{"id":"https://openalex.org/W1500900205","doi":"https://doi.org/10.3390/molecules200610415","title":"Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus","display_name":"Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus","publication_year":2015,"publication_date":"2015-06-05","ids":{"openalex":"https://openalex.org/W1500900205","doi":"https://doi.org/10.3390/molecules200610415","mag":"1500900205","pmid":"https://pubmed.ncbi.nlm.nih.gov/26056814","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6272818"},"language":"en","primary_location":{"id":"doi:10.3390/molecules200610415","doi":"https://doi.org/10.3390/molecules200610415","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules200610415","pdf_url":"https://www.mdpi.com/1420-3049/20/6/10415/pdf?version=1433491697","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/20/6/10415/pdf?version=1433491697","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027851081","display_name":"Vincenzo Carbone","orcid":"https://orcid.org/0000-0003-4231-2785","observed_orcids":["https://orcid.org/0000-0003-4231-2785"]},"institutions":[{"id":"https://openalex.org/I41125697","display_name":"AgResearch","ror":"https://ror.org/0124gwh94","country_code":"NZ","type":"government","lineage":["https://openalex.org/I41125697","https://openalex.org/I4405260297"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Vincenzo Carbone","raw_affiliation_strings":["AgResearch Limited, Grasslands Research Centre, Tennent Drive, Private Bag 11008,  Palmerston North 4442, New Zealand","AgResearch Limited, Grasslands Research Centre, Tennent Drive, Private Bag 11008, Palmerston North 4442, New Zealand. Vince.Carbone@agresearch.co.nz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AgResearch Limited, Grasslands Research Centre, Tennent Drive, Private Bag 11008,  Palmerston North 4442, New Zealand","institution_ids":["https://openalex.org/I41125697"]},{"raw_affiliation_string":"AgResearch Limited, Grasslands Research Centre, Tennent Drive, Private Bag 11008, Palmerston North 4442, New Zealand. Vince.Carbone@agresearch.co.nz","institution_ids":["https://openalex.org/I41125697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028105305","display_name":"Elena K. Schneider\u2010Futschik","orcid":"https://orcid.org/0000-0001-6044-4824","observed_orcids":["https://orcid.org/0000-0001-6044-4824"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Elena Schneider","raw_affiliation_strings":["Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade,  Parkville 3052, Victoria, Australia","Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia. elena.schneider@monash.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade,  Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia. elena.schneider@monash.edu","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061693918","display_name":"Steve Rockman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153402","display_name":"CSL (Australia)","ror":"https://ror.org/044tc0x05","country_code":"AU","type":"company","lineage":["https://openalex.org/I4210153402"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Steve Rockman","raw_affiliation_strings":["CSL Limited Poplar Road, Parkville 3052, Victoria, Australia","CSL Limited Poplar Road, Parkville 3052, Victoria, Australia. Steve.Rockman@biocsl.com.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSL Limited Poplar Road, Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I4210153402"]},{"raw_affiliation_string":"CSL Limited Poplar Road, Parkville 3052, Victoria, Australia. Steve.Rockman@biocsl.com.au","institution_ids":["https://openalex.org/I4210153402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067380502","display_name":"Mark A. Baker","orcid":"https://orcid.org/0000-0003-3933-9784","observed_orcids":["https://orcid.org/0000-0003-3933-9784"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark Baker","raw_affiliation_strings":["Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia","Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia. Mark.Baker@newcastle.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia","institution_ids":["https://openalex.org/I78757542"]},{"raw_affiliation_string":"Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia. Mark.Baker@newcastle.edu.au","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030799138","display_name":"Johnny X. Huang","orcid":"https://orcid.org/0000-0003-3595-208X","observed_orcids":["https://orcid.org/0000-0003-3595-208X"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Johnny Huang","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road St Lucia,  QLD 4072, Brisbane, Australia","Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road St Lucia, QLD 4072, Brisbane, Australia. xiao.huang@imb.uq.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road St Lucia,  QLD 4072, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road St Lucia, QLD 4072, Brisbane, Australia. xiao.huang@imb.uq.edu.au","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chi Ong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153402","display_name":"CSL (Australia)","ror":"https://ror.org/044tc0x05","country_code":"AU","type":"company","lineage":["https://openalex.org/I4210153402"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chi Ong","raw_affiliation_strings":["CSL Limited Poplar Road, Parkville 3052, Victoria, Australia","CSL Limited Poplar Road, Parkville 3052, Victoria, Australia. Chi.Ong@biocsl.com.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSL Limited Poplar Road, Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I4210153402"]},{"raw_affiliation_string":"CSL Limited Poplar Road, Parkville 3052, Victoria, Australia. Chi.Ong@biocsl.com.au","institution_ids":["https://openalex.org/I4210153402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074910442","display_name":"Matthew A. Cooper","orcid":"https://orcid.org/0000-0003-3147-3460","observed_orcids":["https://orcid.org/0000-0003-3147-3460","https://orcid.org/0000-0002-1659-6860"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew Cooper","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road St Lucia,  QLD 4072, Brisbane, Australia","Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road St Lucia, QLD 4072, Brisbane, Australia. m.cooper@imb.uq.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road St Lucia,  QLD 4072, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]},{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road St Lucia, QLD 4072, Brisbane, Australia. m.cooper@imb.uq.edu.au","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085784277","display_name":"Elizabeth Yuriev","orcid":"https://orcid.org/0000-0002-3909-0379","observed_orcids":["https://orcid.org/0000-0002-3909-0379"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Elizabeth Yuriev","raw_affiliation_strings":["Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade,  Parkville 3052, Victoria, Australia","Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia. elizabeth.yuriev@monash.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade,  Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia. elizabeth.yuriev@monash.edu","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402427","display_name":"Jian Li","orcid":"https://orcid.org/0000-0001-7953-8230","observed_orcids":["https://orcid.org/0000-0001-7953-8230"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jian Li","raw_affiliation_strings":["Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade,  Parkville 3052, Victoria, Australia","Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia. jian.li@monash.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade,  Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia. jian.li@monash.edu","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020748618","display_name":"Tony Velkov","orcid":"https://orcid.org/0000-0002-0017-7952","observed_orcids":["https://orcid.org/0000-0002-0017-7952"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Tony Velkov","raw_affiliation_strings":["Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade,  Parkville 3052, Victoria, Australia","Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia. Tony.Velkov@monash.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade,  Parkville 3052, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia. Tony.Velkov@monash.edu","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5020748618"],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.7854,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73574932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"6","first_page":"10415","last_page":"10434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/swine-influenza","display_name":"swine influenza","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"hemagglutinin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glycan-binding-specificity","display_name":"glycan binding specificity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sialic-acid-receptor-binding","display_name":"sialic acid receptor binding","score":0.593999981880188},{"id":"https://openalex.org/keywords/vaccine-strain","display_name":"vaccine strain","score":0.8149999976158142},{"id":"https://openalex.org/keywords/host-range","display_name":"host range","score":0.5920000076293945},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.656000018119812},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.8944991827011108},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.6645923852920532},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.661336362361908},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5441913604736328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5304469466209412},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5303801894187927},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5212891101837158},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.4746849238872528},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4334619641304016},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4217669665813446},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35452449321746826},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.3241526484489441},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2501569390296936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22944092750549316}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053118","descriptor_name":"Influenza A Virus, H1N1 Subtype","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.3390/molecules200610415","doi":"https://doi.org/10.3390/molecules200610415","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules200610415","pdf_url":"https://www.mdpi.com/1420-3049/20/6/10415/pdf?version=1433491697","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5286628","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6272818","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6272818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6272818","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:26056814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26056814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:monash.edu:openaire/264b05e8-dad8-42b3-87bb-a901b699bf4f","doi":null,"is_oa":true,"landing_page_url":"https://research.monash.edu/en/publications/264b05e8-dad8-42b3-87bb-a901b699bf4f","pdf_url":"https://researchmgt.monash.edu/ws/files/235418988/3564053_oa.pdf","source":{"id":"https://openalex.org/S4306402625","display_name":"Monash University Research Portal (Monash University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I56590836","host_organization_name":"Monash University","host_organization_lineage":["https://openalex.org/I56590836"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Carbone, V, Schneider, E K, Rockman, S, Baker, M, Huang, J X, Ong, C, Cooper, M A, Yuriev, E, Li, J & Velkov, T 2015, 'Molecular characterisation of the haemagglutinin glycan-binding specificity of egg-adapted vaccine strains of the pandemic 2009 H1N1 swine influenza A virus', Molecules, vol. 20, no. 6, pp. 10415-10434. https://doi.org/10.3390/molecules200610415","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/233525","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/233525","pdf_url":"http://hdl.handle.net/11343/233525","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3e6334692d7c4d038a0454eefd7ed403","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3e6334692d7c4d038a0454eefd7ed403","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 20, Iss 6, Pp 10415-10434 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/28985405","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Molecular_characterisation_of_the_haemagglutinin_glycan-binding_specificity_of_egg-adapted_vaccine_strains_of_the_pandemic_2009_H1N1_swine_influenza_A_virus/28985405","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:uon:26485","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1959.13/1330830","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3390/molecules200610415","doi":"https://doi.org/10.3390/molecules200610415","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules200610415","pdf_url":"https://www.mdpi.com/1420-3049/20/6/10415/pdf?version=1433491697","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8143751777","display_name":"H1N1 The structure and receptor binding properties of the 2009 swine influenza pandemic Hemagglutinin","funder_award_id":"594875","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1500900205.pdf","grobid_xml":"https://content.openalex.org/works/W1500900205.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W122449497","https://openalex.org/W1481841324","https://openalex.org/W1784069946","https://openalex.org/W1827177868","https://openalex.org/W1964168452","https://openalex.org/W1967608615","https://openalex.org/W1970601906","https://openalex.org/W1972835033","https://openalex.org/W1976653222","https://openalex.org/W1976680858","https://openalex.org/W1993610826","https://openalex.org/W1998561673","https://openalex.org/W2009614075","https://openalex.org/W2010186519","https://openalex.org/W2010811699","https://openalex.org/W2018347072","https://openalex.org/W2026083934","https://openalex.org/W2026391844","https://openalex.org/W2026739436","https://openalex.org/W2029667189","https://openalex.org/W2029834927","https://openalex.org/W2038717515","https://openalex.org/W2041753380","https://openalex.org/W2042318331","https://openalex.org/W2042839347","https://openalex.org/W2046056601","https://openalex.org/W2048555622","https://openalex.org/W2052030759","https://openalex.org/W2053448121","https://openalex.org/W2057314966","https://openalex.org/W2059782458","https://openalex.org/W2066218699","https://openalex.org/W2069322612","https://openalex.org/W2069831575","https://openalex.org/W2072237100","https://openalex.org/W2077095962","https://openalex.org/W2077836700","https://openalex.org/W2079151025","https://openalex.org/W2089157068","https://openalex.org/W2091649526","https://openalex.org/W2092052588","https://openalex.org/W2093897949","https://openalex.org/W2098349861","https://openalex.org/W2101165138","https://openalex.org/W2102335249","https://openalex.org/W2108573701","https://openalex.org/W2109403777","https://openalex.org/W2114289644","https://openalex.org/W2118794822","https://openalex.org/W2120039241","https://openalex.org/W2120113718","https://openalex.org/W2120294060","https://openalex.org/W2123392605","https://openalex.org/W2124026197","https://openalex.org/W2132527856","https://openalex.org/W2152803091","https://openalex.org/W2156202151","https://openalex.org/W2171092736","https://openalex.org/W2171369029","https://openalex.org/W2303451292","https://openalex.org/W4293003482","https://openalex.org/W4302615831"],"related_works":["https://openalex.org/W7097350220","https://openalex.org/W46939618","https://openalex.org/W7221576807","https://openalex.org/W306142781","https://openalex.org/W2794360367","https://openalex.org/W2101165138","https://openalex.org/W1532701839","https://openalex.org/W2109680867","https://openalex.org/W2105794163","https://openalex.org/W2026391844"],"abstract_inverted_index":{"The":[0,63,138,185],"haemagglutinin":[1],"(HA)":[2],"glycan":[3,29,204,211,240,245],"binding":[4,30,127,146,197,212,241,246],"selectivity":[5,65],"of":[6,18,39,51,54,66,124,182,214],"H1N1":[7,58,264],"influenza":[8,60],"viruses":[9],"is":[10],"an":[11,144],"important":[12],"determinant":[13],"for":[14,99,135,148,237],"the":[15,19,37,40,49,55,100,104,108,116,155,173,183,195,202,209,215,238,244,255],"host":[16],"range":[17],"virus":[20,110],"and":[21,43,72,112,151,226],"egg-adaption":[22,181],"during":[23,180],"vaccine":[24,52,69,109,250],"production.":[25],"This":[26],"study":[27],"integrates":[28],"data":[31,247],"with":[32,96,131,221],"structure-recognition":[33,235],"models":[34,225],"to":[35,93,128,165,194,232,253],"examine":[36],"impact":[38,201],"K123N,":[41],"D225G":[42,139,256],"Q226R":[44,117,258],"mutations":[45,79],"(as":[46],"seen":[47],"in":[48,103,154],"HA":[50,90,114,118,142],"strains":[53,111],"pandemic":[56],"2009":[57],"swine":[59],"A":[61],"virus).":[62],"glycan-binding":[64],"three":[67],"A/California/07/09":[68,75,88,140],"production":[70],"strains,":[71],"purified":[73],"recombinant":[74,89,113,141,263],"HAs":[76],"harboring":[77,115],"these":[78],"was":[80,161,176],"examined":[81],"via":[82],"a":[83,121,132,190,234],"solid-phase":[84],"ELISA":[85],"assay.":[86],"Wild-type":[87],"bound":[91],"specifically":[92],"\u03b12,6-linked":[94,136],"sialyl-glycans,":[95,130],"no":[97],"affinity":[98,134,147,160,213],"\u03b12,3-linked":[101,129,152],"sialyl-glycans":[102,153],"array.":[105,156],"In":[106],"contrast,":[107],"mutation":[119,187],"displayed":[120,143],"comparable":[122],"pattern":[123],"highly":[125],"specific":[126],"negligible":[133],"sialyl-glycans.":[137],"enhanced":[145],"both":[149],"\u03b12,6-":[150],"Notably":[157],"its":[158,166],"\u03b12,6-glycan":[159],"generally":[162],"higher":[163],"compared":[164],"\u03b12,3-glycan":[167],"affinity,":[168],"which":[169,188],"may":[170,219],"explain":[171],"why":[172],"double":[174],"mutant":[175],"not":[177,200],"naturally":[178],"selected":[179],"virus.":[184],"K123N":[186],"introduces":[189],"glycosylation":[191,218],"site":[192],"proximal":[193],"receptor":[196,222],"site,":[198],"did":[199],"\u03b12,3/\u03b12,6":[203],"selectivity,":[205],"however,":[206],"it":[207],"lowered":[208],"overall":[210],"HA;":[216],"suggesting":[217],"interfere":[220],"binding.":[223],"Docking":[224],"'per":[227],"residues'":[228],"scoring":[229],"were":[230],"employed":[231],"provide":[233],"rational":[236],"experimental":[239],"data.":[242],"Collectively,":[243],"inform":[248],"future":[249],"design":[251],"strategies":[252],"introduce":[254],"or":[257],"amino":[259],"acid":[260],"substitutions":[261],"into":[262],"viruses.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}