{"id":"https://openalex.org/W1498103298","doi":"https://doi.org/10.4049/jimmunol.192.supp.50.7","title":"Inhibition of B lymphopoiesis by myeloid-derived suppressor cells (HEM2P.262)","display_name":"Inhibition of B lymphopoiesis by myeloid-derived suppressor cells (HEM2P.262)","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W1498103298","doi":"https://doi.org/10.4049/jimmunol.192.supp.50.7","mag":"1498103298"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.192.supp.50.7","doi":"https://doi.org/10.4049/jimmunol.192.supp.50.7","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.50.7","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047499110","display_name":"Domenick E. Kennedy","orcid":"https://orcid.org/0000-0002-5329-3711","observed_orcids":["https://orcid.org/0000-0002-5329-3711"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Domenick Kennedy","raw_affiliation_strings":["Microbiology and Immunology, Loyola University Chicago , Maywood, IL","1Microbiology and Immunology, Loyola University Chicago, Maywood, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, Loyola University Chicago , Maywood, IL","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"1Microbiology and Immunology, Loyola University Chicago, Maywood, IL","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054663414","display_name":"Katherine L. Knight","orcid":"https://orcid.org/0000-0003-2108-9457","observed_orcids":["https://orcid.org/0000-0003-2108-9457"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Knight","raw_affiliation_strings":["Microbiology and Immunology, Loyola University Chicago , Maywood, IL","1Microbiology and Immunology, Loyola University Chicago, Maywood, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, Loyola University Chicago , Maywood, IL","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"1Microbiology and Immunology, Loyola University Chicago, Maywood, IL","institution_ids":["https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1925986"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"192","issue":"Supplement_1","first_page":"50.7","last_page":"50.7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6949999928474426},{"id":"https://openalex.org/keywords/bone-marrow-adipose-tissue","display_name":"bone marrow adipose tissue","score":0.8379999995231628},{"id":"https://openalex.org/keywords/adipocyte-conditioned-medium","display_name":"adipocyte-conditioned medium","score":0.9160000085830688},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.8059999942779541},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cd4-t-cell-proliferation","display_name":"CD4+ T cell proliferation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/op9-stromal-cells","display_name":"OP9 stromal cells","score":0.6940000057220459},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.9102945327758789},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.6333781480789185},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6330252885818481},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5942778587341309},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5643421411514282},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5480556488037109},{"id":"https://openalex.org/C95862172","wikidata":"https://www.wikidata.org/wiki/Q9032597","display_name":"Myelopoiesis","level":4,"score":0.503074586391449},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45788705348968506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4496040940284729},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4319573938846588},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3923177421092987},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3921352028846741},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.38179588317871094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34587645530700684},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.32110005617141724},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.2815595269203186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2534080743789673},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12609511613845825},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.192.supp.50.7","doi":"https://doi.org/10.4049/jimmunol.192.supp.50.7","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.192.supp.50.7","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.41999998688697815}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2353206122","https://openalex.org/W1903506892","https://openalex.org/W2779750417","https://openalex.org/W2310479017","https://openalex.org/W2161434346","https://openalex.org/W4313385673","https://openalex.org/W2304405248","https://openalex.org/W7133126661","https://openalex.org/W2975556782","https://openalex.org/W2732589699"],"abstract_inverted_index":{"Abstract":[0],"B":[1,15,60,107,149,170,182],"lymphopoiesis":[2,16,61,150,171,183],"declines":[3],"with":[4,27,79],"age":[5,24],"in":[6,30,33,45,62,110,184],"humans,":[7],"mice,":[8],"and":[9,25,51,120,123,141,172],"rabbits.":[10],"In":[11],"rabbits,":[12],"loss":[13],"of":[14,23,48,75,95,148,166],"occurs":[17,70],"as":[18,20],"early":[19],"two":[21],"months":[22],"correlates":[26],"an":[28],"increase":[29],"adipose":[31,39],"tissue":[32,40],"the":[34,46,65,91],"bone":[35],"marrow":[36],"(BM).":[37],"Increased":[38],"has":[41],"also":[42],"been":[43],"observed":[44],"BM":[47,77],"aged":[49,185],"humans":[50],"mice.":[52],"We":[53],"showed":[54],"previously":[55,163],"that":[56,85,103,131,146],"adipocyte-derived":[57],"factors":[58],"inhibit":[59,106,169],"vitro;":[63],"however,":[64],"mechanism":[66],"by":[67,151],"which":[68],"this":[69],"is":[71,154],"unknown.":[72],"Through":[73],"co-cultures":[74],"mouse":[76],"cells":[78,105,116,133,138],"OP9":[80],"stromal":[81],"cells,":[82],"we":[83,101],"found":[84,102],"adipocyte":[86],"conditioned":[87,142],"medium":[88,143],"(ACM)":[89],"induces":[90],"generation":[92],"or":[93],"expansion":[94],"CD11b+":[96,114],"Gr1+":[97,115],"myeloid":[98],"cells.":[99],"Further,":[100],"these":[104,132],"cell":[108,128],"development":[109],"vitro.":[111],"The":[112],"ACM-induced":[113,152],"express":[117],"arginase":[118],"(Arg1)":[119],"iNos":[121],"(Nos2),":[122],"functionally":[124],"suppress":[125],"CD4+":[126],"T":[127],"proliferation,":[129],"suggesting":[130],"are":[134],"classical":[135],"myeloid-derived":[136],"suppressor":[137],"(MDSCs).":[139],"Transwell":[140],"experiments":[144],"show":[145],"inhibition":[147],"MDSCs":[153,167],"mediated":[155],"through":[156],"soluble":[157],"factors.":[158],"This":[159],"study":[160],"uncovers":[161],"a":[162,174],"unrecognized":[164],"capacity":[165],"to":[168],"provides":[173],"potential":[175],"target":[176],"for":[177],"therapeutics":[178],"aimed":[179],"at":[180],"restoring":[181],"individuals.":[186]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}