{"id":"https://openalex.org/W1499898280","doi":"https://doi.org/10.4049/jimmunol.192.supp.60.14","title":"Regulatory T cells use LAG-3 as the \u201cbrake\u201d in autoimmune diabetes but the \u201caccelerator\u201d in tumor environment (IRC4P.487)","display_name":"Regulatory T cells use LAG-3 as the \u201cbrake\u201d in autoimmune diabetes but the \u201caccelerator\u201d in tumor environment (IRC4P.487)","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W1499898280","doi":"https://doi.org/10.4049/jimmunol.192.supp.60.14","mag":"1499898280"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.192.supp.60.14","doi":"https://doi.org/10.4049/jimmunol.192.supp.60.14","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.60.14","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035183199","display_name":"Qianxia Zhang","orcid":"https://orcid.org/0000-0002-2885-2147","observed_orcids":["https://orcid.org/0000-0002-2885-2147","https://orcid.org/0000-0002-6229-6711"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qianxia Zhang","raw_affiliation_strings":["Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN","Integrated Biomedical Sciences Program, University of Tennessee Health Science Center , Memphis, TN","1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN","2Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Integrated Biomedical Sciences Program, University of Tennessee Health Science Center , Memphis, TN","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"2Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058759825","display_name":"Amy J. Beres","orcid":"https://orcid.org/0000-0003-4653-0368","observed_orcids":["https://orcid.org/0000-0003-4653-0368"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Beres","raw_affiliation_strings":["Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN","1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001000053","display_name":"Dario A.A. Vignali","orcid":"https://orcid.org/0000-0002-2771-5992","observed_orcids":["https://orcid.org/0000-0002-2771-5992"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dario Vignali","raw_affiliation_strings":["Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN","Integrated Biomedical Sciences Program, University of Tennessee Health Science Center , Memphis, TN","1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN","2Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children\u2019s Research Hospital , Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Integrated Biomedical Sciences Program, University of Tennessee Health Science Center , Memphis, TN","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"2Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"192","issue":"Supplement_1","first_page":"60.14","last_page":"60.14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.7680000066757202},{"id":"https://openalex.org/keywords/autoimmune-diabetes","display_name":"autoimmune diabetes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.6919999718666077},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8159999847412109},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.6150000095367432},{"id":"https://openalex.org/keywords/insulitis","display_name":"insulitis","score":0.47099998593330383},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7296112179756165},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6141901612281799},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5914716124534607},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5789206624031067},{"id":"https://openalex.org/C2778013207","wikidata":"https://www.wikidata.org/wiki/Q1961243","display_name":"NOD mice","level":4,"score":0.5371049046516418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49569737911224365},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4781004786491394},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40031591057777405},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3526015877723694}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.192.supp.60.14","doi":"https://doi.org/10.4049/jimmunol.192.supp.60.14","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.60.14","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2600304928","https://openalex.org/W2604712061","https://openalex.org/W1850631646","https://openalex.org/W7141167891","https://openalex.org/W1988474688","https://openalex.org/W2808896528","https://openalex.org/W4313369046","https://openalex.org/W4320489670","https://openalex.org/W4402223191","https://openalex.org/W4220919207"],"abstract_inverted_index":{"Abstract":[0],"Lymphocyte":[1],"Activation":[2],"Gene-3":[3],"(LAG-3,":[4],"CD223)":[5],"is":[6,11,16,40,89],"an":[7,142,185,188],"inhibitory":[8],"receptor":[9],"that":[10,55],"expressed":[12,66],"upon":[13],"TCR":[14],"activation,":[15],"highly":[17],"up-regulated":[18],"on":[19,182,195],"exhausted":[20],"conventional":[21],"T":[22,26,46],"cells,":[23],"and":[24,30,36,102,116,134],"regulates":[25],"cell":[27,34,47],"expansion,":[28],"homeostasis":[29],"function":[31,63],"via":[32],"both":[33,97,127],"intrinsic":[35],"extrinsic":[37],"mechanisms.":[38],"LAG-3":[39,56,65,76,88,124,167,181,194],"also":[41],"required":[42,170],"for":[43,171,180,201],"maximal":[44],"regulatory":[45],"(Treg)":[48],"function.":[49],"Our":[50],"lab":[51],"has":[52],"previously":[53],"shown":[54],"modulates":[57],"tolerance":[58],"mechanisms,":[59],"but":[60],"the":[61,73,98,108,121,145,150,158,164],"specific":[62],"of":[64,75,110,123,147,160,208],"by":[67,154],"Tregs":[68,112,126,148,183,196],"remains":[69],"unknown.":[70],"To":[71],"elucidate":[72],"role":[74,109],"in":[77,84,92,113,125,136,163,184],"Treg-mediated":[78,172],"immune":[79,173],"suppression,":[80],"we":[81],"generated":[82],"mice":[83,130],"which":[85,156],"active,":[86],"membrane-expressed":[87],"specifically":[90,192],"deleted":[91],"Foxp3+":[93],"Tregs.":[94],"We":[95],"used":[96],"non-obese":[99],"diabetes":[100,115,133],"(NOD)":[101],"B6":[103],"mouse":[104],"backgrounds":[105],"to":[106],"study":[107],"LAG-3-deficient":[111],"autoimmune":[114,132,143],"B16":[117,138],"melanoma,":[118],"respectively.":[119],"Surprisingly,":[120],"deletion":[122],"protected":[128],"NOD":[129],"from":[131],"resulted":[135],"decreased":[137],"melanoma":[139],"growth.":[140],"In":[141],"environment,":[144],"number":[146],"infiltrating":[149],"islets":[151],"was":[152,169],"limited":[153],"LAG-3,":[155],"facilitated":[157],"breakdown":[159],"self-tolerance.":[161],"However,":[162],"tumor":[165,203],"microenvironment,":[166],"activity":[168],"suppression.":[174],"These":[175],"data":[176],"suggest":[177],"opposing":[178],"roles":[179],"inflammatory":[186],"versus":[187],"immunosuppressive":[189],"microenvironment.":[190],"Therefore,":[191],"targeting":[193],"may":[197],"provide":[198],"a":[199],"strategy":[200],"limiting":[202],"growth":[204],"without":[205],"subsequent":[206],"development":[207],"autoimmunity.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
