{"id":"https://openalex.org/W1501966566","doi":"https://doi.org/10.1016/0005-2795(77)90198-2","title":"Studies on human \u03b1-fetoprotein","display_name":"Studies on human \u03b1-fetoprotein","publication_year":1977,"publication_date":"1977-08-01","ids":{"openalex":"https://openalex.org/W1501966566","doi":"https://doi.org/10.1016/0005-2795(77)90198-2","mag":"1501966566","pmid":"https://pubmed.ncbi.nlm.nih.gov/70228"},"language":"en","primary_location":{"id":"doi:10.1016/0005-2795(77)90198-2","doi":"https://doi.org/10.1016/0005-2795(77)90198-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2795(77)90198-2","pdf_url":null,"source":{"id":"https://openalex.org/S4394735817","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure","issn_l":"0005-2795","issn":["0005-2795","1879-2952"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075720529","display_name":"Stanley Yachnin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stanley Yachnin","raw_affiliation_strings":["Departments of Medicine and Biochemistry, The University of Chicago, and The Franklin McLean Memorial Research Institute, Chicago, Ill. 60637 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Biochemistry, The University of Chicago, and The Franklin McLean Memorial Research Institute, Chicago, Ill. 60637 U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110104481","display_name":"Robert Y. Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Hsu","raw_affiliation_strings":["Departments of Medicine and Biochemistry, The University of Chicago, and The Franklin McLean Memorial Research Institute, Chicago, Ill. 60637 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Biochemistry, The University of Chicago, and The Franklin McLean Memorial Research Institute, Chicago, Ill. 60637 U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016822525","display_name":"Robert L. Heinrikson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Heinrikson","raw_affiliation_strings":["Departments of Medicine and Biochemistry, The University of Chicago, and The Franklin McLean Memorial Research Institute, Chicago, Ill. 60637 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Biochemistry, The University of Chicago, and The Franklin McLean Memorial Research Institute, Chicago, Ill. 60637 U.S.A","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071763157","display_name":"John B. Miller","orcid":"https://orcid.org/0000-0002-8438-4413","observed_orcids":["https://orcid.org/0000-0002-8438-4413"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.Bruce Miller","raw_affiliation_strings":["Departments of Medicine and Biochemistry, The University of Chicago, and The Franklin McLean Memorial Research Institute, Chicago, Ill. 60637 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Biochemistry, The University of Chicago, and The Franklin McLean Memorial Research Institute, Chicago, Ill. 60637 U.S.A","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075720529"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":2.4037,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.88249911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"493","issue":"2","first_page":"418","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.2775999903678894,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.2775999903678894,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.2354000061750412,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.21459999680519104,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8479999899864197},{"id":"https://openalex.org/keywords/sialylated-glycoproteins","display_name":"sialylated glycoproteins","score":0.9340000152587891},{"id":"https://openalex.org/keywords/protein-polymers","display_name":"protein polymers","score":0.7120000123977661},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.921999990940094},{"id":"https://openalex.org/keywords/isoelectric-point","display_name":"isoelectric point","score":0.824999988079071},{"id":"https://openalex.org/keywords/nh2-terminal-sequence","display_name":"NH2-terminal sequence","score":0.8370000123977661},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.6660000085830688},{"id":"https://openalex.org/keywords/ascitic-fluid","display_name":"ascitic fluid","score":0.593999981880188},{"id":"https://openalex.org/keywords/serum-proteins","display_name":"serum proteins","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7652873992919922},{"id":"https://openalex.org/C50476208","wikidata":"https://www.wikidata.org/wiki/Q898861","display_name":"Isoelectric focusing","level":3,"score":0.730925440788269},{"id":"https://openalex.org/C96294017","wikidata":"https://www.wikidata.org/wiki/Q308708","display_name":"Isoelectric point","level":3,"score":0.730678915977478},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.6173161864280701},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.5880107879638672},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5479403734207153},{"id":"https://openalex.org/C2779390175","wikidata":"https://www.wikidata.org/wiki/Q855786","display_name":"Immunoelectrophoresis","level":3,"score":0.5310205817222595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5036374926567078},{"id":"https://openalex.org/C58121356","wikidata":"https://www.wikidata.org/wiki/Q182854","display_name":"Molecular mass","level":3,"score":0.4883729815483093},{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.4808119535446167},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4551598131656647},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.41962265968322754},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4188826084136963},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.29573339223861694},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1367579698562622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1299736499786377},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11696746945381165},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007122","descriptor_name":"Immunoelectrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0005-2795(77)90198-2","doi":"https://doi.org/10.1016/0005-2795(77)90198-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2795(77)90198-2","pdf_url":null,"source":{"id":"https://openalex.org/S4394735817","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure","issn_l":"0005-2795","issn":["0005-2795","1879-2952"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure","raw_type":"journal-article"},{"id":"pmid:70228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/70228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.5899999737739563,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1496422979","https://openalex.org/W1527633227","https://openalex.org/W1600918029","https://openalex.org/W1892971240","https://openalex.org/W1971384542","https://openalex.org/W1975023463","https://openalex.org/W1977892135","https://openalex.org/W1982415717","https://openalex.org/W2038345597","https://openalex.org/W2053837208","https://openalex.org/W2059604331","https://openalex.org/W2073879684","https://openalex.org/W2124980843","https://openalex.org/W2132039015","https://openalex.org/W2137302959","https://openalex.org/W2170714579","https://openalex.org/W2394869748","https://openalex.org/W2401608391"],"related_works":["https://openalex.org/W1600918029","https://openalex.org/W1971384542","https://openalex.org/W2091267909","https://openalex.org/W2084100447","https://openalex.org/W2073121763","https://openalex.org/W1982415717","https://openalex.org/W2264734866","https://openalex.org/W2144348183","https://openalex.org/W1532113742","https://openalex.org/W2396847640"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
