{"id":"https://openalex.org/W1500570340","doi":null,"title":"Neurobiology of interleukin-1 receptors: getting the message.","display_name":"Neurobiology of interleukin-1 receptors: getting the message.","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1500570340","mag":"1500570340","pmid":"https://pubmed.ncbi.nlm.nih.gov/11125316"},"language":"en","primary_location":{"id":"pmid:11125316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11125316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Conference Proceedings"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044696234","display_name":"Jan Pieter Konsman","orcid":"https://orcid.org/0000-0001-7247-0472","observed_orcids":["https://orcid.org/0000-0001-7247-0472"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J P Konsman","raw_affiliation_strings":["INRA-INSERM U. 394, Institut Fran\u00e7ois Magendie, rue Camille-Saint-Sa\u00ebns, 33077 Bordeaux Cedex, France. jpkonsman@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA-INSERM U. 394, Institut Fran\u00e7ois Magendie, rue Camille-Saint-Sa\u00ebns, 33077 Bordeaux Cedex, France. jpkonsman@hotmail.com","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015295561","display_name":"Donatienne Blond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Blond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029168875","display_name":"St\u00e9phan Vigues","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Vigues","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.06718062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"4","first_page":"699","last_page":"702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1-receptor","display_name":"interleukin-1 receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.3889999985694885},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glial-inflammation","display_name":"glial inflammation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/sickness-behavior","display_name":"sickness behavior","score":0.4869999885559082},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.871999979019165},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.5379999876022339},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.7789999842643738},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/il-1-receptor-family","display_name":"IL-1 receptor family","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cns-pathology","display_name":"CNS pathology","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6613385081291199},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6429229974746704},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5924075841903687},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.590837299823761},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5341694951057434},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5179404616355896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44498562812805176},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4377394914627075},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4145122766494751},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34492361545562744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18167981505393982}],"mesh":[{"descriptor_ui":"D000210","descriptor_name":"Acute-Phase Reaction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11125316","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11125316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Conference Proceedings"},{"id":"mag:1500570340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11125316","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2098292546","https://openalex.org/W2135339492","https://openalex.org/W4404516898","https://openalex.org/W1998185338","https://openalex.org/W2084131226","https://openalex.org/W2914864332","https://openalex.org/W2081490414","https://openalex.org/W2000663601","https://openalex.org/W1985992224","https://openalex.org/W2166778129"],"abstract_inverted_index":{"Binding":[0],"of":[1,35,41,60,100,143],"the":[2,8,21,42,84,95,101,130,134],"pro-inflammatory":[3],"cytokine":[4],"interleukin-1":[5],"(IL-1)":[6],"in":[7,20,32,58,73,94,115,125,129,138],"brain":[9,22,111],"was":[10,56],"first":[11],"shown":[12,57],"a":[13,30,122],"decade":[14],"ago":[15],"[1].":[16],"Interleukin-1":[17],"receptors":[18],"(IL-1R)":[19],"were,":[23],"at":[24],"that":[25,86],"time,":[26],"proposed":[27],"to":[28,83,90,119],"play":[29],"role":[31],"mediating":[33],"symptoms":[34],"sickness":[36],"such":[37],"as":[38],"fever,":[39],"activation":[40],"hypothalamo-pituitary":[43],"adrenal":[44],"(HPA)-axis,":[45],"behavioural":[46],"depression":[47],"and":[48,76,80,108,136],"increased":[49],"sleeping.":[50],"Two":[51],"years":[52],"later,":[53],"IL-1":[54,71,88,102,112],"immunoreactivity":[55],"microglia":[59],"patients":[61],"with":[62],"Alzheimer's":[63],"disease":[64],"[2].":[65],"Subsequent":[66],"studies":[67],"provided":[68],"evidence":[69],"for":[70,110],"expression":[72],"most":[74],"acute":[75],"chronic":[77],"CNS":[78],"pathologies":[79],"gave":[81],"rise":[82],"concept":[85],"glial":[87],"contributes":[89],"an":[91],"inflammatory":[92],"response":[93],"brain.":[96],"Recently,":[97],"new":[98],"members":[99],"receptor":[103],"family":[104],"have":[105],"been":[106],"discovered":[107],"roles":[109],"other":[113],"than":[114],"inflammation":[116],"are":[117],"starting":[118],"emerge.":[120],"During":[121],"recent":[123],"meeting*":[124],"Biarritz,":[126],"leading":[127],"experts":[128],"field":[131],"reflected":[132],"on":[133],"accomplishments":[135],"prospects":[137],"this":[139],"rapidly":[140],"expanding":[141],"area":[142],"neurobiology.":[144]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}