{"id":"https://openalex.org/W1498098174","doi":"https://doi.org/10.4049/jimmunol.160.10.5136","title":"Quercetin Sensitizes RBL-2H3 Cells to Polybasic Mast Cell Secretagogues Through Increased Expression of Gi GTP-Binding Proteins Linked to a Phospholipase C Signaling Pathway","display_name":"Quercetin Sensitizes RBL-2H3 Cells to Polybasic Mast Cell Secretagogues Through Increased Expression of Gi GTP-Binding Proteins Linked to a Phospholipase C Signaling Pathway","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W1498098174","doi":"https://doi.org/10.4049/jimmunol.160.10.5136","mag":"1498098174","pmid":"https://pubmed.ncbi.nlm.nih.gov/9590266"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.160.10.5136","doi":"https://doi.org/10.4049/jimmunol.160.10.5136","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.160.10.5136","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jan Senyshyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Senyshyn","raw_affiliation_strings":["Laboratory of Molecular Immunology, National Institute of Heart, Lung, and Blood Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, National Institute of Heart, Lung, and Blood Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024058644","display_name":"Rudolf A. Baumgartner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rudolf A Baumgartner","raw_affiliation_strings":["Laboratory of Molecular Immunology, National Institute of Heart, Lung, and Blood Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, National Institute of Heart, Lung, and Blood Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039320260","display_name":"Michael A. Beaven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Beaven","raw_affiliation_strings":["Laboratory of Molecular Immunology, National Institute of Heart, Lung, and Blood Diseases, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunology, National Institute of Heart, Lung, and Blood Diseases, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.6453,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.83964466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"160","issue":"10","first_page":"5136","last_page":"5144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/compound-48-80","display_name":"compound 48/80","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mast-cell-secretion","display_name":"mast cell secretion","score":0.7210000157356262},{"id":"https://openalex.org/keywords/g-protein-alpha-subunit","display_name":"G protein alpha subunit","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/phospholipase-c-beta3","display_name":"phospholipase C beta3","score":0.847000002861023},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8700000047683716},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.7549999952316284},{"id":"https://openalex.org/keywords/phosphoinositide-hydrolysis","display_name":"phosphoinositide hydrolysis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mastoparan","display_name":"mastoparan","score":0.6809999942779541},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9649999737739563},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.650406539440155},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6371439099311829},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.6371287107467651},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.5898801684379578},{"id":"https://openalex.org/C2778492296","wikidata":"https://www.wikidata.org/wiki/Q27147837","display_name":"Mastoparan","level":4,"score":0.5883420705795288},{"id":"https://openalex.org/C66135807","wikidata":"https://www.wikidata.org/wiki/Q24726231","display_name":"Gq alpha subunit","level":4,"score":0.5468882322311401},{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.5285478830337524},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5229343175888062},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.5139257907867432},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4917958080768585},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.45664143562316895},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4341578781604767},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4174676835536957},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41240814328193665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3869014382362366},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.35317325592041016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30486929416656494},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13113906979560852},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07246917486190796}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003189","descriptor_name":"p-Methoxy-N-methylphenethylamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010566","descriptor_name":"Virulence Factors, Bordetella","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D037342","descriptor_name":"Pertussis Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.160.10.5136","doi":"https://doi.org/10.4049/jimmunol.160.10.5136","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.160.10.5136","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:9590266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9590266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W131860850","https://openalex.org/W606928838","https://openalex.org/W1451010299","https://openalex.org/W1484139187","https://openalex.org/W1493349125","https://openalex.org/W1499632436","https://openalex.org/W1503009363","https://openalex.org/W1503670912","https://openalex.org/W1521095349","https://openalex.org/W1530970237","https://openalex.org/W1541467765","https://openalex.org/W1541640909","https://openalex.org/W1545295983","https://openalex.org/W1553372211","https://openalex.org/W1560318935","https://openalex.org/W1560506719","https://openalex.org/W1572564124","https://openalex.org/W1576671418","https://openalex.org/W1589012667","https://openalex.org/W1598950170","https://openalex.org/W1680232320","https://openalex.org/W1704017123","https://openalex.org/W1708853430","https://openalex.org/W1843679593","https://openalex.org/W1935292442","https://openalex.org/W1974555059","https://openalex.org/W1977797021","https://openalex.org/W1977869870","https://openalex.org/W1981182586","https://openalex.org/W1987288311","https://openalex.org/W1988510980","https://openalex.org/W1996755579","https://openalex.org/W1998851722","https://openalex.org/W2001417329","https://openalex.org/W2004351423","https://openalex.org/W2014231457","https://openalex.org/W2030579890","https://openalex.org/W2037111992","https://openalex.org/W2041333313","https://openalex.org/W2041772576","https://openalex.org/W2045917231","https://openalex.org/W2049726997","https://openalex.org/W2051982486","https://openalex.org/W2057887597","https://openalex.org/W2059588956","https://openalex.org/W2068954050","https://openalex.org/W2070706524","https://openalex.org/W2072159809","https://openalex.org/W2072560747","https://openalex.org/W2073259676","https://openalex.org/W2082192343","https://openalex.org/W2087075582","https://openalex.org/W2093351462","https://openalex.org/W2097633303","https://openalex.org/W2099853519","https://openalex.org/W2127968039","https://openalex.org/W2173878330","https://openalex.org/W2181273178","https://openalex.org/W2199103571","https://openalex.org/W2267761447","https://openalex.org/W2270408884","https://openalex.org/W2289432398","https://openalex.org/W2312624006","https://openalex.org/W4298134572","https://openalex.org/W4313317760","https://openalex.org/W4416702902"],"related_works":["https://openalex.org/W1967917712","https://openalex.org/W1908128102","https://openalex.org/W1996887015","https://openalex.org/W2125093361","https://openalex.org/W7097229911","https://openalex.org/W2081679791","https://openalex.org/W1936847024","https://openalex.org/W2065475630","https://openalex.org/W2070706524","https://openalex.org/W2415664290"],"abstract_inverted_index":{"Polybasic":[0],"secretagogues":[1],"such":[2],"as":[3,39],"mastoparan,":[4],"compound":[5,131],"48/80,":[6],"substance":[7],"P,":[8],"and":[9,82,94,109,118,143],"somatostatin":[10],"stimulate":[11],"secretion":[12,86,112,133],"in":[13,59,69,98,110,134,162],"rat":[14],"peritoneal":[15],"mast":[16,29,135],"cells":[17,30,136,164],"through":[18],"direct":[19],"activation":[20],"of":[21,72,75,92,167],"the":[22,49,70,76,119],"heterotrimeric":[23],"G":[24,79],"protein,":[25],"G(i-3).":[26,83],"Cultured":[27],"RBL-2H3":[28,60,163],"do":[31,43],"not":[32],"normally":[33],"respond":[34],"to":[35,48,170],"these":[36],"secretagogues,":[37],"but,":[38],"reported":[40],"here,":[41],"they":[42],"so":[44],"after":[45],"prolonged":[46],"exposure":[47],"kinase":[50,121,145],"inhibitor,":[51,54,123],"quercetin.":[52],"This":[53],"which":[55],"causes":[56],"phenotypic":[57],"changes":[58],"cells,":[61],"induces":[62],"a":[63,95,128],"substantial":[64],"increase":[65,97],"(more":[66],"than":[67],"sevenfold)":[68],"expression":[71],"alpha":[73],"subunits":[74,166],"pertussis":[77,107],"toxin-sensitive":[78],"proteins,":[80],"G(i-2)":[81],"Compound":[84],"48/80-induced":[85,132],"is":[87,113],"associated":[88],"with":[89],"transient":[90,96],"hydrolysis":[91],"phosphoinositides":[93],"cytosolic":[99],"calcium":[100,116],"ions.":[101],"These":[102,125],"responses":[103],"are":[104],"inhibited":[105],"by":[106,115,165],"toxin,":[108],"addition,":[111],"blocked":[114],"chelation":[117],"protein":[120,144],"C":[122],"Ro31-7549.":[124],"results":[126,148],"delineate":[127],"pathway":[129],"for":[130],"via":[137],"Gi":[138,168],"protein(s),":[139],"phospholipase":[140,152,156],"C,":[141,153],"calcium,":[142],"C.":[146],"The":[147],"also":[149],"imply":[150],"that":[151],"most":[154],"likely":[155],"Cbeta3,":[157],"can":[158],"be":[159],"transiently":[160],"activated":[161],"proteins":[169],"induce":[171],"cellular":[172],"responses.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}