{"id":"https://openalex.org/W1499400228","doi":"https://doi.org/10.1007/s00481-006-0439-5","title":"Placebos in klinischen Versuchsreihen","display_name":"Placebos in klinischen Versuchsreihen","publication_year":2006,"publication_date":"2006-08-15","ids":{"openalex":"https://openalex.org/W1499400228","doi":"https://doi.org/10.1007/s00481-006-0439-5","mag":"1499400228"},"language":"de","primary_location":{"id":"doi:10.1007/s00481-006-0439-5","doi":"https://doi.org/10.1007/s00481-006-0439-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00481-006-0439-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00481-006-0439-5.pdf","source":{"id":"https://openalex.org/S159217112","display_name":"Ethik in der Medizin","issn_l":"0935-7335","issn":["0935-7335","1437-1618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethik in der Medizin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00481-006-0439-5.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035672354","display_name":"Hans\u2010J\u00f6rg Ehni","orcid":"https://orcid.org/0000-0001-5900-2228","observed_orcids":["https://orcid.org/0000-0001-5900-2228"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hans-J\u00f6rg Ehni","raw_affiliation_strings":["Institut f\u00fcr Ethik und Geschichte der Medizin,  Bereich Ethik in der Medizin, Schleichstr. 8, 72076, T\u00fcbingen","T\u00fcbingen","Institut f\u00fcr Ethik und Geschichte der Medizin,  Bereich Ethik in der Medizin, T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Ethik und Geschichte der Medizin,  Bereich Ethik in der Medizin, Schleichstr. 8, 72076, T\u00fcbingen","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"T\u00fcbingen","institution_ids":[]},{"raw_affiliation_string":"Institut f\u00fcr Ethik und Geschichte der Medizin,  Bereich Ethik in der Medizin, T\u00fcbingen","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052352635","display_name":"Urban Wiesing","orcid":"https://orcid.org/0000-0003-4957-4323","observed_orcids":["https://orcid.org/0000-0003-4957-4323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Urban Wiesing","raw_affiliation_strings":["T\u00fcbingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"T\u00fcbingen","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035672354"],"corresponding_institution_ids":["https://openalex.org/I8087733"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.3483,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.68228135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"3","first_page":"223","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13147","display_name":"Ethics and bioethics in healthcare","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placebo-use","display_name":"placebo use","score":0.7910000085830688},{"id":"https://openalex.org/keywords/research-ethics","display_name":"research ethics","score":0.8840000033378601},{"id":"https://openalex.org/keywords/moral-norms","display_name":"moral norms","score":0.5370000004768372},{"id":"https://openalex.org/keywords/informed-consent","display_name":"informed consent","score":0.7279999852180481},{"id":"https://openalex.org/keywords/risk-of-harm","display_name":"risk of harm","score":0.8289999961853027},{"id":"https://openalex.org/keywords/research-ethics-committees","display_name":"research ethics committees","score":0.7260000109672546},{"id":"https://openalex.org/keywords/international-regulation","display_name":"international regulation","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.7883656024932861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4238250255584717},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3934541940689087}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s00481-006-0439-5","doi":"https://doi.org/10.1007/s00481-006-0439-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00481-006-0439-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00481-006-0439-5.pdf","source":{"id":"https://openalex.org/S159217112","display_name":"Ethik in der Medizin","issn_l":"0935-7335","issn":["0935-7335","1437-1618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethik in der Medizin","raw_type":"journal-article"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/970578","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/970578","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eweb:298998","raw_type":null},{"id":"mag:1575374879","doi":null,"is_oa":false,"landing_page_url":"https://philpapers.org/rec/EHNPIC","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1007/s00481-006-0439-5","doi":"https://doi.org/10.1007/s00481-006-0439-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00481-006-0439-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00481-006-0439-5.pdf","source":{"id":"https://openalex.org/S159217112","display_name":"Ethik in der Medizin","issn_l":"0935-7335","issn":["0935-7335","1437-1618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ethik in der Medizin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1499400228.pdf","grobid_xml":"https://content.openalex.org/works/W1499400228.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1531605540","https://openalex.org/W1586993522","https://openalex.org/W1594236263","https://openalex.org/W1731081963","https://openalex.org/W1966039035","https://openalex.org/W1973698029","https://openalex.org/W2001985349","https://openalex.org/W2022593462","https://openalex.org/W2032507071","https://openalex.org/W2034980646","https://openalex.org/W2048323653","https://openalex.org/W2062146075","https://openalex.org/W2076505205","https://openalex.org/W2077683585","https://openalex.org/W2088683789","https://openalex.org/W2098994793","https://openalex.org/W2114087987","https://openalex.org/W2121671594","https://openalex.org/W2123438626","https://openalex.org/W2125843934","https://openalex.org/W2149818369","https://openalex.org/W2163544623","https://openalex.org/W2210417879","https://openalex.org/W2312621854","https://openalex.org/W2408081177","https://openalex.org/W3024629007","https://openalex.org/W3206486718","https://openalex.org/W4235038586","https://openalex.org/W4253299409","https://openalex.org/W4294589319","https://openalex.org/W4301078689","https://openalex.org/W4312553447"],"related_works":["https://openalex.org/W2018877492","https://openalex.org/W1974170500","https://openalex.org/W4245084603","https://openalex.org/W1966039035","https://openalex.org/W2331977487","https://openalex.org/W4388359896","https://openalex.org/W2084034816","https://openalex.org/W3023661619","https://openalex.org/W2396833632","https://openalex.org/W2387800292"],"abstract_inverted_index":{"The":[0,41,142,183],"ethical":[1,34,105,200],"aspects":[2],"of":[3,24,51,60,90,107,119,129,139,167,176,186,194,202],"placebo":[4,37,108,203],"control":[5],"in":[6,15,44,74,87,110],"clinical":[7,168],"trials":[8,169],"have":[9],"been":[10],"extensively":[11],"and":[12,32,136,148],"controversially":[13],"debated":[14],"the":[16,25,45,49,61,72,78,88,104,124,127,137,151,157,165,192,199],"last":[17],"decade.":[18],"However,":[19],"a":[20,98,174],"thorough":[21],"analytical":[22],"comparison":[23],"different":[26,125],"existing":[27],"international":[28],"regulations,":[29],"their":[30,33],"terminologies":[31],"principles":[35],"concerning":[36,198],"is":[38,48,156],"still":[39],"missing.":[40],"central":[42],"issue":[43],"ongoing":[46],"controversy":[47],"justification":[50],"placebo-use":[52,81],"if":[53],"proven":[54,140],"treatment":[55],"exists.":[56],"All":[57],"present":[58,97],"versions":[59],"examined":[62,152],"guidelines":[63,161],"propose":[64],"such":[65],"justifications,":[66],"but":[67],"each":[68,84,187],"guideline":[69,85,188],"differs":[70],"from":[71],"others":[73,180],"relevant":[75],"details.":[76],"Therefore":[77],"conditions":[79,120],"justifying":[80],"according":[82],"to":[83,163,170,173],"are":[86],"focus":[89],"our":[91],"attention.":[92],"First,":[93],"we":[94,114],"will":[95,115],"first":[96],"formalized":[99],"general":[100],"principle":[101],"that":[102,159],"defines":[103],"acceptability":[106,201],"use":[109],"all":[111],"regulations.":[112],"Then":[113],"analyse":[116],"three":[117],"categories":[118],"put":[121],"forward":[122],"by":[123],"documents:":[126],"risk":[128,175],"harm":[130],"or":[131,196],"burden,":[132],"compelling":[133],"scientific":[134],"reasons,":[135],"availability":[138],"treatment.":[141],"analysis":[143],"shows":[144],"important":[145],"normative":[146,184],"discrepancies":[147],"contradictions":[149],"between":[150],"guidelines.":[153],"Especially":[154],"striking":[155],"fact":[158],"some":[160],"allow":[162],"expose":[164],"participants":[166],"be":[171],"exposed":[172],"serious":[177],"harm,":[178],"while":[179],"do":[181],"not.":[182],"difference":[185],"could":[189],"influence":[190],"strongly":[191],"decision":[193],"researchers":[195],"IRBs":[197],"use.":[204]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}