{"id":"https://openalex.org/W1501035907","doi":"https://doi.org/10.1159/000320136","title":"APOE \u03b52 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes","display_name":"APOE \u03b52 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1501035907","doi":"https://doi.org/10.1159/000320136","mag":"1501035907","pmid":"https://pubmed.ncbi.nlm.nih.gov/20847553"},"language":"en","primary_location":{"id":"doi:10.1159/000320136","doi":"https://doi.org/10.1159/000320136","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000320136","pdf_url":null,"source":{"id":"https://openalex.org/S195598543","display_name":"Dementia and Geriatric Cognitive Disorders","issn_l":"1420-8008","issn":["1420-8008","1421-9824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and Geriatric Cognitive Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009884101","display_name":"Yawu Liu","orcid":"https://orcid.org/0000-0003-2386-3370","observed_orcids":["https://orcid.org/0000-0003-2386-3370","https://orcid.org/0000-0002-8463-2245"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]},{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Yawu Liu","raw_affiliation_strings":["Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland","Clinical Radiology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland","Departments of Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246","https://openalex.org/I4210092991"]},{"raw_affiliation_string":"Clinical Radiology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246","https://openalex.org/I4210092991"]},{"raw_affiliation_string":"Departments of Neurology and","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085125013","display_name":"Teemu I. Paajanen","orcid":"https://orcid.org/0000-0003-3499-4800","observed_orcids":["https://orcid.org/0000-0003-3499-4800"]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teemu Paajanen","raw_affiliation_strings":["Departments of Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081777822","display_name":"Eric Westman","orcid":"https://orcid.org/0000-0002-3115-2977","observed_orcids":["https://orcid.org/0000-0002-3115-2977"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eric Westman","raw_affiliation_strings":["Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035250882","display_name":"Lars\u2010Olof Wahlund","orcid":"https://orcid.org/0000-0002-9905-8426","observed_orcids":["https://orcid.org/0000-0002-9905-8426"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars-Olof Wahlund","raw_affiliation_strings":["Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067818010","display_name":"Andrew Simmons","orcid":"https://orcid.org/0000-0003-2306-5811","observed_orcids":["https://orcid.org/0000-0003-2306-5811","https://orcid.org/0000-0002-8855-3392"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Simmons","raw_affiliation_strings":["MRC Centre for Neurodegeneration Research, and","NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neurodegeneration Research, and","institution_ids":[]},{"raw_affiliation_string":"NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, London, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I200323923"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059800538","display_name":"Catherine Tunnard","orcid":"https://orcid.org/0000-0001-7059-2580","observed_orcids":["https://orcid.org/0000-0001-7059-2580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Tunnard","raw_affiliation_strings":["MRC Centre for Neurodegeneration Research, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neurodegeneration Research, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108079452","display_name":"Tomasz Sob\u00f3w","orcid":"https://orcid.org/0000-0001-8020-6612","observed_orcids":["https://orcid.org/0000-0001-8020-6612"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["GB","PL"],"is_corresponding":false,"raw_author_name":"Tomasz Sobow","raw_affiliation_strings":["Department of Neuroimaging, Institute of Psychiatry, King\u2019s College London, and","Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroimaging, Institute of Psychiatry, King\u2019s College London, and","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012553649","display_name":"Petroula Proitsi","orcid":"https://orcid.org/0000-0002-2553-6974","observed_orcids":["https://orcid.org/0000-0002-2553-6974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petroula Proitsi","raw_affiliation_strings":["MRC Centre for Neurodegeneration Research, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neurodegeneration Research, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011932191","display_name":"John F. Powell","orcid":"https://orcid.org/0000-0001-6124-439X","observed_orcids":["https://orcid.org/0000-0001-6124-439X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Powell","raw_affiliation_strings":["MRC Centre for Neurodegeneration Research, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neurodegeneration Research, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017384636","display_name":"Patrizia Mecocci","orcid":"https://orcid.org/0000-0003-0729-5246","observed_orcids":["https://orcid.org/0000-0003-0729-5246"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Patrizia Mecocci","raw_affiliation_strings":["Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062687221","display_name":"Magda Tsolaki","orcid":"https://orcid.org/0000-0002-2072-8010","observed_orcids":["https://orcid.org/0000-0002-2072-8010"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Magda Tsolaki","raw_affiliation_strings":["Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049484291","display_name":"Bruno J. Vellas","orcid":"https://orcid.org/0000-0002-7678-5065","observed_orcids":["https://orcid.org/0000-0002-7678-5065","https://orcid.org/0009-0004-5560-1898"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Vellas","raw_affiliation_strings":["Toulouse Gerontopole University Hospital, Universit\u00e9 Paul Sabatier, INSERM U 558, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toulouse Gerontopole University Hospital, Universit\u00e9 Paul Sabatier, INSERM U 558, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041997202","display_name":"Sebastian Muehlboeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sebastian Muehlboeck","raw_affiliation_strings":["McConnell Brain Imaging Center, McGill University, Montreal, Que., Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McConnell Brain Imaging Center, McGill University, Montreal, Que., Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011305571","display_name":"Alan Charles Evans","orcid":"https://orcid.org/0000-0003-3841-6098","observed_orcids":["https://orcid.org/0000-0003-3841-6098"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alan Evans","raw_affiliation_strings":["McConnell Brain Imaging Center, McGill University, Montreal, Que., Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McConnell Brain Imaging Center, McGill University, Montreal, Que., Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025678539","display_name":"Christian Spenger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christian Spenger","raw_affiliation_strings":["Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Care Sciences and Society, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002493210","display_name":"Simon Lovestone","orcid":"https://orcid.org/0000-0003-0473-4565","observed_orcids":["https://orcid.org/0000-0003-0473-4565"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Lovestone","raw_affiliation_strings":["MRC Centre for Neurodegeneration Research, and","NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neurodegeneration Research, and","institution_ids":[]},{"raw_affiliation_string":"NIHR Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King's College London, London, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I200323923"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079862221","display_name":"Hilkka S. Soininen","orcid":"https://orcid.org/0000-0002-2785-9937","observed_orcids":["https://orcid.org/0000-0002-2785-9937"]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hilkka Soininen","raw_affiliation_strings":["Departments of Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and","institution_ids":["https://openalex.org/I4210147155"]}]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2616,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.90859817,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"30","issue":"3","first_page":"229","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoe-epsilon2-allele","display_name":"APOE \u03b52 allele","score":0.968999981880188},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.972000002861023},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cortical-bone-volume","display_name":"cortical volume","score":0.7789999842643738},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.6980000138282776},{"id":"https://openalex.org/keywords/lateral-ventricle","display_name":"lateral ventricle","score":0.8629999756813049},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.9330000281333923},{"id":"https://openalex.org/keywords/parahippocampal-gyrus","display_name":"parahippocampal gyrus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.6693354845046997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6420904397964478},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5781944394111633},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.5084470510482788},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48482978343963623},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4750150144100189},{"id":"https://openalex.org/C2778048536","wikidata":"https://www.wikidata.org/wiki/Q1545429","display_name":"Parahippocampal gyrus","level":4,"score":0.4442678391933441},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4327648878097534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4143088459968567},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18313062191009521},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.16664427518844604},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06715130805969238},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053329","descriptor_name":"Apolipoprotein E2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1159/000320136","doi":"https://doi.org/10.1159/000320136","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000320136","pdf_url":null,"source":{"id":"https://openalex.org/S195598543","display_name":"Dementia and Geriatric Cognitive Disorders","issn_l":"1420-8008","issn":["1420-8008","1421-9824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and Geriatric Cognitive Disorders","raw_type":"journal-article"},{"id":"pmid:20847553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20847553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and geriatric cognitive disorders","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/2cbe2a39-b0c8-40f6-b194-52270a0b66ae","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/2cbe2a39-b0c8-40f6-b194-52270a0b66ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Liu, Y, Paajanen, T, Westman, E, Zhang, Y, Wahlund, L-O, Simmons, A, Tunnard, C, Sobow, T, Proitsi, P, Powell, J, Mecocci, P, Tsolaki, M, Vellas, B, Muehlboeck, S, Evans, A, Spenger, C, Lovestone, S & Soininen, H 2010, 'APOE epsilon 2 Allele Is Associated with Larger Regional Cortical Thicknesses and Volumes', Dementia and Geriatric Cognitive Disorders, vol. 30, no. 3, pp. 229 - 237. https://doi.org/10.1159/000320136","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1526540789","https://openalex.org/W1847168837","https://openalex.org/W1953027527","https://openalex.org/W1965780119","https://openalex.org/W1968577432","https://openalex.org/W1985137206","https://openalex.org/W1994554610","https://openalex.org/W1999670317","https://openalex.org/W2001791518","https://openalex.org/W2004293194","https://openalex.org/W2004582236","https://openalex.org/W2018763082","https://openalex.org/W2048363354","https://openalex.org/W2048994130","https://openalex.org/W2061639197","https://openalex.org/W2062073930","https://openalex.org/W2064316695","https://openalex.org/W2078524519","https://openalex.org/W2092189536","https://openalex.org/W2097583483","https://openalex.org/W2102782858","https://openalex.org/W2105762907","https://openalex.org/W2110208125","https://openalex.org/W2111774300","https://openalex.org/W2113708991","https://openalex.org/W2117156629","https://openalex.org/W2120534045","https://openalex.org/W2121369614","https://openalex.org/W2122058578","https://openalex.org/W2131792847","https://openalex.org/W2136250824","https://openalex.org/W2140880195","https://openalex.org/W2152681705","https://openalex.org/W2156220037","https://openalex.org/W2159011576","https://openalex.org/W2159122349","https://openalex.org/W2410768732","https://openalex.org/W4210821588"],"related_works":["https://openalex.org/W2122058578","https://openalex.org/W2163962821","https://openalex.org/W2140218187","https://openalex.org/W4367297031","https://openalex.org/W4200384071","https://openalex.org/W4312038500","https://openalex.org/W2035888786","https://openalex.org/W2980421389","https://openalex.org/W2765929088","https://openalex.org/W2146839662"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,159],"protective":[2],"effect":[3,151],"of":[4],"the":[5,24,62,67,75,83,98,104,107,129,132,155],"apolipoprotein":[6],"E":[7],"(APOE)":[8],"\u03b52":[9,25,68,108,161],"allele":[10,26,162],"against":[11],"Alzheimer's":[12],"disease":[13],"(AD)":[14],"is":[15,163],"controversial.":[16],"OBJECTIVE:":[17],"Our":[18],"purpose":[19],"was":[20,152],"to":[21],"clarify":[22],"if":[23],"affects":[27],"regional":[28,72,167],"cortical":[29,35,168],"thicknesses":[30,36,169],"and":[31,37,55,79,87,93,100,114,124,135,141,170,176],"volumes.":[32],"METHODS:":[33],"Regional":[34],"volumes":[38,171],"were":[39],"measured":[40],"with":[41,48,85,131,165],"an":[42],"automated":[43],"pipeline":[44],"in":[45,154,172],"109":[46],"subjects":[47,84,130],"mild":[49,63,173],"cognitive":[50,64,174],"impairment,":[51],"114":[52],"AD":[53,105],"patients":[54],"105":[56],"age-matched":[57],"healthy":[58],"controls.":[59],"RESULTS:":[60],"In":[61,103],"impairment":[65,175],"group,":[66,106],"carriers":[69,109],"had":[70,110],"thicker":[71,112,138],"cortices":[73],"at":[74],"transverse":[76,115],"temporal":[77,116],"cortex":[78,140],"parahippocampal":[80],"gyrus":[81],"than":[82,97,128,146],"\u03b53/\u03b53,":[86],"a":[88,118,136],"larger":[89,119,142,166],"cerebral":[90,121,143],"gray":[91,122,144],"matter":[92,145],"smaller":[94,125],"lateral":[95,126],"ventricles":[96,127],"\u03b53/\u03b53":[99,133],"\u03b54":[101,147],"carriers.":[102,148],"significantly":[111,137],"entorhinal":[113,139],"cortices,":[117],"whole":[120],"matter,":[123],"genotype,":[134],"No":[149],"APOE2":[150],"found":[153],"control":[156],"group.":[157],"CONCLUSION:":[158],"APOE":[160],"associated":[164],"AD.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}