{"id":"https://openalex.org/W1499515790","doi":"https://doi.org/10.1002/9780470048672.wecb455","title":"PLP \u2010Dependent Enzymes, Chemistry of","display_name":"PLP \u2010Dependent Enzymes, Chemistry of","publication_year":2008,"publication_date":"2008-05-15","ids":{"openalex":"https://openalex.org/W1499515790","doi":"https://doi.org/10.1002/9780470048672.wecb455","mag":"1499515790"},"language":"en","primary_location":{"id":"doi:10.1002/9780470048672.wecb455","doi":"https://doi.org/10.1002/9780470048672.wecb455","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470048672.wecb455","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley Encyclopedia of Chemical Biology","raw_type":"other"},"volume":{"id":"https://openalex.org/W605885627","display_name":"Wiley Encyclopedia of Chemical Biology"},"type":"reference-entry","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078366579","display_name":"Michael D. Toney","orcid":"https://orcid.org/0000-0001-8337-5075","observed_orcids":["https://orcid.org/0000-0001-8337-5075"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael D. Toney","raw_affiliation_strings":["University of California\u2014Davis, Departments of Chemistry and Molecular and Cellular Biology, Davis, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California\u2014Davis, Departments of Chemistry and Molecular and Cellular Biology, Davis, California","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078366579"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.06700000166893005,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyridoxal-5-phosphate","display_name":"pyridoxal phosphate","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pyridoxal-phosphate-dependent-enzymes","display_name":"pyridoxal phosphate-dependent enzymes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tryptophan-synthase","display_name":"tryptophan synthase","score":0.828000009059906},{"id":"https://openalex.org/keywords/alanine-racemase","display_name":"alanine racemase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/d-amino-acid-aminotransferase","display_name":"D-amino acid aminotransferase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glycogen-phosphorylase","display_name":"glycogen phosphorylase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carbanionic-intermediates","display_name":"carbanionic intermediates","score":0.8029999732971191},{"id":"https://openalex.org/keywords/external-aldimine","display_name":"external aldimine","score":0.7870000004768372},{"id":"https://openalex.org/keywords/stereoelectronic-effects","display_name":"stereoelectronic effects","score":0.9869999885559082},{"id":"https://openalex.org/keywords/reaction-specificity","display_name":"reaction specificity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/enzyme-classification","display_name":"enzyme classification","score":0.5519999861717224},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7279999852180481},{"id":"https://openalex.org/keywords/amine-metabolism","display_name":"amine metabolism","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8109159469604492},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6822636723518372},{"id":"https://openalex.org/C2780859938","wikidata":"https://www.wikidata.org/wiki/Q3065731","display_name":"Pyridoxal","level":3,"score":0.6591694951057434},{"id":"https://openalex.org/C2776834122","wikidata":"https://www.wikidata.org/wiki/Q418957","display_name":"Pyridoxal phosphate","level":4,"score":0.6299731135368347},{"id":"https://openalex.org/C204779464","wikidata":"https://www.wikidata.org/wiki/Q412061","display_name":"Glycogen phosphorylase","level":3,"score":0.6208292841911316},{"id":"https://openalex.org/C67524406","wikidata":"https://www.wikidata.org/wiki/Q408057","display_name":"Aldimine","level":3,"score":0.5726518034934998},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5323171019554138},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.47031867504119873},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4588582515716553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35582125186920166},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.26753073930740356},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.14668095111846924}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9780470048672.wecb455","doi":"https://doi.org/10.1002/9780470048672.wecb455","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470048672.wecb455","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley Encyclopedia of Chemical Biology","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1482739959","https://openalex.org/W1583558678","https://openalex.org/W1890047923","https://openalex.org/W1969151014","https://openalex.org/W1975447328","https://openalex.org/W1989541582","https://openalex.org/W1998974197","https://openalex.org/W1999728411","https://openalex.org/W2001518535","https://openalex.org/W2007648987","https://openalex.org/W2008550447","https://openalex.org/W2013414388","https://openalex.org/W2037525379","https://openalex.org/W2043006564","https://openalex.org/W2052885069","https://openalex.org/W2054304585","https://openalex.org/W2060177102","https://openalex.org/W2060975426","https://openalex.org/W2064113629","https://openalex.org/W2074589586","https://openalex.org/W2086316530","https://openalex.org/W2110094991","https://openalex.org/W2125294775","https://openalex.org/W2314415344"],"related_works":["https://openalex.org/W2089530500","https://openalex.org/W2042955504","https://openalex.org/W2346771083","https://openalex.org/W2920573059","https://openalex.org/W4252102794","https://openalex.org/W2325883851","https://openalex.org/W53439854","https://openalex.org/W4247383339","https://openalex.org/W2045949787","https://openalex.org/W7033413141"],"abstract_inverted_index":{"Abstract":[0],"Pyridoxal":[1],"phosphate\u2010dependent":[2],"enzymes":[3,79,97],"catalyze":[4],"a":[5,72],"wide":[6],"variety":[7],"of":[8,65,86,105,113],"reaction":[9,37],"types":[10],"on":[11],"amines":[12],"and":[13,29,142],"amino":[14],"acids,":[15],"generally":[16],"by":[17,35],"stabilizing":[18],"carbanionic":[19,89],"intermediates,":[20],"which":[21,36,59,114],"makes":[22],"them":[23],"very":[24],"common":[25],"in":[26,51],"both":[27],"primary":[28],"secondary":[30],"metabolism.":[31],"A":[32],"fundamental":[33],"mechanism":[34],"specificity":[38],"is":[39,41,57,60,109,117],"enforced":[40],"stereoelectronic":[42],"effects;":[43],"the":[44,52,66,84,87,110,118,123],"bond":[45,73],"to":[46,63,74],"C\u03b1":[47,75],"that":[48,58],"gets":[49],"broken":[50],"universal":[53],"external":[54],"aldimine":[55],"intermediate":[56],"aligned":[61],"parallel":[62],"theporbitals":[64],"conjugated,":[67],"electron\u2010deficient":[68],"\u03c0":[69],"system.":[70],"When":[71],"has":[76],"been":[77],"broken,":[78],"must":[80],"also":[81],"carefully":[82],"control":[83],"fate":[85],"resulting":[88],"intermediate.":[90],"Structurally,":[91],"all":[92],"known":[93],"pyridoxal":[94],"5\u2032\u2010phosphate":[95],"(PLP)\u2010dependent":[96],"are":[98,126],"separated":[99],"into":[100],"five":[101],"groups.":[102],"The":[103,120],"largest":[104],"these,":[106],"Type":[107,129,133,137,143],"1,":[108],"aminotransferase":[111,116],"group,":[112],"aspartate":[115],"prototype.":[119],"prototypes":[121],"for":[122],"other":[124],"groups":[125],"as":[127],"follows:":[128],"2,":[130],"tryptophan":[131],"synthetase;":[132],"3,":[134],"alanine":[135],"racemase;":[136],"4,":[138],"D\u2010amino":[139],"acid":[140],"aminotransferase;":[141],"5,":[144],"glycogen":[145],"phosphorylase.":[146]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
