{"id":"https://openalex.org/W1500943192","doi":null,"title":"Regulation of cellular function by connexin hemichannels.","display_name":"Regulation of cellular function by connexin hemichannels.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1500943192","mag":"1500943192","pmid":"https://pubmed.ncbi.nlm.nih.gov/21968837","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3180094"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2190482","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3180094","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3180094","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112276693","display_name":"Sirisha Burra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sirisha Burra","raw_affiliation_strings":["Department of Biochemistry, University of Texas Health Science Center San Antonio, TX 78229 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Health Science Center San Antonio, TX 78229 USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050766937","display_name":"Jean Xin Jiang","orcid":"https://orcid.org/0000-0002-2185-5716","observed_orcids":["https://orcid.org/0000-0002-2185-5716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean X Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4979,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.8048555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"2","issue":"2","first_page":"119","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connexin-hemichannels","display_name":"connexin hemichannels","score":0.9819999933242798},{"id":"https://openalex.org/keywords/connexins","display_name":"connexins","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gap-junctions","display_name":"gap junctions","score":0.9959999918937683},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7080000042915344},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8730000257492065},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.7250000238418579},{"id":"https://openalex.org/keywords/tissue-homeostasis","display_name":"tissue homeostasis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.93919837474823},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.8173660039901733},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7496532201766968},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.6700788736343384},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.6075610518455505},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5119341611862183},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4726742208003998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4641353487968445},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.4566795229911804},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3644503653049469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3240312933921814},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15489423274993896},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.14665880799293518},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11023157835006714}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2190482","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3180094","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3180094","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3180094","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Biochem Mol Biol","raw_type":"Text"},{"id":"pmid:21968837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21968837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biochemistry and molecular biology","raw_type":"Journal Article"},{"id":"mag:1500943192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21968837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2739351207","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Jean_Jiang/publication/51690508_Regulation_of_cellular_function_by_connexin_hemichannels/links/02e7e5241e433151d1000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2190482","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3180094","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6747762219","display_name":"Osteocyte Function and Effects of Mechanical Strain","funder_award_id":"P01AR046798","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W1486819284","https://openalex.org/W1899391511","https://openalex.org/W1963881210","https://openalex.org/W1971070905","https://openalex.org/W1975173830","https://openalex.org/W1976759540","https://openalex.org/W1977494277","https://openalex.org/W1981919734","https://openalex.org/W1987594610","https://openalex.org/W1989813676","https://openalex.org/W1989832881","https://openalex.org/W1991158727","https://openalex.org/W1992170663","https://openalex.org/W1992576846","https://openalex.org/W1995041648","https://openalex.org/W1995256270","https://openalex.org/W1997215245","https://openalex.org/W2002791970","https://openalex.org/W2005494591","https://openalex.org/W2006653167","https://openalex.org/W2007854449","https://openalex.org/W2009257155","https://openalex.org/W2015820951","https://openalex.org/W2019717438","https://openalex.org/W2020025443","https://openalex.org/W2024955205","https://openalex.org/W2025174728","https://openalex.org/W2026615083","https://openalex.org/W2033341081","https://openalex.org/W2033803440","https://openalex.org/W2035491839","https://openalex.org/W2036120792","https://openalex.org/W2038281275","https://openalex.org/W2039836112","https://openalex.org/W2040646847","https://openalex.org/W2043291090","https://openalex.org/W2044581359","https://openalex.org/W2045092834","https://openalex.org/W2046400378","https://openalex.org/W2049572499","https://openalex.org/W2050159014","https://openalex.org/W2052260767","https://openalex.org/W2053682958","https://openalex.org/W2058675712","https://openalex.org/W2060466803","https://openalex.org/W2062125301","https://openalex.org/W2064382301","https://openalex.org/W2065738044","https://openalex.org/W2068007378","https://openalex.org/W2069072273","https://openalex.org/W2070689340","https://openalex.org/W2076449317","https://openalex.org/W2081367763","https://openalex.org/W2083346530","https://openalex.org/W2083920483","https://openalex.org/W2085123274","https://openalex.org/W2087917186","https://openalex.org/W2089599089","https://openalex.org/W2093488642","https://openalex.org/W2093709717","https://openalex.org/W2093826483","https://openalex.org/W2095803953","https://openalex.org/W2098872610","https://openalex.org/W2100099676","https://openalex.org/W2101299206","https://openalex.org/W2102922226","https://openalex.org/W2103746819","https://openalex.org/W2104357869","https://openalex.org/W2104573014","https://openalex.org/W2104988801","https://openalex.org/W2105432265","https://openalex.org/W2106841325","https://openalex.org/W2109229819","https://openalex.org/W2113984277","https://openalex.org/W2118055942","https://openalex.org/W2118549246","https://openalex.org/W2120796647","https://openalex.org/W2124017577","https://openalex.org/W2127130496","https://openalex.org/W2131306660","https://openalex.org/W2134046709","https://openalex.org/W2144088780","https://openalex.org/W2145356867","https://openalex.org/W2146217294","https://openalex.org/W2151377064","https://openalex.org/W2152022639","https://openalex.org/W2156116480","https://openalex.org/W2158127821","https://openalex.org/W2161930006","https://openalex.org/W2162811587","https://openalex.org/W2166809896","https://openalex.org/W2170547622","https://openalex.org/W2171863507","https://openalex.org/W2184443027","https://openalex.org/W2238683554","https://openalex.org/W2323243689","https://openalex.org/W2617595209"],"related_works":["https://openalex.org/W2739351207","https://openalex.org/W2162569984","https://openalex.org/W2074589379","https://openalex.org/W2397975465","https://openalex.org/W2135566053","https://openalex.org/W4416119589","https://openalex.org/W1987710661","https://openalex.org/W2068023769","https://openalex.org/W2105703558","https://openalex.org/W1834171181"],"abstract_inverted_index":{"Gap":[0,33],"junctions":[1,34],"and":[2,24,35,65,101,115,143,160],"hemichannels":[3,36,94,108,156],"are":[4,37,71],"formed":[5],"by":[6],"a":[7,42,110,145],"family":[8],"of":[9,41,44,63,78,92,112,131],"proteins":[10,70],"called":[11],"connexins.":[12],"Till":[13],"date":[14],"up":[15],"to":[16,29,73,136],"twenty":[17],"one":[18],"different":[19],"connexins":[20,64],"have":[21],"been":[22],"characterized":[23],"their":[25,66],"expression":[26],"was":[27],"observed":[28],"be":[30,74],"spatio-temporally":[31],"regulated.":[32],"involved":[38],"in":[39,148],"transfer":[40,154],"variety":[43,111],"less":[45],"than":[46],"1":[47],"kDa":[48],"small":[49,54],"molecules":[50],"such":[51,119],"as,":[52,120],"ions,":[53],"metabolites,":[55],"cAMP,":[56],"ATP,":[57],"IP3,":[58],"prostaglandins,":[59],"etc.":[60],"Post-translational":[61],"modifications":[62],"interaction":[67],"with":[68],"other":[69],"reported":[72,139],"the":[75,83,89,96,99,107,132,138,152],"key":[76],"regulators":[77],"channel":[79],"functions.":[80,161],"Studies":[81],"during":[82],"past":[84],"decade":[85],"or":[86],"so,":[87],"suggest":[88],"physiological":[90],"important":[91],"connexin":[93],"mediating":[95],"communication":[97],"between":[98],"cell":[100,121],"its":[102],"environment.":[103],"Molecules":[104],"conveyed":[105],"through":[106,155],"elicit":[109],"signaling":[113,159],"pathways":[114],"influence":[116],"cellular":[117,158],"functions":[118],"cycle,":[122],"tissue":[123],"homeostasis,":[124],"migration,":[125],"mechanotransduction,":[126],"oxidative":[127],"stress.":[128],"The":[129],"purpose":[130],"current":[133],"review":[134],"is":[135],"compile":[137],"studies":[140],"so":[141],"far":[142],"provide":[144],"general":[146],"overview":[147],"our":[149],"understanding":[150],"how":[151],"molecular":[153],"regulates":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}