid":[156],"bilayers":[157],"FSR,":[159,182],"while":[160,183],"such":[161],"disordering":[162],"caffeine.":[167],"On":[168],"other":[170],"hand,":[171],"caffeine":[172],"definite":[176],"did":[185],"not.":[186],"These":[187],"results":[188],"indicate":[189],"protein":[198],"conformations":[199,222],"can":[200],"be":[201],"well":[202],"characterized":[203],"level":[207],"technique":[214],"some":[217],"specific":[218],"necessary":[227]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}