{"id":"https://openalex.org/W1501422236","doi":"https://doi.org/10.4049/jimmunol.1402571","title":"Survival of Effector CD8+ T Cells during Influenza Infection Is Dependent on Autophagy","display_name":"Survival of Effector CD8+ T Cells during Influenza Infection Is Dependent on Autophagy","publication_year":2015,"publication_date":"2015-04-02","ids":{"openalex":"https://openalex.org/W1501422236","doi":"https://doi.org/10.4049/jimmunol.1402571","mag":"1501422236","pmid":"https://pubmed.ncbi.nlm.nih.gov/25833396"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.1402571","doi":"https://doi.org/10.4049/jimmunol.1402571","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1402571","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048434043","display_name":"Katrin Schlie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Katrin Schlie","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021520939","display_name":"Ashley Westerback","orcid":"https://orcid.org/0009-0004-2317-4633","observed_orcids":["https://orcid.org/0009-0004-2317-4633"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ashley Westerback","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084754178","display_name":"Lindsay DeVorkin","orcid":"https://orcid.org/0000-0003-2787-5387","observed_orcids":["https://orcid.org/0000-0003-2787-5387"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Lindsay DeVorkin","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044659252","display_name":"Luke R. K. Hughson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Luke R Hughson","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019713573","display_name":"Jillian M Brandon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jillian M Brandon","raw_affiliation_strings":["Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002223965","display_name":"Sarah MacPherson","orcid":"https://orcid.org/0000-0001-7690-1620","observed_orcids":["https://orcid.org/0000-0001-7690-1620"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sarah MacPherson","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066857616","display_name":"Izabelle Gadawski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Izabelle Gadawski","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074655421","display_name":"Katelin N. Townsend","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Katelin N Townsend","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021814323","display_name":"Vincent Isaac Poon","orcid":"https://orcid.org/0000-0002-3080-3061","observed_orcids":["https://orcid.org/0000-0002-3080-3061"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vincent I Poon","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012328333","display_name":"Mary A. Elrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mary A Elrick","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102821320","display_name":"H\u00e9l\u00e8ne C F C\u00f4t\u00e9","orcid":"https://orcid.org/0000-0002-0535-8576","observed_orcids":["https://orcid.org/0000-0002-0535-8576"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Helene C F C\u00f4t\u00e9","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ninan Abraham","orcid":"https://orcid.org/0000-0002-2747-1246","observed_orcids":["https://orcid.org/0000-0002-2747-1246"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ninan Abraham","raw_affiliation_strings":["Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","Department of Zoology, Life Sciences Institute, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2747-1246","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Zoology, Life Sciences Institute, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057824723","display_name":"E. John Wherry","orcid":"https://orcid.org/0000-0003-0477-1956","observed_orcids":["https://orcid.org/0000-0003-0477-1956"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E John Wherry","raw_affiliation_strings":["Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038112377","display_name":"Noboru Mizushima","orcid":"https://orcid.org/0000-0002-6258-6444","observed_orcids":["https://orcid.org/0000-0002-6258-6444"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noboru Mizushima","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, University of Tokyo , Tokyo 113-0033 ,","Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, University of Tokyo , Tokyo 113-0033 ,","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047684237","display_name":"Julian J. Lum","orcid":"https://orcid.org/0000-0002-5624-3541","observed_orcids":["https://orcid.org/0000-0002-5624-3541"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julian J Lum","raw_affiliation_strings":["Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria , Victoria, British Columbia V8W 3P6 ,","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency , Victoria, British Columbia V8R 6V5 ,","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia V8R 6V5, Canada","institution_ids":["https://openalex.org/I1289530486"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002223965","https://openalex.org/A5021520939","https://openalex.org/A5048434043","https://openalex.org/A5084754178"],"corresponding_institution_ids":["https://openalex.org/I1289530486","https://openalex.org/I212119943"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.7074,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.94553207,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"194","issue":"9","first_page":"4277","last_page":"4286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2517000138759613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/effector-cd8-t-cells","display_name":"CD8+ effector T cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/influenza","display_name":"influenza","score":0.9210000038146973},{"id":"https://openalex.org/keywords/t-cell-survival","display_name":"T cell survival","score":0.9190000295639038},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6209999918937683},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9779999852180481},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.921999990940094},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8600000143051147},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.8908187747001648},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8305634260177612},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6627723574638367},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5562983751296997},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49385005235671997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.444098562002182},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39623427391052246},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36527204513549805},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23024719953536987},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09443992376327515},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.07939687371253967},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071187","descriptor_name":"Autophagy-Related Protein 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.1402571","doi":"https://doi.org/10.4049/jimmunol.1402571","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.1402571","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:25833396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25833396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2512667845","display_name":null,"funder_award_id":"MOP97909","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G4822655395","display_name":null,"funder_award_id":"25111005","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1481208898","https://openalex.org/W1568778024","https://openalex.org/W1591146540","https://openalex.org/W1600858326","https://openalex.org/W1781304070","https://openalex.org/W1882193637","https://openalex.org/W1965277605","https://openalex.org/W1965827991","https://openalex.org/W1970101770","https://openalex.org/W1970400427","https://openalex.org/W1971979468","https://openalex.org/W1974135904","https://openalex.org/W1975783419","https://openalex.org/W1976855961","https://openalex.org/W1981629491","https://openalex.org/W1983365529","https://openalex.org/W1991066138","https://openalex.org/W1995571717","https://openalex.org/W1998052953","https://openalex.org/W1999195849","https://openalex.org/W1999324987","https://openalex.org/W2006696441","https://openalex.org/W2014219207","https://openalex.org/W2022030273","https://openalex.org/W2026919841","https://openalex.org/W2027558005","https://openalex.org/W2030371558","https://openalex.org/W2043793366","https://openalex.org/W2044712849","https://openalex.org/W2063461007","https://openalex.org/W2064876347","https://openalex.org/W2068193025","https://openalex.org/W2081420986","https://openalex.org/W2089230333","https://openalex.org/W2089574530","https://openalex.org/W2090530862","https://openalex.org/W2097821680","https://openalex.org/W2099585712","https://openalex.org/W2103265231","https://openalex.org/W2104014368","https://openalex.org/W2105697998","https://openalex.org/W2113206573","https://openalex.org/W2120539781","https://openalex.org/W2122341467","https://openalex.org/W2128537698","https://openalex.org/W2130682212","https://openalex.org/W2132780898","https://openalex.org/W2133465414","https://openalex.org/W2141218575","https://openalex.org/W2141730355","https://openalex.org/W2145675056","https://openalex.org/W2147263332","https://openalex.org/W2154663531","https://openalex.org/W2158217645","https://openalex.org/W2160985360","https://openalex.org/W2163375884"],"related_works":["https://openalex.org/W1975783419","https://openalex.org/W2246842710","https://openalex.org/W2163769396","https://openalex.org/W2937057550","https://openalex.org/W4205870405","https://openalex.org/W2020715887","https://openalex.org/W99864735","https://openalex.org/W2766221230","https://openalex.org/W4408063358","https://openalex.org/W15565145"],"abstract_inverted_index":{"The":[0,46,187],"activation":[1,191],"and":[2,15,26,34,44,56,61,69,78,127,144,237],"expansion":[3],"of":[4,48,104,141,184,189,197],"effector":[5,76,99,125,136,166,227],"CD8(+)":[6,114,167,228],"T":[7,22,49,75,97,115,168,229],"cells":[8,23,50,77,116,169,230],"are":[9,81],"essential":[10],"for":[11,53],"controlling":[12],"viral":[13,244],"infections":[14],"tumor":[16],"surveillance.":[17],"During":[18],"an":[19],"immune":[20],"response,":[21],"encounter":[24],"extrinsic":[25],"intrinsic":[27],"factors,":[28],"including":[29],"oxidative":[30],"stress,":[31],"nutrient":[32],"availability,":[33],"inflammation,":[35],"that":[36,71,164,175,202,211,226],"can":[37],"modulate":[38],"their":[39,79],"capacity":[40,120],"to":[41,95,110,121,130,153,233,242],"activate,":[42],"proliferate,":[43],"survive.":[45],"dependency":[47],"on":[51],"autophagy":[52,73,92,232],"in":[54,57,74,147,181,204,240],"vitro":[55],"vivo":[58],"activation,":[59],"expansion,":[60],"memory":[62,156],"remains":[63],"unclear.":[64],"Moreover,":[65],"the":[66,102,123,135,145,218],"specific":[67],"signals":[68],"mechanisms":[70],"activate":[72],"survival":[80,239],"not":[82],"known.":[83],"In":[84,108],"this":[85],"study,":[86],"we":[87],"generated":[88],"a":[89,105,118,139,155,159,172,209,243],"novel":[90],"inducible":[91],"knockout":[93],"mouse":[94],"study":[96],"cell":[98,132,149,207,235],"responses":[100],"during":[101,134],"course":[103],"virus":[106],"infection.":[107,245],"response":[109,126,157,241],"influenza":[111],"infection,":[112],"Atg5(-/-)":[113,165],"had":[117],"decreased":[119],"reach":[122],"peak":[124],"were":[128],"unable":[129],"maintain":[131,238],"viability":[133],"phase.":[137],"As":[138],"consequence":[140],"Atg5":[142],"deletion":[143],"impairment":[146],"effector-to-memory":[148],"survival,":[150],"mice":[151],"fail":[152],"mount":[154],"following":[158],"secondary":[160],"challenge.":[161],"We":[162],"found":[163],"upregulated":[170],"p53,":[171],"transcriptional":[173],"state":[174],"was":[176,192],"concomitant":[177],"with":[178,194,217],"widespread":[179],"hypoxia":[180],"lymphoid":[182],"tissues":[183],"infected":[185],"mice.":[186],"onset":[188],"p53":[190],"concurrent":[193],"higher":[195],"levels":[196],"reactive":[198],"oxygen":[199],"species":[200],"(ROS)":[201],"resulted":[203],"ROS-dependent":[205],"apoptotic":[206],"death,":[208],"fate":[210],"could":[212],"be":[213],"rescued":[214],"by":[215],"treating":[216],"ROS":[219],"scavenger":[220],"N-acetylcysteine.":[221],"Collectively,":[222],"these":[223],"results":[224],"demonstrate":[225],"require":[231],"suppress":[234],"death":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}