{"id":"https://openalex.org/W1500720540","doi":null,"title":"NMR in drug discovery. From screening to structure-based design of antitumoral agents","display_name":"NMR in drug discovery. From screening to structure-based design of antitumoral agents","publication_year":2006,"publication_date":"2006-10-05","ids":{"openalex":"https://openalex.org/W1500720540","mag":"1500720540"},"language":"en","primary_location":{"id":"pmh:oai:diposit.ub.edu:2445/42922","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2445/42922","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tesis Doctorals - Departament - Qu\u00edmica Org\u00e0nica","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.tdx.cat/TDX-0315107-093107","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059011831","display_name":"Rodr\u00edguez M\u00edas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodr\u00edguez M\u00edas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045021711","display_name":"Ricard Aleix","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ricard Aleix","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.7839999794960022},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8790000081062317},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.777999997138977},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9959999918937683},{"id":"https://openalex.org/keywords/protein-ligand-binding","display_name":"protein-ligand binding","score":0.7390000224113464},{"id":"https://openalex.org/keywords/fragment-based-drug-discovery","display_name":"fragment-based drug discovery","score":0.7739999890327454},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.6539999842643738},{"id":"https://openalex.org/keywords/protein-protein-interaction-inhibitors","display_name":"protein-protein interaction inhibitors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8920000195503235},{"id":"https://openalex.org/keywords/kahalalide-f","display_name":"kahalalide F","score":0.9300000071525574},{"id":"https://openalex.org/keywords/depsipeptides","display_name":"depsipeptides","score":0.8209999799728394},{"id":"https://openalex.org/keywords/membrane-mimics","display_name":"membrane mimetics","score":0.7120000123977661},{"id":"https://openalex.org/keywords/sodium-dodecyl-sulfate-micelles","display_name":"sodium dodecyl sulfate micelles","score":0.871999979019165},{"id":"https://openalex.org/keywords/peptide-conformational-flexibility","display_name":"peptide conformational flexibility","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.7459524869918823},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7081701755523682},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6120877861976624},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5714064836502075},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5421872735023499},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4870739281177521},{"id":"https://openalex.org/C2780430158","wikidata":"https://www.wikidata.org/wiki/Q7685902","display_name":"Target protein","level":3,"score":0.41189542412757874},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3247188925743103},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2998616695404053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28611528873443604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21031597256660461},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17534863948822021},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.15732857584953308},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.11940288543701172},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08416366577148438},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:diposit.ub.edu:2445/42922","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2445/42922","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tesis Doctorals - Departament - Qu\u00edmica Org\u00e0nica","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:dnet:tdr_________::965c03bc2d74d83a6763b2a91062109f","doi":null,"is_oa":false,"landing_page_url":"http://www.tdx.cat/TDX-0315107-093107","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/2804","doi":null,"is_oa":true,"landing_page_url":"http://www.tdx.cat/TDX-0315107-093107","pdf_url":"http://www.tdx.cat/TDX-0315107-093107","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1500720540","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/42922/1/01.RARM_Introduction_objectives.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.tdx.cat:10803/2804","doi":null,"is_oa":true,"landing_page_url":"http://www.tdx.cat/TDX-0315107-093107","pdf_url":"http://www.tdx.cat/TDX-0315107-093107","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1500720540.pdf","grobid_xml":"https://content.openalex.org/works/W1500720540.grobid-xml"},"referenced_works_count":215,"referenced_works":["https://openalex.org/W2497645","https://openalex.org/W2846204","https://openalex.org/W60468736","https://openalex.org/W72561416","https://openalex.org/W115748941","https://openalex.org/W154686786","https://openalex.org/W384364580","https://openalex.org/W424670343","https://openalex.org/W1500228509","https://openalex.org/W1518078436","https://openalex.org/W1520252425","https://openalex.org/W1531494225","https://openalex.org/W1532861168","https://openalex.org/W1539571840","https://openalex.org/W1552774315","https://openalex.org/W1557686543","https://openalex.org/W1601592303","https://openalex.org/W1607777232","https://openalex.org/W1775942876","https://openalex.org/W1872921923","https://openalex.org/W1900730650","https://openalex.org/W1964311344","https://openalex.org/W1965217295","https://openalex.org/W1967651152","https://openalex.org/W1967968677","https://openalex.org/W1968619018","https://openalex.org/W1969061926","https://openalex.org/W1969156185","https://openalex.org/W1969262500","https://openalex.org/W1971914602","https://openalex.org/W1972091733","https://openalex.org/W1972171404","https://openalex.org/W1972237128","https://openalex.org/W1973621188","https://openalex.org/W1975071709","https://openalex.org/W1976230851","https://openalex.org/W1976935037","https://openalex.org/W1977179663","https://openalex.org/W1979598348","https://openalex.org/W1980102481","https://openalex.org/W1983041459","https://openalex.org/W1984689230","https://openalex.org/W1985913381","https://openalex.org/W1986765845","https://openalex.org/W1986962635","https://openalex.org/W1988326008","https://openalex.org/W1988620274","https://openalex.org/W1993257312","https://openalex.org/W1995601809","https://openalex.org/W1996211903","https://openalex.org/W1996913951","https://openalex.org/W1997282155","https://openalex.org/W1998274788","https://openalex.org/W1999187807","https://openalex.org/W1999350919","https://openalex.org/W1999474252","https://openalex.org/W2000292756","https://openalex.org/W2000624254","https://openalex.org/W2000880755","https://openalex.org/W2001648837","https://openalex.org/W2002586148","https://openalex.org/W2004967944","https://openalex.org/W2005476159","https://openalex.org/W2005923596","https://openalex.org/W2006842696","https://openalex.org/W2007042842","https://openalex.org/W2009488215","https://openalex.org/W2011395093","https://openalex.org/W2012815507","https://openalex.org/W2013600324","https://openalex.org/W2014196693","https://openalex.org/W2014860988","https://openalex.org/W2015879631","https://openalex.org/W2017312554","https://openalex.org/W2018221677","https://openalex.org/W2019074781","https://openalex.org/W2024105848","https://openalex.org/W2025297513","https://openalex.org/W2027318109","https://openalex.org/W2028212425","https://openalex.org/W2029031988","https://openalex.org/W2029412165","https://openalex.org/W2029651134","https://openalex.org/W2030608812","https://openalex.org/W2030829227","https://openalex.org/W2031703162","https://openalex.org/W2032745254","https://openalex.org/W2034444864","https://openalex.org/W2034893085","https://openalex.org/W2035833108","https://openalex.org/W2037490361","https://openalex.org/W2038821178","https://openalex.org/W2039597975","https://openalex.org/W2039811523","https://openalex.org/W2040590040","https://openalex.org/W2040987426","https://openalex.org/W2041774091","https://openalex.org/W2042584758","https://openalex.org/W2043922597","https://openalex.org/W2044628667","https://openalex.org/W2045446885","https://openalex.org/W2045775374","https://openalex.org/W2046318731","https://openalex.org/W2048451837","https://openalex.org/W2049259261","https://openalex.org/W2049331965","https://openalex.org/W2050505498","https://openalex.org/W2050813637","https://openalex.org/W2051710717","https://openalex.org/W2052767109","https://openalex.org/W2053147080","https://openalex.org/W2053155636","https://openalex.org/W2053867269","https://openalex.org/W2054191418","https://openalex.org/W2054602599","https://openalex.org/W2058617759","https://openalex.org/W2059149964","https://openalex.org/W2059397441","https://openalex.org/W2059518315","https://openalex.org/W2059998193","https://openalex.org/W2060105958","https://openalex.org/W2060391020","https://openalex.org/W2061151008","https://openalex.org/W2061690334","https://openalex.org/W2062195965","https://openalex.org/W2062876104","https://openalex.org/W2062974764","https://openalex.org/W2063619185","https://openalex.org/W2063915017","https://openalex.org/W2067323612","https://openalex.org/W2068261875","https://openalex.org/W2068649588","https://openalex.org/W2074053793","https://openalex.org/W2078291117","https://openalex.org/W2078684251","https://openalex.org/W2079618743","https://openalex.org/W2079919603","https://openalex.org/W2081256532","https://openalex.org/W2083203598","https://openalex.org/W2083805576","https://openalex.org/W2083963151","https://openalex.org/W2084564584","https://openalex.org/W2084740377","https://openalex.org/W2088206660","https://openalex.org/W2088240599","https://openalex.org/W2088250351","https://openalex.org/W2090270307","https://openalex.org/W2090791780","https://openalex.org/W2092320553","https://openalex.org/W2093317402","https://openalex.org/W2094022774","https://openalex.org/W2094985040","https://openalex.org/W2095447949","https://openalex.org/W2096775086","https://openalex.org/W2097382995","https://openalex.org/W2104802653","https://openalex.org/W2105922835","https://openalex.org/W2106799894","https://openalex.org/W2106902529","https://openalex.org/W2107651677","https://openalex.org/W2109050242","https://openalex.org/W2109116257","https://openalex.org/W2109863561","https://openalex.org/W2110187492","https://openalex.org/W2111108708","https://openalex.org/W2111139603","https://openalex.org/W2114320763","https://openalex.org/W2114668205","https://openalex.org/W2116087305","https://openalex.org/W2120525208","https://openalex.org/W2122536720","https://openalex.org/W2122862042","https://openalex.org/W2123513769","https://openalex.org/W2125715557","https://openalex.org/W2127287358","https://openalex.org/W2127375496","https://openalex.org/W2130137989","https://openalex.org/W2130712055","https://openalex.org/W2132169858","https://openalex.org/W2133371934","https://openalex.org/W2134197455","https://openalex.org/W2134661315","https://openalex.org/W2135010069","https://openalex.org/W2135579845","https://openalex.org/W2135603829","https://openalex.org/W2135732933","https://openalex.org/W2138979179","https://openalex.org/W2139574393","https://openalex.org/W2140583034","https://openalex.org/W2142228943","https://openalex.org/W2146088099","https://openalex.org/W2147281292","https://openalex.org/W2150641072","https://openalex.org/W2154502317","https://openalex.org/W2155292823","https://openalex.org/W2157805786","https://openalex.org/W2158596237","https://openalex.org/W2158919479","https://openalex.org/W2159307624","https://openalex.org/W2159482845","https://openalex.org/W2162123587","https://openalex.org/W2162948493","https://openalex.org/W2165757703","https://openalex.org/W2166405062","https://openalex.org/W2168865322","https://openalex.org/W2169459642","https://openalex.org/W2169637929","https://openalex.org/W2170984545","https://openalex.org/W2178621881","https://openalex.org/W2224433893","https://openalex.org/W2318657222","https://openalex.org/W2324491595","https://openalex.org/W2399924328","https://openalex.org/W2416761003","https://openalex.org/W2891301307"],"related_works":["https://openalex.org/W153253579","https://openalex.org/W1983592663","https://openalex.org/W153018810","https://openalex.org/W3200714125","https://openalex.org/W2095172134","https://openalex.org/W148952499","https://openalex.org/W2770891044","https://openalex.org/W4384662907","https://openalex.org/W2006842696","https://openalex.org/W1981121013"],"abstract_inverted_index":{"Nuclear":[0],"Magnetic":[1],"Resonance":[2],"has":[3,14],"experienced":[4],"an":[5],"increasing":[6],"interest":[7],"in":[8,79,121,165,188,231,278,355],"the":[9,31,40,59,65,105,114,122,147,155,160,175,182,191,217,226,248,259,288,356,358,373,389,405],"drug":[10,25,168],"discovery":[11,169],"field":[12],"that":[13,386,399],"led":[15],"to":[16,36,45,55,87,113,146,159,181,196,267,286,333,361,368,404],"its":[17,340,411],"wide":[18],"use":[19,37,115],"on":[20,225,301],"nearly":[21],"every":[22],"stage":[23,174],"of":[24,39,69,109,116,124,149,162,184,209,228,239,275,290,376,388,407],"development.":[26],"For":[27],"this":[28,74,197,273,400],"reason,":[29],"during":[30],"present":[32],"thesis":[33],"we":[34,53,98,284,299],"propose":[35,268,369],"some":[38],"tools":[41,178],"offered":[42],"by":[43,295],"NMR":[44,60,95,107,177,263],"target":[46],"various":[47,76,251],"systems":[48],"related":[49],"with":[50,58,308],"cancer.":[51],"Initially":[52],"intended":[54],"get":[56],"acquainted":[57],"most":[61],"outstanding":[62],"methodologies":[63,103],"for":[64,73,104,132,152,190,213,272,372],"detection":[66],"and":[67,72,83,92,142,154,195,244,258,313,350,398],"characterization":[68,123,289,336],"binding":[70,270],"events;":[71],"goal":[75],"proteins":[77],"involved":[78],"cellular":[80],"apoptosis":[81],"(XIAP":[82],"Bcl-XL)":[84],"were":[85,144,179,202,253,345],"used":[86],"set":[88],"up":[89],"both":[90],"ligand":[91,135],"receptor":[93],"based":[94,136],"experiments.":[96,246],"First":[97],"developed":[99],"two":[100,199],"novel":[101],"labeling":[102,242],"selective":[106,241],"observation":[108],"Trp,":[110],"which":[111],"coupled":[112],"receptor-based":[117,245],"experiments":[118,137,264],"provided":[119],"insight":[120],"XIAP-ligand":[125],"complexes,":[126],"as":[127,129,139,255],"well":[128],"significant":[130],"advantages":[131],"HTS.":[133],"Later,":[134],"such":[138,327],"STD,":[140],"WaterLOGSY":[141],"iLOE":[143],"applied":[145,158,180],"screening":[148],"weak":[150,214],"binders":[151,164,257],"Bcl-XL,":[153],"resulting":[156],"information":[157,260],"reconstruction":[161],"dual":[163],"a":[166,172,205,237,269,279,291,304,315,323,331,363,370,383,395,408],"fragment-based":[167,219],"approach.":[170],"In":[171,247,297],"second":[173,222],"same":[176],"development":[183],"protein-protein":[185],"interaction":[186],"inhibitors,":[187],"particular":[189,298],"pro-angiogenic":[192],"protein":[193],"VEGF;":[194],"end":[198],"different":[200],"strategies":[201],"proposed.":[203],"First,":[204],"small":[206],"diverse":[207],"library":[208],"D-oligopeptides":[210],"was":[211],"screened":[212],"ligands":[215],"using":[216,236],"former":[218],"strategy.":[220],"A":[221],"approach":[223],"consisted":[224],"identification":[227],"active":[229],"compounds":[230],"complex":[232],"plant":[233],"extract":[234],"mixtures":[235],"combination":[238],"methionine":[240],"schemes":[243],"latter":[249,357],"case":[250],"flavonoids":[252],"identified":[254],"VEGF":[256],"harvested":[261],"from":[262,322,339],"allowed":[265],"us":[266,367],"mode":[271],"type":[274],"molecules.":[276],"Lastly,":[277],"much":[280],"more":[281],"classic":[282],"context,":[283],"decided":[285],"attempt":[287],"medium":[292],"sized":[293],"oligopeptide":[294],"NMR.":[296],"focused":[300],"Kahalalide":[302,377],"F":[303,378],"marine":[305],"origin":[306],"depsipeptide":[307],"very":[309,320],"promising":[310],"anticancer":[311],"activity;":[312],"although":[314],"SAR":[316],"profile":[317],"would":[318],"be":[319],"useful":[321],"medicinal":[324],"chemistry":[325],"perspective":[326],"molecules":[328],"still":[329],"pose":[330],"challenge":[332],"their":[334],"structural":[335],"particularly":[337],"stemming":[338],"intrinsic":[341],"flexibility.":[342],"Several":[343],"media":[344],"explored":[346],"including":[347],"H2O,":[348],"DMSO,":[349],"membrane":[351,396],"mimics":[352],"(SDS":[353],"micelles);":[354],"peptide":[359],"seems":[360],"adopt":[362],"preferred":[364],"structure":[365],"allowing":[366],"model":[371,384],"monomeric":[374],"insertion":[375],"within":[379,410],"membrane-like":[380],"environments.":[381],"Such":[382],"supports":[385],"part":[387],"peptide's":[390],"cytotoxic":[391],"activity":[392,401],"occurs":[393],"at":[394],"level":[397],"is":[402],"linked":[403],"formation":[406],"turn":[409],"N-terminus":[412],"section.":[413]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}