{"id":"https://openalex.org/W1499809123","doi":null,"title":"Hydroxyl radical production and human DNA damage induced by ferric nitrilotriacetate and hydrogen peroxide.","display_name":"Hydroxyl radical production and human DNA damage induced by ferric nitrilotriacetate and hydrogen peroxide.","publication_year":1987,"publication_date":"1987-12-15","ids":{"openalex":"https://openalex.org/W1499809123","mag":"1499809123","pmid":"https://pubmed.ncbi.nlm.nih.gov/2824034"},"language":"en","primary_location":{"id":"pmid:2824034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2824034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024548116","display_name":"Satoshi Inoue","orcid":"https://orcid.org/0000-0003-1247-3844","observed_orcids":["https://orcid.org/0000-0003-1247-3844"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Inoue","raw_affiliation_strings":["Department of Public Health, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077773100","display_name":"Shosuke Kawanishi","orcid":"https://orcid.org/0000-0002-7525-7658","observed_orcids":["https://orcid.org/0000-0002-7525-7658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kawanishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8084,"has_fulltext":false,"cited_by_count":192,"citation_normalized_percentile":{"value":0.9596562,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"47","issue":"24 Pt 1","first_page":"6522","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferric-nitrilotriacetate","display_name":"ferric nitrilotriacetate","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.7329999804496765},{"id":"https://openalex.org/keywords/dna-cleavage","display_name":"DNA cleavage","score":0.8190000057220459},{"id":"https://openalex.org/keywords/aminopolycarboxylic-acids","display_name":"aminopolycarboxylic acids","score":0.847000002861023},{"id":"https://openalex.org/keywords/piperidine","display_name":"piperidine","score":0.5669999718666077},{"id":"https://openalex.org/keywords/hydrogen-peroxide-decomposition","display_name":"hydrogen peroxide decomposition","score":0.6520000100135803},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6399999856948853},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9189808368682861},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.7835168242454529},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.696833610534668},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.6898602843284607},{"id":"https://openalex.org/C2777709666","wikidata":"https://www.wikidata.org/wiki/Q192454","display_name":"Deoxyribose","level":3,"score":0.6484663486480713},{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.6312704682350159},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.5653910636901855},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.491224467754364},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3980928957462311},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3343169093132019},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.30694299936294556},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19885942339897156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006878","descriptor_name":"Hydroxides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009571","descriptor_name":"Nitrilotriacetic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2824034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2824034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1499809123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2824034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W591832344","https://openalex.org/W1558516755","https://openalex.org/W1563317426","https://openalex.org/W1632355607","https://openalex.org/W1980237844","https://openalex.org/W1985422263","https://openalex.org/W1985859389","https://openalex.org/W2001923549","https://openalex.org/W2022472966","https://openalex.org/W2064450459","https://openalex.org/W2094481836","https://openalex.org/W2159178548","https://openalex.org/W2166355500","https://openalex.org/W7164816779"],"related_works":["https://openalex.org/W2039356219","https://openalex.org/W7145549280","https://openalex.org/W2145131343","https://openalex.org/W2023138072","https://openalex.org/W1964265098","https://openalex.org/W1987155374","https://openalex.org/W2089973048","https://openalex.org/W2046716686","https://openalex.org/W2037217405","https://openalex.org/W1970004294"],"abstract_inverted_index":{"Reactivities":[0],"of":[1,4,50,65,73,90,104,123,126,139,153,167,187],"Fe3+":[2,63,124],"chelates":[3,64,125],"aminopolycarboxylic":[5,67,127],"acids":[6,68],"with":[7,59,110],"DNA":[8,18,45,55,77,180],"were":[9],"investigated":[10],"by":[11,32,79,189],"the":[12,22,27,48,71,102,131,151,163,178,183],"DNA-sequencing":[13],"technique":[14],"using":[15,117],"32P":[16],"5'-end-labeled":[17],"fragments":[19],"obtained":[20],"from":[21],"human":[23],"c-Ha-ras-1":[24],"protooncogene,":[25],"and":[26,106,169,171],"reaction":[28],"mechanism":[29],"was":[30,57,97,130],"studied":[31],"electron":[33],"spin":[34,114],"resonance":[35,115],"spectroscopy.":[36],"Ferric":[37],"nitrilotriacetate":[38],"(Fe3+-NTA)":[39],"plus":[40,81],"hydrogen":[41,74,82,136,154],"peroxide":[42,83,155],"caused":[43],"strong":[44,164],"cleavage":[46,56,78,96],"in":[47,70,135],"presence":[49,72],"albumin.":[51],"No":[52],"or":[53,62],"little":[54],"observed":[58],"ferric":[60],"chloride":[61],"other":[66],"tested":[69],"peroxide.":[75],"The":[76,145,175],"Fe3+-NTA":[80,129,149,190],"without":[84],"piperidine":[85,111],"treatment":[86],"occurred":[87],"at":[88,101],"positions":[89,103],"every":[91],"nucleotide":[92],"although":[93],"a":[94],"specific":[95],"observed,":[98],"whereas":[99],"cleavages":[100],"guanine":[105,168],"thymine":[107],"increased":[108],"predominantly":[109],"treatment.":[112],"Electron":[113],"studies":[116],"free":[118],"radical":[119],"traps":[120],"demonstrated":[121],"that":[122,148,177],"acids,":[128],"most":[132],"effective":[133],"catalyst":[134],"peroxide-derived":[137],"production":[138],"hydroxyl":[140,158],"radicals":[141],"under":[142],"our":[143],"conditions.":[144],"results":[146],"suggest":[147],"catalyzes":[150],"decomposition":[152],"to":[156],"produce":[157],"radicals,":[159],"which":[160],"subsequently":[161],"cause":[162],"base":[165],"alterations":[166],"thymine,":[170],"deoxyribose-phosphate":[172],"backbone":[173],"breakages.":[174],"possibility":[176],"Fe3+-NTA-induced":[179],"damage":[181],"is":[182,191],"initiation":[184],"and/or":[185],"promotion":[186],"carcinogenesis":[188],"discussed.":[192]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}