{"id":"https://openalex.org/W1498765613","doi":null,"title":"The intravitreal penetration of ceftriaxone in man following systemic administration.","display_name":"The intravitreal penetration of ceftriaxone in man following systemic administration.","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W1498765613","mag":"1498765613","pmid":"https://pubmed.ncbi.nlm.nih.gov/2793358"},"language":"en","primary_location":{"id":"pmid:2793358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2793358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076964552","display_name":"Mordechai Sharir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Sharir","raw_affiliation_strings":["Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035361116","display_name":"Giora Triester","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"G Triester","raw_affiliation_strings":["Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078735833","display_name":"Johannes Kneer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"J Kneer","raw_affiliation_strings":["Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799810450"]}]},{"author_position":"last","author":{"id":null,"display_name":"E Rubinstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"E Rubinstein","raw_affiliation_strings":["Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799810450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.06666667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"10","first_page":"2179","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceftriaxone","display_name":"ceftriaxone","score":1.0},{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.7350000143051147},{"id":"https://openalex.org/keywords/intramuscular-administration","display_name":"intramuscular administration","score":0.9210000038146973},{"id":"https://openalex.org/keywords/vitrectomy","display_name":"vitrectomy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/antibiotic-prophylaxis","display_name":"antibiotic prophylaxis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cephalosporins","display_name":"cephalosporins","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2776520383","wikidata":"https://www.wikidata.org/wiki/Q421713","display_name":"Ceftriaxone","level":3,"score":0.9866894483566284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8144742250442505},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6774035692214966},{"id":"https://openalex.org/C2776291583","wikidata":"https://www.wikidata.org/wiki/Q432083","display_name":"Intramuscular injection","level":2,"score":0.5412177443504333},{"id":"https://openalex.org/C3020081911","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Serum concentration","level":2,"score":0.47839581966400146},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4755648970603943},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46949484944343567},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.4388967454433441},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33749067783355713},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2699713110923767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23317649960517883},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.11407199501991272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08424210548400879},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002443","descriptor_name":"Ceftriaxone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002443","descriptor_name":"Ceftriaxone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2793358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2793358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:1498765613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2793358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W74578043","https://openalex.org/W1972599772","https://openalex.org/W1993455226","https://openalex.org/W1997149871","https://openalex.org/W2001506634","https://openalex.org/W2005784434","https://openalex.org/W2029389098","https://openalex.org/W2063883634","https://openalex.org/W2157378566","https://openalex.org/W2165894256","https://openalex.org/W2437007838"],"related_works":["https://openalex.org/W2063883634","https://openalex.org/W204032371","https://openalex.org/W2091928088","https://openalex.org/W2466198386","https://openalex.org/W2347664549","https://openalex.org/W2090735359","https://openalex.org/W2079106460","https://openalex.org/W2029526405","https://openalex.org/W2437826442","https://openalex.org/W2016886476"],"abstract_inverted_index":{"Seventeen":[0],"patients":[1,37],"who":[2],"underwent":[3],"vitreal":[4,97],"surgery":[5],"received":[6],"ceftriaxone":[7,26,43,50,75],"(Rocephin)":[8],"1-2":[9],"g":[10],"intramuscularly":[11],"at":[12,45,52],"various":[13],"time":[14,47],"intervals":[15],"before":[16],"surgery.":[17,98],"Specimens":[18],"of":[19,60],"serum":[20],"and":[21,31,67],"vitreous":[22,40,77,110],"were":[23,79],"assayed":[24],"for":[25,104],"concentrations":[27,44,78],"both":[28],"by":[29],"bioassay":[30],"high":[32],"pressure":[33],"liquid":[34],"chromatography.":[35],"All":[36],"had":[38],"detectable":[39],"(and":[41],"serum)":[42],"all":[46],"periods.":[48],"Vitreous":[49],"levels":[51],"the":[53,58,61,101,109],"first":[54,102],"4.5":[55],"hr":[56,73],"following":[57,74,113],"administration":[59,76,87],"antibiotic":[62,103],"ranged":[63],"from":[64],"1.4-19.4":[65],"micrograms/ml":[66],"averaged":[68],"5.9":[69],"micrograms/ml.":[70,83],"At":[71],"12-13":[72],"11.5":[80],"(+/-":[81],"9.0)":[82],"Ceftriaxone":[84,99],"in":[85,96],"intramuscular":[86,114],"could":[88],"be":[89],"used":[90],"as":[91],"prophylaxis":[92],"against":[93],"ceftriaxone-susceptible":[94],"microorganisms":[95],"is":[100,111],"which":[105],"reliable":[106],"penetration":[107],"into":[108],"demonstrable":[112],"administration.":[115]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
