{"id":"https://openalex.org/W1501219953","doi":"https://doi.org/10.1002/ejhf.190","title":"Impact of Chronic Changes in Arterial Compliance and Resistance on Left Ventricular Ageing in Humans","display_name":"Impact of Chronic Changes in Arterial Compliance and Resistance on Left Ventricular Ageing in Humans","publication_year":2014,"publication_date":"2014-10-31","ids":{"openalex":"https://openalex.org/W1501219953","doi":"https://doi.org/10.1002/ejhf.190","mag":"1501219953","pmid":"https://pubmed.ncbi.nlm.nih.gov/25359272","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4906540"},"language":"en","primary_location":{"id":"doi:10.1002/ejhf.190","doi":"https://doi.org/10.1002/ejhf.190","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ejhf.190","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ejhf.190","source":{"id":"https://openalex.org/S87609158","display_name":"European Journal of Heart Failure","issn_l":"1388-9842","issn":["1388-9842","1879-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Heart Failure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ejhf.190","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011309968","display_name":"Peter Wohlfahrt","orcid":"https://orcid.org/0000-0003-2390-526X","observed_orcids":["https://orcid.org/0000-0003-2390-526X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210114565","display_name":"International Clinical Research Center, St. Anne's University Hospital Brno","ror":"https://ror.org/027v97282","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]},{"id":"https://openalex.org/I4210144209","display_name":"Thomayer University Hospital","ror":"https://ror.org/04hyq8434","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210144209"]}],"countries":["CZ","US"],"is_corresponding":false,"raw_author_name":"Peter Wohlfahrt","raw_affiliation_strings":["Center for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital , Prague ,","Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine- IKEM , Prague ,","Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","International Clinical Research Center, St. Anne\u2019s University Hospital , Brno ,","Center for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic","Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine- IKEM, Prague, Czech Republic","Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA","International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital , Prague ,","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210144209"]},{"raw_affiliation_string":"Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine- IKEM , Prague ,","institution_ids":["https://openalex.org/I4210127955"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"International Clinical Research Center, St. Anne\u2019s University Hospital , Brno ,","institution_ids":["https://openalex.org/I4210114565"]},{"raw_affiliation_string":"Center for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210144209"]},{"raw_affiliation_string":"Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine- IKEM, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210114565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028644714","display_name":"Margaret M. Redfield","orcid":"https://orcid.org/0000-0002-0946-7518","observed_orcids":["https://orcid.org/0000-0002-0946-7518"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret M. Redfield","raw_affiliation_strings":["Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069131955","display_name":"Vojt\u011bch Melenovsk\u00fd","orcid":"https://orcid.org/0000-0001-8921-7078","observed_orcids":["https://orcid.org/0000-0001-8921-7078"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ","US"],"is_corresponding":false,"raw_author_name":"Vojtech Melenovsky","raw_affiliation_strings":["Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM , Prague ,","Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic","Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM , Prague ,","institution_ids":["https://openalex.org/I4210127955"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Cardiology, Institute for Clinical and Experimental Medicine-IKEM, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001963115","display_name":"Francisco Alejandro L\u00f3pez-Jim\u00e9nez","orcid":"https://orcid.org/0000-0001-5788-9734","observed_orcids":["https://orcid.org/0000-0001-5788-9734"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco Lopez-Jimenez","raw_affiliation_strings":["Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049008362","display_name":"Richard J. Rodeheffer","orcid":"https://orcid.org/0000-0001-7305-805X","observed_orcids":["https://orcid.org/0000-0001-7305-805X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Rodeheffer","raw_affiliation_strings":["Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030461468","display_name":"Barry A. Borlaug","orcid":"https://orcid.org/0000-0001-9375-0596","observed_orcids":["https://orcid.org/0000-0001-9375-0596"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Barry A. Borlaug","raw_affiliation_strings":["Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester , MN ,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5030461468"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":null,"fwci":2.2844,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88649146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"27","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.1509000062942505,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arterial-compliance","display_name":"arterial compliance","score":0.9520000219345093},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/arterial-elastance","display_name":"arterial elastance","score":0.8769999742507935},{"id":"https://openalex.org/keywords/left-ventricular-diastolic-stiffness","display_name":"left ventricular diastolic stiffness","score":0.8889999985694885},{"id":"https://openalex.org/keywords/left-ventricular-end-diastolic-volume","display_name":"left ventricular end-diastolic volume","score":0.8949999809265137},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.6520000100135803},{"id":"https://openalex.org/keywords/aortic-compliance","display_name":"aortic compliance","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cardiac-aging","display_name":"cardiac aging","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8710705637931824},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7992208003997803},{"id":"https://openalex.org/C2781460075","wikidata":"https://www.wikidata.org/wiki/Q1399332","display_name":"Compliance (psychology)","level":2,"score":0.7874318361282349},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.7711738348007202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7043401002883911},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.7029060125350952},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.6181845664978027},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.5812917351722717},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4803939461708069},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.44984883069992065},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.39088335633277893},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.3011625111103058},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.1031067967414856},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003187","descriptor_name":"Compliance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059289","descriptor_name":"Vascular Stiffness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/ejhf.190","doi":"https://doi.org/10.1002/ejhf.190","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ejhf.190","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ejhf.190","source":{"id":"https://openalex.org/S87609158","display_name":"European Journal of Heart Failure","issn_l":"1388-9842","issn":["1388-9842","1879-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Heart Failure","raw_type":"journal-article"},{"id":"pmid:25359272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25359272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of heart failure","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3872283","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4906540","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4906540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4906540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Eur J Heart Fail","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/ejhf.190","doi":"https://doi.org/10.1002/ejhf.190","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ejhf.190","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ejhf.190","source":{"id":"https://openalex.org/S87609158","display_name":"European Journal of Heart Failure","issn_l":"1388-9842","issn":["1388-9842","1879-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Heart Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2076590604","display_name":null,"funder_award_id":"R01- 55502","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G3192554969","display_name":"Prevalence of Asymptomatic Ventricular Dysfunction","funder_award_id":"R01HL055502","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3906006332","display_name":null,"funder_award_id":"RO1- 55502","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G722131588","display_name":null,"funder_award_id":"Z.1.05/1.1.00/02.0123","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1501219953.pdf","grobid_xml":"https://content.openalex.org/works/W1501219953.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W34051893","https://openalex.org/W1578964091","https://openalex.org/W1604481401","https://openalex.org/W1792854258","https://openalex.org/W1949339388","https://openalex.org/W1983969449","https://openalex.org/W1999291203","https://openalex.org/W2015525046","https://openalex.org/W2026166943","https://openalex.org/W2042210603","https://openalex.org/W2055701973","https://openalex.org/W2060482892","https://openalex.org/W2073139861","https://openalex.org/W2074283369","https://openalex.org/W2074989777","https://openalex.org/W2076911162","https://openalex.org/W2082703095","https://openalex.org/W2085286166","https://openalex.org/W2106814693","https://openalex.org/W2111359734","https://openalex.org/W2136802272","https://openalex.org/W2141402104","https://openalex.org/W2145217500","https://openalex.org/W2153969492","https://openalex.org/W2162217713","https://openalex.org/W2166214037","https://openalex.org/W2167286125","https://openalex.org/W2268959684","https://openalex.org/W2884084009","https://openalex.org/W3192569039","https://openalex.org/W3196596234"],"related_works":["https://openalex.org/W2884084009","https://openalex.org/W2022466172","https://openalex.org/W7216835915","https://openalex.org/W2511037061","https://openalex.org/W2256593311","https://openalex.org/W1976977433","https://openalex.org/W7005440210","https://openalex.org/W2397362406","https://openalex.org/W2062522210","https://openalex.org/W2982137994"],"abstract_inverted_index":{"AIMS:":[0],"Left":[1],"ventricular":[2],"systolic":[3,209],"elastance":[4,8,13],"(Ees)":[5],"and":[6,25,45,49,58,96,104,115,150,181,214,222,226,235,250],"diastolic":[7,161,227],"(Eed)":[9],"correlate":[10,50],"with":[11,35,52,141,155,176,191,203,220],"arterial":[12,23,47,102,128,179,201,233],"(Ea),":[14],"but":[15,137],"it":[16],"is":[17],"unknown":[18],"how":[19],"chronic":[20,41],"changes":[21,42,54,112,134,142,217],"in":[22,43,55,60,72,76,113,124,127,135,143,159,171,187,194,199],"compliance":[24,129,152,180,240],"resistance,":[26],"which":[27],"determine":[28],"Ea,":[29,100,136],"might":[30],"differentially":[31],"affect":[32],"cardiac":[33,248],"properties":[34],"ageing.":[36],"We":[37],"sought":[38],"to":[39,122,207,231,237,244],"characterize":[40],"pulsatile":[44,200,213],"resistive":[46,215],"load":[48,202],"them":[51],"longitudinal":[53],"LV":[56,93,160,195,208],"structure":[57],"function":[59],"a":[61,77,169],"prospective,":[62],"community-based":[63,80],"study.":[64],"METHODS":[65],"AND":[66],"RESULTS:":[67],"Comprehensive":[68],"echocardiography":[69],"was":[70,153,166],"performed":[71],"722":[73],"subjects":[74,175],"participating":[75],"randomly":[78],"selected":[79],"study":[81],"at":[82,108],"two":[83],"examinations":[84],"separated":[85],"by":[86,168],"4":[87],"years,":[88],"allowing":[89],"for":[90],"assessment":[91],"of":[92,147],"Ees,":[94],"Eed,":[95],"end-diastolic":[97],"volume":[98],"(EDV),":[99],"total":[101],"compliance,":[103],"systemic":[105],"vascular":[106],"resistance":[107,114,149,183,234],"both":[109,177],"examinations.":[110],"Chronic":[111],"heart":[116],"rate":[117],"were":[118,138],"the":[119,156],"dominant":[120],"contributors":[121],"change":[123],"Ea.":[125],"Changes":[126],"had":[130],"little":[131],"impact":[132],"on":[133],"strongly":[139],"associated":[140,154,219],"Ees.":[144],"The":[145],"combination":[146],"increased":[148],"decreased":[151,182],"largest":[157],"increase":[158,186,193],"stiffness,":[162],"an":[163,185],"effect":[164],"that":[165],"mediated":[167],"decrease":[170],"LVEDV.":[172],"In":[173],"contrast,":[174],"improved":[178],"displayed":[184],"LVEDV":[188],"over":[189],"time,":[190],"no":[192],"Eed.":[196],"CONCLUSION:":[197],"Increases":[198],"ageing":[204,249],"contribute":[205],"more":[206],"stiffening,":[210],"while":[211],"combined":[212],"loading":[216],"are":[218],"positive":[221],"negative":[223],"chamber":[224],"remodelling":[225],"stiffness.":[228],"Therapies":[229],"designed":[230],"improve":[232],"particularly":[236],"enhance":[238],"aortic":[239],"may":[241],"hold":[242],"promise":[243],"prevent":[245],"or":[246],"reverse":[247],"its":[251],"sequelae.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}