{"id":"https://openalex.org/W1498044569","doi":null,"title":"Mitochondrial transport regulation in Parkinson\u2019s disease","display_name":"Mitochondrial transport regulation in Parkinson\u2019s disease","publication_year":2015,"publication_date":"2015-04-28","ids":{"openalex":"https://openalex.org/W1498044569","mag":"1498044569"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1461035","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1461035/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062446287","display_name":"Nicol Birsa","orcid":"https://orcid.org/0000-0002-8271-540X","observed_orcids":["https://orcid.org/0000-0002-8271-540X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nicol Birsa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062446287"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mitochondrial-transport","display_name":"mitochondrial transport","score":0.9610000252723694},{"id":"https://openalex.org/keywords/miro1","display_name":"Miro1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":1.0},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mitochondrial-quality-control","display_name":"mitochondrial quality control","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.753000020980835},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/outer-mitochondrial-membrane","display_name":"mitochondrial outer membrane","score":0.6700000166893005},{"id":"https://openalex.org/keywords/kinesin-motor-protein","display_name":"kinesin motor protein","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.9739165902137756},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.9317114949226379},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.8309646844863892},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6699103713035583},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6234489679336548},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.6126500964164734},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5491079688072205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.539096474647522},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4256768226623535},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2714153528213501},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.23541483283042908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.215535968542099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08184036612510681},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05253550410270691},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.051431894302368164},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1461035","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1461035/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:1498044569","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1461035/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135309234","https://openalex.org/W2472312437","https://openalex.org/W2903556244","https://openalex.org/W2148819754","https://openalex.org/W2149090315","https://openalex.org/W4411712603","https://openalex.org/W2891893589","https://openalex.org/W2050653572","https://openalex.org/W2953975624","https://openalex.org/W2524324468"],"abstract_inverted_index":{"Mitochondrial":[0],"transport":[1,253],"plays":[2],"an":[3,20],"important":[4],"role":[5],"in":[6,73,75,143,187,268],"matching":[7],"mitochondrial":[8,22,35,77,84,158,252],"distribution":[9],"to":[10,46,49,56,124,135,193],"localised":[11],"energy":[12],"production":[13],"and":[14,63,104,172,257],"calcium":[15],"buffering":[16],"requirements.":[17],"Miro":[18,231],"is":[19,82,133,178,191,214,232],"outer":[21],"membrane":[23],"(OMM)":[24],"protein":[25],"that,":[26],"via":[27],"its":[28],"interaction":[29],"with":[30],"the":[31,38,93,99,113,121,125,140,150,167,205,227,246,250],"kinesin":[32],"motors,":[33],"mediates":[34],"trafficking":[36],"along":[37],"cytoskeletal":[39],"tracks.":[40],"Mitochondria,":[41],"however,":[42],"not":[43,60],"only":[44],"need":[45,55],"be":[47,57,136,194,266],"delivered":[48],"specific":[50],"cellular":[51],"sites,":[52],"but":[53,202],"also":[54,233,258],"retrieved":[58],"when":[59],"functional.":[61],"PINK1":[62,81,95,171],"Parkin":[64,115,212,225,237],"are":[65],"two":[66],"Parkinson\u2019s":[67],"disease":[68],"(PD)-associated":[69],"proteins":[70],"that":[71,157,213,230,260],"work":[72],"concert":[74],"a":[76,83,107,137,182,236],"quality":[78],"control":[79],"system.":[80],"serine-threonine":[85],"kinase":[86],"generally":[87],"present":[88],"at":[89,199],"low":[90],"levels":[91],"on":[92,98,120,166,170,181,204,226],"OMM.":[94],"selectively":[96],"accumulates":[97],"OMM":[100],"of":[101,127,139,149,152,164,176,196,224,235,249,262],"damaged":[102],"mitochondria,":[103],"recruits":[105],"Parkin,":[106],"cytosolic":[108],"E3":[109],"ubiquitin":[110],"ligase":[111],"from":[112],"cytosol.":[114],"then":[116,179],"ubiquitinates":[117],"several":[118],"substrates":[119],"OMM,":[122,168,228],"leading":[123],"initiation":[126],"mitophagy.":[128],"In":[129],"this":[130,263],"thesis":[131],"Miro1":[132,153,165,177,185,197,219],"shown":[134],"substrate":[138],"PINK1/Parkin":[141,256],"pathway":[142],"human":[144],"dopaminergic":[145,188],"neuroblastoma":[146,189],"cells.":[147],"Analysis":[148],"kinetics":[151],"ubiquitination,":[154],"further":[155],"demonstrates":[156],"damage":[159],"triggers":[160],"rapid":[161],"K27-type":[162],"ubiquitination":[163,186],"dependent":[169,203],"Parkin.":[173],"Proteasomal":[174],"degradation":[175],"seen":[180],"slower":[183],"timescale.":[184],"cells":[190],"found":[192],"independent":[195],"phosphorylation":[198],"serine":[200,208],"156,":[201],"recently":[206],"identified":[207],"65":[209],"residue":[210],"within":[211],"phosphorylated":[215],"by":[216,255],"PINK1.":[217],"Interestingly,":[218],"can":[220],"stabilise":[221],"phospho-mutant":[222],"versions":[223],"suggesting":[229],"part":[234],"receptor":[238],"complex.":[239],"These":[240],"results":[241],"provide":[242],"new":[243],"insights":[244],"into":[245],"ubiquitination-dependent":[247],"regulation":[248,264],"Miro-mediated":[251],"machinery":[254],"suggest":[259],"disruption":[261],"may":[265],"implicated":[267],"PD":[269],"pathogenesis.":[270]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
